ZA200410286B - Chewable soft capsule. - Google Patents

Chewable soft capsule. Download PDF

Info

Publication number: ZA200410286B
Authority: ZA; South Africa
Prior art keywords: capsule; gelatin; agent; starch; aqueous solution
Prior art date: 2002-06-07

Application number

ZA200410286A

Other languages

English (en)

Inventor

Hirokazu Makino

Hideo Suzuki

Yoko Sumino

Tomohisa Mastushita

Original Assignee

Scherer Technologies Inc R P

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-06-07

Filing date

2004-12-21

Publication date

2005-10-10

2004-12-21 Application filed by Scherer Technologies Inc R P filed Critical Scherer Technologies Inc R P

2005-10-10 Publication of ZA200410286B publication Critical patent/ZA200410286B/en

Links

239000007901 soft capsule Substances 0.000 title description 4
239000002775 capsule Substances 0.000 claims description 104
108010010803 Gelatin Proteins 0.000 claims description 93
229920000159 gelatin Polymers 0.000 claims description 93
235000019322 gelatine Nutrition 0.000 claims description 93
235000011852 gelatine desserts Nutrition 0.000 claims description 93
239000008273 gelatin Substances 0.000 claims description 87
239000003795 chemical substances by application Substances 0.000 claims description 60
239000000499 gel Substances 0.000 claims description 54
PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 48
239000007903 gelatin capsule Substances 0.000 claims description 38
239000004014 plasticizer Substances 0.000 claims description 38
229920002472 Starch Polymers 0.000 claims description 37
235000019698 starch Nutrition 0.000 claims description 37
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 37
239000008107 starch Substances 0.000 claims description 36
239000000203 mixture Substances 0.000 claims description 35
230000007704 transition Effects 0.000 claims description 35
239000007864 aqueous solution Substances 0.000 claims description 34
241000251468 Actinopterygii Species 0.000 claims description 23
235000011187 glycerol Nutrition 0.000 claims description 22
229920002261 Corn starch Polymers 0.000 claims description 19
239000008120 corn starch Substances 0.000 claims description 19
239000000463 material Substances 0.000 claims description 14
229920000881 Modified starch Polymers 0.000 claims description 11
239000011248 coating agent Substances 0.000 claims description 11
238000000576 coating method Methods 0.000 claims description 11
229920005862 polyol Polymers 0.000 claims description 8
150000003077 polyols Chemical group 0.000 claims description 8
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 7
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 7
239000000600 sorbitol Substances 0.000 claims description 7
239000003086 colorant Substances 0.000 claims description 5
229920001592 potato starch Polymers 0.000 claims description 3
238000003860 storage Methods 0.000 description 20
238000004519 manufacturing process Methods 0.000 description 18
102000008186 Collagen Human genes 0.000 description 12
108010035532 Collagen Proteins 0.000 description 12
238000009472 formulation Methods 0.000 description 12
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 11
229920001436 collagen Polymers 0.000 description 11
238000012360 testing method Methods 0.000 description 11
238000002474 experimental method Methods 0.000 description 10
239000002253 acid Substances 0.000 description 9
238000000034 method Methods 0.000 description 9
239000000843 powder Substances 0.000 description 8
108010011485 Aspartame Proteins 0.000 description 7
239000000605 aspartame Substances 0.000 description 7
235000010357 aspartame Nutrition 0.000 description 7
IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 7
229960003438 aspartame Drugs 0.000 description 7
239000001913 cellulose Substances 0.000 description 7
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235000010980 cellulose Nutrition 0.000 description 7
235000018102 proteins Nutrition 0.000 description 7
102000004169 proteins and genes Human genes 0.000 description 7
108090000623 proteins and genes Proteins 0.000 description 7
238000004090 dissolution Methods 0.000 description 6
239000000126 substance Substances 0.000 description 6
OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 6
241001465754 Metazoa Species 0.000 description 5
239000003814 drug Substances 0.000 description 5
230000008569 process Effects 0.000 description 5
239000000047 product Substances 0.000 description 5
239000000243 solution Substances 0.000 description 5
ZFOZVQLOBQUTQQ-UHFFFAOYSA-N Tributyl citrate Chemical compound CCCCOC(=O)CC(O)(C(=O)OCCCC)CC(=O)OCCCC ZFOZVQLOBQUTQQ-UHFFFAOYSA-N 0.000 description 4
239000000654 additive Substances 0.000 description 4
239000007902 hard capsule Substances 0.000 description 4
230000007935 neutral effect Effects 0.000 description 4
229920001223 polyethylene glycol Polymers 0.000 description 4
108090000765 processed proteins & peptides Proteins 0.000 description 4
241000251730 Chondrichthyes Species 0.000 description 3
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 3
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
229930195725 Mannitol Natural products 0.000 description 3
244000061456 Solanum tuberosum Species 0.000 description 3
235000002595 Solanum tuberosum Nutrition 0.000 description 3
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
229930006000 Sucrose Natural products 0.000 description 3
230000015572 biosynthetic process Effects 0.000 description 3
210000000988 bone and bone Anatomy 0.000 description 3
230000008859 change Effects 0.000 description 3
230000001055 chewing effect Effects 0.000 description 3
239000007788 liquid Substances 0.000 description 3
239000000594 mannitol Substances 0.000 description 3
235000010355 mannitol Nutrition 0.000 description 3
238000012545 processing Methods 0.000 description 3
239000005720 sucrose Substances 0.000 description 3
CDOUZKKFHVEKRI-UHFFFAOYSA-N 3-bromo-n-[(prop-2-enoylamino)methyl]propanamide Chemical compound BrCCC(=O)NCNC(=O)C=C CDOUZKKFHVEKRI-UHFFFAOYSA-N 0.000 description 2
229920000856 Amylose Polymers 0.000 description 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
241000283690 Bos taurus Species 0.000 description 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
239000005715 Fructose Substances 0.000 description 2
229930091371 Fructose Natural products 0.000 description 2
RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 2
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
239000002202 Polyethylene glycol Substances 0.000 description 2
DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 description 2
235000010724 Wisteria floribunda Nutrition 0.000 description 2
TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 2
150000001298 alcohols Chemical class 0.000 description 2
239000007963 capsule composition Substances 0.000 description 2
238000005266 casting Methods 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 description 2
238000001035 drying Methods 0.000 description 2
238000010410 dusting Methods 0.000 description 2
238000005538 encapsulation Methods 0.000 description 2
238000011156 evaluation Methods 0.000 description 2
239000003337 fertilizer Substances 0.000 description 2
235000013305 food Nutrition 0.000 description 2
235000013373 food additive Nutrition 0.000 description 2
239000002778 food additive Substances 0.000 description 2
235000003599 food sweetener Nutrition 0.000 description 2
230000006870 function Effects 0.000 description 2
238000001879 gelation Methods 0.000 description 2
239000000416 hydrocolloid Substances 0.000 description 2
238000002844 melting Methods 0.000 description 2
230000008018 melting Effects 0.000 description 2
HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 2
229920001206 natural gum Polymers 0.000 description 2
239000002994 raw material Substances 0.000 description 2
230000002441 reversible effect Effects 0.000 description 2
210000003296 saliva Anatomy 0.000 description 2
239000007787 solid Substances 0.000 description 2
230000000638 stimulation Effects 0.000 description 2
239000003765 sweetening agent Substances 0.000 description 2
239000006188 syrup Substances 0.000 description 2
235000020357 syrup Nutrition 0.000 description 2
239000001069 triethyl citrate Substances 0.000 description 2
VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 2
235000013769 triethyl citrate Nutrition 0.000 description 2
239000002699 waste material Substances 0.000 description 2
238000005303 weighing Methods 0.000 description 2
239000000811 xylitol Substances 0.000 description 2
HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 2
235000010447 xylitol Nutrition 0.000 description 2
229960002675 xylitol Drugs 0.000 description 2
FALRKNHUBBKYCC-UHFFFAOYSA-N 2-(chloromethyl)pyridine-3-carbonitrile Chemical compound ClCC1=NC=CC=C1C#N FALRKNHUBBKYCC-UHFFFAOYSA-N 0.000 description 1
229920001685 Amylomaize Polymers 0.000 description 1
206010002383 Angina Pectoris Diseases 0.000 description 1
229920006310 Asahi-Kasei Polymers 0.000 description 1
DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
229920001353 Dextrin Polymers 0.000 description 1
239000004375 Dextrin Substances 0.000 description 1
108010028690 Fish Proteins Proteins 0.000 description 1
239000004471 Glycine Substances 0.000 description 1
229920000569 Gum karaya Polymers 0.000 description 1
101000582320 Homo sapiens Neurogenic differentiation factor 6 Proteins 0.000 description 1
DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 1
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
240000007472 Leucaena leucocephala Species 0.000 description 1
235000010643 Leucaena leucocephala Nutrition 0.000 description 1
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235000016735 Manihot esculenta subsp esculenta Nutrition 0.000 description 1
241001214257 Mene Species 0.000 description 1
235000006679 Mentha X verticillata Nutrition 0.000 description 1
235000002899 Mentha suaveolens Nutrition 0.000 description 1
235000001636 Mentha x rotundifolia Nutrition 0.000 description 1
102100030589 Neurogenic differentiation factor 6 Human genes 0.000 description 1
240000009305 Pometia pinnata Species 0.000 description 1
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ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
101150107341 RERE gene Proteins 0.000 description 1
241000934878 Sterculia Species 0.000 description 1
241000282887 Suidae Species 0.000 description 1
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 1
241000209140 Triticum Species 0.000 description 1
235000021307 Triticum Nutrition 0.000 description 1
QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
240000008042 Zea mays Species 0.000 description 1
235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
235000002017 Zea mays subsp mays Nutrition 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
230000000996 additive effect Effects 0.000 description 1
230000001464 adherent effect Effects 0.000 description 1
150000001299 aldehydes Chemical class 0.000 description 1
239000003513 alkali Substances 0.000 description 1
235000001014 amino acid Nutrition 0.000 description 1
229940024606 amino acid Drugs 0.000 description 1
150000001413 amino acids Chemical class 0.000 description 1
238000013459 approach Methods 0.000 description 1
229960001230 asparagine Drugs 0.000 description 1
235000009582 asparagine Nutrition 0.000 description 1
238000003556 assay Methods 0.000 description 1
235000015278 beef Nutrition 0.000 description 1
238000009835 boiling Methods 0.000 description 1
150000001768 cations Chemical class 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
235000019864 coconut oil Nutrition 0.000 description 1
239000003240 coconut oil Substances 0.000 description 1
239000013065 commercial product Substances 0.000 description 1
238000013329 compounding Methods 0.000 description 1
238000001816 cooling Methods 0.000 description 1
235000005822 corn Nutrition 0.000 description 1
229910021488 crystalline silicon dioxide Inorganic materials 0.000 description 1
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238000004925 denaturation Methods 0.000 description 1
230000036425 denaturation Effects 0.000 description 1
230000006866 deterioration Effects 0.000 description 1
235000019425 dextrin Nutrition 0.000 description 1
239000007884 disintegrant Substances 0.000 description 1
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239000002552 dosage form Substances 0.000 description 1
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239000003797 essential amino acid Substances 0.000 description 1
235000020776 essential amino acid Nutrition 0.000 description 1
230000001747 exhibiting effect Effects 0.000 description 1
235000012041 food component Nutrition 0.000 description 1
239000005417 food ingredient Substances 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
239000011521 glass Substances 0.000 description 1
239000003292 glue Substances 0.000 description 1
ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
230000007062 hydrolysis Effects 0.000 description 1
238000006460 hydrolysis reaction Methods 0.000 description 1
210000000936 intestine Anatomy 0.000 description 1
239000000231 karaya gum Substances 0.000 description 1
235000010494 karaya gum Nutrition 0.000 description 1
229940039371 karaya gum Drugs 0.000 description 1
238000007567 mass-production technique Methods 0.000 description 1
230000018984 mastication Effects 0.000 description 1
238000010077 mastication Methods 0.000 description 1
150000004667 medium chain fatty acids Chemical class 0.000 description 1
239000012528 membrane Substances 0.000 description 1
229930182817 methionine Natural products 0.000 description 1
239000003094 microcapsule Substances 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
239000006187 pill Substances 0.000 description 1
238000005498 polishing Methods 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
238000007670 refining Methods 0.000 description 1
235000019613 sensory perceptions of taste Nutrition 0.000 description 1
239000003352 sequestering agent Substances 0.000 description 1
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229940014800 succinic anhydride Drugs 0.000 description 1
230000000153 supplemental effect Effects 0.000 description 1
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235000019586 texture sensation Nutrition 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
238000000108 ultra-filtration Methods 0.000 description 1
238000007738 vacuum evaporation Methods 0.000 description 1
229940100445 wheat starch Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Medicinal Preparation (AREA)
General Preparation And Processing Of Foods (AREA)
Grain Derivatives (AREA)
Jellies, Jams, And Syrups (AREA)
Medical Preparation Storing Or Oral Administration Devices (AREA)

ZA200410286A 2002-06-07 2004-12-21 Chewable soft capsule. ZA200410286B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2002167041A JP4226846B2 (ja)	2002-06-07	2002-06-07	口腔内で崩壊可能なソフトカプセル剤

Publications (1)

Publication Number	Publication Date
ZA200410286B true ZA200410286B (en)	2005-10-10

Family

ID=29727651

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200410286A ZA200410286B (en)	2002-06-07	2004-12-21	Chewable soft capsule.

Country Status (8)

Country	Link
US (1)	US20030232076A1 (de)
EP (1)	EP1534249B1 (de)
JP (1)	JP4226846B2 (de)
AU (1)	AU2003273932B2 (de)
MX (1)	MXPA05000280A (de)
NO (1)	NO20045551L (de)
WO (1)	WO2003103639A1 (de)
ZA (1)	ZA200410286B (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6616942B1 (en)	1999-03-29	2003-09-09	Soft Gel Technologies, Inc.	Coenzyme Q10 formulation and process methodology for soft gel capsules manufacturing
ES2665464T3 (es) *	2003-03-28	2018-04-25	Sigmoid Pharma Limited	Forma de dosificación oral sólida que contiene microcápsulas sin costuras
US8124072B2 (en)	2003-09-29	2012-02-28	Soft Gel Technologies, Inc.	Solubilized CoQ-10
US8105583B2 (en)	2003-09-29	2012-01-31	Soft Gel Technologies, Inc.	Solubilized CoQ-10
US7169385B2 (en)	2003-09-29	2007-01-30	Ronald G. Udell	Solubilized CoQ-10 and carnitine
US9241902B2 (en) *	2003-12-17	2016-01-26	R.P. Scherer Technologies, Llc	Chewable soft capsules containing ungelatinized starch
DE602005001881T2 (de) *	2004-04-15	2008-04-24	Reg Toronto MacQuarrie	Essbare Filmüberzugzusammensetzung für Lebensmittelherstellung
EP1802287A2 (de) *	2004-09-27	2007-07-04	Sigmoid Biotechnologies Limited	Minikapsel-formulierungen
US20060275361A1 (en) *	2005-06-03	2006-12-07	Cadbury Adams Usa Llc.	Rapidly dissolving gelatin compositions and products made therefrom
US20070292501A1 (en) *	2006-06-05	2007-12-20	Udell Ronald G	Chewable soft gelatin capsules
US20080020022A1 (en) *	2006-06-05	2008-01-24	Udell Ronald G	Chewable co-enzyme q-10 capsule
US7908992B2 (en) *	2007-01-09	2011-03-22	R.P. Scherer Technologies, Llc	System and method for dusting soft capsules
US8343541B2 (en)	2007-03-15	2013-01-01	Soft Gel Technologies, Inc.	Ubiquinol and alpha lipoic acid compositions
ES2393814T3 (es)	2007-04-04	2012-12-28	Sigmoid Pharma Limited	Una composición farmacéutica oral
CA2685118C (en) *	2007-04-26	2016-11-01	Sigmoid Pharma Limited	Manufacture of multiple minicapsules
WO2008132712A2 (en) *	2007-05-01	2008-11-06	Sigmoid Pharma Limited	Combination pharmaceutical compositions
GB0801643D0 (en) *	2008-01-29	2008-03-05	Probio Nutraceuticals As	Product
US20100092548A1 (en)	2008-08-28	2010-04-15	Viva Pharmaceuticals Inc.	Chewable softgel capsules
ES2530049T3 (es)	2009-05-18	2015-02-26	Sigmoid Pharma Limited	Composición que comprende gotas de aceite
CN102573802A (zh)	2009-08-12	2012-07-11	希格默伊德药业有限公司	包含聚合物基质和油相的免疫调节组合物
GB201020032D0 (en)	2010-11-25	2011-01-12	Sigmoid Pharma Ltd	Composition
CN102525994A (zh) *	2010-12-10	2012-07-04	上海春芝堂生物制品有限公司	一种鱼明胶软胶囊及其制备方法
CN102813275B (zh) *	2011-06-10	2015-09-30	杭州养生堂保健品有限公司	一种咀嚼型软胶囊皮和咀嚼型软胶囊
US9474513B2 (en)	2011-06-30	2016-10-25	Karl Storz Gmbh & Co. Kg	Medical manipulator
US10087401B2 (en)	2012-03-16	2018-10-02	Monosol, Llc	Water soluble compositions incorporating enzymes, and method of making same
US9394092B2 (en)	2012-04-16	2016-07-19	Monosol, Llc	Powdered pouch and method of making same
GB201212010D0 (en)	2012-07-05	2012-08-22	Sigmoid Pharma Ltd	Formulations
CN103784418A (zh) *	2012-10-26	2014-05-14	中国科学院烟台海岸带研究所	一种鱼皮明胶空心胶囊及其制备方法
GB201319791D0 (en)	2013-11-08	2013-12-25	Sigmoid Pharma Ltd	Formulations
JP6716582B2 (ja)	2014-11-07	2020-07-01	サブリミティ・セラピューティクス・リミテッドＳｕｂｌｉｍｉｔｙＴｈｅｒａｐｅｕｔｉｃｓＬｉｍｉｔｅｄ	シクロスポリンを含む組成物
BR112017022523B1 (pt)	2015-04-23	2023-12-19	Basf Se	Formulação para cápsulas de gel, cápsula de gel, e, processo para produção de uma formulação
CN105412044B (zh) *	2015-12-31	2018-10-30	广东国方医药科技有限公司	一种含纳米SiO2的空心胶囊及其制备方法
JP6942342B2 (ja) *	2016-11-02	2021-09-29	富士カプセル株式会社	ソフトカプセル皮膜
CN106561963B (zh) *	2016-11-16	2020-10-09	上海应用技术大学	一种含有明胶-辛烯基琥珀酸淀粉酯-l-薄荷醇微胶囊的口香糖及其制备方法
CN113447356B (zh) *	2021-07-12	2022-02-18	广州白云山星群(药业)股份有限公司	一种软胶囊囊皮机械性能测试方法及设备
KR102694863B1 (ko) *	2024-01-25	2024-08-13	콜마비앤에이치 주식회사	라폰티신을 포함하는 안정성이 개선된 연질 캡슐 조성물

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US24678A (en) *		1859-07-05		Cast-ikon tike fob railroad-wheels
NL63297C (de) *	1947-01-11
JPS5279020A (en) *	1975-12-25	1977-07-02	Tsumura Juntendo Kk	Production of starch capsule
DE3529694A1 (de) *	1985-08-20	1987-02-26	Scherer Gmbh R P	Gelatinekapseln und verfahren zu ihrer herstellung
US4935243A (en) *	1988-12-19	1990-06-19	Pharmacaps, Inc.	Chewable, edible soft gelatin capsule
US4953243A (en) *	1989-08-09	1990-09-04	Amedco Health Care, Inc.	Electronic control with emergency CPR feature for adjustable bed
JPH03255024A (ja) *	1990-03-05	1991-11-13	Tokai Capsule Kk	口中易溶軟カプセル剤
EP0559827B1 (de) *	1990-11-28	1997-08-27	R.P. Scherer Corporation	Gelatinkapseln substituiert durch stärke mit hohem amyloseanteil
JPH06218028A (ja) *	1992-10-02	1994-08-09	Eisai Co Ltd	湿製錠の成型方法とその装置及び湿製錠
KR100219918B1 (ko) *	1997-07-03	1999-09-01	김윤	대장선택적 약물전달용 조성물
JP2000044465A (ja) *	1998-05-28	2000-02-15	Fuji Capsule Kk	軟カプセル剤
US6423346B1 (en) *	1998-08-25	2002-07-23	Basf Health & Nutrition A/S	Fish gelatinous composition for use as an ingredient in tablets
JP2000128778A (ja) *	1998-10-20	2000-05-09	Tokai Capsule Kk	捩じり切り開披型ソフトカプセル
US6258380B1 (en) *	1999-03-05	2001-07-10	Banner Pharmacaps, Inc.	Chewable soft capsule
JP4295387B2 (ja) *	1999-05-18	2009-07-15	ゼライス株式会社	分解ペプチド類の製造法
US6340473B1 (en) *	1999-07-07	2002-01-22	R.P. Scherer Technologies, Inc.	Film forming compositions comprising modified starches and iota-carrageenan and methods for manufacturing soft capsules using same
RU2002112751A (ru) *	1999-11-12	2004-02-27	Файброджен, Инк. (Us)	Рекомбинантные желатины
US6387400B1 (en) *	2000-08-29	2002-05-14	R.P. Scherer Technologies, Inc.	Process for preparing pharmaceutical compositions for use with soft gelatin formulations

2002
- 2002-06-07 JP JP2002167041A patent/JP4226846B2/ja not_active Expired - Fee Related
2003
- 2003-06-06 MX MXPA05000280A patent/MXPA05000280A/es active IP Right Grant
- 2003-06-06 EP EP03741881A patent/EP1534249B1/de not_active Expired - Lifetime
- 2003-06-06 US US10/456,450 patent/US20030232076A1/en not_active Abandoned
- 2003-06-06 AU AU2003273932A patent/AU2003273932B2/en not_active Ceased
- 2003-06-06 WO PCT/US2003/017746 patent/WO2003103639A1/en not_active Ceased
2004
- 2004-12-17 NO NO20045551A patent/NO20045551L/no not_active Application Discontinuation
- 2004-12-21 ZA ZA200410286A patent/ZA200410286B/en unknown

Also Published As

Publication number	Publication date
JP2004010546A (ja)	2004-01-15
EP1534249B1 (de)	2012-09-19
MXPA05000280A (es)	2005-03-31
AU2003273932B2 (en)	2010-04-22
AU2003273932A1 (en)	2003-12-22
WO2003103639A1 (en)	2003-12-18
EP1534249A4 (de)	2009-02-18
EP1534249A1 (de)	2005-06-01
JP4226846B2 (ja)	2009-02-18
NO20045551L (no)	2005-03-01
US20030232076A1 (en)	2003-12-18

Publication	Publication Date	Title
AU2003273932B2 (en)	2010-04-22	Chewable soft capsule
US7662406B1 (en)	2010-02-16	Chewable softgel capsules
JP2000128778A (ja)	2000-05-09	捩じり切り開披型ソフトカプセル
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JP5402753B2 (ja)	2014-01-29	コラーゲンペプチド高含有キャンディ様構造物
JPH07322867A (ja)	1995-12-12	耐熱軟質ゼリー入り飲料の製法
JP2005151827A (ja)	2005-06-16	食用組成物
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JPS6265649A (ja)	1987-03-24	食品用凝固剤及びこれを使用した成形食品の製法
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JP2000063266A (ja)	2000-02-29	糖衣錠
JPWO2000072702A1 (ja)	2002-12-24	人工粒状物用組成物及びそれを用いた人工粒状物の製造方法及びそれにより得られた人工粒状物
HK1108362B (en)	2019-06-21	Process for formulating fast dispensing dosage forms comprising at least one fish gelatine selected on the basis of molecular weight
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