ZA200510324B - Novel method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof - Google Patents

Novel method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof

Info

Publication number
ZA200510324B
ZA200510324B ZA200510324A ZA200510324A ZA200510324B ZA 200510324 B ZA200510324 B ZA 200510324B ZA 200510324 A ZA200510324 A ZA 200510324A ZA 200510324 A ZA200510324 A ZA 200510324A ZA 200510324 B ZA200510324 B ZA 200510324B
Authority
ZA
South Africa
Prior art keywords
perindopril
synthesis
pharmaceutically acceptable
acceptable salts
novel method
Prior art date
Application number
ZA200510324A
Other languages
English (en)
Inventor
Dubuffet Thierry
Lecouve Jean-Pierre
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of ZA200510324B publication Critical patent/ZA200510324B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA200510324A 2003-06-30 2004-06-28 Novel method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof ZA200510324B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03291600A EP1362864B1 (fr) 2003-06-30 2003-06-30 Nouveau procédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables

Publications (1)

Publication Number Publication Date
ZA200510324B true ZA200510324B (en) 2007-03-28

Family

ID=29266055

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200510324A ZA200510324B (en) 2003-06-30 2004-06-28 Novel method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof

Country Status (19)

Country Link
US (1) US7220776B2 (pl)
EP (1) EP1362864B1 (pl)
JP (1) JP4347342B2 (pl)
CN (1) CN100383159C (pl)
AR (1) AR044943A1 (pl)
AT (1) ATE360638T1 (pl)
AU (1) AU2004255899B2 (pl)
CY (1) CY1106471T1 (pl)
DE (1) DE60313391T2 (pl)
DK (1) DK1362864T3 (pl)
EA (1) EA009458B1 (pl)
ES (1) ES2286393T3 (pl)
MY (1) MY136938A (pl)
NZ (1) NZ544004A (pl)
PL (1) PL211491B1 (pl)
PT (1) PT1362864E (pl)
SI (1) SI1362864T1 (pl)
WO (1) WO2005005461A2 (pl)
ZA (1) ZA200510324B (pl)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1922149A (zh) 2003-12-29 2007-02-28 塞普拉科公司 吡咯和吡唑daao抑制剂
PT1679072E (pt) 2005-01-06 2008-12-22 Ipca Lab Ltd Processo para a síntese de derivados de ácido (2s,3as,7as)-1-(s)-alanil-octa-hidro-1h-indole-2-carboxílico e utilização na síntese de perindopril
CA2614282A1 (en) 2005-07-06 2007-01-11 Sepracor Inc. Combinations of eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders
KR101381768B1 (ko) 2006-01-06 2014-04-07 선오비온 파마슈티컬스 인코포레이티드 테트랄론-기재 모노아민 재흡수 저해제
EP1976513B1 (en) 2006-01-06 2016-08-24 Sunovion Pharmaceuticals Inc. Cycloalkylamines as monoamine reuptake inhibitors
PT2816024T (pt) 2006-03-31 2017-10-20 Sunovion Pharmaceuticals Inc Aminas quirais
US7884124B2 (en) 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
JP2008019214A (ja) * 2006-07-13 2008-01-31 Shiono Chemical Co Ltd ペリンドプリルまたはその誘導体の製造方法
US7902252B2 (en) 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
WO2008151156A1 (en) 2007-05-31 2008-12-11 Sepracor Inc. Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors
PH12018502155B1 (en) 2016-04-20 2024-03-27 Servier Lab Pharmaceutical composition comprising a beta blocker, a converting enzyme inhibitor and an antihypertensive or an nsaid
CN111116709B (zh) * 2019-12-31 2022-06-24 北京鑫开元医药科技有限公司 一种培哚普利制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
DK1321471T3 (da) * 2003-03-12 2005-08-29 Servier Lab Ny syntesefremgangsmåde til perindopril og farmaceutisk acceptable salte heraf
SI1367061T1 (sl) * 2003-06-30 2006-04-30 Servier Lab Nov postopek za sintezo perindoprila in njegovih farmacevtsko sprejemljivih soli

Also Published As

Publication number Publication date
EP1362864A1 (fr) 2003-11-19
HK1089187A1 (zh) 2006-11-24
EP1362864B1 (fr) 2007-04-25
ES2286393T3 (es) 2007-12-01
PL211491B1 (pl) 2012-05-31
SI1362864T1 (sl) 2007-08-31
CY1106471T1 (el) 2012-01-25
JP4347342B2 (ja) 2009-10-21
JP2008500263A (ja) 2008-01-10
MY136938A (en) 2008-11-28
NZ544004A (en) 2009-03-31
AU2004255899B2 (en) 2008-03-13
ATE360638T1 (de) 2007-05-15
EA009458B1 (ru) 2007-12-28
AR044943A1 (es) 2005-10-12
EA200501900A1 (ru) 2006-06-30
DK1362864T3 (da) 2007-09-17
PT1362864E (pt) 2007-07-23
DE60313391T2 (de) 2008-01-17
US20060148884A1 (en) 2006-07-06
DE60313391D1 (de) 2007-06-06
CN1805972A (zh) 2006-07-19
US7220776B2 (en) 2007-05-22
PL379630A1 (pl) 2006-10-30
AU2004255899A1 (en) 2005-01-20
WO2005005461A3 (fr) 2005-03-31
WO2005005461A2 (fr) 2005-01-20
CN100383159C (zh) 2008-04-23

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