ZA200601236B - Improved recombinant human interferon-beta-1b polypeptides - Google Patents

Improved recombinant human interferon-beta-1b polypeptides Download PDF

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Publication number
ZA200601236B
ZA200601236B ZA200601236A ZA200601236A ZA200601236B ZA 200601236 B ZA200601236 B ZA 200601236B ZA 200601236 A ZA200601236 A ZA 200601236A ZA 200601236 A ZA200601236 A ZA 200601236A ZA 200601236 B ZA200601236 B ZA 200601236B
Authority
ZA
South Africa
Prior art keywords
ifn
composition
polypeptide
improved
specific activity
Prior art date
Application number
ZA200601236A
Other languages
English (en)
Inventor
Nestaas Eirik
Pungor Erno
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of ZA200601236B publication Critical patent/ZA200601236B/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ZA200601236A 2003-07-11 2006-02-10 Improved recombinant human interferon-beta-1b polypeptides ZA200601236B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US48665703P 2003-07-11 2003-07-11

Publications (1)

Publication Number Publication Date
ZA200601236B true ZA200601236B (en) 2007-05-30

Family

ID=34193062

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200601236A ZA200601236B (en) 2003-07-11 2006-02-10 Improved recombinant human interferon-beta-1b polypeptides

Country Status (15)

Country Link
US (1) US20050008616A1 (de)
EP (1) EP1646397B1 (de)
JP (1) JP2007530419A (de)
KR (1) KR20060034286A (de)
CN (1) CN100408090C (de)
AU (1) AU2004264855A1 (de)
BR (1) BRPI0412477A (de)
CA (1) CA2528514A1 (de)
ES (1) ES2393783T3 (de)
IL (2) IL172269A0 (de)
MX (1) MXPA06000460A (de)
NO (1) NO20060675L (de)
RU (1) RU2006104023A (de)
WO (1) WO2005016371A1 (de)
ZA (1) ZA200601236B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006015165A2 (en) * 2004-07-26 2006-02-09 Enzon Pharmaceuticals, Inc. Optimized interferon-beta gene
AU2006263331B2 (en) 2005-06-29 2012-02-16 Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science Recombinant interferon alpha2 (IFNalpha2) mutants
JP5313129B2 (ja) 2006-05-02 2013-10-09 アロザイン， インコーポレイテッド 非天然アミノ酸置換ポリペプチド
US8114630B2 (en) 2007-05-02 2012-02-14 Ambrx, Inc. Modified interferon beta polypeptides and their uses
CA2707840A1 (en) 2007-08-20 2009-02-26 Allozyne, Inc. Amino acid substituted molecules
EP2207890A4 (de) * 2007-10-05 2010-12-15 Barofold Inc Hochdruckbehandlung aggregierter interferone
CN103898123B (zh) * 2012-12-28 2019-03-15 北京韩美药品有限公司 重组人IFN-β-1a及其生产和纯化方法
CN108841793B (zh) * 2018-06-08 2021-08-27 东北农业大学 抗鸭Mx-A单克隆抗体及其在检测鸭Mx蛋白的应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5326859A (en) 1979-10-30 1994-07-05 Juridical Foundation, Japanese Foundation For Cancer Research DNA and recombinant plasmid
US4588585A (en) * 1982-10-19 1986-05-13 Cetus Corporation Human recombinant cysteine depleted interferon-β muteins
IL90047A (en) * 1982-10-19 1992-12-01 Cetus Oncology Corp Cysteine-depleted biologically active muteins other than interferon - '
US4530787A (en) 1984-03-28 1985-07-23 Cetus Corporation Controlled oxidation of microbially produced cysteine-containing proteins
US4572798A (en) 1984-12-06 1986-02-25 Cetus Corporation Method for promoting disulfide bond formation in recombinant proteins
US5814485A (en) 1995-06-06 1998-09-29 Chiron Corporation Production of interferon-β (IFN-β) in E. coli
AR034749A1 (es) * 2001-07-09 2004-03-17 Schering Ag Formulaciones de interferon beta humano

Also Published As

Publication number Publication date
WO2005016371A1 (en) 2005-02-24
WO2005016371A8 (en) 2006-06-15
CA2528514A1 (en) 2005-02-24
CN100408090C (zh) 2008-08-06
IL172269A0 (en) 2006-04-10
US20050008616A1 (en) 2005-01-13
IL207422A0 (en) 2010-12-30
MXPA06000460A (es) 2006-04-07
EP1646397B1 (de) 2012-08-22
CN1822852A (zh) 2006-08-23
JP2007530419A (ja) 2007-11-01
BRPI0412477A (pt) 2006-09-19
AU2004264855A1 (en) 2005-02-24
RU2006104023A (ru) 2006-07-27
KR20060034286A (ko) 2006-04-21
NO20060675L (no) 2006-04-06
EP1646397A1 (de) 2006-04-19
ES2393783T3 (es) 2012-12-28

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