ZA200601698B - 8-chloro-2,3-benzodiazephine derivatives - Google Patents

8-chloro-2,3-benzodiazephine derivatives Download PDF

Info

Publication number: ZA200601698B
Authority: ZA; South Africa
Prior art keywords: general formula; compounds; pharmaceutically acceptable; group; methyl
Prior art date: 2003-08-04

Application number

ZA200601698A

Other languages

English (en)

Inventor

Barkoczy Jozsef

Ling Istvan

Simig Gyula

Szenasi Gabor

Gigler Gabor

Kertesz Szabolcs

Szuecs Gyula

Szabo Geza

Miklos Vegh

Harsing Laszlo Gabor

Original Assignee

Egis Gyogyszergysrt Rt

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-08-04

Filing date

2004-07-29

Publication date

2007-05-30

2004-07-29 Application filed by Egis Gyogyszergysrt Rt filed Critical Egis Gyogyszergysrt Rt

2007-05-30 Publication of ZA200601698B publication Critical patent/ZA200601698B/en

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125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
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229910000041 hydrogen chloride Inorganic materials 0.000 description 1
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230000001404 mediated effect Effects 0.000 description 1
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
MGJXBDMLVWIYOQ-UHFFFAOYSA-N methylazanide Chemical compound [NH-]C MGJXBDMLVWIYOQ-UHFFFAOYSA-N 0.000 description 1
LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Vascular Medicine (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Psychology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

ZA200601698A 2003-08-04 2004-07-29 8-chloro-2,3-benzodiazephine derivatives ZA200601698B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HU0302449A HUP0302449A3 (en)	2003-08-04	2003-08-04	8-chloro-2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for producing them

Publications (1)

Publication Number	Publication Date
ZA200601698B true ZA200601698B (en)	2007-05-30

Family

ID=89981556

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200601698A ZA200601698B (en)	2003-08-04	2004-07-29	8-chloro-2,3-benzodiazephine derivatives

Country Status (23)

Country	Link
US (1)	US7960375B2 (de)
EP (1)	EP1660462B1 (de)
JP (1)	JP4752011B2 (de)
KR (1)	KR20060120578A (de)
CN (1)	CN100551915C (de)
AT (1)	ATE414695T1 (de)
AU (1)	AU2004261491B2 (de)
BG (1)	BG109462A (de)
CA (1)	CA2534458A1 (de)
CZ (1)	CZ2006131A3 (de)
DE (1)	DE602004017878D1 (de)
DK (1)	DK1660462T3 (de)
EA (1)	EA009373B1 (de)
ES (1)	ES2317038T3 (de)
HU (1)	HUP0302449A3 (de)
IL (1)	IL173476A (de)
PL (2)	PL379245A1 (de)
PT (1)	PT1660462E (de)
SI (1)	SI1660462T1 (de)
SK (1)	SK50212006A3 (de)
UA (1)	UA84159C2 (de)
WO (1)	WO2005012265A1 (de)
ZA (1)	ZA200601698B (de)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU179018B (en) *	1978-10-19	1982-08-28	Gyogyszerkutato Intezet	Process for producing new 5h-2,3-benzodiazepine derivatives
HU191702B (en)	1984-06-27	1987-03-30	Gyogyszerkutato Intezet	New process for preparing 1-aryl-5 h-2,3-benzodiazepines
HU191698B (en) *	1984-07-27	1987-03-30	Gyogyszerkutato Intezet	Process for producing new 1-aryl-5h-2beta-benzodiazepines
HU195788B (en) *	1986-05-21	1988-07-28	Gyogyszerkutato Intezet	Process for producing 1-/hydroxy-stiryl/-5h-2,3-benzobiazepines and pharmaceutical compositions containing them
HU206719B (en)	1990-12-21	1992-12-28	Gyogyszerkutato Intezet	Process for producing 1-/4-acylamino-phenyl/-7,8-methylenedioxy-5h-2,3-benzodiazepine derivatives, acid addicional salts and pharmaceutical compositions containing them
DE19604920A1 (de) *	1996-02-01	1997-08-07	Schering Ag	Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel
HU9600871D0 (en) *	1996-04-04	1996-05-28	Gyogyszerkutato Intezet	New 2,3-benzodiazepine derivatives
HU225100B1 (hu) *	2000-12-21	2006-06-28	Egyt Gyogyszervegyeszeti Gyar	2,3-Benzodiazepinszármazékok, ilyen hatóanyagot tartalmazó gyógyászati készítmények és alkalmazásuk

2003
- 2003-08-04 HU HU0302449A patent/HUP0302449A3/hu unknown
2004
- 2004-07-29 PT PT04769081T patent/PT1660462E/pt unknown
- 2004-07-29 AT AT04769081T patent/ATE414695T1/de active
- 2004-07-29 SI SI200431033T patent/SI1660462T1/sl unknown
- 2004-07-29 AU AU2004261491A patent/AU2004261491B2/en not_active Ceased
- 2004-07-29 EP EP04769081A patent/EP1660462B1/de not_active Expired - Lifetime
- 2004-07-29 CA CA002534458A patent/CA2534458A1/en not_active Abandoned
- 2004-07-29 ZA ZA200601698A patent/ZA200601698B/en unknown
- 2004-07-29 PL PL379245A patent/PL379245A1/pl not_active Application Discontinuation
- 2004-07-29 EA EA200600373A patent/EA009373B1/ru not_active IP Right Cessation
- 2004-07-29 WO PCT/HU2004/000082 patent/WO2005012265A1/en not_active Ceased
- 2004-07-29 CZ CZ20060131A patent/CZ2006131A3/cs unknown
- 2004-07-29 DK DK04769081T patent/DK1660462T3/da active
- 2004-07-29 UA UAA200602304A patent/UA84159C2/ru unknown
- 2004-07-29 ES ES04769081T patent/ES2317038T3/es not_active Expired - Lifetime
- 2004-07-29 PL PL04769081T patent/PL1660462T3/pl unknown
- 2004-07-29 JP JP2006522422A patent/JP4752011B2/ja not_active Expired - Fee Related
- 2004-07-29 SK SK5021-2006A patent/SK50212006A3/sk unknown
- 2004-07-29 KR KR1020067002464A patent/KR20060120578A/ko not_active Abandoned
- 2004-07-29 CN CNB2004800254093A patent/CN100551915C/zh not_active Expired - Fee Related
- 2004-07-29 US US10/567,598 patent/US7960375B2/en not_active Expired - Fee Related
- 2004-07-29 DE DE602004017878T patent/DE602004017878D1/de not_active Expired - Lifetime
2006
- 2006-01-31 IL IL173476A patent/IL173476A/en not_active IP Right Cessation
- 2006-03-02 BG BG109462A patent/BG109462A/en unknown

Also Published As

Publication number	Publication date
PL1660462T3 (pl)	2009-07-31
EA200600373A1 (ru)	2006-08-25
SK50212006A3 (sk)	2006-08-03
BG109462A (en)	2006-11-30
IL173476A0 (en)	2006-06-11
AU2004261491A1 (en)	2005-02-10
HUP0302449A3 (en)	2005-06-28
SI1660462T1 (sl)	2009-04-30
HUP0302449A2 (hu)	2005-04-28
WO2005012265A1 (en)	2005-02-10
JP4752011B2 (ja)	2011-08-17
ES2317038T3 (es)	2009-04-16
US20080153814A1 (en)	2008-06-26
US7960375B2 (en)	2011-06-14
CA2534458A1 (en)	2005-02-10
CZ2006131A3 (cs)	2006-12-13
KR20060120578A (ko)	2006-11-27
DK1660462T3 (da)	2009-03-16
HU0302449D0 (en)	2003-10-28
AU2004261491B2 (en)	2009-12-17
EA009373B1 (ru)	2007-12-28
CN1871223A (zh)	2006-11-29
EP1660462A1 (de)	2006-05-31
PL379245A1 (pl)	2006-08-07
IL173476A (en)	2013-01-31
JP2007501216A (ja)	2007-01-25
CN100551915C (zh)	2009-10-21
PT1660462E (pt)	2009-02-20
UA84159C2 (en)	2008-09-25
DE602004017878D1 (de)	2009-01-02
EP1660462B1 (de)	2008-11-19
ATE414695T1 (de)	2008-12-15

Publication	Publication Date	Title
US7348448B2 (en)	2008-03-25	Phenylcarboxylate beta-secretase inhibitors for the treatment of alzheimer's disease
RU2102387C1 (ru)	1998-01-20	Производные n-ацил-2,3-бензодиазепина, или их стереоизомеры, или кислые соли присоединения, обладающие биологической активностью, связанной с воздействием на центральную нервную систему, и фармакологически активная композиция на их основе
AU660854B2 (en)	1995-07-06	New arylalkyl (thio)amides, process for preparing them and pharmaceutical compositions containing them
US5519019A (en)	1996-05-21	N-acyl-2,3-benzoidazepine derivatives, pharmaceutical compositions containing them and process for preparing same
HU197002B (en)	1989-02-28	Process for producing glutarimide derivatives
EP0867436A1 (de)	1998-09-30	N-Aryl-piperidinderivate und ihre Verwendung als 5-HT1B-Rezeptorliganden
US6200970B1 (en)	2001-03-13	2,3-benzodiazepine derivatives and their use as AMPA-receptor inhibitors
US5639751A (en)	1997-06-17	N-acyl-2,3-benzodiazepine derivatives for treating acute and chronic neurodegenerative disorders
US5521174A (en)	1996-05-28	N-acyl-2,3-benzodiazepine derivatives and a method of treating spasms of the skeletal musculature therewith
US20070117791A1 (en)	2007-05-24	Bicyclic compounds
SK282258B6 (sk)	2001-12-03	Deriváty 2,3-benzodiazepínu, farmaceutická kompozícia, ich použitie, spôsob ich prípravy a medziprodukt
AU2004261491B2 (en)	2009-12-17	8-chloro-2,3-benzodiazepine derivatives
FR2760014A1 (fr)	1998-08-28	Nouveaux composes de 2-amino indane, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP1015457B1 (de)	2003-11-26	1-3 dioxolo/4.5-h//2,3-benzodiazepin derivate als ampa/kainate-rezeptor-hemmer
PT1697194E (pt)	2009-02-20	Sistema de controlo da aceleração lateral
WO2000040574A1 (en)	2000-07-13	1,4-diazacycloheptane compounds, process for their preparation, and their use as medicaments
BG66199B1 (bg)	2012-01-31	2,3-беhзодиазепинови производни и фармацевтични състави, които ги съдържат като активен компонент
IL114388A (en)	1999-01-26	Use of 2-amino-n-(1,2-diphenyl-1-methylethyl) acetamide and salts thereof in the manufacture of neuroprotective pharmaceutical compositions
MXPA00001487A (en)	2001-12-04	1,3-dioxolo/4,5-h//2,3/benzodiazepine derivatives as ampa/kainate receptor inhibitors
HK1240927B (zh)	2020-04-24	氨基环丁烷衍生物、其制备方法及其用作药物的用途
HK1212968B (en)	2018-04-13	Aminocyclobutane derivatives, method for preparing same and the use thereof as drugs