ZA200603181B - 3-(4-aminophenyl) thienopyrimid-4-one derivatives as MCH R1 antagonists for the treatment of obesity, diabetes, depression and anxiety - Google Patents

3-(4-aminophenyl) thienopyrimid-4-one derivatives as MCH R1 antagonists for the treatment of obesity, diabetes, depression and anxiety Download PDF

Info

Publication number: ZA200603181B
Authority: ZA; South Africa
Prior art keywords: formula; compound; group; ring; alkoxy
Prior art date: 2003-10-23

Application number

ZA200603181A

Other languages

English (en)

Inventor

Kevin K Barvian

Donald L Hertzog

Anthony L Handlon

Clifton E Hyman

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-10-23

Filing date

2006-04-20

Publication date

2008-01-30

2006-04-20 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2008-01-30 Publication of ZA200603181B publication Critical patent/ZA200603181B/en

Links

208000008589 Obesity Diseases 0.000 title claims description 22
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238000011282 treatment Methods 0.000 title claims description 19
206010012601 diabetes mellitus Diseases 0.000 title claims description 13
208000019901 Anxiety disease Diseases 0.000 title claims description 10
230000036506 anxiety Effects 0.000 title claims description 10
239000005557 antagonist Substances 0.000 title claims description 8
LVAGVGLOKJYPSZ-UHFFFAOYSA-N 3-(4-aminophenyl)thieno[3,2-d]pyrimidin-4-one Chemical class C1=CC(N)=CC=C1N1C(=O)C(SC=C2)=C2N=C1 LVAGVGLOKJYPSZ-UHFFFAOYSA-N 0.000 title 1
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239000007885 tablet disintegrant Substances 0.000 description 1
150000003505 terpenes Chemical class 0.000 description 1
235000007586 terpenes Nutrition 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
MHXBHWLGRWOABW-UHFFFAOYSA-N tetradecyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCC MHXBHWLGRWOABW-UHFFFAOYSA-N 0.000 description 1
239000002562 thickening agent Substances 0.000 description 1
RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
229940033663 thimerosal Drugs 0.000 description 1
239000004408 titanium dioxide Substances 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
230000037317 transdermal delivery Effects 0.000 description 1
ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 description 1
BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
150000003672 ureas Chemical class 0.000 description 1
235000012141 vanillin Nutrition 0.000 description 1
MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
239000000341 volatile oil Substances 0.000 description 1
238000009736 wetting Methods 0.000 description 1
239000000230 xanthan gum Substances 0.000 description 1
235000010493 xanthan gum Nutrition 0.000 description 1
229920001285 xanthan gum Polymers 0.000 description 1
229940082509 xanthan gum Drugs 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
239000011701 zinc Substances 0.000 description 1
XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
229930195724 β-lactose Natural products 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Obesity (AREA)
Neurology (AREA)
Hematology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Child & Adolescent Psychology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)

ZA200603181A 2003-10-23 2006-04-20 3-(4-aminophenyl) thienopyrimid-4-one derivatives as MCH R1 antagonists for the treatment of obesity, diabetes, depression and anxiety ZA200603181B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US51380003P	2003-10-23	2003-10-23

Publications (1)

Publication Number	Publication Date
ZA200603181B true ZA200603181B (en)	2008-01-30

Family

ID=34549304

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200603181A ZA200603181B (en)	2003-10-23	2006-04-20	3-(4-aminophenyl) thienopyrimid-4-one derivatives as MCH R1 antagonists for the treatment of obesity, diabetes, depression and anxiety

Country Status (15)

Country	Link
US (1)	US20070078125A1 (fr)
EP (1)	EP1678184A1 (fr)
JP (1)	JP2007509158A (fr)
KR (1)	KR20060100412A (fr)
CN (1)	CN1871242A (fr)
AU (1)	AU2004285913A1 (fr)
BR (1)	BRPI0415667A (fr)
CA (1)	CA2543122A1 (fr)
CO (1)	CO5690599A2 (fr)
IL (1)	IL174693A0 (fr)
MA (1)	MA28111A1 (fr)
MX (1)	MXPA06003997A (fr)
NO (1)	NO20061909L (fr)
WO (1)	WO2005042541A1 (fr)
ZA (1)	ZA200603181B (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2007011284A1 (fr) *	2005-07-15	2007-01-25	Astrazeneca Ab	Agents thérapeutiques
WO2007039462A2 (fr)	2005-09-30	2007-04-12	F. Hoffmann-La Roche Ag	Derives d'indane utilises comme antagonistes du recepteur mch
US7745447B2 (en) *	2005-10-26	2010-06-29	Bristol-Myers Squibb Company	Substituted thieno[3,2-D]pyrimidines as non-basic melanin concentrating hormone receptor-1 antagonists
US8618115B2 (en)	2005-10-26	2013-12-31	Bristol-Myers Squibb Company	Substituted thieno[3,2-d]pyrimidinones as MCHR1 antagonists and methods for using them
ES2412007T3 (es)	2005-12-21	2013-07-09	Janssen Pharmaceutica, N.V.	Derivados de pirazinona sustituida novedosos para uso en enfermedades mediadas por MCH-1
US7553836B2 (en)	2006-02-06	2009-06-30	Bristol-Myers Squibb Company	Melanin concentrating hormone receptor-1 antagonists
DE602007011897D1 (de) *	2006-02-15	2011-02-24	Sanofi Aventis	Neue aminoalkohol-substituierte aryldihydroisochinolinone, herstellungsverfahren und ihre verwendung als medikamente
CN101384605A (zh)	2006-02-15	2009-03-11	塞诺菲-安万特股份有限公司	新的氨基醇取代的芳基噻吩并嘧啶酮、其制备方法以及其作为药物的用途
AU2007214709A1 (en) *	2006-02-15	2007-08-23	Sanofi-Aventis	Azacyclyl-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments
BRPI0707869A2 (pt) *	2006-02-15	2011-05-10	Sanofi Aventis	ariltienopirimidinonas substituÍdas com azaciclil, processo para a sua preparaÇço e seus usos como medicamentos
CA2652385A1 (fr) *	2006-06-08	2007-12-21	Eli Lilly And Company	Nouveaux antagonistes de recepteur de mch
EP2121703A4 (fr)	2006-08-18	2011-12-28	Astrazeneca Ab	Dérivés de thiénopyrimidin-4-one et de thiénopyridazin-7-one en tant qu'antagonistes du mch rl
NZ578096A (en)	2007-01-10	2011-11-25	Albany Molecular Res Inc	5-pyridinone substituted indazoles
JP2010525077A (ja)	2007-04-25	2010-07-22	ブリストル−マイヤーズスクイブカンパニー	非塩基性メラニン凝集ホルモン受容体−１アンタゴニスト
ES2382982T3 (es)	2007-07-21	2012-06-15	Albany Molecular Research, Inc.	Indazoles sustituidos con 5-piridinona y composiciones farmacéuticas de los mismos
PE20091928A1 (es)	2008-05-29	2009-12-31	Bristol Myers Squibb Co	Tienopirimidinas hidroxisustituidas como antagonistas de receptor-1 de hormona concentradora de melanina no basicos
US8278316B2 (en)	2009-03-09	2012-10-02	Bristol-Myers Squibb Company	Aza pyridone analogs useful as melanin concentrating hormone receptor-1 antagonists
HUP1100241A3 (en)	2011-05-06	2013-12-30	Richter Gedeon Nyrt	Oxetane substituted pyrimidones
KR20130013199A (ko) *	2011-07-27	2013-02-06	한미약품 주식회사	신규 피리미딘 유도체 및 이를 활성성분으로 포함하는 약학 조성물
JP6283811B2 (ja)	2011-08-26	2018-02-28	オーエヌライトサイエンシーズインコーポレイテッド	タトゥ除去システム及び方法
CN115350184A (zh) *	2020-01-10	2022-11-18	康圣博施医药有限公司	药物的治疗组合以及其使用方法
HUP2200222A1 (hu)	2022-06-17	2023-12-28	Richter Gedeon Nyrt	MCHR1 antagonisták a Prader-Willi szindróma kezelésére

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GB0124627D0 (en) *	2001-10-15	2001-12-05	Smithkline Beecham Plc	Novel compounds

2004
- 2004-10-21 WO PCT/US2004/034846 patent/WO2005042541A1/fr not_active Ceased
- 2004-10-21 EP EP04795941A patent/EP1678184A1/fr not_active Withdrawn
- 2004-10-21 US US10/576,765 patent/US20070078125A1/en not_active Abandoned
- 2004-10-21 KR KR1020067009417A patent/KR20060100412A/ko not_active Withdrawn
- 2004-10-21 CN CNA2004800313000A patent/CN1871242A/zh active Pending
- 2004-10-21 BR BRPI0415667-6A patent/BRPI0415667A/pt not_active IP Right Cessation
- 2004-10-21 CA CA002543122A patent/CA2543122A1/fr not_active Abandoned
- 2004-10-21 JP JP2006536779A patent/JP2007509158A/ja active Pending
- 2004-10-21 AU AU2004285913A patent/AU2004285913A1/en not_active Abandoned
- 2004-10-21 MX MXPA06003997A patent/MXPA06003997A/es unknown
2006
- 2006-03-30 IL IL174693A patent/IL174693A0/en unknown
- 2006-04-20 ZA ZA200603181A patent/ZA200603181B/en unknown
- 2006-04-21 CO CO06038136A patent/CO5690599A2/es not_active Application Discontinuation
- 2006-04-25 MA MA28965A patent/MA28111A1/fr unknown
- 2006-04-28 NO NO20061909A patent/NO20061909L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
IL174693A0 (en)	2006-08-20
JP2007509158A (ja)	2007-04-12
AU2004285913A1 (en)	2005-05-12
CO5690599A2 (es)	2006-10-31
CN1871242A (zh)	2006-11-29
CA2543122A1 (fr)	2005-05-12
BRPI0415667A (pt)	2006-12-19
NO20061909L (no)	2006-05-03
US20070078125A1 (en)	2007-04-05
EP1678184A1 (fr)	2006-07-12
MA28111A1 (fr)	2006-08-01
WO2005042541A1 (fr)	2005-05-12
KR20060100412A (ko)	2006-09-20
MXPA06003997A (es)	2006-07-05

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WO2014165090A1 (fr)	2014-10-09	Composés pour le traitement de la tuberculose
US20070078125A1 (en)	2007-04-05	Arylamine mch r1 antagonists
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