ZA200609110B - Pharmaceutical compositions comprising ZD6474 - Google Patents

Pharmaceutical compositions comprising ZD6474 Download PDF

Info

Publication number: ZA200609110B
Authority: ZA; South Africa
Prior art keywords: diluent; tablets; tablet; formulation; brittle
Prior art date: 2004-05-21

Application number

ZA200609110A

Other languages

English (en)

Inventor

Stott Paul William

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-05-21

Filing date

2006-11-01

Publication date

2008-06-25

2006-11-01 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2008-06-25 Publication of ZA200609110B publication Critical patent/ZA200609110B/en

Links

UHTHHESEBZOYNR-UHFFFAOYSA-N vandetanib Chemical compound COC1=CC(C(/N=CN2)=N/C=3C(=CC(Br)=CC=3)F)=C2C=C1OCC1CCN(C)CC1 UHTHHESEBZOYNR-UHFFFAOYSA-N 0.000 title claims description 72
229960000241 vandetanib Drugs 0.000 title claims description 71
239000008194 pharmaceutical composition Substances 0.000 title claims description 57
239000003085 diluting agent Substances 0.000 claims description 54
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FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical group [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims description 18
235000019700 dicalcium phosphate Nutrition 0.000 claims description 18
229940095079 dicalcium phosphate anhydrous Drugs 0.000 claims description 18
229920000168 Microcrystalline cellulose Polymers 0.000 claims description 17
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238000000034 method Methods 0.000 description 26
239000000463 material Substances 0.000 description 23
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 22
238000004519 manufacturing process Methods 0.000 description 19
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 18
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 18
239000000945 filler Substances 0.000 description 18
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WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 description 10
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QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 7
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 6
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DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 3
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229910052749 magnesium Inorganic materials 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
239000000395 magnesium oxide Substances 0.000 description 1
CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
159000000003 magnesium salts Chemical class 0.000 description 1
AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
230000009401 metastasis Effects 0.000 description 1
230000005012 migration Effects 0.000 description 1
238000013508 migration Methods 0.000 description 1
239000003605 opacifier Substances 0.000 description 1
230000001575 pathological effect Effects 0.000 description 1
229940124531 pharmaceutical excipient Drugs 0.000 description 1
230000035790 physiological processes and functions Effects 0.000 description 1
239000004014 plasticizer Substances 0.000 description 1
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
229920001184 polypeptide Polymers 0.000 description 1
XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
102000004196 processed proteins & peptides Human genes 0.000 description 1
108090000765 processed proteins & peptides Proteins 0.000 description 1
230000035755 proliferation Effects 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
239000008213 purified water Substances 0.000 description 1
238000001959 radiotherapy Methods 0.000 description 1
210000000664 rectum Anatomy 0.000 description 1
230000009467 reduction Effects 0.000 description 1
230000001850 reproductive effect Effects 0.000 description 1
238000011160 research Methods 0.000 description 1
238000002271 resection Methods 0.000 description 1
210000001210 retinal vessel Anatomy 0.000 description 1
238000012552 review Methods 0.000 description 1
206010039073 rheumatoid arthritis Diseases 0.000 description 1
238000009490 roller compaction Methods 0.000 description 1
238000000926 separation method Methods 0.000 description 1
230000009919 sequestration Effects 0.000 description 1
230000019491 signal transduction Effects 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
239000007901 soft capsule Substances 0.000 description 1
239000007909 solid dosage form Substances 0.000 description 1
239000008247 solid mixture Substances 0.000 description 1
238000012430 stability testing Methods 0.000 description 1
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230000004614 tumor growth Effects 0.000 description 1
125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
230000006426 vascular sprouting Effects 0.000 description 1
239000004066 vascular targeting agent Substances 0.000 description 1
230000004862 vasculogenesis Effects 0.000 description 1
210000003905 vulva Anatomy 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Inorganic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Steroid Compounds (AREA)

ZA200609110A 2004-05-21 2006-11-01 Pharmaceutical compositions comprising ZD6474 ZA200609110B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0411378.3A GB0411378D0 (en)	2004-05-21	2004-05-21	Pharmaceutical compositions

Publications (1)

Publication Number	Publication Date
ZA200609110B true ZA200609110B (en)	2008-06-25

Family

ID=32607743

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200609110A ZA200609110B (en)	2004-05-21	2006-11-01	Pharmaceutical compositions comprising ZD6474

Country Status (33)

Country	Link
US (1)	US8067427B2 (sr)
EP (1)	EP1753431B1 (sr)
JP (1)	JP4740947B2 (sr)
KR (1)	KR101192935B1 (sr)
CN (1)	CN101031303B (sr)
AR (2)	AR049059A1 (sr)
AT (1)	ATE439841T1 (sr)
AU (1)	AU2005244650B2 (sr)
BR (1)	BRPI0511253B8 (sr)
CA (1)	CA2565513C (sr)
CY (1)	CY1109500T1 (sr)
DE (1)	DE602005016105D1 (sr)
DK (1)	DK1753431T3 (sr)
ES (1)	ES2330025T3 (sr)
GB (1)	GB0411378D0 (sr)
HR (1)	HRP20090547T1 (sr)
IL (1)	IL178928A (sr)
ME (2)	ME01505B (sr)
MX (1)	MXPA06013501A (sr)
MY (1)	MY138868A (sr)
NO (1)	NO338324B1 (sr)
NZ (1)	NZ550931A (sr)
PL (1)	PL1753431T3 (sr)
PT (1)	PT1753431E (sr)
RS (1)	RS51112B (sr)
RU (1)	RU2383343C2 (sr)
SA (1)	SA05260133B1 (sr)
SI (1)	SI1753431T1 (sr)
TW (1)	TWI355269B (sr)
UA (1)	UA81732C2 (sr)
UY (1)	UY28901A1 (sr)
WO (1)	WO2005112934A1 (sr)
ZA (1)	ZA200609110B (sr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2278511B1 (es) *	2005-07-28	2008-06-16	Laboratorios Almirall S.A.	Comprimidos con perfil de disolucion mejorado.
JP6612232B2 (ja)	2013-08-28	2019-11-27	クラウンバイオサイエンスインコーポレイテッド（タイカン）	対象のマルチキナーゼ阻害剤に対する応答性を予測する遺伝子発現シグネチャ、及びその使用
WO2025256594A1 (en) *	2024-06-12	2025-12-18	Centre for Eye and Vision Research Limited	Methods and compositions for treating refractive errors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9718972D0 (en) *	1996-09-25	1997-11-12	Zeneca Ltd	Chemical compounds
CN100376567C (zh) *	1999-11-05	2008-03-26	阿斯特拉曾尼卡有限公司	作为vegf抑制剂的喹唑啉衍生物
GB0001621D0 (en) *	2000-01-26	2000-03-15	Astrazeneca Ab	Pharmaceutical compositions
KR100419555B1 (ko) *	2000-05-29	2004-02-19	주식회사유한양행	비형간염바이러스의 에스-표면항원을 인식하는단일클론항체의 가변영역 및 이를 코딩하는 유전자
GB0126879D0 (en) *	2001-11-08	2002-01-02	Astrazeneca Ab	Combination therapy
JP4542783B2 (ja) *	2002-03-05	2010-09-15	エーザイ・アール・アンド・ディー・マネジメント株式会社	スルホンアミド含有複素環化合物及び血管新生抑制剤とを組み合わせてなる抗腫瘍剤

2004
- 2004-05-21 GB GBGB0411378.3A patent/GB0411378D0/en not_active Ceased
2005
- 2005-05-09 TW TW094114935A patent/TWI355269B/zh not_active IP Right Cessation
- 2005-05-17 UY UY28901A patent/UY28901A1/es unknown
- 2005-05-18 JP JP2007517415A patent/JP4740947B2/ja not_active Expired - Lifetime
- 2005-05-18 RU RU2006145357/15A patent/RU2383343C2/ru active Protection Beyond IP Right Term
- 2005-05-18 CA CA2565513A patent/CA2565513C/en not_active Expired - Lifetime
- 2005-05-18 AT AT05744858T patent/ATE439841T1/de active
- 2005-05-18 WO PCT/GB2005/001931 patent/WO2005112934A1/en not_active Ceased
- 2005-05-18 SI SI200530793T patent/SI1753431T1/sl unknown
- 2005-05-18 DK DK05744858T patent/DK1753431T3/da active
- 2005-05-18 DE DE602005016105T patent/DE602005016105D1/de not_active Expired - Lifetime
- 2005-05-18 EP EP05744858A patent/EP1753431B1/en not_active Expired - Lifetime
- 2005-05-18 MX MXPA06013501A patent/MXPA06013501A/es active IP Right Grant
- 2005-05-18 UA UAA200613289A patent/UA81732C2/ru unknown
- 2005-05-18 KR KR1020067026603A patent/KR101192935B1/ko not_active Expired - Lifetime
- 2005-05-18 US US11/596,979 patent/US8067427B2/en active Active
- 2005-05-18 ES ES05744858T patent/ES2330025T3/es not_active Expired - Lifetime
- 2005-05-18 ME MEP-2013-50A patent/ME01505B/me unknown
- 2005-05-18 SA SA05260133A patent/SA05260133B1/ar unknown
- 2005-05-18 HR HR20090547T patent/HRP20090547T1/xx unknown
- 2005-05-18 PT PT05744858T patent/PT1753431E/pt unknown
- 2005-05-18 CN CN2005800162448A patent/CN101031303B/zh not_active Expired - Lifetime
- 2005-05-18 PL PL05744858T patent/PL1753431T3/pl unknown
- 2005-05-18 AU AU2005244650A patent/AU2005244650B2/en active Active
- 2005-05-18 BR BRPI0511253A patent/BRPI0511253B8/pt not_active IP Right Cessation
- 2005-05-18 ME MEP-2009-458A patent/ME02778B/me unknown
- 2005-05-18 NZ NZ550931A patent/NZ550931A/en not_active IP Right Cessation
- 2005-05-18 RS RSP-2009/0458A patent/RS51112B/sr unknown
- 2005-05-19 MY MYPI20052271A patent/MY138868A/en unknown
- 2005-05-20 AR ARP050102087A patent/AR049059A1/es not_active Application Discontinuation
2006
- 2006-10-29 IL IL178928A patent/IL178928A/en active IP Right Grant
- 2006-11-01 ZA ZA200609110A patent/ZA200609110B/en unknown
- 2006-12-12 NO NO20065735A patent/NO338324B1/no not_active IP Right Cessation
2009
- 2009-10-15 CY CY20091101075T patent/CY1109500T1/el unknown
2017
- 2017-11-09 AR ARP170103128A patent/AR110045A2/es unknown

Also Published As

Publication number	Publication date
AR049059A1 (es)	2006-06-21
TWI355269B (en)	2012-01-01
HK1099220A1 (en)	2007-08-10
JP2007538060A (ja)	2007-12-27
SA05260133B1 (ar)	2008-12-23
ES2330025T3 (es)	2009-12-03
KR101192935B1 (ko)	2012-10-18
PL1753431T3 (pl)	2009-12-31
ME01505B (me)	2014-04-20
BRPI0511253A (pt)	2007-11-27
PT1753431E (pt)	2009-10-14
RU2006145357A (ru)	2008-06-27
UY28901A1 (es)	2005-12-30
US20070244323A1 (en)	2007-10-18
JP4740947B2 (ja)	2011-08-03
GB0411378D0 (en)	2004-06-23
TW200612953A (en)	2006-05-01
ME02778B (me)	2010-10-31
DK1753431T3 (da)	2009-11-16
CY1109500T1 (el)	2014-08-13
WO2005112934A1 (en)	2005-12-01
AU2005244650B2 (en)	2008-04-10
SI1753431T1 (sl)	2009-12-31
MY138868A (en)	2009-08-28
NZ550931A (en)	2009-05-31
CN101031303B (zh)	2011-08-31
BRPI0511253B8 (pt)	2021-05-25
CN101031303A (zh)	2007-09-05
CA2565513C (en)	2010-10-19
EP1753431A1 (en)	2007-02-21
CA2565513A1 (en)	2005-12-01
AU2005244650A1 (en)	2005-12-01
RU2383343C2 (ru)	2010-03-10
IL178928A0 (en)	2007-03-08
AR110045A2 (es)	2019-02-20
ATE439841T1 (de)	2009-09-15
EP1753431B1 (en)	2009-08-19
IL178928A (en)	2012-04-30
NO338324B1 (no)	2016-08-08
KR20070034499A (ko)	2007-03-28
DE602005016105D1 (de)	2009-10-01
US8067427B2 (en)	2011-11-29
RS51112B (sr)	2010-10-31
MXPA06013501A (es)	2007-06-12
UA81732C2 (ru)	2008-01-25
HRP20090547T1 (hr)	2009-11-30
NO20065735L (no)	2006-12-19
BRPI0511253B1 (pt)	2020-03-31

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