ZA200610477B - Opioids for the treatment of the restless leg syndrome - Google Patents

Opioids for the treatment of the restless leg syndrome Download PDF

Info

Publication number: ZA200610477B
Authority: ZA; South Africa
Prior art keywords: opioid; release; oxycodone; matrix; dosage form
Prior art date: 2004-06-08

Application number

ZA200610477A

Other languages

English (en)

Inventor

Fleischer Wolfgang

Reimer Karen

Gawora Karin

Original Assignee

Euro Celtique Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-06-08

Filing date

2006-12-14

Publication date

2007-12-27

2006-12-14 Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa

2007-12-27 Publication of ZA200610477B publication Critical patent/ZA200610477B/en

Links

208000005793 Restless legs syndrome Diseases 0.000 title claims abstract description 37
238000011282 treatment Methods 0.000 title claims description 11
229940005483 opioid analgesics Drugs 0.000 title description 6
238000013270 controlled release Methods 0.000 claims abstract description 45
239000006186 oral dosage form Substances 0.000 claims abstract description 27
238000004519 manufacturing process Methods 0.000 claims abstract description 17
239000003814 drug Substances 0.000 claims abstract description 8
239000000203 mixture Substances 0.000 claims description 81
-1 hydsromorphone Chemical compound 0.000 claims description 45
BRUQQQPBMZOVGD-XFKAJCMBSA-N Oxycodone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C BRUQQQPBMZOVGD-XFKAJCMBSA-N 0.000 claims description 29
229960002085 oxycodone Drugs 0.000 claims description 28
238000002360 preparation method Methods 0.000 claims description 26
UZHSEJADLWPNLE-GRGSLBFTSA-N naloxone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(O)C2=C5[C@@]13CCN4CC=C UZHSEJADLWPNLE-GRGSLBFTSA-N 0.000 claims description 21
229960004127 naloxone Drugs 0.000 claims description 21
BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims description 12
150000003839 salts Chemical class 0.000 claims description 12
150000001875 compounds Chemical class 0.000 claims description 11
239000000556 agonist Substances 0.000 claims description 10
230000002459 sustained effect Effects 0.000 claims description 7
229960005181 morphine Drugs 0.000 claims description 6
OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 claims description 5
238000003860 storage Methods 0.000 claims description 5
XYYVYLMBEZUESM-UHFFFAOYSA-N dihydrocodeine Natural products C1C(N(CCC234)C)C2C=CC(=O)C3OC2=C4C1=CC=C2OC XYYVYLMBEZUESM-UHFFFAOYSA-N 0.000 claims description 4
USSIQXCVUWKGNF-UHFFFAOYSA-N 6-(dimethylamino)-4,4-diphenylheptan-3-one Chemical compound C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 USSIQXCVUWKGNF-UHFFFAOYSA-N 0.000 claims description 3
WJBLNOPPDWQMCH-MBPVOVBZSA-N Nalmefene Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=C)O)CC1)O)CC1CC1 WJBLNOPPDWQMCH-MBPVOVBZSA-N 0.000 claims description 3
229960002428 fentanyl Drugs 0.000 claims description 3
LLPOLZWFYMWNKH-CMKMFDCUSA-N hydrocodone Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)CC(=O)[C@@H]1OC1=C2C3=CC=C1OC LLPOLZWFYMWNKH-CMKMFDCUSA-N 0.000 claims description 3
229960000240 hydrocodone Drugs 0.000 claims description 3
229960001797 methadone Drugs 0.000 claims description 3
229960005297 nalmefene Drugs 0.000 claims description 3
LLPOLZWFYMWNKH-UHFFFAOYSA-N trans-dihydrocodeinone Natural products C1C(N(CCC234)C)C2CCC(=O)C3OC2=C4C1=CC=C2OC LLPOLZWFYMWNKH-UHFFFAOYSA-N 0.000 claims description 3
239000003402 opiate agonist Substances 0.000 claims description 2
239000000825 pharmaceutical preparation Substances 0.000 claims description 2
235000002020 sage Nutrition 0.000 claims description 2
GGCSSNBKKAUURC-UHFFFAOYSA-N sufentanil Chemical group C1CN(CCC=2SC=CC=2)CCC1(COC)N(C(=O)CC)C1=CC=CC=C1 GGCSSNBKKAUURC-UHFFFAOYSA-N 0.000 claims description 2
239000012458 free base Substances 0.000 claims 3
PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 claims 1
VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 claims 1
125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims 1
239000011159 matrix material Substances 0.000 description 67
239000000463 material Substances 0.000 description 61
238000009472 formulation Methods 0.000 description 57
238000000576 coating method Methods 0.000 description 53
238000013268 sustained release Methods 0.000 description 46
239000012730 sustained-release form Substances 0.000 description 46
239000011248 coating agent Substances 0.000 description 42
229920001577 copolymer Polymers 0.000 description 34
230000002209 hydrophobic effect Effects 0.000 description 34
239000006185 dispersion Substances 0.000 description 32
239000011324 bead Substances 0.000 description 30
239000004014 plasticizer Substances 0.000 description 29
239000003795 chemical substances by application Substances 0.000 description 24
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 23
239000011230 binding agent Substances 0.000 description 22
ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 21
239000008187 granular material Substances 0.000 description 21
229920000642 polymer Polymers 0.000 description 19
230000000694 effects Effects 0.000 description 18
229920001249 ethyl cellulose Polymers 0.000 description 18
235000019325 ethyl cellulose Nutrition 0.000 description 18
238000000034 method Methods 0.000 description 18
239000001856 Ethyl cellulose Substances 0.000 description 17
NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 17
229960004667 ethyl cellulose Drugs 0.000 description 17
239000002552 dosage form Substances 0.000 description 16
229920000058 polyacrylate Polymers 0.000 description 16
208000024891 symptom Diseases 0.000 description 15
DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 description 12
239000004925 Acrylic resin Substances 0.000 description 12
229920000178 Acrylic resin Polymers 0.000 description 12
239000013543 active substance Substances 0.000 description 12
239000012530 fluid Substances 0.000 description 12
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 11
239000004480 active ingredient Substances 0.000 description 11
229920013820 alkyl cellulose Polymers 0.000 description 11
229920002678 cellulose Polymers 0.000 description 11
239000001913 cellulose Substances 0.000 description 11
235000010980 cellulose Nutrition 0.000 description 11
239000000243 solution Substances 0.000 description 11
239000000758 substrate Substances 0.000 description 11
229920003134 Eudragit® polymer Polymers 0.000 description 10
229940063557 methacrylate Drugs 0.000 description 10
239000003826 tablet Substances 0.000 description 10
239000001993 wax Substances 0.000 description 10
CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 9
230000001419 dependent effect Effects 0.000 description 9
229920013821 hydroxy alkyl cellulose Polymers 0.000 description 9
210000002414 leg Anatomy 0.000 description 9
229940063559 methacrylic acid Drugs 0.000 description 9
GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 9
239000000546 pharmaceutical excipient Substances 0.000 description 9
230000035807 sensation Effects 0.000 description 9
235000019615 sensations Nutrition 0.000 description 9
235000014113 dietary fatty acids Nutrition 0.000 description 8
238000004090 dissolution Methods 0.000 description 8
239000000194 fatty acid Substances 0.000 description 8
229930195729 fatty acid Natural products 0.000 description 8
239000004615 ingredient Substances 0.000 description 8
208000023515 periodic limb movement disease Diseases 0.000 description 8
229920003229 poly(methyl methacrylate) Polymers 0.000 description 8
239000000047 product Substances 0.000 description 8
230000001225 therapeutic effect Effects 0.000 description 8
208000008705 Nocturnal Myoclonus Syndrome Diseases 0.000 description 7
239000005557 antagonist Substances 0.000 description 7
239000000314 lubricant Substances 0.000 description 7
229920001515 polyalkylene glycol Polymers 0.000 description 7
239000000126 substance Substances 0.000 description 7
229940127450 Opioid Agonists Drugs 0.000 description 6
239000003086 colorant Substances 0.000 description 6
239000011162 core material Substances 0.000 description 6
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 6
230000035699 permeability Effects 0.000 description 6
229920003151 Eudragit® RL polymer Polymers 0.000 description 5
229920003152 Eudragit® RS polymer Polymers 0.000 description 5
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 5
208000035475 disorder Diseases 0.000 description 5
150000004665 fatty acids Chemical class 0.000 description 5
210000001035 gastrointestinal tract Anatomy 0.000 description 5
239000008240 homogeneous mixture Substances 0.000 description 5
229930195733 hydrocarbon Natural products 0.000 description 5
150000002430 hydrocarbons Chemical class 0.000 description 5
229920003145 methacrylic acid copolymer Polymers 0.000 description 5
239000004926 polymethyl methacrylate Substances 0.000 description 5
125000001453 quaternary ammonium group Chemical group 0.000 description 5
239000007787 solid Substances 0.000 description 5
SFPNZPQIIAJXGL-UHFFFAOYSA-N 2-ethoxyethyl 2-methylprop-2-enoate Chemical class CCOCCOC(=O)C(C)=C SFPNZPQIIAJXGL-UHFFFAOYSA-N 0.000 description 4
CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 4
229920000168 Microcrystalline cellulose Polymers 0.000 description 4
229920001800 Shellac Polymers 0.000 description 4
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 description 4
239000002253 acid Substances 0.000 description 4
239000002775 capsule Substances 0.000 description 4
OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 description 4
FLKPEMZONWLCSK-UHFFFAOYSA-N diethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 description 4
230000001079 digestive effect Effects 0.000 description 4
239000003085 diluting agent Substances 0.000 description 4
229940079593 drug Drugs 0.000 description 4
238000001125 extrusion Methods 0.000 description 4
150000002191 fatty alcohols Chemical class 0.000 description 4
230000002496 gastric effect Effects 0.000 description 4
239000007903 gelatin capsule Substances 0.000 description 4
BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 4
125000004356 hydroxy functional group Chemical group O* 0.000 description 4
238000010348 incorporation Methods 0.000 description 4
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
229940117841 methacrylic acid copolymer Drugs 0.000 description 4
229940016286 microcrystalline cellulose Drugs 0.000 description 4
235000019813 microcrystalline cellulose Nutrition 0.000 description 4
239000008108 microcrystalline cellulose Substances 0.000 description 4
239000003960 organic solvent Substances 0.000 description 4
230000000704 physical effect Effects 0.000 description 4
235000013874 shellac Nutrition 0.000 description 4
239000004208 shellac Substances 0.000 description 4
229940113147 shellac Drugs 0.000 description 4
ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 4
239000000454 talc Substances 0.000 description 4
229910052623 talc Inorganic materials 0.000 description 4
239000001069 triethyl citrate Substances 0.000 description 4
VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 4
235000013769 triethyl citrate Nutrition 0.000 description 4
235000015112 vegetable and seed oil Nutrition 0.000 description 4
239000008158 vegetable oil Substances 0.000 description 4
229920003169 water-soluble polymer Polymers 0.000 description 4
230000004584 weight gain Effects 0.000 description 4
235000019786 weight gain Nutrition 0.000 description 4
SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 3
NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 3
206010012335 Dependence Diseases 0.000 description 3
229920003161 Eudragit® RS 30 D Polymers 0.000 description 3
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
229920002125 Sokalan® Polymers 0.000 description 3
229920002494 Zein Polymers 0.000 description 3
229950005506 acetylmethadol Drugs 0.000 description 3
239000007864 aqueous solution Substances 0.000 description 3
239000012754 barrier agent Substances 0.000 description 3
235000013871 bee wax Nutrition 0.000 description 3
239000012166 beeswax Substances 0.000 description 3
239000004359 castor oil Substances 0.000 description 3
235000019438 castor oil Nutrition 0.000 description 3
229940082500 cetostearyl alcohol Drugs 0.000 description 3
238000001816 cooling Methods 0.000 description 3
235000019441 ethanol Nutrition 0.000 description 3
ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 3
238000005469 granulation Methods 0.000 description 3
239000012729 immediate-release (IR) formulation Substances 0.000 description 3
239000008101 lactose Substances 0.000 description 3
238000002844 melting Methods 0.000 description 3
230000008018 melting Effects 0.000 description 3
150000002734 metacrylic acid derivatives Chemical class 0.000 description 3
238000002156 mixing Methods 0.000 description 3
GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 3
230000007935 neutral effect Effects 0.000 description 3
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 3
239000003401 opiate antagonist Substances 0.000 description 3
230000003204 osmotic effect Effects 0.000 description 3
239000002245 particle Substances 0.000 description 3
229920002401 polyacrylamide Polymers 0.000 description 3
229920001223 polyethylene glycol Polymers 0.000 description 3
229920000193 polymethacrylate Polymers 0.000 description 3
239000003381 stabilizer Substances 0.000 description 3
239000000725 suspension Substances 0.000 description 3
OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 3
239000005019 zein Substances 0.000 description 3
229940093612 zein Drugs 0.000 description 3
WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 2
BQNSLJQRJAJITR-UHFFFAOYSA-N 1,1,2-trichloro-1,2-difluoroethane Chemical compound FC(Cl)C(F)(Cl)Cl BQNSLJQRJAJITR-UHFFFAOYSA-N 0.000 description 2
LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 2
NVVDPSZOAIMZLZ-UHFFFAOYSA-N 5-(diethylamino)-2-methylpent-2-enoic acid Chemical compound CCN(CC)CCC=C(C)C(O)=O NVVDPSZOAIMZLZ-UHFFFAOYSA-N 0.000 description 2
QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 2
239000004215 Carbon black (E152) Substances 0.000 description 2
229920000623 Cellulose acetate phthalate Polymers 0.000 description 2
PYGXAGIECVVIOZ-UHFFFAOYSA-N Dibutyl decanedioate Chemical compound CCCCOC(=O)CCCCCCCCC(=O)OCCCC PYGXAGIECVVIOZ-UHFFFAOYSA-N 0.000 description 2
206010052804 Drug tolerance Diseases 0.000 description 2
UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 description 2
VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 2
ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 2
239000005642 Oleic acid Substances 0.000 description 2
UQCNKQCJZOAFTQ-ISWURRPUSA-N Oxymorphone Chemical compound O([C@H]1C(CC[C@]23O)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O UQCNKQCJZOAFTQ-ISWURRPUSA-N 0.000 description 2
206010041349 Somnolence Diseases 0.000 description 2
229920002472 Starch Polymers 0.000 description 2
235000021355 Stearic acid Nutrition 0.000 description 2
ZFOZVQLOBQUTQQ-UHFFFAOYSA-N Tributyl citrate Chemical compound CCCCOC(=O)CC(O)(C(=O)OCCCC)CC(=O)OCCCC ZFOZVQLOBQUTQQ-UHFFFAOYSA-N 0.000 description 2
230000002159 abnormal effect Effects 0.000 description 2
229920006243 acrylic copolymer Polymers 0.000 description 2
229920006397 acrylic thermoplastic Polymers 0.000 description 2
150000001298 alcohols Chemical class 0.000 description 2
125000001931 aliphatic group Chemical group 0.000 description 2
QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 2
229940081734 cellulose acetate phthalate Drugs 0.000 description 2
229960000541 cetyl alcohol Drugs 0.000 description 2
239000008199 coating composition Substances 0.000 description 2
229960004126 codeine Drugs 0.000 description 2
DOIRQSBPFJWKBE-UHFFFAOYSA-N dibutyl phthalate Chemical compound CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC DOIRQSBPFJWKBE-UHFFFAOYSA-N 0.000 description 2
230000001804 emulsifying effect Effects 0.000 description 2
230000007613 environmental effect Effects 0.000 description 2
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
FSXVSUSRJXIJHB-UHFFFAOYSA-M ethyl prop-2-enoate;methyl 2-methylprop-2-enoate;trimethyl-[2-(2-methylprop-2-enoyloxy)ethyl]azanium;chloride Chemical compound [Cl-].CCOC(=O)C=C.COC(=O)C(C)=C.CC(=C)C(=O)OCC[N+](C)(C)C FSXVSUSRJXIJHB-UHFFFAOYSA-M 0.000 description 2
IVLVTNPOHDFFCJ-UHFFFAOYSA-N fentanyl citrate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 IVLVTNPOHDFFCJ-UHFFFAOYSA-N 0.000 description 2
239000007888 film coating Substances 0.000 description 2
238000009501 film coating Methods 0.000 description 2
239000000796 flavoring agent Substances 0.000 description 2
235000019634 flavors Nutrition 0.000 description 2
230000006870 function Effects 0.000 description 2
230000003179 granulation Effects 0.000 description 2
230000026781 habituation Effects 0.000 description 2
238000000265 homogenisation Methods 0.000 description 2
239000012943 hotmelt Substances 0.000 description 2
WVLOADHCBXTIJK-YNHQPCIGSA-N hydromorphone Chemical compound O([C@H]1C(CC[C@H]23)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O WVLOADHCBXTIJK-YNHQPCIGSA-N 0.000 description 2
229960001410 hydromorphone Drugs 0.000 description 2
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 2
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 2
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 2
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 2
230000006872 improvement Effects 0.000 description 2
239000003701 inert diluent Substances 0.000 description 2
QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 2
239000004922 lacquer Substances 0.000 description 2
230000033001 locomotion Effects 0.000 description 2
235000019359 magnesium stearate Nutrition 0.000 description 2
125000005397 methacrylic acid ester group Chemical group 0.000 description 2
125000005395 methacrylic acid group Chemical group 0.000 description 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
239000002480 mineral oil Substances 0.000 description 2
239000003887 narcotic antagonist Substances 0.000 description 2
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
239000003921 oil Substances 0.000 description 2
235000019198 oils Nutrition 0.000 description 2
ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 2
229960003617 oxycodone hydrochloride Drugs 0.000 description 2
229960005118 oxymorphone Drugs 0.000 description 2
208000035824 paresthesia Diseases 0.000 description 2
239000008188 pellet Substances 0.000 description 2
239000008194 pharmaceutical composition Substances 0.000 description 2
239000000049 pigment Substances 0.000 description 2
229940100467 polyvinyl acetate phthalate Drugs 0.000 description 2
229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
239000000843 powder Substances 0.000 description 2
230000008569 process Effects 0.000 description 2
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
238000007493 shaping process Methods 0.000 description 2
210000000813 small intestine Anatomy 0.000 description 2
238000005507 spraying Methods 0.000 description 2
235000019698 starch Nutrition 0.000 description 2
239000008107 starch Substances 0.000 description 2
239000008117 stearic acid Substances 0.000 description 2
125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
210000002784 stomach Anatomy 0.000 description 2
239000004094 surface-active agent Substances 0.000 description 2
239000006188 syrup Substances 0.000 description 2
235000020357 syrup Nutrition 0.000 description 2
ISXSCDLOGDJUNJ-UHFFFAOYSA-N tert-butyl prop-2-enoate Chemical compound CC(C)(C)OC(=O)C=C ISXSCDLOGDJUNJ-UHFFFAOYSA-N 0.000 description 2
HLZKNKRTKFSKGZ-UHFFFAOYSA-N tetradecan-1-ol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 description 2
229920001169 thermoplastic Polymers 0.000 description 2
239000004416 thermosoftening plastic Substances 0.000 description 2
239000004408 titanium dioxide Substances 0.000 description 2
URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 2
229920003176 water-insoluble polymer Polymers 0.000 description 2
238000005550 wet granulation Methods 0.000 description 2
NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 2
LGFMXOTUSSVQJV-NEYUFSEYSA-N (4r,4ar,7s,7ar,12bs)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol;(4r,4ar,7s,7ar,12bs)-3-methyl-2,4,4a,7,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol;1-[(3,4-dimethoxyphenyl)methyl]-6 Chemical compound Cl.Cl.Cl.O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC.C1=C(OC)C(OC)=CC=C1CC1=NC=CC2=CC(OC)=C(OC)C=C12 LGFMXOTUSSVQJV-NEYUFSEYSA-N 0.000 description 1
ACSGYQDUMAPFHC-ONHRPZMOSA-N (4r,4as,7ar,12bs)-4a,9-dihydroxy-3-prop-2-enyl-2,4,5,6,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one;(4r,4as,7ar,12bs)-4a-hydroxy-9-methoxy-3-methyl-2,4,5,6,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C.O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(O)C2=C5[C@@]13CCN4CC=C ACSGYQDUMAPFHC-ONHRPZMOSA-N 0.000 description 1
LLPOLZWFYMWNKH-NXHIVTLCSA-N (4r,7ar,12bs)-9-methoxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one Chemical compound C1([C@H](N(CC[C@@]112)C)C3)CCC(=O)[C@@H]1OC1=C2C3=CC=C1OC LLPOLZWFYMWNKH-NXHIVTLCSA-N 0.000 description 1
WCOXQTXVACYMLM-UHFFFAOYSA-N 2,3-bis(12-hydroxyoctadecanoyloxy)propyl 12-hydroxyoctadecanoate Chemical compound CCCCCCC(O)CCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCC(O)CCCCCC)COC(=O)CCCCCCCCCCC(O)CCCCCC WCOXQTXVACYMLM-UHFFFAOYSA-N 0.000 description 1
KMZHZAAOEWVPSE-UHFFFAOYSA-N 2,3-dihydroxypropyl acetate Chemical compound CC(=O)OCC(O)CO KMZHZAAOEWVPSE-UHFFFAOYSA-N 0.000 description 1
XMSWGYQEWPUOKA-UHFFFAOYSA-N 2-[3-(3-hydroxyphenyl)-2,3-dimethylpiperidin-1-yl]-1-phenylethanone Chemical compound C1CCC(C=2C=C(O)C=CC=2)(C)C(C)N1CC(=O)C1=CC=CC=C1 XMSWGYQEWPUOKA-UHFFFAOYSA-N 0.000 description 1
VKNASXZDGZNEDA-UHFFFAOYSA-N 2-cyanoethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCC#N VKNASXZDGZNEDA-UHFFFAOYSA-N 0.000 description 1
SSONCJTVDRSLNK-UHFFFAOYSA-N 2-methylprop-2-enoic acid;hydrochloride Chemical compound Cl.CC(=C)C(O)=O SSONCJTVDRSLNK-UHFFFAOYSA-N 0.000 description 1
VFUGCQKESINERB-UHFFFAOYSA-N 3-(1-methyl-3-propylpyrrolidin-3-yl)phenol Chemical compound C=1C=CC(O)=CC=1C1(CCC)CCN(C)C1 VFUGCQKESINERB-UHFFFAOYSA-N 0.000 description 1
FEWJPZIEWOKRBE-UHFFFAOYSA-M 3-carboxy-2,3-dihydroxypropanoate Chemical compound OC(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-M 0.000 description 1
244000215068 Acacia senegal Species 0.000 description 1
HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
229920002126 Acrylic acid copolymer Polymers 0.000 description 1
229920000856 Amylose Polymers 0.000 description 1
CQVSFRQJOZPSGM-UHFFFAOYSA-N CCNC1=NC(CCC2)=C2C(N(CC(NC2=C3)=O)C2=CC=C3OC)=N1 Chemical compound CCNC1=NC(CCC2)=C2C(N(CC(NC2=C3)=O)C2=CC=C3OC)=N1 CQVSFRQJOZPSGM-UHFFFAOYSA-N 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
206010010774 Constipation Diseases 0.000 description 1
229920002261 Corn starch Polymers 0.000 description 1
208000007590 Disorders of Excessive Somnolence Diseases 0.000 description 1
101100456896 Drosophila melanogaster metl gene Proteins 0.000 description 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical class CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 description 1
OGDVEMNWJVYAJL-LEPYJNQMSA-N Ethyl morphine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OCC OGDVEMNWJVYAJL-LEPYJNQMSA-N 0.000 description 1
OGDVEMNWJVYAJL-UHFFFAOYSA-N Ethylmorphine Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OCC OGDVEMNWJVYAJL-UHFFFAOYSA-N 0.000 description 1
229920003148 Eudragit® E polymer Polymers 0.000 description 1
229920003136 Eudragit® L polymer Polymers 0.000 description 1
229920003137 Eudragit® S polymer Polymers 0.000 description 1
206010017062 Formication Diseases 0.000 description 1
VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
229920000084 Gum arabic Polymers 0.000 description 1
241000238631 Hexapoda Species 0.000 description 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 1
LFVLUOAHQIVABZ-UHFFFAOYSA-N Iodofenphos Chemical compound COP(=S)(OC)OC1=CC(Cl)=C(I)C=C1Cl LFVLUOAHQIVABZ-UHFFFAOYSA-N 0.000 description 1
JAQUASYNZVUNQP-USXIJHARSA-N Levorphanol Chemical compound C1C2=CC=C(O)C=C2[C@]23CCN(C)[C@H]1[C@@H]2CCCC3 JAQUASYNZVUNQP-USXIJHARSA-N 0.000 description 1
XADCESSVHJOZHK-UHFFFAOYSA-N Meperidine Chemical compound C=1C=CC=CC=1C1(C(=O)OCC)CCN(C)CC1 XADCESSVHJOZHK-UHFFFAOYSA-N 0.000 description 1
HOKDBMAJZXIPGC-UHFFFAOYSA-N Mequitazine Chemical compound C12=CC=CC=C2SC2=CC=CC=C2N1CC1C(CC2)CCN2C1 HOKDBMAJZXIPGC-UHFFFAOYSA-N 0.000 description 1
206010028347 Muscle twitching Diseases 0.000 description 1
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
UIQMVEYFGZJHCZ-SSTWWWIQSA-N Nalorphine Chemical compound C([C@@H](N(CC1)CC=C)[C@@H]2C=C[C@@H]3O)C4=CC=C(O)C5=C4[C@@]21[C@H]3O5 UIQMVEYFGZJHCZ-SSTWWWIQSA-N 0.000 description 1
239000006057 Non-nutritive feed additive Substances 0.000 description 1
APSUXPSYBJVPPS-YAUKWVCOSA-N Norbinaltorphimine Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CC=2C=3C[C@]4(O)[C@]67CCN(CC8CC8)[C@@H]4CC=4C7=C(C(=CC=4)O)O[C@H]6C=3NC=25)O)CC1)O)CC1CC1 APSUXPSYBJVPPS-YAUKWVCOSA-N 0.000 description 1
101150050192 PIGM gene Proteins 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
229920002845 Poly(methacrylic acid) Polymers 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
208000004756 Respiratory Insufficiency Diseases 0.000 description 1
206010038678 Respiratory depression Diseases 0.000 description 1
206010040026 Sensory disturbance Diseases 0.000 description 1
208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
208000032140 Sleepiness Diseases 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
VOKSWYLNZZRQPF-UHFFFAOYSA-N Talwin Chemical compound C1C2=CC=C(O)C=C2C2(C)C(C)C1N(CC=C(C)C)CC2 VOKSWYLNZZRQPF-UHFFFAOYSA-N 0.000 description 1
241000906446 Theraps Species 0.000 description 1
239000000205 acacia gum Substances 0.000 description 1
235000010489 acacia gum Nutrition 0.000 description 1
230000009471 action Effects 0.000 description 1
239000000654 additive Substances 0.000 description 1
238000005054 agglomeration Methods 0.000 description 1
230000002776 aggregation Effects 0.000 description 1
239000012670 alkaline solution Substances 0.000 description 1
UVAZQQHAVMNMHE-XJKSGUPXSA-N alphaprodine Chemical compound C=1C=CC=CC=1[C@@]1(OC(=O)CC)CCN(C)C[C@@H]1C UVAZQQHAVMNMHE-XJKSGUPXSA-N 0.000 description 1
229960001349 alphaprodine Drugs 0.000 description 1
239000004411 aluminium Substances 0.000 description 1
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
229910052782 aluminium Inorganic materials 0.000 description 1
125000004103 aminoalkyl group Chemical group 0.000 description 1
229940035676 analgesics Drugs 0.000 description 1
229960002512 anileridine Drugs 0.000 description 1
LKYQLAWMNBFNJT-UHFFFAOYSA-N anileridine Chemical compound C1CC(C(=O)OCC)(C=2C=CC=CC=2)CCN1CCC1=CC=C(N)C=C1 LKYQLAWMNBFNJT-UHFFFAOYSA-N 0.000 description 1
210000003423 ankle Anatomy 0.000 description 1
239000000730 antalgic agent Substances 0.000 description 1
229940125681 anticonvulsant agent Drugs 0.000 description 1
239000001961 anticonvulsive agent Substances 0.000 description 1
239000012736 aqueous medium Substances 0.000 description 1
239000007900 aqueous suspension Substances 0.000 description 1
210000000617 arm Anatomy 0.000 description 1
125000003118 aryl group Chemical group 0.000 description 1
239000012752 auxiliary agent Substances 0.000 description 1
230000006399 behavior Effects 0.000 description 1
229940049706 benzodiazepine Drugs 0.000 description 1
150000001557 benzodiazepines Chemical class 0.000 description 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
230000033228 biological regulation Effects 0.000 description 1
230000037058 blood plasma level Effects 0.000 description 1
239000006189 buccal tablet Substances 0.000 description 1
239000000872 buffer Substances 0.000 description 1
RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 description 1
229960001736 buprenorphine Drugs 0.000 description 1
NEDGUIRITORSKL-UHFFFAOYSA-N butyl 2-methylprop-2-enoate;2-(dimethylamino)ethyl 2-methylprop-2-enoate;methyl 2-methylprop-2-enoate Chemical compound COC(=O)C(C)=C.CCCCOC(=O)C(C)=C.CN(C)CCOC(=O)C(C)=C NEDGUIRITORSKL-UHFFFAOYSA-N 0.000 description 1
229940077731 carbohydrate nutrients Drugs 0.000 description 1
150000001720 carbohydrates Chemical class 0.000 description 1
235000014633 carbohydrates Nutrition 0.000 description 1
239000004203 carnauba wax Substances 0.000 description 1
235000013869 carnauba wax Nutrition 0.000 description 1
239000000969 carrier Substances 0.000 description 1
229920003086 cellulose ether Polymers 0.000 description 1
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical class OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 1
DGBIGWXXNGSACT-UHFFFAOYSA-N clonazepam Chemical compound C12=CC([N+](=O)[O-])=CC=C2NC(=O)CN=C1C1=CC=CC=C1Cl DGBIGWXXNGSACT-UHFFFAOYSA-N 0.000 description 1
229960003120 clonazepam Drugs 0.000 description 1
238000004040 coloring Methods 0.000 description 1
239000012141 concentrate Substances 0.000 description 1
239000000470 constituent Substances 0.000 description 1
239000008120 corn starch Substances 0.000 description 1
229940099112 cornstarch Drugs 0.000 description 1
238000005520 cutting process Methods 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
230000006735 deficit Effects 0.000 description 1
239000003405 delayed action preparation Substances 0.000 description 1
238000011161 development Methods 0.000 description 1
230000018109 developmental process Effects 0.000 description 1
WDEFBBTXULIOBB-WBVHZDCISA-N dextilidine Chemical compound C=1C=CC=CC=1[C@@]1(C(=O)OCC)CCC=C[C@H]1N(C)C WDEFBBTXULIOBB-WBVHZDCISA-N 0.000 description 1
229960004193 dextropropoxyphene Drugs 0.000 description 1
XLMALTXPSGQGBX-GCJKJVERSA-N dextropropoxyphene Chemical compound C([C@](OC(=O)CC)([C@H](C)CN(C)C)C=1C=CC=CC=1)C1=CC=CC=C1 XLMALTXPSGQGBX-GCJKJVERSA-N 0.000 description 1
229940099371 diacetylated monoglycerides Drugs 0.000 description 1
AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 description 1
229960003529 diazepam Drugs 0.000 description 1
238000009792 diffusion process Methods 0.000 description 1
229960000920 dihydrocodeine Drugs 0.000 description 1
RBOXVHNMENFORY-DNJOTXNNSA-N dihydrocodeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC RBOXVHNMENFORY-DNJOTXNNSA-N 0.000 description 1
229950004655 dimepheptanol Drugs 0.000 description 1
201000010099 disease Diseases 0.000 description 1
239000012738 dissolution medium Substances 0.000 description 1
230000009429 distress Effects 0.000 description 1
208000002173 dizziness Diseases 0.000 description 1
LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 1
125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
230000003291 dopaminomimetic effect Effects 0.000 description 1
239000006196 drop Substances 0.000 description 1
239000003937 drug carrier Substances 0.000 description 1
238000001035 drying Methods 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
230000002708 enhancing effect Effects 0.000 description 1
238000009505 enteric coating Methods 0.000 description 1
239000002702 enteric coating Substances 0.000 description 1
230000003628 erosive effect Effects 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
150000002170 ethers Chemical class 0.000 description 1
229960004578 ethylmorphine Drugs 0.000 description 1
239000003925 fat Substances 0.000 description 1
239000000945 filler Substances 0.000 description 1
239000012467 final product Substances 0.000 description 1
230000010006 flight Effects 0.000 description 1
210000002683 foot Anatomy 0.000 description 1
229960002870 gabapentin Drugs 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
239000007897 gelcap Substances 0.000 description 1
230000009477 glass transition Effects 0.000 description 1
150000004676 glycans Polymers 0.000 description 1
125000005908 glyceryl ester group Chemical group 0.000 description 1
239000001087 glyceryl triacetate Substances 0.000 description 1
235000013773 glyceryl triacetate Nutrition 0.000 description 1
VOZRXNHHFUQHIL-UHFFFAOYSA-N glycidyl methacrylate Chemical compound CC(=C)C(=O)OCC1CO1 VOZRXNHHFUQHIL-UHFFFAOYSA-N 0.000 description 1
125000003827 glycol group Chemical group 0.000 description 1
150000002334 glycols Chemical class 0.000 description 1
210000004247 hand Anatomy 0.000 description 1
239000007902 hard capsule Substances 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
125000001183 hydrocarbyl group Chemical group 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-M hydrogensulfate Chemical compound OS([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-M 0.000 description 1
239000001863 hydroxypropyl cellulose Substances 0.000 description 1
235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 description 1
229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 description 1
229940071676 hydroxypropylcellulose Drugs 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
238000011221 initial treatment Methods 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
239000002198 insoluble material Substances 0.000 description 1
206010022437 insomnia Diseases 0.000 description 1
230000000968 intestinal effect Effects 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
239000001034 iron oxide pigment Substances 0.000 description 1
239000010410 layer Substances 0.000 description 1
229960003406 levorphanol Drugs 0.000 description 1
239000007788 liquid Substances 0.000 description 1
230000007774 longterm Effects 0.000 description 1
229940049920 malate Drugs 0.000 description 1
BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
239000000155 melt Substances 0.000 description 1
DCUFMVPCXCSVNP-UHFFFAOYSA-N methacrylic anhydride Chemical compound CC(=C)C(=O)OC(=O)C(C)=C DCUFMVPCXCSVNP-UHFFFAOYSA-N 0.000 description 1
NPZXCTIHHUUEEJ-CMKMFDCUSA-N metopon Chemical compound O([C@@]1(C)C(=O)CC[C@@H]23)C4=C5[C@@]13CCN(C)[C@@H]2CC5=CC=C4O NPZXCTIHHUUEEJ-CMKMFDCUSA-N 0.000 description 1
229950006080 metopon Drugs 0.000 description 1
239000011859 microparticle Substances 0.000 description 1
239000004005 microsphere Substances 0.000 description 1
235000010755 mineral Nutrition 0.000 description 1
235000010446 mineral oil Nutrition 0.000 description 1
150000002772 monosaccharides Chemical class 0.000 description 1
229940043348 myristyl alcohol Drugs 0.000 description 1
125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
DNKKLDKIFMDAPT-UHFFFAOYSA-N n,n-dimethylmethanamine;2-methylprop-2-enoic acid Chemical compound CN(C)C.CC(=C)C(O)=O.CC(=C)C(O)=O DNKKLDKIFMDAPT-UHFFFAOYSA-N 0.000 description 1
NETZHAKZCGBWSS-CEDHKZHLSA-N nalbuphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]1(O)CC[C@@H]3O)CN2CC1CCC1 NETZHAKZCGBWSS-CEDHKZHLSA-N 0.000 description 1
229960000805 nalbuphine Drugs 0.000 description 1
229960000938 nalorphine Drugs 0.000 description 1
DQCKKXVULJGBQN-XFWGSAIBSA-N naltrexone Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=O)O)CC1)O)CC1CC1 DQCKKXVULJGBQN-XFWGSAIBSA-N 0.000 description 1
229960003086 naltrexone Drugs 0.000 description 1
229920001206 natural gum Polymers 0.000 description 1
229960004300 nicomorphine Drugs 0.000 description 1
HNDXBGYRMHRUFN-CIVUWBIHSA-N nicomorphine Chemical compound O([C@H]1C=C[C@H]2[C@H]3CC=4C5=C(C(=CC=4)OC(=O)C=4C=NC=CC=4)O[C@@H]1[C@]52CCN3C)C(=O)C1=CC=CN=C1 HNDXBGYRMHRUFN-CIVUWBIHSA-N 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
239000000014 opioid analgesic Substances 0.000 description 1
239000008203 oral pharmaceutical composition Substances 0.000 description 1
239000007935 oral tablet Substances 0.000 description 1
229940096978 oral tablet Drugs 0.000 description 1
150000002923 oximes Chemical class 0.000 description 1
125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
229960003294 papaveretum Drugs 0.000 description 1
239000012188 paraffin wax Substances 0.000 description 1
239000002304 perfume Substances 0.000 description 1
229960000482 pethidine Drugs 0.000 description 1
229940124531 pharmaceutical excipient Drugs 0.000 description 1
DHTRHEVNFFZCNU-OAHLLOKOSA-N phenampromide Chemical compound C([C@@H](C)N(C(=O)CC)C=1C=CC=CC=1)N1CCCCC1 DHTRHEVNFFZCNU-OAHLLOKOSA-N 0.000 description 1
229950007248 phenampromide Drugs 0.000 description 1
229960004315 phenoperidine Drugs 0.000 description 1
IPOPQVVNCFQFRK-UHFFFAOYSA-N phenoperidine Chemical compound C1CC(C(=O)OCC)(C=2C=CC=CC=2)CCN1CCC(O)C1=CC=CC=C1 IPOPQVVNCFQFRK-UHFFFAOYSA-N 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
XNGIFLGASWRNHJ-UHFFFAOYSA-N phthalic acid Chemical class OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 description 1
239000006187 pill Substances 0.000 description 1
229940068170 pirinitramide Drugs 0.000 description 1
IHEHEFLXQFOQJO-UHFFFAOYSA-N piritramide Chemical compound C1CC(C(=O)N)(N2CCCCC2)CCN1CCC(C#N)(C=1C=CC=CC=1)C1=CC=CC=C1 IHEHEFLXQFOQJO-UHFFFAOYSA-N 0.000 description 1
238000005498 polishing Methods 0.000 description 1
229920001281 polyalkylene Polymers 0.000 description 1
229920001282 polysaccharide Polymers 0.000 description 1
239000005017 polysaccharide Substances 0.000 description 1
150000004804 polysaccharides Polymers 0.000 description 1
229920000136 polysorbate Polymers 0.000 description 1
229920002744 polyvinyl acetate phthalate Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
229940069328 povidone Drugs 0.000 description 1
239000000651 prodrug Substances 0.000 description 1
229940002612 prodrug Drugs 0.000 description 1
229950004859 profadol Drugs 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
ZBAFFZBKCMWUHM-UHFFFAOYSA-N propiram Chemical compound C=1C=CC=NC=1N(C(=O)CC)C(C)CN1CCCCC1 ZBAFFZBKCMWUHM-UHFFFAOYSA-N 0.000 description 1
229950003779 propiram Drugs 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
239000011347 resin Substances 0.000 description 1
229920005989 resin Polymers 0.000 description 1
239000012266 salt solution Substances 0.000 description 1
238000001878 scanning electron micrograph Methods 0.000 description 1
RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
235000012239 silicon dioxide Nutrition 0.000 description 1
239000002356 single layer Substances 0.000 description 1
230000037321 sleepiness Effects 0.000 description 1
239000007901 soft capsule Substances 0.000 description 1
239000002195 soluble material Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
230000002269 spontaneous effect Effects 0.000 description 1
239000007921 spray Substances 0.000 description 1
229940012831 stearyl alcohol Drugs 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
229910021653 sulphate ion Inorganic materials 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
208000011580 syndromic disease Diseases 0.000 description 1
239000002562 thickening agent Substances 0.000 description 1
229960001402 tilidine Drugs 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
229960002622 triacetin Drugs 0.000 description 1
150000003626 triacylglycerols Chemical class 0.000 description 1
GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 1
210000000689 upper leg Anatomy 0.000 description 1
239000003981 vehicle Substances 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Disintegrating Or Milling (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

ZA200610477A 2004-06-08 2006-12-14 Opioids for the treatment of the restless leg syndrome ZA200610477B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP04013469A EP1604667A1 (fr)	2004-06-08	2004-06-08	Opioides pour le traitement des impatiences des membres inférieurs

Publications (1)

Publication Number	Publication Date
ZA200610477B true ZA200610477B (en)	2007-12-27

Family

ID=34925286

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200610477A ZA200610477B (en)	2004-06-08	2006-12-14	Opioids for the treatment of the restless leg syndrome

Country Status (25)

Country	Link
US (2)	US20070185147A1 (fr)
EP (3)	EP1604667A1 (fr)
JP (2)	JP2008501742A (fr)
KR (2)	KR101200869B1 (fr)
CN (2)	CN1984659A (fr)
AT (1)	ATE486603T1 (fr)
AU (1)	AU2005251445C1 (fr)
BR (1)	BRPI0511300A (fr)
CA (1)	CA2569742C (fr)
CY (1)	CY1111512T1 (fr)
DE (1)	DE602005024571D1 (fr)
DK (1)	DK1781291T3 (fr)
ES (1)	ES2355247T3 (fr)
HR (1)	HRP20110049T2 (fr)
IL (1)	IL179896A (fr)
ME (1)	ME01238B (fr)
MX (1)	MXPA06014391A (fr)
NO (1)	NO337890B1 (fr)
NZ (1)	NZ552430A (fr)
PL (1)	PL1781291T3 (fr)
PT (1)	PT1781291E (fr)
RS (1)	RS51573B (fr)
SI (1)	SI1781291T1 (fr)
WO (1)	WO2005120506A1 (fr)
ZA (1)	ZA200610477B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK1685839T3 (da)	1997-12-22	2013-06-24	Euro Celtique Sa	Farmaceutisk oral doseringsform omfattende en kombination af en opioidagonist og opioidantagonist
US6375957B1 (en)	1997-12-22	2002-04-23	Euro-Celtique, S.A.	Opioid agonist/opioid antagonist/acetaminophen combinations
CN1525851A (zh)	2001-05-11	2004-09-01	��ҩ��޹�˾	抗滥用阿片样物质控释剂型
CA2478515C (fr)	2002-04-05	2010-09-28	Purdue Pharma	Preparation pharmaceutique contenant oxycodone et naloxone
EP1604666A1 (fr)	2004-06-08	2005-12-14	Euro-Celtique S.A.	Opioides pour le traitement de la bronchopneumopathie chronique obstructive
EP1702558A1 (fr)	2005-02-28	2006-09-20	Euro-Celtique S.A.	Procédé et dispositif pour évaluer la fonction de l'activité intestinale
US8445018B2 (en)	2006-09-15	2013-05-21	Cima Labs Inc.	Abuse resistant drug formulation
US8632805B2 (en) *	2008-06-20	2014-01-21	Mutual Pharmaceutical Company, Inc.	Controlled-release formulations, method of manufacture, and use thereof
US7794750B2 (en) *	2008-06-20	2010-09-14	Mutual Pharmaceutical Company, Inc.	Controlled-release formulations, method of manufacture, and use thereof
WO2010103039A1 (fr)	2009-03-10	2010-09-16	Euro-Celtique S.A.	Compositions pharmaceutiques à libération immédiate comportant de l'oxycodone et du naloxone
KR20130030260A (ko)	2010-05-10	2013-03-26	유로-셀티큐 에스.에이.	히드로모르폰 및 날록손을 포함하는 제약 조성물
NZ603173A (en)	2010-05-10	2014-10-31	Euro Celtique Sa	Manufacturing of active-free granules and tablets comprising the same
WO2011141490A1 (fr)	2010-05-10	2011-11-17	Euro-Celtique S.A.	Combinaison de granules chargés de principe actif et de principes actifs supplémentaires
US20180264013A1 (en) *	2010-07-08	2018-09-20	Wellesley Pharmaceuticals, Llc	Composition and methods for treating sleep disorders
PH12013500172A1 (en) *	2010-08-13	2022-10-24	Euro Celtique Sa	Use of binders for manufacturing storage stable formulations
KR20180037074A (ko)	2013-07-23	2018-04-10	유로-셀티큐 에스.에이.	장내 세균총이상을 초래하고/하거나 장내 박테리아 전위에 대한 위험을 증가시키는 질환과 통증으로 인해 고통받고 있는 환자에서 통증을 치료하는데 사용하기 위한 옥시코돈과 날록손의 조합물
EP3068397A1 (fr)	2013-11-13	2016-09-21	Euro-Celtique S.A.	Hydromorphone et naloxone utilisées pour le traitement de la douleur et du syndrome de dysfonctionnement intestinal dû aux opioïdes

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3173876A (en)	1960-05-27	1965-03-16	John C Zobrist	Cleaning methods and compositions
NL271831A (fr)	1960-11-29
US3276586A (en)	1963-08-30	1966-10-04	Rosaen Filter Co	Indicating means for fluid filters
NL6714885A (fr)	1967-11-02	1969-05-06
US3541006A (en)	1968-07-03	1970-11-17	Amicon Corp	Ultrafiltration process
US3541005A (en)	1969-02-05	1970-11-17	Amicon Corp	Continuous ultrafiltration of macromolecular solutions
US3773955A (en) *	1970-08-03	1973-11-20	Bristol Myers Co	Analgetic compositions
FR2183546B1 (fr) *	1972-05-10	1975-06-20	Servier Lab
US3845770A (en)	1972-06-05	1974-11-05	Alza Corp	Osmatic dispensing device for releasing beneficial agent
US3916899A (en)	1973-04-25	1975-11-04	Alza Corp	Osmotic dispensing device with maximum and minimum sizes for the passageway
US3916889A (en)	1973-09-28	1975-11-04	Sandoz Ag	Patient ventilator apparatus
GB1478759A (en)	1974-11-18	1977-07-06	Alza Corp	Process for forming outlet passageways in pills using a laser
US3966040A (en) *	1975-03-05	1976-06-29	Hazelwood John E	Combined vibratory feeder drive unit, vibratory feeder bowl, and parts separator
US4077407A (en)	1975-11-24	1978-03-07	Alza Corporation	Osmotic devices having composite walls
US4126684A (en) *	1976-02-11	1978-11-21	Ciba-Geigy Corporation	4-amino-3-p-halophenylbutyric acids and their derivatives used in the control of narcotic abuse
US4063064A (en)	1976-02-23	1977-12-13	Coherent Radiation	Apparatus for tracking moving workpiece by a laser beam
US4200098A (en)	1978-10-23	1980-04-29	Alza Corporation	Osmotic system with distribution zone for dispensing beneficial agent
US4285987A (en)	1978-10-23	1981-08-25	Alza Corporation	Process for manufacturing device with dispersion zone
US4457933A (en) *	1980-01-24	1984-07-03	Bristol-Myers Company	Prevention of analgesic abuse
GB8332556D0 (en) *	1983-12-06	1984-01-11	Reckitt & Colmann Prod Ltd	Analgesic compositions
US4668685A (en) *	1984-07-05	1987-05-26	E.I. Du Pont De Nemours And Company	Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists
US4769372A (en) *	1986-06-18	1988-09-06	The Rockefeller University	Method of treating patients suffering from chronic pain or chronic cough
US4861598A (en)	1986-07-18	1989-08-29	Euroceltique, S.A.	Controlled release bases for pharmaceuticals
DE3812567A1 (de)	1988-04-15	1989-10-26	Basf Ag	Verfahren zur herstellung pharmazeutischer mischungen
US5236714A (en) *	1988-11-01	1993-08-17	Alza Corporation	Abusable substance dosage form having reduced abuse potential
US5266331A (en)	1991-11-27	1993-11-30	Euroceltique, S.A.	Controlled release oxycodone compositions
US5656295A (en) *	1991-11-27	1997-08-12	Euro-Celtique, S.A.	Controlled release oxycodone compositions
US5478577A (en) *	1993-11-23	1995-12-26	Euroceltique, S.A.	Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
US5968551A (en) *	1991-12-24	1999-10-19	Purdue Pharma L.P.	Orally administrable opioid formulations having extended duration of effect
US5681585A (en) *	1991-12-24	1997-10-28	Euro-Celtique, S.A.	Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer
US5273760A (en)	1991-12-24	1993-12-28	Euroceltigue, S.A.	Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer
US5286493A (en)	1992-01-27	1994-02-15	Euroceltique, S.A.	Stabilized controlled release formulations having acrylic polymer coating
US5472712A (en)	1991-12-24	1995-12-05	Euroceltique, S.A.	Controlled-release formulations coated with aqueous dispersions of ethylcellulose
US5324351A (en)	1992-08-13	1994-06-28	Euroceltique	Aqueous dispersions of zein and preparation thereof
NZ260408A (en) *	1993-05-10	1996-05-28	Euro Celtique Sa	Controlled release preparation comprising tramadol
IL110014A (en) *	1993-07-01	1999-11-30	Euro Celtique Sa	Solid controlled-release oral dosage forms of opioid analgesics
US5411745A (en)	1994-05-25	1995-05-02	Euro-Celtique, S.A.	Powder-layered morphine sulfate formulations
US5866154A (en) *	1994-10-07	1999-02-02	The Dupont Merck Pharmaceutical Company	Stabilized naloxone formulations
US5965161A (en) *	1994-11-04	1999-10-12	Euro-Celtique, S.A.	Extruded multi-particulates
US20020006964A1 (en) *	1995-05-16	2002-01-17	Young James W.	Methods of using and compositions comprising (+) sibutramine optionally in combination with other pharmacologically active compounds
DE19651551C2 (de) *	1996-12-11	2000-02-03	Klinge Co Chem Pharm Fab	Opioidantagonisthaltige galenische Formulierung
US6207142B1 (en) *	1997-04-14	2001-03-27	Janssen Pharmaceutica N.V.	Compositions containing an antifungal and a cationic agent
WO1999001111A1 (fr) *	1997-07-02	1999-01-14	Euro-Celtique, S.A.	Formulations de tramadol stabilisees a liberation prolongee
CN1204890C (zh) *	1997-12-22	2005-06-08	欧罗赛铁克股份有限公司	防止阿片样物质滥用的方法
DK1685839T3 (da) *	1997-12-22	2013-06-24	Euro Celtique Sa	Farmaceutisk oral doseringsform omfattende en kombination af en opioidagonist og opioidantagonist
CN1303286A (zh) *	1998-03-27	2001-07-11	法玛西雅厄普约翰美国公司	卡麦角林在治疗多动腿综合征中的应用
SE9803760D0 (sv) *	1998-11-04	1998-11-04	Jan Hedner	Sätt att behandla och diagnostisera syndromet restless legs och motsvarande medel
DE19918325A1 (de)	1999-04-22	2000-10-26	Euro Celtique Sa	Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion
US20030178031A1 (en) *	1999-05-07	2003-09-25	Du Pen, Inc.	Method for cancer pain treatment
US20030118641A1 (en) *	2000-07-27	2003-06-26	Roxane Laboratories, Inc.	Abuse-resistant sustained-release opioid formulation
DE19938823A1 (de) *	1999-08-19	2001-02-22	Boehringer Ingelheim Pharma	Medikamentöse Behandlung des Restless Leg Syndroms
US6258042B1 (en) *	1999-09-17	2001-07-10	James S. Factor	Visual analog scale and method of use for the diagnosis and/or treatment of physical pain
US6716449B2 (en) *	2000-02-08	2004-04-06	Euro-Celtique S.A.	Controlled-release compositions containing opioid agonist and antagonist
AU776666B2 (en) *	2000-02-08	2004-09-16	Euro-Celtique S.A.	Tamper-resistant oral opioid agonist formulations
US7223421B2 (en) *	2000-06-30	2007-05-29	Mcneil-Ppc, Inc.	Teste masked pharmaceutical particles
AR031152A1 (es) *	2000-10-31	2003-09-10	Upjohn Co	Tratamientos nuevos para el sindrome de piernas inquietas
WO2002085839A1 (fr) *	2001-04-19	2002-10-31	Warner-Lambert Company Llc	Acides amnines bicycliques ou tricycliques fondus
CN1525851A (zh) *	2001-05-11	2004-09-01	��ҩ��޹�˾	抗滥用阿片样物质控释剂型
CN1592609A (zh) *	2001-05-11	2005-03-09	恩德制药公司	抗滥用阿片样物质剂型
US7943173B2 (en) *	2001-07-18	2011-05-17	Purdue Pharma L.P.	Pharmaceutical combinations of oxycodone and naloxone
US20030044458A1 (en) *	2001-08-06	2003-03-06	Curtis Wright	Oral dosage form comprising a therapeutic agent and an adverse-effect agent
WO2003026676A1 (fr) *	2001-09-24	2003-04-03	Ortho-Mcneil Pharmaceutical, Inc.	Derives anticonvulsifs utiles dans le traitement du syndrome des membres sans repos et du mouvement involontaire des membres
CA2478515C (fr) *	2002-04-05	2010-09-28	Purdue Pharma	Preparation pharmaceutique contenant oxycodone et naloxone
US20030191147A1 (en) *	2002-04-09	2003-10-09	Barry Sherman	Opioid antagonist compositions and dosage forms
EP1364649A1 (fr) *	2002-05-23	2003-11-26	Cilag AG	Produits d'addition de tramadol et topiramate et son utilization
JP4694207B2 (ja) *	2002-07-05	2011-06-08	コルジウムファーマシューティカル，インコーポレイテッド	オピオイドおよび他の薬物に関する乱用抑止性の薬学的組成物
US7700626B2 (en) *	2004-06-04	2010-04-20	Adolor Corporation	Compositions containing opioid antagonists
EP1604666A1 (fr) *	2004-06-08	2005-12-14	Euro-Celtique S.A.	Opioides pour le traitement de la bronchopneumopathie chronique obstructive
EP1695700A1 (fr) *	2005-02-28	2006-08-30	Euro-Celtique S.A.	Forme posologique contenant de l'oxycodone et de la naloxone

2004
- 2004-06-08 EP EP04013469A patent/EP1604667A1/fr not_active Withdrawn
2005
- 2005-06-01 AU AU2005251445A patent/AU2005251445C1/en not_active Expired
- 2005-06-01 RS RS20110030A patent/RS51573B/sr unknown
- 2005-06-01 EP EP10175878A patent/EP2255808A3/fr not_active Withdrawn
- 2005-06-01 KR KR1020097016692A patent/KR101200869B1/ko not_active Expired - Lifetime
- 2005-06-01 DE DE602005024571T patent/DE602005024571D1/de not_active Expired - Lifetime
- 2005-06-01 CN CNA2005800231113A patent/CN1984659A/zh active Pending
- 2005-06-01 NZ NZ552430A patent/NZ552430A/en not_active IP Right Cessation
- 2005-06-01 CN CN2013102699069A patent/CN103394090A/zh active Pending
- 2005-06-01 MX MXPA06014391A patent/MXPA06014391A/es active IP Right Grant
- 2005-06-01 DK DK05754710.1T patent/DK1781291T3/da active
- 2005-06-01 KR KR1020077000489A patent/KR20070037485A/ko not_active Ceased
- 2005-06-01 JP JP2007526247A patent/JP2008501742A/ja not_active Withdrawn
- 2005-06-01 PL PL05754710T patent/PL1781291T3/pl unknown
- 2005-06-01 ME MEP-2011-18A patent/ME01238B/fr unknown
- 2005-06-01 ES ES05754710T patent/ES2355247T3/es not_active Expired - Lifetime
- 2005-06-01 AT AT05754710T patent/ATE486603T1/de active
- 2005-06-01 HR HR20110049A patent/HRP20110049T2/hr unknown
- 2005-06-01 SI SI200531198T patent/SI1781291T1/sl unknown
- 2005-06-01 BR BRPI0511300-8A patent/BRPI0511300A/pt not_active Application Discontinuation
- 2005-06-01 WO PCT/EP2005/005888 patent/WO2005120506A1/fr not_active Ceased
- 2005-06-01 US US11/570,222 patent/US20070185147A1/en not_active Abandoned
- 2005-06-01 EP EP05754710A patent/EP1781291B9/fr not_active Expired - Lifetime
- 2005-06-01 CA CA2569742A patent/CA2569742C/fr not_active Expired - Fee Related
- 2005-06-01 PT PT05754710T patent/PT1781291E/pt unknown
2006
- 2006-12-06 IL IL179896A patent/IL179896A/en active IP Right Grant
- 2006-12-14 ZA ZA200610477A patent/ZA200610477B/en unknown
2007
- 2007-01-08 NO NO20070113A patent/NO337890B1/no not_active IP Right Cessation
2011
- 2011-02-03 CY CY20111100121T patent/CY1111512T1/el unknown
- 2011-02-18 JP JP2011033064A patent/JP5774865B2/ja not_active Expired - Fee Related
- 2011-12-21 US US13/333,719 patent/US20120172387A1/en not_active Abandoned

Also Published As

Publication number	Publication date
SI1781291T1 (sl)	2011-02-28
JP5774865B2 (ja)	2015-09-09
IL179896A0 (en)	2007-05-15
PT1781291E (pt)	2011-01-06
WO2005120506A1 (fr)	2005-12-22
ES2355247T9 (es)	2011-11-03
CA2569742A1 (fr)	2005-12-22
CN1984659A (zh)	2007-06-20
NZ552430A (en)	2008-09-26
EP1781291A1 (fr)	2007-05-09
ATE486603T1 (de)	2010-11-15
AU2005251445C1 (en)	2009-04-09
EP1781291B1 (fr)	2010-11-03
CN103394090A (zh)	2013-11-20
ES2355247T3 (es)	2011-03-24
ME01238B (fr)	2011-08-31
NO337890B1 (no)	2016-07-04
JP2008501742A (ja)	2008-01-24
JP2011137020A (ja)	2011-07-14
AU2005251445B2 (en)	2008-09-04
KR20090089921A (ko)	2009-08-24
BRPI0511300A (pt)	2007-12-04
KR101200869B1 (ko)	2012-11-13
HRP20110049T2 (hr)	2011-10-31
EP1781291B9 (fr)	2011-08-31
IL179896A (en)	2013-07-31
DK1781291T3 (da)	2011-02-07
MXPA06014391A (es)	2007-02-19
AU2005251445A1 (en)	2005-12-22
CA2569742C (fr)	2011-03-22
US20070185147A1 (en)	2007-08-09
EP2255808A2 (fr)	2010-12-01
AU2005251445B8 (en)	2008-09-18
RS51573B (sr)	2011-08-31
EP1604667A1 (fr)	2005-12-14
DE602005024571D1 (de)	2010-12-16
HRP20110049T1 (en)	2011-02-28
NO20070113L (no)	2007-03-02
CY1111512T1 (el)	2015-08-05
EP2255808A3 (fr)	2011-05-11
KR20070037485A (ko)	2007-04-04
PL1781291T3 (pl)	2011-06-30
US20120172387A1 (en)	2012-07-05

Publication	Publication Date	Title
US10076516B2 (en)	2018-09-18	Methods of manufacturing oral dosage forms
JP5774865B2 (ja)	2015-09-09	下肢静止不能症候群の治療用オピオイド
US10179130B2 (en)	2019-01-15	Controlled release hydrocodone formulations
HK1151245A (en)	2012-01-27	Opioids for the treatment of the restlessness of the lower limbs
HK1156214A (en)	2012-06-08	Controlled release hydrocodone formulations