ZA200800208B - Imaging 18F or 11C-labelled alkylthiophenyl guanidines - Google Patents

Imaging 18F or 11C-labelled alkylthiophenyl guanidines

Info

Publication number
ZA200800208B
ZA200800208B ZA200800208A ZA200800208A ZA200800208B ZA 200800208 B ZA200800208 B ZA 200800208B ZA 200800208 A ZA200800208 A ZA 200800208A ZA 200800208 A ZA200800208 A ZA 200800208A ZA 200800208 B ZA200800208 B ZA 200800208B
Authority
ZA
South Africa
Prior art keywords
alkylthiophenyl
guanidines
labelled
imaging
labelled alkylthiophenyl
Prior art date
Application number
ZA200800208A
Other languages
English (en)
Inventor
Robins Edward George
Arstad Erik
Original Assignee
Hammersmith Imanet Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hammersmith Imanet Ltd filed Critical Hammersmith Imanet Ltd
Publication of ZA200800208B publication Critical patent/ZA200800208B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/46—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms
    • C07C323/48—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43—Y being a hetero atom
    • C07C323/44—X or Y being nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/46—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
ZA200800208A 2005-06-23 2008-01-08 Imaging 18F or 11C-labelled alkylthiophenyl guanidines ZA200800208B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0512770.9A GB0512770D0 (en) 2005-06-23 2005-06-23 Imaging compounds

Publications (1)

Publication Number Publication Date
ZA200800208B true ZA200800208B (en) 2008-12-31

Family

ID=34855999

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200800208A ZA200800208B (en) 2005-06-23 2008-01-08 Imaging 18F or 11C-labelled alkylthiophenyl guanidines

Country Status (19)

Country Link
US (1) US8058311B2 (da)
EP (1) EP1896400B1 (da)
JP (1) JP5015919B2 (da)
KR (1) KR101409549B1 (da)
CN (2) CN101253149A (da)
AU (1) AU2006260666B2 (da)
BR (1) BRPI0612272A2 (da)
CA (1) CA2610744C (da)
DK (1) DK1896400T3 (da)
ES (1) ES2435077T3 (da)
GB (1) GB0512770D0 (da)
IL (1) IL187750A (da)
MX (1) MX2007015437A (da)
NO (1) NO339982B1 (da)
NZ (1) NZ563812A (da)
PL (1) PL1896400T3 (da)
RU (1) RU2420516C2 (da)
WO (1) WO2006136846A1 (da)
ZA (1) ZA200800208B (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI618544B (zh) 2006-12-26 2018-03-21 藍瑟斯醫學影像公司 使心臟神經分布顯像之配位體
AU2011253052B2 (en) 2010-05-11 2015-05-14 Lantheus Medical Imaging, Inc. Compositions, methods and systems for the synthesis and use of imaging agents
GB201008047D0 (en) * 2010-05-14 2010-06-30 Ge Healthcare Ltd Method of synthesis
WO2012157900A2 (ko) * 2011-05-13 2012-11-22 서강대학교산학협력단 18f-표지 pet 방사성의약품의 전구체 및 그 제조방법
NL2006875C2 (en) * 2011-05-31 2012-12-03 Vereniging Voor Christelijk Hoger Onderwijs N,n-substituted guanidine compound.
EP2753605B1 (en) 2011-09-09 2019-03-27 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
US9745257B2 (en) * 2011-10-11 2017-08-29 Universidad Nacional De Quilmes Phenyl-guanidine derivatives
GB201117786D0 (en) * 2011-10-14 2011-11-30 Ge Healthcare Ltd Eluent vial
GB201117785D0 (en) * 2011-10-14 2011-11-30 Ge Healthcare Ltd Improved radiosynthesis method
GB201607572D0 (en) * 2016-04-29 2016-06-15 Ge Healthcare Ltd Ip And Kings College London Alyklation method
CN110117257B (zh) 2018-02-05 2022-12-06 安徽省新星药物开发有限责任公司 一种含胍基的p2y12受体拮抗剂、制备方法及其用途
CN111153840A (zh) * 2020-01-09 2020-05-15 复旦大学附属华山医院 [18f]-ge-179的合成方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0216621D0 (en) * 2002-07-17 2002-08-28 Imaging Res Solutions Ltd Imaging compounds

Also Published As

Publication number Publication date
GB0512770D0 (en) 2005-07-27
NO20076402L (no) 2008-02-15
NZ563812A (en) 2011-03-31
MX2007015437A (es) 2008-02-19
CN101253149A (zh) 2008-08-27
CN103351317A (zh) 2013-10-16
DK1896400T3 (da) 2013-11-18
RU2007146237A (ru) 2009-07-27
ES2435077T3 (es) 2013-12-18
EP1896400B1 (en) 2013-10-16
JP5015919B2 (ja) 2012-09-05
CA2610744C (en) 2014-09-23
NO339982B1 (no) 2017-02-27
BRPI0612272A2 (pt) 2012-04-24
KR20080016873A (ko) 2008-02-22
AU2006260666B2 (en) 2011-10-20
IL187750A (en) 2012-08-30
AU2006260666A1 (en) 2006-12-28
WO2006136846A1 (en) 2006-12-28
RU2420516C2 (ru) 2011-06-10
US20100143252A1 (en) 2010-06-10
IL187750A0 (en) 2008-04-13
PL1896400T3 (pl) 2014-03-31
EP1896400A1 (en) 2008-03-12
JP2008546755A (ja) 2008-12-25
CA2610744A1 (en) 2006-12-28
US8058311B2 (en) 2011-11-15
KR101409549B1 (ko) 2014-06-19

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