ZA200810676B - Novel aminoglycoside antibiotics - Google Patents

Novel aminoglycoside antibiotics

Info

Publication number
ZA200810676B
ZA200810676B ZA200810676A ZA200810676A ZA200810676B ZA 200810676 B ZA200810676 B ZA 200810676B ZA 200810676 A ZA200810676 A ZA 200810676A ZA 200810676 A ZA200810676 A ZA 200810676A ZA 200810676 B ZA200810676 B ZA 200810676B
Authority
ZA
South Africa
Prior art keywords
aminoglycoside antibiotics
novel aminoglycoside
novel
antibiotics
aminoglycoside
Prior art date
Application number
ZA200810676A
Other languages
English (en)
Inventor
Yoshihiko Kobayashi
Yoshihisa Akiyama
Takeshi Murakami
Nobuto Minowa
Masaki Tsushima
Yukiko Hiraiwa
Shoichi Murakami
Mitsuhiro Abe
Kazushige Sasaki
Shigeru Hoshiko
Toshiaki Miyake
Yoshiaki Takahashi
Daishiro Ikeda
Original Assignee
Meiji Seika Kaisha
Microbial Chem Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Kaisha, Microbial Chem Res Found filed Critical Meiji Seika Kaisha
Publication of ZA200810676B publication Critical patent/ZA200810676B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
ZA200810676A 2006-06-02 2007-06-01 Novel aminoglycoside antibiotics ZA200810676B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2006155062 2006-06-02

Publications (1)

Publication Number Publication Date
ZA200810676B true ZA200810676B (en) 2010-03-31

Family

ID=38801405

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200810676A ZA200810676B (en) 2006-06-02 2007-06-01 Novel aminoglycoside antibiotics

Country Status (14)

Country Link
US (4) US8148504B2 (pt)
EP (1) EP2036917B1 (pt)
JP (1) JP5160419B2 (pt)
KR (1) KR101458223B1 (pt)
CN (2) CN101495493B (pt)
AU (1) AU2007255856B2 (pt)
BR (1) BRPI0712312A2 (pt)
CA (1) CA2654561A1 (pt)
ES (1) ES2557992T3 (pt)
MX (1) MX2008015280A (pt)
RU (1) RU2458931C2 (pt)
UA (1) UA97245C2 (pt)
WO (1) WO2007142150A1 (pt)
ZA (1) ZA200810676B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011143497A1 (en) * 2010-05-12 2011-11-17 Rempex Pharmaceuticals, Inc. Aminoglycoside derivatives
ES2682931T3 (es) * 2013-05-30 2018-09-24 Meiji Seika Pharma Co., Ltd. Derivado de arbekacina y producción y uso del mismo
EP3330275A4 (en) * 2015-07-30 2018-12-05 Microbial Chemistry Research Foundation Novel aminoglycoside antibiotic effective against multidrug-resistant bacteria
JP2019001718A (ja) * 2015-11-02 2019-01-10 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 アミノグリコシド系抗生物質の製造方法
JP2019001717A (ja) * 2015-11-02 2019-01-10 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 アミノグリコシド系抗生物質の製造方法
JP2019001716A (ja) * 2015-11-02 2019-01-10 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 アミノグリコシド系抗生物質の製造方法
KR20210096160A (ko) * 2018-11-25 2021-08-04 티엔티 메디칼 코포레이션 젬시타빈의 경구 활성 전구약물

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1349302A (en) * 1970-07-29 1974-04-03 Microbial Chem Res Found 3,-4,-dideoxykanamycin b active against resistant bacteria and its synthesis
JPS5233629B2 (pt) * 1972-10-19 1977-08-30
US4107424A (en) * 1972-10-06 1978-08-15 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai 1-N-[(S)-α-hydroxy-ω-aminoacyl] derivatives of 3',4'-dideoxykanamycin B and 3'-deoxykanamycin B antibiotics
US4001208A (en) 1972-10-06 1977-01-04 Zaidan Hojin Biseibutsu Kagaku Kenkyo Kai 1-N-[(S)-α-hydroxy-ω-aminoacyl]
JPS5148634A (en) * 1974-10-08 1976-04-26 Microbial Chem Res Found Taiseikinnyukona 11nn * arufua hidorokishi omega aminoashiru * 6**nn mechiru 3* *hh jideokishikanamaishin b no seizoho
US4396609A (en) * 1975-02-18 1983-08-02 Sterling Drug Inc. Aminocyclitol antibiotics, pharmaceutical compositions and method of using same
GB1529376A (en) 1975-02-18 1978-10-18 Sterling Drug Inc Aminocyclitol antibiotics and processes therefor
US3982996A (en) * 1975-09-22 1976-09-28 Sterling Drug Inc. Process for preparing aminocyclitol antibiotics
US4147861A (en) * 1975-09-24 1979-04-03 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai 1N-(α-Hydroxy-ω-aminoalkanoyl)-6'N-methyl-3',4'-dideoxykanamycin B and the production thereof
JPS55164696A (en) 1979-06-12 1980-12-22 Microbial Chem Res Found Preparation of protected derivative of aminoglycoside antibiotic substance wherein amino groups other than 1-position are selectively protected, and preparation of 1-n- alpha-hydroxy-omega-aminoalkanoyl -aminoglycoside antibiotic substance
JPS55151597A (en) * 1979-05-11 1980-11-26 Kyowa Hakko Kogyo Co Ltd New material 2-hydroxysagamicin and its preparation
JPS5753496A (en) * 1980-08-12 1982-03-30 Microbial Chem Res Found 1-n-acyl derivative of 5,3',4'-trideoxykanamycin b or 5,3',4',6'- tetradeoxykanamycin b, and their preparation
US4410516A (en) * 1981-07-21 1983-10-18 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai 1-N(αHydroxy-ω-aminoalkanoyl) derivatives of 5,3',4'-trideoxy- or 5,3', 4'-trideoxy-6'-N- methyl- or 5, 3', 4',6"-tetradeoxykannamyci B and production thereof
JPS5815994A (ja) * 1981-07-22 1983-01-29 Microbial Chem Res Found ２′位修飾カナマイシン誘導体およびその製造法
JPH07121859B2 (ja) 1986-03-18 1995-12-25 第一製薬株式会社 徐放性カプセル剤
CN1197869C (zh) * 2002-12-09 2005-04-20 北京大学 具有抗病毒活性的氨基糖苷类化合物及其制备方法
US20070161581A1 (en) * 2004-01-21 2007-07-12 Nobuto Minowa Novel aminoglycoside antibiotics effective against methicillin resistant staphylococcus auerus (mrsas)
JP2006155062A (ja) 2004-11-26 2006-06-15 Pfu Ltd ネットワーク検疫システム

Also Published As

Publication number Publication date
CN101495493B (zh) 2012-11-14
KR20090014309A (ko) 2009-02-09
RU2458931C2 (ru) 2012-08-20
US9260465B2 (en) 2016-02-16
EP2036917A4 (en) 2014-09-03
JPWO2007142150A1 (ja) 2009-10-22
JP5160419B2 (ja) 2013-03-13
AU2007255856B2 (en) 2012-08-16
CN101495493A (zh) 2009-07-29
EP2036917B1 (en) 2015-10-07
EP2036917A1 (en) 2009-03-18
MX2008015280A (es) 2009-01-28
US20090186841A1 (en) 2009-07-23
CN102942603A (zh) 2013-02-27
US20120165283A1 (en) 2012-06-28
CN102942603B (zh) 2016-01-20
ES2557992T3 (es) 2016-02-01
BRPI0712312A2 (pt) 2012-03-06
US20160152653A1 (en) 2016-06-02
US8148504B2 (en) 2012-04-03
KR101458223B1 (ko) 2014-11-04
UA97245C2 (en) 2012-01-25
US20130345411A1 (en) 2013-12-26
AU2007255856A1 (en) 2007-12-13
US8541394B2 (en) 2013-09-24
CA2654561A1 (en) 2007-12-13
RU2008152358A (ru) 2010-07-20
WO2007142150A1 (ja) 2007-12-13

Similar Documents

Publication Publication Date Title
EP2062585A4 (en) ANTIBIOTIC COMPOSITION WITH AMINOGLY COSID ANTIBIOTICS
PL2144910T3 (pl) Antybiotyki oksazolidynonowe
IL173221A0 (en) Devics
EP2056133A4 (en) GLASS
IL196883A0 (en) Antibiotic composition
IL192799A0 (en) Substituted 4-phenylpiperidines
IL205301A0 (en) Carbacephem ?? - lactam antibiotics
ZA200810676B (en) Novel aminoglycoside antibiotics
ZA200900318B (en) Mechanical tailgate
ZA200903382B (en) Substituted 4-imidazoles
GB2435896B (en) Double glazed units
GB0617222D0 (en) Antibiotics
GB0600031D0 (en) Assay
EP2030982A4 (en) ANTIBIOTIC DERIVATIVE OF A GLYCOPEPTIDE
IL173634A0 (en) Devics
GB0603529D0 (en) Unspillable glass
AU2006907220A0 (en) Non-consecutive linear batching
HK1145678A (en) Carbacephem ss -lactam antibiotics
GB0610722D0 (en) Novel aluminium-air barreries
GB0604310D0 (en) Corcost one
AU2006907197A0 (en) Linear batching
HU3283U (en) Airgun smot
AU309858S (en) Glass
GB0621453D0 (en) Glass
AU308748S (en) Figurine