ZA200901680B - Recombinant human interferon-like proteins - Google Patents

Recombinant human interferon-like proteins

Info

Publication number: ZA200901680B
Authority: ZA; South Africa
Prior art keywords: proteins; recombinant human; human interferon; interferon; recombinant
Prior art date: 2007-06-18

Application number

ZA200901680A

Other languages

English (en)

Inventor

Haitao Wang

Chunsheng Mao

Jizhi Li

Ling Wang

Yong Du

Lkongbin Liu

Jing Xu

Rui Zhang

Original Assignee

Novagen Holding Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-06-18

Filing date

2009-03-10

Publication date

2010-03-31

2009-03-10 Application filed by Novagen Holding Corp filed Critical Novagen Holding Corp

2010-03-31 Publication of ZA200901680B publication Critical patent/ZA200901680B/xx

Links

102000004169 proteins and genes Human genes 0.000 title 1
108090000623 proteins and genes Proteins 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Immunology (AREA)
Oncology (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Endocrinology (AREA)
Virology (AREA)
Hematology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Physics & Mathematics (AREA)
Dermatology (AREA)
Communicable Diseases (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Epidemiology (AREA)

ZA200901680A 2007-06-18 2009-03-10 Recombinant human interferon-like proteins ZA200901680B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US11/764,786 US7625555B2 (en)	2007-06-18	2007-06-18	Recombinant human interferon-like proteins

Publications (1)

Publication Number	Publication Date
ZA200901680B true ZA200901680B (en)	2010-03-31

Family

ID=40132903

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200901680A ZA200901680B (en)	2007-06-18	2009-03-10	Recombinant human interferon-like proteins

Country Status (20)

Country	Link
US (8)	US7625555B2 (pl)
EP (3)	EP3133161A1 (pl)
JP (3)	JP5439189B2 (pl)
KR (2)	KR101384307B1 (pl)
CN (3)	CN103483443A (pl)
AU (1)	AU2007355415B2 (pl)
BR (1)	BRPI0716948B1 (pl)
CA (1)	CA2692358C (pl)
DK (2)	DK2078082T3 (pl)
ES (2)	ES2524251T3 (pl)
IL (1)	IL196673A (pl)
MX (1)	MX2009001366A (pl)
MY (1)	MY167485A (pl)
NZ (1)	NZ574306A (pl)
PL (2)	PL2465935T3 (pl)
PT (2)	PT2465935T (pl)
RU (1)	RU2469091C2 (pl)
TW (1)	TWI375716B (pl)
WO (1)	WO2008154719A1 (pl)
ZA (1)	ZA200901680B (pl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7625555B2 (en) *	2007-06-18	2009-12-01	Novagen Holding Corporation	Recombinant human interferon-like proteins
WO2011109556A2 (en) *	2010-03-04	2011-09-09	Pfenex Inc.	Method for producing soluble recombinant interferon protein without denaturing
TWI696630B (zh) *	2013-09-20	2020-06-21	獨立行政法人醫藥基盤研究所	含有具有免疫賦活活性之寡核苷酸之複合體及其用途
LT6164B (lt)	2013-10-15	2015-06-25	Uab Biotechnologinės Farmacijos Centras "Biotechpharma"	Sulieti interferono-alfa 5 baltymai su kitu citokinu ir jų gamybos būdas
WO2016009451A2 (en) *	2014-07-14	2016-01-21	Gennova Biopharmaceuticals Limited	A novel process for purification of rhu-gcsf
CA3035293A1 (en) *	2016-09-01	2018-03-08	Proqr Therapeutics Ii B.V.	Chemically modified single-stranded rna-editing oligonucleotides
WO2018101151A1 (ja) *	2016-12-02	2018-06-07	興人ライフサイエンス株式会社	リボース含有酵母調味料
US10780931B2 (en) *	2018-05-21	2020-09-22	Ronald Siwicki	Kickstand assembly
CN109627343A (zh) *	2018-12-27	2019-04-16	北京美福源生物医药科技有限公司	长效细胞因子基因衍生物融合蛋白
CN113289006A (zh) *	2020-02-24	2021-08-24	杰华生物技术(青岛)有限公司	一种重组细胞因子基因衍生蛋白或其片段的用途

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US369922A (en)		1887-09-13		Jacket for steam-cylinders
US2004200A (en) *	1931-10-02	1935-06-11	Union Switch & Signal Co	Lamp socket adapter
US3699222A (en)	1958-03-11	1972-10-17	Nat Res Dev	Production of viral interfering substances
US4179337A (en)	1973-07-20	1979-12-18	Davis Frank F	Non-immunogenic polypeptides
US4640835A (en)	1981-10-30	1987-02-03	Nippon Chemiphar Company, Ltd.	Plasminogen activator derivatives
GB2148299B (en)	1983-09-01	1988-01-06	Hybritech Inc	Antibody compositions of therapeutic agents having an extended serum half-life
US4496689A (en)	1983-12-27	1985-01-29	Miles Laboratories, Inc.	Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
GB8412564D0 (en)	1984-05-17	1984-06-20	Searle & Co	Structure and properties
DE3685996T2 (de)	1985-06-11	1993-01-14	Ciba Geigy Ag	Hybrid-interferone.
US4791192A (en)	1986-06-26	1988-12-13	Takeda Chemical Industries, Ltd.	Chemically modified protein with polyethyleneglycol
GB8803365D0 (en)	1988-02-13	1988-03-16	Ciba Geigy Ag	Antiviral combination
US5705363A (en)	1989-03-02	1998-01-06	The Women's Research Institute	Recombinant production of human interferon τ polypeptides and nucleic acids
US5681811A (en)	1993-05-10	1997-10-28	Protein Delivery, Inc.	Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same
DE69430251T2 (de)	1993-11-10	2002-11-07	Enzon, Inc.	Verbesserte interferon-polymerkonjugate
US6335160B1 (en)	1995-02-17	2002-01-01	Maxygen, Inc.	Methods and compositions for polypeptide engineering
US5605793A (en)	1994-02-17	1997-02-25	Affymax Technologies N.V.	Methods for in vitro recombination
US5738846A (en)	1994-11-10	1998-04-14	Enzon, Inc.	Interferon polymer conjugates and process for preparing the same
FR2741892B1 (fr)	1995-12-04	1998-02-13	Pasteur Merieux Serums Vacc	Procede de preparation d'une banque multicombinatoire de vecteurs d'expression de genes d'anticorps, banque et systemes d'expression d'anticorps "coliclonaux" obtenus
US5723125A (en)	1995-12-28	1998-03-03	Tanox Biosystems, Inc.	Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide
WO1999029863A1 (en)	1997-12-08	1999-06-17	Genentech, Inc.	Human interferon-epsilon: a type i interferon
US6685933B1 (en)	1998-07-28	2004-02-03	The United States Of America As Represented By The Department Of Health And Human Services	Interferon α hybrids
US6514729B1 (en)	1999-05-12	2003-02-04	Xencor, Inc.	Recombinant interferon-beta muteins
WO2001015736A2 (en)	1999-08-27	2001-03-08	Maxygen Aps	Interferon-beta conjugates
US6531122B1 (en)	1999-08-27	2003-03-11	Maxygen Aps	Interferon-β variants and conjugates
US7431921B2 (en)	1999-08-27	2008-10-07	Maxygen Aps	Interferon beta-like molecules
US20040002474A1 (en)	1999-10-07	2004-01-01	Maxygen Inc.	IFN-alpha homologues
CA2385045A1 (en)	1999-10-07	2001-04-12	Maxygen, Inc.	Ifn-alpha homologues
SK8292002A3 (en)	1999-11-12	2002-12-03	Maxygen Holdings Ltd	A conjugate exhibiting interferon gamma activity, nucleotide sequence encoding for a polypeptide fraction of conjugate, an expression vector and a host cell containing nucleotide sequence, pharmaceutical composition comprising the same and use thereof
IT1317835B1 (it) *	2000-02-15	2003-07-15	San Raffaele Centro Fond	Citochine modificate per uso nella terapia del cancro.
CA2404511A1 (en)	2000-03-31	2001-10-04	Mochida Pharmaceutical Co., Ltd.	Tlr/cd14 binding inhibitor
WO2002036628A2 (en)	2000-11-02	2002-05-10	Maxygen Aps	New multimeric interferon beta polypeptides
WO2002036627A2 (en)	2000-11-03	2002-05-10	Pbl Biomedical Laboratories	Interferons, uses and compositions related thereto
PL367154A1 (pl)	2001-02-27	2005-02-21	Maxygen Aps	Nowe cząsteczki podobne do interferonu beta
US7038015B2 (en)	2001-04-06	2006-05-02	Maxygen Holdings, Ltd.	Interferon gamma polypeptide variants
US6958388B2 (en)	2001-04-06	2005-10-25	Maxygen, Aps	Interferon gamma polypeptide variants
KR20030094336A (ko)	2001-04-06	2003-12-11	맥시겐 홀딩스 엘티디	인터페론 감마 폴리펩티드 변이체
FR2825102B1 (fr) *	2001-05-23	2003-08-29	Genodyssee	Nouveaux polynucleotides et polypeptides de l'interferon alpha 14
CA2452364A1 (en)	2001-06-29	2003-01-09	Maxygen Aps	Stabilized formulations of interferons with sulfoalkyl ether cyclodextrins
CN1431018A (zh)	2002-01-10	2003-07-23	北京东康龙病毒生物技术工程研究中心	抗HSV感染和镇痛的人甲硫氨酸脑啡肽干扰素α－m融合蛋白制剂
MXPA04008798A (es)	2002-03-12	2004-11-26	Maxygen Aps	Moleculas semejantes a interferon beta para el tratamiento de evento cerebrovascular.
WO2004005341A2 (en)	2002-07-03	2004-01-15	Maxygen Holdings Ltd.	Full-length interferon gamma polypeptide variants
AU2003254641A1 (en)	2002-08-28	2004-03-19	Maxygen Aps	Interferon beta-like molecules for treatment of cancer
CA2498319A1 (en)	2002-09-09	2004-03-18	Nautilus Biotech	Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
US7314613B2 (en)	2002-11-18	2008-01-01	Maxygen, Inc.	Interferon-alpha polypeptides and conjugates
US20040219131A1 (en)	2002-11-18	2004-11-04	Maxygen, Inc.	Interferon-alpha polypeptides and conjugates
WO2005023290A2 (en) *	2003-05-23	2005-03-17	Pestka Biomedical Laboratories, Inc.	Uses of interferons for the treatment of severe acute respiratory syndrome and other viral infections
CA2566247A1 (en)	2004-05-19	2005-12-01	Maxygen, Inc.	Interferon-alpha polypeptides and conjugates
CA2576030A1 (en)	2004-08-09	2006-02-23	Alios Biopharma Inc.	Synthetic hyperglycosylated, protease-resistant polypeptide variants, oral formulations and methods of using the same
US20060051859A1 (en)	2004-09-09	2006-03-09	Yan Fu	Long acting human interferon analogs
MX2007014524A (es)	2005-05-18	2008-02-07	Maxygen Inc	Polipeptidos desarrollados de interferon-alfa.
US7625555B2 (en)	2007-06-18	2009-12-01	Novagen Holding Corporation	Recombinant human interferon-like proteins

2007
- 2007-06-18 US US11/764,786 patent/US7625555B2/en active Active
- 2007-06-22 ES ES07720038.4T patent/ES2524251T3/es active Active
- 2007-06-22 PL PL12159128T patent/PL2465935T3/pl unknown
- 2007-06-22 CA CA2692358A patent/CA2692358C/en active Active
- 2007-06-22 ES ES12159128.3T patent/ES2586398T3/es active Active
- 2007-06-22 EP EP16170023.2A patent/EP3133161A1/en not_active Withdrawn
- 2007-06-22 KR KR1020097003909A patent/KR101384307B1/ko active Active
- 2007-06-22 JP JP2009545766A patent/JP5439189B2/ja active Active
- 2007-06-22 DK DK07720038.4T patent/DK2078082T3/en active
- 2007-06-22 DK DK12159128.3T patent/DK2465935T3/en active
- 2007-06-22 BR BRPI0716948-5A patent/BRPI0716948B1/pt active IP Right Grant
- 2007-06-22 RU RU2009104749/10A patent/RU2469091C2/ru active
- 2007-06-22 MX MX2009001366A patent/MX2009001366A/es active IP Right Grant
- 2007-06-22 PT PT121591283T patent/PT2465935T/pt unknown
- 2007-06-22 EP EP12159128.3A patent/EP2465935B1/en active Active
- 2007-06-22 PT PT77200384T patent/PT2078082E/pt unknown
- 2007-06-22 EP EP07720038.4A patent/EP2078082B1/en active Active
- 2007-06-22 WO PCT/CA2007/001123 patent/WO2008154719A1/en not_active Ceased
- 2007-06-22 MY MYPI20080140A patent/MY167485A/en unknown
- 2007-06-22 NZ NZ574306A patent/NZ574306A/en unknown
- 2007-06-22 CN CN201310296591.7A patent/CN103483443A/zh active Pending
- 2007-06-22 CN CN2011101550823A patent/CN102250918A/zh active Pending
- 2007-06-22 CN CN200780000441XA patent/CN101432428B/zh active Active
- 2007-06-22 AU AU2007355415A patent/AU2007355415B2/en active Active
- 2007-06-22 US US12/665,682 patent/US8425895B2/en active Active
- 2007-06-22 KR KR1020137002067A patent/KR20130027043A/ko not_active Ceased
- 2007-06-22 PL PL07720038T patent/PL2078082T3/pl unknown
- 2007-12-07 TW TW096146800A patent/TWI375716B/zh active
2009
- 2009-01-22 IL IL196673A patent/IL196673A/en active IP Right Grant
- 2009-03-10 ZA ZA200901680A patent/ZA200901680B/xx unknown
- 2009-09-08 US US12/555,759 patent/US7867482B2/en active Active
- 2009-09-08 US US12/555,762 patent/US7868151B2/en active Active
2013
- 2013-03-15 US US13/841,679 patent/US9234022B2/en active Active
- 2013-08-23 JP JP2013173596A patent/JP6099095B2/ja active Active
2016
- 2016-01-11 US US14/992,591 patent/US9982028B2/en active Active
- 2016-03-04 JP JP2016042061A patent/JP2016117753A/ja active Pending
2018
- 2018-04-30 US US15/967,125 patent/US10538565B2/en active Active
2019
- 2019-12-04 US US16/703,760 patent/US20200369741A1/en not_active Abandoned

Also Published As

Publication number	Publication date
PT2465935T (pt)	2016-08-05
BRPI0716948B1 (pt)	2022-04-05
IL196673A0 (en)	2011-08-01
US20100099612A1 (en)	2010-04-22
MX2009001366A (es)	2009-04-17
CN103483443A (zh)	2014-01-01
US7868151B2 (en)	2011-01-11
US7867482B2 (en)	2011-01-11
US20130189226A1 (en)	2013-07-25
US9982028B2 (en)	2018-05-29
CN101432428B (zh)	2013-06-19
US20200369741A1 (en)	2020-11-26
PT2078082E (pt)	2014-11-27
CA2692358A1 (en)	2008-12-24
RU2469091C2 (ru)	2012-12-10
US7625555B2 (en)	2009-12-01
JP5439189B2 (ja)	2014-03-12
NZ574306A (en)	2012-07-27
EP2465935B1 (en)	2016-05-18
US10538565B2 (en)	2020-01-21
US20100303759A1 (en)	2010-12-02
TWI375716B (en)	2012-11-01
CA2692358C (en)	2012-11-20
JP2010515466A (ja)	2010-05-13
EP2078082B1 (en)	2014-08-20
EP2465935A3 (en)	2012-08-15
KR20100033468A (ko)	2010-03-30
JP6099095B2 (ja)	2017-03-22
JP2014036657A (ja)	2014-02-27
PL2078082T3 (pl)	2015-02-27
US20080312148A1 (en)	2008-12-18
MY167485A (en)	2018-08-30
ES2524251T3 (es)	2014-12-04
IL196673A (en)	2015-08-31
US20190077843A1 (en)	2019-03-14
EP3133161A1 (en)	2017-02-22
DK2078082T3 (en)	2014-12-01
PL2465935T3 (pl)	2017-08-31
CN101432428A (zh)	2009-05-13
EP2078082A4 (en)	2009-12-16
EP2465935A2 (en)	2012-06-20
WO2008154719A1 (en)	2008-12-24
RU2009104749A (ru)	2010-11-20
DK2465935T3 (en)	2016-08-22
AU2007355415B2 (en)	2012-07-26
EP2078082A1 (en)	2009-07-15
HK1171048A1 (en)	2013-03-15
TW200900504A (en)	2009-01-01
US8425895B2 (en)	2013-04-23
US9234022B2 (en)	2016-01-12
US20100129904A1 (en)	2010-05-27
KR20130027043A (ko)	2013-03-14
US20170015723A1 (en)	2017-01-19
HK1129128A1 (zh)	2009-11-20
KR101384307B1 (ko)	2014-05-21
CN102250918A (zh)	2011-11-23
JP2016117753A (ja)	2016-06-30
ES2586398T3 (es)	2016-10-14
BRPI0716948A2 (pt)	2013-02-19
AU2007355415A1 (en)	2008-12-24

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