ZA200901782B - Processes for the preparation of 1, 2, 4-oxadiazole benzoic acids - Google Patents

Processes for the preparation of 1, 2, 4-oxadiazole benzoic acids

Info

Publication number
ZA200901782B
ZA200901782B ZA200901782A ZA200901782A ZA200901782B ZA 200901782 B ZA200901782 B ZA 200901782B ZA 200901782 A ZA200901782 A ZA 200901782A ZA 200901782 A ZA200901782 A ZA 200901782A ZA 200901782 B ZA200901782 B ZA 200901782B
Authority
ZA
South Africa
Prior art keywords
processes
preparation
benzoic acids
oxadiazole benzoic
oxadiazole
Prior art date
Application number
ZA200901782A
Other languages
English (en)
Inventor
Neil G Almstead
Peter Seongwoo Hwang
Seemon Pines
Young-Choon Moon
James J Takasugi
Original Assignee
Ptc Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ptc Therapeutics Inc filed Critical Ptc Therapeutics Inc
Publication of ZA200901782B publication Critical patent/ZA200901782B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA200901782A 2006-09-08 2007-09-06 Processes for the preparation of 1, 2, 4-oxadiazole benzoic acids ZA200901782B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US84359506P 2006-09-08 2006-09-08

Publications (1)

Publication Number Publication Date
ZA200901782B true ZA200901782B (en) 2010-06-30

Family

ID=38935880

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200901782A ZA200901782B (en) 2006-09-08 2007-09-06 Processes for the preparation of 1, 2, 4-oxadiazole benzoic acids

Country Status (24)

Country Link
US (2) US7678922B2 (fr)
EP (1) EP2059513B1 (fr)
JP (2) JP5955494B2 (fr)
KR (1) KR101466368B1 (fr)
CN (1) CN101535284B (fr)
AR (3) AR062715A1 (fr)
AU (1) AU2007292915B2 (fr)
BR (1) BRPI0716996B8 (fr)
CA (2) CA2842625C (fr)
CL (1) CL2007002606A1 (fr)
DK (1) DK2059513T3 (fr)
ES (1) ES2404348T3 (fr)
IL (1) IL197445A (fr)
MX (1) MX2009002439A (fr)
MY (1) MY148598A (fr)
NZ (2) NZ575511A (fr)
PE (2) PE20120669A1 (fr)
PL (1) PL2059513T3 (fr)
PT (1) PT2059513E (fr)
RU (1) RU2495030C2 (fr)
TW (1) TWI482761B (fr)
UA (1) UA99265C2 (fr)
WO (1) WO2008030570A1 (fr)
ZA (1) ZA200901782B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2887054T3 (es) 2003-04-11 2021-12-21 Ptc Therapeutics Inc Compuesto de ácido 1,2,4-oxadiazol benzoico y su uso para la supresión sin sentido y el tratamiento de enfermedades
CA2603402C (fr) 2005-04-08 2017-10-31 Ptc Therapeutics, Inc. Compositions de 1,2,4-oxadiazole oralement actives pour un traitement de suppression de mutations non-sens
IN2014CN04406A (fr) * 2006-03-30 2015-09-04 Ptc Therapeutics Inc
PT2059513E (pt) * 2006-09-08 2013-04-30 Ptc Therapeutics Inc Processo para a preparação de ácidos 1,2,4-oxadiazolebenzóicos
SG10201609581TA (en) 2006-09-25 2016-12-29 Ptc Therapeutics Inc Crystalline forms of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid
WO2008130370A1 (fr) 2006-09-25 2008-10-30 Ptc Therapeutics, Inc. Composés d'acide 1,2,4-oxadiozole benzoïque hydroxylé,leurs compositions et leur utilisation pour une suppression non-sens
CL2007002923A1 (es) 2006-10-12 2008-06-06 Ptc Therapeutics Inc Soc Organ Metodo para el tratamiento, prevencion o manejo de una enfermedad asociada con una mutacion sin sentido tal como cancer, diabetes o enfermedad pulmonar, que consiste en administrar a un paciente una cantidad efectiva de acido 3-[5-(2-fluoro-fenil)-[1
CN101714009A (zh) * 2009-05-14 2010-05-26 翁印嵩 集成通用电话功能的计算机
US9050347B2 (en) 2011-01-25 2015-06-09 Viviabiotech, S.L. 1,2,4-oxadiazole derivatives as drugs modulating the GLP-1 peptide receptor
CA2876215A1 (fr) 2012-07-02 2014-01-09 Monsanto Technology Llc Procedes de preparation de 1,2,4-oxadiazoles 3,5-disubstitues
TWI695717B (zh) * 2014-03-06 2020-06-11 美商 Ptc 治療公司 １,２,４-二唑苯甲酸之鹽及醫藥組合物
CN105461650B (zh) * 2014-09-12 2018-04-13 杭州普晒医药科技有限公司 一种噁二唑化合物的溶剂化物及其制备方法
CN106316885B (zh) * 2015-07-03 2019-02-12 普济生物科技（台州）有限公司 一种3-[5-(2-氟苯基)-1,2,4-噁二唑-3-基]苯甲酸的制备方法
HK1251965A1 (zh) 2015-10-30 2019-05-10 Ptc医疗公司 用於治疗癫痫的方法
TW201808922A (zh) 2016-06-20 2018-03-16 台灣神隆股份有限公司 製備阿塔魯仁及其中間體的方法
WO2020128816A2 (fr) 2018-12-20 2020-06-25 Pfizer Inc. Compositions pharmaceutiques et méthodes comprenant une combinaison d'un stabilisateur de transthyrétine benzoxazole et d'un agent thérapeutique supplémentaire
JP2022526643A (ja) 2019-04-10 2022-05-25 ピーティーシー セラピューティクス，インコーポレーテッド 小児患者においてナンセンス変異が介在するデュシェンヌ型筋ジストロフィーを治療するための方法
WO2022112919A1 (fr) 2020-11-25 2022-06-02 Pfizer Inc. Composés de pyrazole substitués par (aza)benzothiazolyle
CN113045510B (zh) * 2021-03-31 2022-05-27 北京大学生命科学华东产业研究院 一种阿塔鲁伦的制备方法
CN114920667B (zh) * 2022-06-30 2024-06-21 湖南大学 一种阿塔鲁伦酯的电化学制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2801509A1 (de) * 1978-01-12 1979-07-19 Schering Ag 1,2,4-oxadiazolderivate, verfahren zur herstellung dieser verbindungen sowie diese enthaltende selektive herbizide mittel
DE3905242A1 (de) * 1989-02-21 1990-08-23 Basf Ag Verfahren zur herstellung von phenyloxdiazolylanilinen
NZ234760A (en) * 1989-08-18 1991-09-25 Sterling Drug Inc Antiviral oxazole compounds and compositions
DE4425794A1 (de) * 1994-07-21 1996-01-25 Basf Ag Nitrofarbstoffe
US6660753B2 (en) * 1999-08-19 2003-12-09 Nps Pharmaceuticals, Inc. Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
CA2449544A1 (fr) * 2001-06-08 2002-12-19 Cytovia, Inc. 3-aryl-5-aryl-[1,2,4]-oxadiazoles et leurs analogues, activateurs des caspases et inducteurs de l'apoptose, et leurs utilisations
MY151199A (en) * 2001-11-02 2014-04-30 Rigel Pharmaceuticals Inc Substituted diphenyl heterocycles useful for treating hcv infection
TW200424183A (en) * 2002-08-09 2004-11-16 Nps Pharma Inc New compounds
GB0303503D0 (en) 2003-02-14 2003-03-19 Novartis Ag Organic compounds
ES2887054T3 (es) * 2003-04-11 2021-12-21 Ptc Therapeutics Inc Compuesto de ácido 1,2,4-oxadiazol benzoico y su uso para la supresión sin sentido y el tratamiento de enfermedades
WO2004110351A2 (fr) * 2003-05-14 2004-12-23 Anadys Pharmaceuticals, Inc. Composes heterocycliques pour traiter le virus de l'hepatite c
CA2603402C (fr) 2005-04-08 2017-10-31 Ptc Therapeutics, Inc. Compositions de 1,2,4-oxadiazole oralement actives pour un traitement de suppression de mutations non-sens
PT2059513E (pt) * 2006-09-08 2013-04-30 Ptc Therapeutics Inc Processo para a preparação de ácidos 1,2,4-oxadiazolebenzóicos

Also Published As

Publication number Publication date
ES2404348T3 (es) 2013-05-27
MY148598A (en) 2013-05-15
CA2662749A1 (fr) 2008-03-13
US20100063297A1 (en) 2010-03-11
NZ598012A (en) 2013-08-30
PE20120669A1 (es) 2012-06-01
IL197445A (en) 2014-01-30
NZ575511A (en) 2012-02-24
EP2059513B1 (fr) 2013-01-23
AU2007292915B2 (en) 2012-07-26
CA2842625C (fr) 2016-07-12
IL197445A0 (en) 2009-12-24
US7678922B2 (en) 2010-03-16
AU2007292915A1 (en) 2008-03-13
DK2059513T3 (da) 2013-05-06
PL2059513T3 (pl) 2013-06-28
AR062715A1 (es) 2008-11-26
CA2662749C (fr) 2015-01-20
KR101466368B1 (ko) 2014-11-27
RU2009113019A (ru) 2010-10-20
TW200823180A (en) 2008-06-01
PT2059513E (pt) 2013-04-30
KR20090054464A (ko) 2009-05-29
CN101535284B (zh) 2014-12-10
AR118922A2 (es) 2021-11-10
PE20080771A1 (es) 2008-06-13
CA2842625A1 (fr) 2008-03-13
JP2010502715A (ja) 2010-01-28
BRPI0716996B8 (pt) 2021-05-25
CL2007002606A1 (es) 2008-04-18
BRPI0716996A2 (pt) 2013-10-08
EP2059513A1 (fr) 2009-05-20
JP5955494B2 (ja) 2016-07-20
US8367841B2 (en) 2013-02-05
HK1134094A1 (en) 2010-04-16
US20080139818A1 (en) 2008-06-12
TWI482761B (zh) 2015-05-01
JP2014193896A (ja) 2014-10-09
CN101535284A (zh) 2009-09-16
WO2008030570A1 (fr) 2008-03-13
UA99265C2 (ru) 2012-08-10
MX2009002439A (es) 2009-03-27
AR107474A2 (es) 2018-05-02
BRPI0716996B1 (pt) 2021-02-09
RU2495030C2 (ru) 2013-10-10

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