ZA200904302B - Method for the production of a plant-based medicament - Google Patents

Method for the production of a plant-based medicament Download PDF

Info

Publication number: ZA200904302B
Authority: ZA; South Africa
Prior art keywords: extract; plant; production; medicament according; based medicament
Prior art date: 2008-06-26

Application number

ZA200904302A

Other languages

English (en)

Inventor

Willi Kuper

Wulf Dr Becker

Original Assignee

Steigerwald Arzneimittelwerk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-06-26

Filing date

2009-06-19

Publication date

2010-10-27

2009-06-19 Application filed by Steigerwald Arzneimittelwerk filed Critical Steigerwald Arzneimittelwerk

2010-10-27 Publication of ZA200904302B publication Critical patent/ZA200904302B/en

Links

239000003814 drug Substances 0.000 title claims description 111
238000004519 manufacturing process Methods 0.000 title claims description 49
238000000034 method Methods 0.000 title claims description 42
239000000284 extract Substances 0.000 claims description 154
241000196324 Embryophyta Species 0.000 claims description 67
239000000203 mixture Substances 0.000 claims description 63
229940079593 drug Drugs 0.000 claims description 53
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 34
240000004804 Iberis amara Species 0.000 claims description 31
235000012633 Iberis amara Nutrition 0.000 claims description 31
239000000419 plant extract Substances 0.000 claims description 19
241000628997 Flos Species 0.000 claims description 18
239000004615 ingredient Substances 0.000 claims description 16
239000012675 alcoholic extract Substances 0.000 claims description 7
229930003935 flavonoid Natural products 0.000 claims description 6
150000002215 flavonoids Chemical class 0.000 claims description 6
235000017173 flavonoids Nutrition 0.000 claims description 6
LNSXRXFBSDRILE-UHFFFAOYSA-N Cucurbitacin Natural products CC(=O)OC(C)(C)C=CC(=O)C(C)(O)C1C(O)CC2(C)C3CC=C4C(C)(C)C(O)C(O)CC4(C)C3(C)C(=O)CC12C LNSXRXFBSDRILE-UHFFFAOYSA-N 0.000 claims description 5
150000001904 cucurbitacins Chemical class 0.000 claims description 5
NDYMQXYDSVBNLL-LAMASETHSA-N (23E)-25-acetyloxy-2,16alpha,20-trihydroxy-9beta-methyl-19-nor-10alpha-lanosta-1,5,23-triene-3,11,22-trione Chemical compound C([C@H]1[C@]2(C)C[C@@H](O)[C@@H]([C@]2(CC(=O)[C@]11C)C)[C@@](C)(O)C(=O)C=CC(C)(C)OC(=O)C)C=C2[C@H]1C=C(O)C(=O)C2(C)C NDYMQXYDSVBNLL-LAMASETHSA-N 0.000 claims description 4
NDYMQXYDSVBNLL-UHFFFAOYSA-N (9beta,10alpha,16alpha,23E)-25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione Natural products CC12C(=O)CC3(C)C(C(C)(O)C(=O)C=CC(C)(C)OC(=O)C)C(O)CC3(C)C1CC=C1C2C=C(O)C(=O)C1(C)C NDYMQXYDSVBNLL-UHFFFAOYSA-N 0.000 claims description 4
PTCAIPUXGKZZBJ-UHFFFAOYSA-N 11-deoxocucurbitacin I Natural products CC12CCC3(C)C(C(C)(O)C(=O)C=CC(C)(O)C)C(O)CC3(C)C1CC=C1C2C=C(O)C(=O)C1(C)C PTCAIPUXGKZZBJ-UHFFFAOYSA-N 0.000 claims description 4
IVGSDBLLLAUYTL-UHFFFAOYSA-N cucurbitacin E Natural products CC(=O)OC(C)(C)C=CC(=O)C(C)(O)C1C(O)CC2(C)C3CC=C4C(C=C(O)C(=O)C4(C)C)C3(C)CCC12C IVGSDBLLLAUYTL-UHFFFAOYSA-N 0.000 claims description 4
NISPVUDLMHQFRQ-ILFSFOJUSA-N cucurbitacin I Natural products CC(C)(O)C=CC(=O)[C@](C)(O)[C@H]1[C@H](O)C[C@@]2(C)[C@@H]3CC=C4[C@@H](C=C(O)C(=O)C4(C)C)[C@]3(C)C(=O)C[C@]12C NISPVUDLMHQFRQ-ILFSFOJUSA-N 0.000 claims description 4
NISPVUDLMHQFRQ-MKIKIEMVSA-N cucurbitacin I Chemical compound C([C@H]1[C@]2(C)C[C@@H](O)[C@@H]([C@]2(CC(=O)[C@]11C)C)[C@@](C)(O)C(=O)/C=C/C(C)(O)C)C=C2[C@H]1C=C(O)C(=O)C2(C)C NISPVUDLMHQFRQ-MKIKIEMVSA-N 0.000 claims description 4
230000001741 anti-phlogistic effect Effects 0.000 claims description 3
201000006549 dyspepsia Diseases 0.000 claims description 3
230000002496 gastric effect Effects 0.000 claims description 3
FGUUSXIOTUKUDN-IBGZPJMESA-N C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 Chemical compound C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 FGUUSXIOTUKUDN-IBGZPJMESA-N 0.000 claims description 2
208000025865 Ulcer Diseases 0.000 claims description 2
239000002260 anti-inflammatory agent Substances 0.000 claims description 2
230000003110 anti-inflammatory effect Effects 0.000 claims description 2
239000003963 antioxidant agent Substances 0.000 claims description 2
230000003078 antioxidant effect Effects 0.000 claims description 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
208000035475 disorder Diseases 0.000 claims description 2
210000004051 gastric juice Anatomy 0.000 claims description 2
210000001035 gastrointestinal tract Anatomy 0.000 claims description 2
239000002516 radical scavenger Substances 0.000 claims description 2
231100000397 ulcer Toxicity 0.000 claims description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
239000013078 crystal Substances 0.000 description 14
239000000126 substance Substances 0.000 description 10
230000015572 biosynthetic process Effects 0.000 description 9
239000013049 sediment Substances 0.000 description 8
235000018142 Hedysarum alpinum var americanum Nutrition 0.000 description 7
240000006461 Hedysarum alpinum var. americanum Species 0.000 description 7
HPUXDMUGCAWDFW-UHFFFAOYSA-N Osthole Natural products COc1ccc2CCC(=O)Oc2c1C=CC(=O)C HPUXDMUGCAWDFW-UHFFFAOYSA-N 0.000 description 7
229940021584 osthol Drugs 0.000 description 7
MBRLOUHOWLUMFF-UHFFFAOYSA-N osthole Chemical compound C1=CC(=O)OC2=C(CC=C(C)C)C(OC)=CC=C21 MBRLOUHOWLUMFF-UHFFFAOYSA-N 0.000 description 7
241000125175 Angelica Species 0.000 description 6
240000000467 Carum carvi Species 0.000 description 6
235000005747 Carum carvi Nutrition 0.000 description 6
235000001287 Guettarda speciosa Nutrition 0.000 description 6
244000062730 Melissa officinalis Species 0.000 description 6
235000010654 Melissa officinalis Nutrition 0.000 description 6
WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 description 6
239000002245 particle Substances 0.000 description 6
239000006228 supernatant Substances 0.000 description 6
241001233914 Chelidonium majus Species 0.000 description 5
239000000047 product Substances 0.000 description 5
235000007866 Chamaemelum nobile Nutrition 0.000 description 4
244000042664 Matricaria chamomilla Species 0.000 description 4
235000007232 Matricaria chamomilla Nutrition 0.000 description 4
241000320380 Silybum Species 0.000 description 4
235000010841 Silybum marianum Nutrition 0.000 description 4
238000007792 addition Methods 0.000 description 4
239000001180 angelica archangelica l. root extract Substances 0.000 description 4
239000009458 iberogast Substances 0.000 description 4
241001406989 Iberis Species 0.000 description 3
238000004458 analytical method Methods 0.000 description 3
239000001771 mentha piperita Substances 0.000 description 3
229940107126 milk thistle fruit Drugs 0.000 description 3
238000003860 storage Methods 0.000 description 3
244000246386 Mentha pulegium Species 0.000 description 2
235000016257 Mentha pulegium Nutrition 0.000 description 2
235000004357 Mentha x piperita Nutrition 0.000 description 2
229910000831 Steel Inorganic materials 0.000 description 2
229940070641 chamomile flowers Drugs 0.000 description 2
235000001050 hortel pimenta Nutrition 0.000 description 2
230000001965 increasing effect Effects 0.000 description 2
IYRMWMYZSQPJKC-UHFFFAOYSA-N kaempferol Chemical compound C1=CC(O)=CC=C1C1=C(O)C(=O)C2=C(O)C=C(O)C=C2O1 IYRMWMYZSQPJKC-UHFFFAOYSA-N 0.000 description 2
239000003550 marker Substances 0.000 description 2
238000005259 measurement Methods 0.000 description 2
238000002156 mixing Methods 0.000 description 2
239000000590 phytopharmaceutical Substances 0.000 description 2
238000001556 precipitation Methods 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
238000011084 recovery Methods 0.000 description 2
239000010959 steel Substances 0.000 description 2
239000000341 volatile oil Substances 0.000 description 2
SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 1
UBSCDKPKWHYZNX-UHFFFAOYSA-N Demethoxycapillarisin Natural products C1=CC(O)=CC=C1OC1=CC(=O)C2=C(O)C=C(O)C=C2O1 UBSCDKPKWHYZNX-UHFFFAOYSA-N 0.000 description 1
244000303040 Glycyrrhiza glabra Species 0.000 description 1
235000006200 Glycyrrhiza glabra Nutrition 0.000 description 1
235000006679 Mentha X verticillata Nutrition 0.000 description 1
235000002899 Mentha suaveolens Nutrition 0.000 description 1
235000001636 Mentha x rotundifolia Nutrition 0.000 description 1
239000008186 active pharmaceutical agent Substances 0.000 description 1
235000006708 antioxidants Nutrition 0.000 description 1
230000033228 biological regulation Effects 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
235000013399 edible fruits Nutrition 0.000 description 1
230000000694 effects Effects 0.000 description 1
238000000605 extraction Methods 0.000 description 1
229930182470 glycoside Natural products 0.000 description 1
150000002338 glycosides Chemical class 0.000 description 1
LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
238000003306 harvesting Methods 0.000 description 1
239000000321 herbal drug Substances 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
238000011835 investigation Methods 0.000 description 1
MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 1
235000008777 kaempferol Nutrition 0.000 description 1
239000007788 liquid Substances 0.000 description 1
235000011477 liquorice Nutrition 0.000 description 1
239000000463 material Substances 0.000 description 1
UXOUKMQIEVGVLY-UHFFFAOYSA-N morin Natural products OC1=CC(O)=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)O)=C1 UXOUKMQIEVGVLY-UHFFFAOYSA-N 0.000 description 1
230000001314 paroxysmal effect Effects 0.000 description 1
238000011170 pharmaceutical development Methods 0.000 description 1
229930182490 saponin Natural products 0.000 description 1
150000007949 saponins Chemical class 0.000 description 1
235000017709 saponins Nutrition 0.000 description 1
238000004062 sedimentation Methods 0.000 description 1
230000002048 spasmolytic effect Effects 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
230000007704 transition Effects 0.000 description 1
238000010200 validation analysis Methods 0.000 description 1
238000005303 weighing Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/235—Foeniculum (fennel)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants

Landscapes

Health & Medical Sciences (AREA)
Natural Medicines & Medicinal Plants (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Botany (AREA)
Mycology (AREA)
Epidemiology (AREA)
Medical Informatics (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Alternative & Traditional Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Nutrition Science (AREA)
Rheumatology (AREA)
Toxicology (AREA)
Biochemistry (AREA)
Medicines Containing Plant Substances (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)

ZA200904302A 2008-06-26 2009-06-19 Method for the production of a plant-based medicament ZA200904302B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE102008002685A DE102008002685A1 (de)	2008-06-26	2008-06-26	Verfahren zur Herstellung eines Arzneimittels auf pflanzlicher Basis

Publications (1)

Publication Number	Publication Date
ZA200904302B true ZA200904302B (en)	2010-10-27

Family

ID=41202489

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200904302A ZA200904302B (en)	2008-06-26	2009-06-19	Method for the production of a plant-based medicament

Country Status (32)

Country	Link
US (1)	US7985433B2 (pl)
EP (1)	EP2138182B1 (pl)
JP (1)	JP5105373B2 (pl)
KR (1)	KR101517247B1 (pl)
CN (2)	CN101612206A (pl)
AR (1)	AR072298A1 (pl)
AU (1)	AU2009202537B2 (pl)
BR (1)	BRPI0902143B8 (pl)
CA (1)	CA2670659C (pl)
CL (1)	CL2009001480A1 (pl)
CO (1)	CO6200113A1 (pl)
DE (1)	DE102008002685A1 (pl)
EA (1)	EA019477B1 (pl)
ES (1)	ES2551934T3 (pl)
GE (1)	GEP20125561B (pl)
HR (1)	HRP20151236T1 (pl)
HU (1)	HUE028151T2 (pl)
IL (1)	IL199473A (pl)
MA (1)	MA31073B1 (pl)
ME (1)	ME00815B (pl)
MX (1)	MX2009006862A (pl)
MY (1)	MY145794A (pl)
NZ (1)	NZ577867A (pl)
PE (1)	PE20100088A1 (pl)
PL (1)	PL2138182T3 (pl)
PT (1)	PT2138182E (pl)
SA (1)	SA109300416B1 (pl)
SG (1)	SG158057A1 (pl)
SI (1)	SI2138182T1 (pl)
TW (1)	TWI392501B (pl)
UA (1)	UA94635C2 (pl)
ZA (1)	ZA200904302B (pl)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US10993979B2 (en)	2017-11-20	2021-05-04	The Trustees Of Columbia University	Botanical tinctures

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4125024A1 (de)	1991-07-29	1993-02-04	Steigerwald Arzneimittelwerk	Arzneimittel auf pflanzlicher basis zur tonuserhoehung und zur tonusmodulierung der glatt muskulaeren organe
US7572469B2 (en) *	2002-04-15	2009-08-11	Tetsuo Santo	Therapeutic lotion for dermatitis
KR20050080882A (ko) *	2004-02-11	2005-08-18	채규윤	애기똥풀의 잎으로부터 분리한 스틸로핀을 유효성분으로함유하는 항염증제 조성물
CN1899570A (zh) *	2006-07-03	2007-01-24	丛吉兵	一种治疗消化系统疾病的药物

2008
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Also Published As

Publication number	Publication date
HRP20151236T1 (hr)	2016-03-11
HK1137350A1 (en)	2010-07-30
EP2138182A3 (de)	2011-08-10
BRPI0902143B8 (pt)	2021-05-25
AR072298A1 (es)	2010-08-18
AU2009202537A1 (en)	2010-01-14
MY145794A (en)	2012-04-30
PL2138182T3 (pl)	2016-01-29
ES2551934T3 (es)	2015-11-24
SI2138182T1 (sl)	2015-12-31
CO6200113A1 (es)	2010-09-20
JP2010013445A (ja)	2010-01-21
AU2009202537B2 (en)	2010-06-24
PE20100088A1 (es)	2010-03-03
NZ577867A (en)	2011-01-28
CL2009001480A1 (es)	2009-08-21
US7985433B2 (en)	2011-07-26
IL199473A (en)	2012-10-31
CA2670659A1 (en)	2009-12-26
ME00815B (me)	2012-03-20
US20090324755A1 (en)	2009-12-31
GEP20125561B (en)	2012-06-25
TW201002335A (en)	2010-01-16
MA31073B1 (fr)	2010-01-04
HUE028151T2 (en)	2016-12-28
UA94635C2 (uk)	2011-05-25
PT2138182E (pt)	2015-11-23
CA2670659C (en)	2015-08-11
KR20100002172A (ko)	2010-01-06
JP5105373B2 (ja)	2012-12-26
SA109300416B1 (ar)	2013-10-03
KR101517247B1 (ko)	2015-04-30
EA200900746A1 (ru)	2010-02-26
CN105147783A (zh)	2015-12-16
EP2138182B1 (de)	2015-08-26
BRPI0902143B1 (pt)	2021-01-12
BRPI0902143A2 (pt)	2010-04-13
IL199473A0 (en)	2011-08-01
MX2009006862A (es)	2010-02-17
EA019477B1 (ru)	2014-04-30
TWI392501B (zh)	2013-04-11
SG158057A1 (en)	2010-01-29
EP2138182A2 (de)	2009-12-30
CN101612206A (zh)	2009-12-30
DE102008002685A1 (de)	2009-12-31

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