ZA200904311B - Process for preparing 5-biphenyl-4-amino-2 methyl pentanoic acid - Google Patents

Process for preparing 5-biphenyl-4-amino-2 methyl pentanoic acid

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Publication number
ZA200904311B
ZA200904311B ZA200904311A ZA200904311A ZA200904311B ZA 200904311 B ZA200904311 B ZA 200904311B ZA 200904311 A ZA200904311 A ZA 200904311A ZA 200904311 A ZA200904311 A ZA 200904311A ZA 200904311 B ZA200904311 B ZA 200904311B
Authority
ZA
South Africa
Prior art keywords
biphenyl
amino
preparing
pentanoic acid
methyl pentanoic
Prior art date
Application number
ZA200904311A
Other languages
English (en)
Inventor
David Hook
Thomas Ruch
Bernhard Riss
Bernhard Wietfeld
Gottfried Sedelmeier
Matthias Napp
Markus Baenziger
Steven Hawker
Lech Ciszewski
Liladhar Murlidhar Waykole
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38124137&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200904311(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ZA200904311B publication Critical patent/ZA200904311B/xx

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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
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    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
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Families Citing this family (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101580067B1 (ko) * 2007-01-12 2015-12-23 노파르티스 아게 5-바이페닐-4-아미노-2-메틸 펜탄산의 제조 방법
PE20091364A1 (es) 2008-01-17 2009-10-13 Novartis Ag Proceso para la preparacion de inhibidores de nep
AU2012202949B2 (en) * 2008-01-17 2015-01-22 Novartis Ag Process and intermediates for the preparation of 5-biphenyl-4-yl-2-methylpentanoic acid derivatives
EP2435402B1 (fr) 2009-05-28 2016-04-13 Novartis AG Dérivés aminobutyriques substitués en tant qu'inhibiteurs de néprilysine
CN103896796B (zh) 2009-05-28 2016-04-27 诺华股份有限公司 作为脑啡肽酶抑制剂的取代的氨基丙酸衍生物
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
KR101463670B1 (ko) * 2010-01-22 2014-11-19 노파르티스 아게 중성 엔도펩티다제 억제제의 중간체 및 그의 제조 방법
MX2013002149A (es) 2010-08-23 2013-04-03 Novartis Ag Nuevo proceso para la preparacion de intermediarios utiles para la elaboracion de inhibidores de nep.
RU2588572C2 (ru) 2010-08-23 2016-07-10 Новартис Аг Способ получения промежуточных соединений для получения ингибиторов nep
US8877815B2 (en) * 2010-11-16 2014-11-04 Novartis Ag Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
US8673974B2 (en) * 2010-11-16 2014-03-18 Novartis Ag Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
US8993631B2 (en) 2010-11-16 2015-03-31 Novartis Ag Method of treating contrast-induced nephropathy
US8586536B2 (en) 2010-12-15 2013-11-19 Theravance, Inc. Neprilysin inhibitors
ES2548887T3 (es) 2010-12-15 2015-10-21 Theravance Biopharma R&D Ip, Llc Inhibidores de neprilisina
KR101854874B1 (ko) 2011-02-17 2018-05-04 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 네프릴리신 억제제로서 치환된 아미노부티릭 유도체
JP5959066B2 (ja) 2011-02-17 2016-08-02 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー ネプリライシン阻害剤としての置換アミノ酪酸誘導体
WO2012166389A1 (fr) 2011-05-31 2012-12-06 Theravance, Inc. Inhibiteurs de néprilysine
ES2653215T3 (es) 2011-05-31 2018-02-06 Theravance Biopharma R&D Ip, Llc Inhibidores de neprilisina
JP5959075B2 (ja) 2011-05-31 2016-08-02 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー ネプリライシン阻害剤
TWI560172B (en) 2011-11-02 2016-12-01 Theravance Biopharma R&D Ip Llc Neprilysin inhibitors
AR089955A1 (es) * 2012-02-15 2014-10-01 Theravance Inc Proceso para preparar compuestos de acido 4-amino-5-bifenil-4-il-2-hidroximetil-2-metil-pentanoico
ES2609810T3 (es) 2012-05-31 2017-04-24 Theravance Biopharma R&D Ip, Llc Inhibidores de neprilisina donadores de óxido nítrico
CN104470521B (zh) 2012-06-08 2017-04-12 施万生物制药研发Ip有限责任公司 脑啡肽酶抑制剂
MX356260B (es) 2012-06-08 2018-05-21 Theravance Biopharma R&D Ip Llc Inhibidores de la neprilisina.
MX366149B (es) 2012-08-08 2019-06-28 Theravance Biopharma R&D Ip Llc Inhibidores de neprilisina.
CU24330B1 (es) 2013-02-14 2018-03-13 Novartis Ag Derivados del ácido 4-((1,1) bifenil-4-il)-3-(3-fosfonopropanamido) butanoico, activos como inhibidores de nep (endopeptidasa neutral)
US9102635B2 (en) 2013-02-14 2015-08-11 Novartis Ag Substituted bisphenyl butanoic acid derivatives as NEP inhibitors with improved in vivo efficacy
CA2902456A1 (fr) 2013-03-05 2014-09-12 Theravance Biopharma R&D Ip, Llc Inhibiteurs de la neprilysine
CN104230865B (zh) * 2013-06-13 2018-01-09 上海翰森生物医药科技有限公司 联芳基取代的4‑氨基丁酸衍生物及其制备方法和用途
US9585882B2 (en) 2014-01-30 2017-03-07 Theravance Biopharma R&D Ip, Llc Neprilysin inhibitors
WO2015116786A1 (fr) 2014-01-30 2015-08-06 Theravance Biopharma R&D Ip, Llc Inhibiteurs de la néprilysine
WO2016074651A1 (fr) 2014-11-14 2016-05-19 Zentiva, K.S. Procédé de préparation, d'isolation et de purification de formes pharmaceutiquement applicables de ahu-377
WO2016086798A1 (fr) * 2014-12-03 2016-06-09 上海翰森生物医药科技有限公司 Acide libre cristallin d'inhibiteur de l'endopeptidase neutre (nep), polymorphe de sel de calcium de celui-ci, leur procédé de préparation et leurs applications
CN104557600B (zh) * 2015-01-26 2016-05-04 苏州明锐医药科技有限公司 沙库比曲的制备方法
KR102640906B1 (ko) 2015-02-11 2024-02-27 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 네프릴리신 저해제로서 (2s,4r)-5-(5''-클로로-2''-플루오로비페닐-4-일)-4-(에톡시옥살릴아미노)-2-히드록시메틸-2-메틸펜타노익산
TW201632493A (zh) 2015-02-13 2016-09-16 諾華公司 新穎方法
CN107250119B (zh) 2015-02-19 2020-09-22 施万生物制药研发Ip有限责任公司 (2r,4r)-5-(5′-氯-2′-氟联苯-4-基)-2-羟基-4-[(5-甲基恶唑-2-羰基)氨基]戊酸
WO2016135751A1 (fr) 2015-02-25 2016-09-01 Mylan Laboratories Limited Nouveau procédé pour la préparation de sacubitril et de ses intermédiaires
CN106187808A (zh) * 2015-05-08 2016-12-07 苏州鹏旭医药科技有限公司 Ahu-377的制备方法、ahu-377中间体及ahu-377中间体的制备方法
CN104926707B (zh) * 2015-05-12 2017-10-27 江苏福瑞生物医药有限公司 一种药物中间体的合成方法
CN104829514B (zh) * 2015-05-12 2017-10-03 江苏福瑞生物医药有限公司 一种药物中间体的合成方法
CN104860894B (zh) * 2015-06-10 2017-05-17 北京博全健医药科技有限公司 一种抗心衰药lcz696的制备方法
WO2016203500A2 (fr) * 2015-06-19 2016-12-22 Actavis Group Ptc Ehf. Préparation de sacubitril ou de son sel et nouveaux intermédiaires dans la préparation de sacubitril
SI3317248T1 (sl) * 2015-07-02 2021-01-29 Novartis Ag Sakubitril kalcijeve soli
WO2017006254A1 (fr) 2015-07-08 2017-01-12 Novartis Ag Combinaison de médicaments comprenant un antagoniste du récepteur de l'angiotensine ii, un inhibiteur d'endopeptidase neutre et un antagoniste du récepteur de minéralocorticoïdes
CN105061263B (zh) * 2015-08-11 2017-03-15 苏州楚凯药业有限公司 一种nep抑制剂中间体的制备方法
CN105168205A (zh) * 2015-08-18 2015-12-23 泰力特医药（湖北）有限公司 一种血管紧张素ii受体和脑啡肽酶受体双重抑制剂lcz696的制备方法
WO2017033128A1 (fr) 2015-08-25 2017-03-02 Novartis Ag Dérivés d'acide 4-aminé-butyrique substitués par le biphényle, et leur utilisation dans la synthèse d'inhibiteurs de nep
CN105130869B (zh) * 2015-09-07 2017-12-26 曾伟 一种Entresto中间体(S)‑5‑(联苯‑4‑羰基)吡咯烷‑2‑酮的合成方法
WO2017051326A1 (fr) 2015-09-23 2017-03-30 Novartis Ag Nouveaux procédés et intermédiaires utiles dans la synthèse d'inhibiteurs d'endopeptidase neutre (nep)
CN105348209B (zh) 2015-12-09 2017-12-26 浙江天宇药业股份有限公司 一种抗心衰药lcz696的制备方法
CN105523964B (zh) * 2015-12-09 2017-05-24 苏州楚凯药业有限公司 一种抗心衰药物中间体的制备方法
CA3006254A1 (fr) * 2015-12-10 2017-06-15 Novartis Ag Nouveau procede et composes intermediaires
EP3386945A1 (fr) 2015-12-11 2018-10-17 Zentiva, K.S. Formes solides d'ester éthylique d'acide (2r,4s)-5-(biphényl-4-yl)-4-[(3-carboxypropionyl)amino]-2-méthylpentanoïque, ses sels et son procédé de préparation
CN106977415B (zh) * 2016-01-15 2021-03-26 广东东阳光药业有限公司 一种沙库必曲的中间体及其制备方法
CN105566194A (zh) * 2016-02-01 2016-05-11 张伯引 一种Sacubitril中间体的制备方法
EP3424899B1 (fr) * 2016-02-29 2022-05-11 Sunshine Lake Pharma Co., Ltd. Intermédiaire de sacubitril et procédé de préparation correspondant
SMT202100434T1 (it) 2016-03-08 2021-09-14 Theravance Biopharma R&D Ip Llc Acido (2s,4r)-5-(5’-cloro-2-fluoro-[1,1’-bifenil]-4-il)-2-(etossimetil)-4-(3-idrossiisossazol-5-carbossammido)-2-metilpentanoico cristallino e suoi usi
WO2017191620A1 (fr) * 2016-05-06 2017-11-09 Sun Pharmaceutical Industries Limited Forme cristalline d'un sel de sacubitril et procédé pour le préparer
CN105924355B (zh) * 2016-05-11 2018-08-17 浙江宏元药业有限公司 沙库比曲中间体及沙库比曲中间体和沙库比曲的制备方法
CN109415308B (zh) * 2016-07-05 2022-09-06 诺华股份有限公司 用于早期沙卡布曲中间体的新方法
CN107602399B (zh) * 2016-07-11 2020-09-25 江西东邦药业有限公司 一种脑啡肽酶抑制剂中间体的制备方法
US10851059B2 (en) 2016-08-17 2020-12-01 Novartis Ag Processes and intermediates for NEP inhibitor synthesis
CN106496055A (zh) * 2016-10-09 2017-03-15 杭州科巢生物科技有限公司 一种抗心衰新药的关键组分沙库比曲的新合成方法
WO2018069833A1 (fr) * 2016-10-10 2018-04-19 Laurus Labs Limited Forme amorphe stable d'un complexe de sacubitril-valsartan trisodique et ses procédés de préparation
JP7138106B2 (ja) 2016-12-23 2022-09-15 ノバルティス アーゲー 初期サクビトリル中間体のための新規な方法
CN107311909A (zh) * 2017-06-22 2017-11-03 东南大学 一种lcz696杂质对照品的制备方法
CN109206419B (zh) * 2017-06-29 2023-07-14 上海迪赛诺化学制药有限公司 沙库比曲中间体及其制备方法和应用
BR112020009418B1 (pt) * 2017-12-05 2023-10-10 Basf Se Processo para a síntese de sais de ácido sulfônico orgânico de ésteres de aminoácido, e, sal de ácido sulfônico orgânico de um éster de aminoácido
UY38072A (es) 2018-02-07 2019-10-01 Novartis Ag Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos
CN110407733A (zh) * 2018-04-26 2019-11-05 鲁南制药集团股份有限公司 一种沙库巴曲杂质化合物
CN110551151A (zh) * 2018-05-30 2019-12-10 微宏动力系统（湖州）有限公司 一种磷酸酯或亚磷酸酯的制备方法、电解液及二次电池
CN108727213B (zh) * 2018-06-29 2021-06-08 中国科学院上海有机化学研究所 一种沙库必曲的制备方法
WO2020039394A1 (fr) 2018-08-24 2020-02-27 Novartis Ag Nouvelles combinaisons de médicaments
CN109456212A (zh) * 2018-12-03 2019-03-12 康化（上海）新药研发有限公司 一种沙库比曲中间体的合成方法
CN109400504A (zh) * 2018-12-11 2019-03-01 重庆三圣实业股份有限公司 Lcz696中间体非对映异构体的分离纯化方法
EP3908572B1 (fr) * 2019-01-08 2024-06-19 Basf Se Procédé de préparation de sels organosulfatés d'esters d'acides aminés
CN109912486B (zh) * 2019-04-25 2022-09-27 东北制药集团股份有限公司 一种联苯甲基内酰胺化合物的制备方法
CN110878039A (zh) * 2019-12-18 2020-03-13 株洲千金药业股份有限公司 一种沙库巴曲缬沙坦钠杂质的制备方法
JP7064527B2 (ja) * 2020-05-01 2022-05-10 ノバルティス アーゲー サクビトリルカルシウム塩
AU2021306216B2 (en) 2020-07-09 2023-12-21 Advansix Resins & Chemicals Llc Branched amino acid surfactants
CA3298099A1 (en) 2020-07-13 2026-03-02 Advansix Resins & Chemicals Llc Branched amino acid surfactants for electronics products
WO2022015604A1 (fr) 2020-07-13 2022-01-20 Advansix Resins & Chemicals Llc Tensioactifs acides aminés ramifiés pour produits de soins personnels et produits cosmétiques
AU2021307397B2 (en) 2020-07-13 2024-06-13 Advansix Resins & Chemicals Llc Branched amino acid surfactants for use in healthcare products
EP4179038A1 (fr) 2020-07-13 2023-05-17 AdvanSix Resins & Chemicals LLC Tensioactifs d'acides aminés ramifiés pour la production d'huile et de gaz
CN116057130B (zh) 2020-07-13 2024-05-28 艾德凡斯化学公司 用于油墨、涂料和胶粘剂的支链氨基酸表面活性剂
CN116075582B (zh) 2020-07-13 2025-08-19 艾德凡斯化学公司 用于清洁产品的支链氨基酸表面活性剂
CN115677521B (zh) * 2022-11-16 2024-02-02 迪嘉药业集团股份有限公司 一种高纯度沙库巴曲钙的制备方法
CN117447341B (zh) * 2023-09-06 2025-11-18 杭州国瑞生物科技有限公司 一种沙库巴曲缬沙坦钠中间体的精制方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5015793B2 (fr) 1972-06-07 1975-06-07
EP0055175B1 (fr) 1980-12-23 1984-06-13 Air Industrie Installations thermo-électriques
FR2597100A1 (fr) 1986-01-21 1987-10-16 Nippon Shinyaku Co Ltd Derives du pyroglutamide
PH24872A (en) 1986-08-25 1990-12-26 Schering Corp (5r,6s,8r)-6-(-1-hydroxyethyl)-2-(3r-pyrrolidin-2-one-3-yl)thiopenem-3-carboxylic acid
JPH07103101B2 (ja) * 1989-07-24 1995-11-08 キッセイ薬品工業株式会社 ピログルタミン酸誘導体
IL97219A (en) 1990-02-19 1995-12-08 Ciba Geigy Ag Biphenyl substituted aliphatic amino compounds process for their preparation and pharmaceutical compositions containing them
US5273990A (en) 1992-09-03 1993-12-28 Ciba-Geigy Corporation Phosphono substituted tetrazole derivatives
US5250522A (en) * 1992-10-09 1993-10-05 Ciba-Geigy Corporation Phosphono/biaryl substituted amino acid derivatives
US5217996A (en) 1992-01-22 1993-06-08 Ciba-Geigy Corporation Biaryl substituted 4-amino-butyric acid amides
EP0599512B1 (fr) 1992-11-17 1999-03-24 Sankyo Company Limited Dérivé de carbapénème cristallin
ZA938438B (en) * 1992-11-17 1994-06-20 Sankyo Co Crystalline carbapenem derivative
US5550119A (en) 1995-03-02 1996-08-27 Ciba-Geigy Corporation Phosphono substituted tetrazole derivatives as ECE inhibitors
CN1216522A (zh) * 1996-02-19 1999-05-12 日本烟草产业株式会社 糖尿病治疗剂
AU5653799A (en) * 1998-09-21 2000-04-10 Takeda Chemical Industries Ltd. Novel thiol derivatives, process for producing the same and utilization thereof
DK1467728T3 (da) 2002-01-17 2007-12-27 Novartis Ag Farmaceutiske sammensætninger indeholdende valsartan og NEP-inhibitorer
WO2003082837A1 (fr) 2002-03-29 2003-10-09 Senju Pharmaceutical Co., Ltd. Derive de l'hydroxymorpholinone et ses utilisations medicales
US7618981B2 (en) 2004-05-06 2009-11-17 Cytokinetics, Inc. Imidazopyridinyl-benzamide anti-cancer agents
US7671225B2 (en) 2004-05-07 2010-03-02 Umicore Ag & Co. Kg Ferrocenyl ligands for homogeneous, enantioselective hydrogenation catalysts
GB0418046D0 (en) 2004-08-12 2004-09-15 Prosidion Ltd Eantioselective process
MY146830A (en) 2005-02-11 2012-09-28 Novartis Ag Combination of organic compounds
EP1903027A1 (fr) * 2006-09-13 2008-03-26 Novartis AG Procédé de préparation de l' acide amino-4 butyrique ou de ses derivés et leur utilisation pour la préparation des inhibiteurs NEP
KR101580067B1 (ko) * 2007-01-12 2015-12-23 노파르티스 아게 5-바이페닐-4-아미노-2-메틸 펜탄산의 제조 방법

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CA2674291A1 (fr) 2008-07-17
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TW200844092A (en) 2008-11-16
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AU2008204546A1 (en) 2008-07-17
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CL2008000077A1 (es) 2008-08-18
US8115016B2 (en) 2012-02-14
US20150166468A1 (en) 2015-06-18
US8716495B2 (en) 2014-05-06
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