ZA200905536B - Pharmaceutical composition comprising pyrazine derivative, and method of using pyrazine derivative in combination - Google Patents

Pharmaceutical composition comprising pyrazine derivative, and method of using pyrazine derivative in combination

Info

Publication number
ZA200905536B
ZA200905536B ZA200905536A ZA200905536A ZA200905536B ZA 200905536 B ZA200905536 B ZA 200905536B ZA 200905536 A ZA200905536 A ZA 200905536A ZA 200905536 A ZA200905536 A ZA 200905536A ZA 200905536 B ZA200905536 B ZA 200905536B
Authority
ZA
South Africa
Prior art keywords
pyrazine derivative
combination
pharmaceutical composition
pyrazine
derivative
Prior art date
Application number
ZA200905536A
Other languages
English (en)
Inventor
Masako Maekawa
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Publication of ZA200905536B publication Critical patent/ZA200905536B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA200905536A 2007-02-16 2008-02-14 Pharmaceutical composition comprising pyrazine derivative, and method of using pyrazine derivative in combination ZA200905536B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2007035975 2007-02-16

Publications (1)

Publication Number Publication Date
ZA200905536B true ZA200905536B (en) 2010-10-27

Family

ID=39690101

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200905536A ZA200905536B (en) 2007-02-16 2008-02-14 Pharmaceutical composition comprising pyrazine derivative, and method of using pyrazine derivative in combination

Country Status (21)

Country Link
US (1) US8759354B2 (de)
EP (1) EP2123276B1 (de)
JP (1) JP5255456B2 (de)
KR (1) KR101479083B1 (de)
CN (1) CN101610772B (de)
AU (1) AU2008215397B2 (de)
BR (1) BRPI0807597B8 (de)
CA (1) CA2677905C (de)
CY (1) CY1113435T1 (de)
DK (1) DK2123276T3 (de)
ES (1) ES2396595T3 (de)
HR (1) HRP20130111T1 (de)
IL (1) IL200285A (de)
MX (1) MX2009008779A (de)
NZ (1) NZ578989A (de)
PL (1) PL2123276T3 (de)
PT (1) PT2123276E (de)
RU (1) RU2463051C2 (de)
SI (1) SI2123276T1 (de)
WO (1) WO2008099874A1 (de)
ZA (1) ZA200905536B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010117114A1 (en) * 2009-04-09 2010-10-14 Lg Electronics Inc. Display apparatus
EP2568976B1 (de) * 2010-05-10 2015-09-30 Academia Sinica Zanamivir-phosphinat-kongenere mit antigrippewirkung und bestimmung der oseltamivir-empfänglichkeit von influenzaviren
ES2561878T3 (es) 2010-09-30 2016-03-01 Toyama Chemical Co., Ltd. Sal de meglumina de 6-fluoro-3-hidroxi-2-pirazinacarboxamida
HRP20151263T1 (hr) * 2010-09-30 2015-12-18 Toyama Chemical Co., Ltd. Natrijeva sol 6-fluoro-3-hidroksi-2-pirazinkarboksamida
AT510585B1 (de) 2010-11-18 2012-05-15 Apeptico Forschung & Entwicklung Gmbh Zusammensetzung umfassend ein peptid und ein hemmstoff der viralen neuraminidase
CA2911424C (en) * 2013-05-14 2021-11-30 Biocryst Pharmaceuticals, Inc. Anti-influenza imino-ribose pyrrolopyrimidine derivatives
CN104402833B (zh) * 2014-11-20 2016-08-24 广东东阳光药业有限公司 含有环丁烷取代基的吡嗪类化合物及其组合物及用途
CN104447584B (zh) * 2014-11-20 2016-08-24 广东东阳光药业有限公司 含有环丁烷取代基的吡嗪类化合物及其组合物及用途
CN104447585B (zh) * 2014-11-20 2016-08-24 广东东阳光药业有限公司 吡嗪类化合物及其组合物及用途
CN104447583B (zh) * 2014-11-20 2016-08-24 广东东阳光药业有限公司 含有环丁烷取代基的吡嗪类化合物及其组合物及用途
CN104496918B (zh) * 2014-12-10 2016-08-24 广东东阳光药业有限公司 吡嗪衍生物及其用途
CN104817511B (zh) * 2015-04-27 2017-04-19 济南大学 一种丁烯二酸酐制备法匹拉韦关键中间体的方法
JP6323860B2 (ja) * 2015-12-15 2018-05-16 塩野義製薬株式会社 キャップ依存的エンドヌクレアーゼ阻害剤及び抗インフルエンザ薬を組み合わせることを特徴とするインフルエンザ治療用医薬
US20220096468A1 (en) 2018-12-25 2022-03-31 Fujifilm Toyama Chemical Co., Ltd. Therapeutic agent for RNA viral infection comprising a combination of pyrazine derivative and compound which increases amount of pyrazine derivative ribose triphosphate in cell
EP4144353A4 (de) * 2020-04-30 2024-08-28 FUJIFILM Toyama Chemical Co., Ltd. Coronavirus-infektionstherapeutikum aus einer kombination aus einem pyrazinderivat und einem anderen coronavirus-infektionstherapeutikum
EP4159215A4 (de) * 2020-05-27 2023-11-22 FUJIFILM Toyama Chemical Co., Ltd. Therapeutisches mittel gegen rna-virusinfektion durch kombination eines pyrazinderivats und eines thiopurinderivats

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01197437A (ja) * 1988-01-29 1989-08-09 Dso Pharmachim 抗ウイルス薬
HU227475B1 (en) * 1998-08-20 2011-07-28 Toyama Chemical Co Ltd Nitrogenous heterocyclic carboxamide derivatives or salts thereof and antiviral agents containing them
JP4370164B2 (ja) * 2001-08-14 2009-11-25 富山化学工業株式会社 新規なウイルス増殖阻害・殺ウイルス方法および新規なピラジンヌクレオチド・ピラジンヌクレオシド類似体
JP2005354833A (ja) * 2004-06-11 2005-12-22 Fujinon Corp アクチュエータ
JP4689989B2 (ja) * 2004-08-27 2011-06-01 オリンパス株式会社 振動波リニアモータ及びそれを用いたレンズ装置
DE102008031715A1 (de) 2008-07-04 2010-01-07 Henkel Ag & Co. Kgaa Haarkonditionierende Mittel mit Imidazolinen

Also Published As

Publication number Publication date
DK2123276T3 (da) 2013-01-02
AU2008215397B2 (en) 2012-09-06
KR20090121289A (ko) 2009-11-25
EP2123276A4 (de) 2011-05-18
PT2123276E (pt) 2013-01-16
CN101610772B (zh) 2013-01-16
US8759354B2 (en) 2014-06-24
CN101610772A (zh) 2009-12-23
EP2123276A1 (de) 2009-11-25
CY1113435T1 (el) 2016-06-22
KR101479083B1 (ko) 2015-01-07
CA2677905A1 (en) 2008-08-21
JPWO2008099874A1 (ja) 2010-05-27
IL200285A0 (en) 2010-04-29
RU2009134516A (ru) 2011-03-27
US20100087447A1 (en) 2010-04-08
CA2677905C (en) 2015-03-24
PL2123276T3 (pl) 2013-04-30
HRP20130111T1 (hr) 2013-02-28
ES2396595T3 (es) 2013-02-22
AU2008215397A1 (en) 2008-08-21
JP5255456B2 (ja) 2013-08-07
IL200285A (en) 2014-06-30
BRPI0807597B1 (pt) 2021-03-02
SI2123276T1 (sl) 2013-03-29
WO2008099874A1 (ja) 2008-08-21
EP2123276B1 (de) 2012-11-28
BRPI0807597B8 (pt) 2021-05-25
MX2009008779A (es) 2009-11-05
NZ578989A (en) 2011-07-29
RU2463051C2 (ru) 2012-10-10
BRPI0807597A2 (pt) 2014-05-06

Similar Documents

Publication Publication Date Title
IL200285A0 (en) Pharmaceutical composition comprising pyrazine derivative, and method of using pyrazine derivative in combination
IL275854A (en) Pharmaceutical composition and its administration
PT1902706T (pt) Composições farmacêuticas estáveis de tetraciclinas em solução, seu método de obtenção e suas utilizações
EP2230241A4 (de) Tetrahydro-imidazo[1,5-a]pyrazinderivate, herstellungdsverfahren und ihre medizinische verwendung
ZA201206062B (en) Aminotetraline derivatives,pharmaceutical compositions containing them,and their use in therapy
IL203292A (en) History of n-indazolil affluent, process for preparation, intermediates obtained in this process and pharmacological preparations containing the history
IL205977A (en) Annals of 5-phenylamino-imidazo [5,1- a] (pyridine / pyrazine) and pharmaceuticals containing them
ZA200711040B (en) Method and composition for transdermal drug delivery
ZA200901132B (en) Human GLP-1 mimetibodies, compositions, methods and uses
IL213570A (en) History 8 - Alkoxy - s - Triazolo [5,1 - a] pyridine and pharmaceutical preparations containing them
IL206594A (en) The history of azinone-tetrahydropyridoindole and its containing pharmaceutical preparations
IL212707A0 (en) Compounds, pharmaceutical composition and methods for use in treating metabolic disorders
AP2590A (en) Derivatives of 7-alkynyl-1,8-naphthyridones, preparation method thereof and use of same in therapeutics
ZA201201727B (en) Indenone derivative and pharmaceutical composition comprising same
IL210446A (en) History of fibrin and medicinal preparations containing them
EP2345416A4 (de) Pharmazeutische zusammensetzung zur reinigung von venen und herstellungsverfahren dafür
IL202677A0 (en) Derivatives of 7-alkynyl-1,8-naphthyridones, preparation method thereof and use of same in therapeutics
IL206420A0 (en) Azetidine derivatives, their preparation and their application in therapy
IL207298A (en) A derivative of benzenesulfonamide, pharmaceutical preparations containing it and its uses
EP1896038A4 (de) Verfahren und zusammensetzung für die transdermale abgabe von arzneimitteln
PL2236145T3 (pl) Kompozycja farmaceutyczna i lek złożony
IL215551A (en) An indolite derivative, a pharmaceutical preparation containing it and its uses
HK1159603A (en) Aminotetraline derivatives, pharmaceutical compositions containing them, and their use in therapy
HK1142615A (en) Anti-cd20 therapeutic compositions and methods
HK1158182A (en) Compounds, pharmaceutical composition and methods for use in treating metabolic disorders