ZA200906423B - Pyrazolone derivatives as PDE4 inhibitors - Google Patents

Pyrazolone derivatives as PDE4 inhibitors

Info

Publication number: ZA200906423B
Authority: ZA; South Africa
Prior art keywords: pde4 inhibitors; pyrazolone derivatives; pyrazolone; derivatives; pde4
Prior art date: 2007-05-16

Application number

ZA200906423A

Other languages

English (en)

Inventor

Beate Schmidt

Juergen Volz

Rolf-Peter Hummel

Christof Zitt

Degenhard Marx

Deborah Ockert

Johannes A M Christiaans

Wiro M P B Menge

Christian Scheufler

Martin P Feth

Armin Hatzelmann

Andrea Wohlsen

Hans-Peter Kley

Anke Heuser

Geert Jan Sterk

Original Assignee

Nycomed Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-05-16

Filing date

2009-09-15

Publication date

2010-06-30

2009-09-15 Application filed by Nycomed Gmbh filed Critical Nycomed Gmbh

2010-06-30 Publication of ZA200906423B publication Critical patent/ZA200906423B/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
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- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
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- A61P17/06—Antipsoriatics
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- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Pulmonology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Orthopedic Medicine & Surgery (AREA)
Cardiology (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Transplantation (AREA)
Heart & Thoracic Surgery (AREA)
Reproductive Health (AREA)
Otolaryngology (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Gastroenterology & Hepatology (AREA)
Hospice & Palliative Care (AREA)
Gynecology & Obstetrics (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)

ZA200906423A 2007-05-16 2009-09-15 Pyrazolone derivatives as PDE4 inhibitors ZA200906423B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP07108314		2007-05-16

Publications (1)

Publication Number	Publication Date
ZA200906423B true ZA200906423B (en)	2010-06-30

Family

ID=38179942

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200906423A ZA200906423B (en)	2007-05-16	2009-09-15	Pyrazolone derivatives as PDE4 inhibitors

Country Status (30)

Country	Link
US (3)	US8304436B2 (fr)
EP (3)	EP2402330B1 (fr)
JP (2)	JP5529010B2 (fr)
KR (1)	KR101601284B1 (fr)
CN (2)	CN101657441B (fr)
AR (1)	AR066576A1 (fr)
AT (1)	ATE526326T1 (fr)
AU (1)	AU2008250069B2 (fr)
BR (1)	BRPI0811214A2 (fr)
CA (1)	CA2686909C (fr)
CO (1)	CO6220956A2 (fr)
CY (1)	CY1112152T1 (fr)
DK (1)	DK2148876T3 (fr)
EA (1)	EA018984B1 (fr)
EC (1)	ECSP099738A (fr)
ES (2)	ES2374337T3 (fr)
HR (1)	HRP20110940T1 (fr)
IL (1)	IL201959A (fr)
ME (1)	ME00952B (fr)
MX (1)	MX2009012062A (fr)
MY (1)	MY154498A (fr)
NZ (1)	NZ581547A (fr)
PL (1)	PL2148876T3 (fr)
PT (1)	PT2148876E (fr)
RS (1)	RS52074B (fr)
SI (1)	SI2148876T1 (fr)
TW (2)	TWI460174B (fr)
UA (1)	UA100019C2 (fr)
WO (1)	WO2008138939A1 (fr)
ZA (1)	ZA200906423B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2686909C (fr) *	2007-05-16	2016-07-05	Nycomed Gmbh	Derives de pyrazolone en tant qu'inhibiteurs de la pde4
AR074318A1 (es) *	2008-11-14	2011-01-05	Nycomed Gmbh	Derivados heterociclicos de pirazolona, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades de las vias respiratorias.
JP5642661B2 (ja) *	2009-03-05	2014-12-17	塩野義製薬株式会社	Ｎｐｙｙ５受容体拮抗作用を有するピペリジンおよびピロリジン誘導体
WO2011136752A1 (fr) *	2010-04-26	2011-11-03	Mahmut Bilgic	Composition pharmaceutique combinée comprenant du carmotérol et du ciclésonide pour le traitement de maladies respiratoires
JP5609614B2 (ja) *	2010-12-15	2014-10-22	東ソー株式会社	新規アリールアミンデンドリマー状化合物、その製造方法およびその用途
US10202366B2 (en)	2013-03-15	2019-02-12	Karyopharm Therapeutics Inc.	Methods of promoting wound healing using CRM1 inhibitors
WO2021245192A1 (fr)	2020-06-04	2021-12-09	Topadur Pharma Ag	Nouveaux activateurs de la guanylate cyclase soluble à double mode d'action et inhibiteurs de phosphodiestérase et leurs utilisations

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2903460A (en)	1956-04-07	1959-09-08	Sandoz Ag	Pyrazolone derivatives
US4550119A (en)	1983-05-23	1985-10-29	Warner-Lambert Company	2,4-Dihydro-5-[(substituted)phenyl]-4,4-disubstituted-3H-pyrazol-3-ones
IE71647B1 (en)	1991-01-28	1997-02-26	Rhone Poulenc Rorer Ltd	Benzamide derivatives
CZ14795A3 (en)	1992-07-28	1996-07-17	Rhone Poulenc Rorer Ltd	Benzene derivative containing phenyl group bound to aryl or heteroaryl fraction through an aliphatic or hetero atom containing group, process of its preparation and pharmaceutical composition containing thereof
ES2176252T3 (es)	1993-07-02	2002-12-01	Altana Pharma Ag	Benzamidas sustituidas con fluoro-alcoxi y su utilizacion como agentes inhibidores de fosfodiesterasas de nucleotidos ciclicos.
KR100381584B1 (ko)	1994-07-22	2003-08-21	알타나 파마 아게	디히드로벤조푸란
TR199901653T2 (xx) *	1997-01-15	1999-10-21	Byk Gulden Lomberg Chemische Fabrik Gmbh	Fitalazinonlar.
US6418201B1 (en)	2000-02-22	2002-07-09	Intel Corporation	Multiple platform voice processing system with optimized resource allocation
EE05386B1 (et)	2001-02-15	2011-02-15	ALTANA�Pharma�AG	Ftalasinoon-piperidinoderivaadid,ÁnendeÁkasutamineÁjaÁravim
AU2002234836B2 (en)	2001-04-20	2007-08-23	Pfizer Products Inc.	Process for the preparation of 1,3-substituted indenes and aryl-fused azapolycyclic compounds
NZ529221A (en)	2001-04-25	2005-04-29	Altana Pharma Ag	Phthalazinones with PDE-inhibiting properties for treatment of airway disorders and other inflammatory conditions
AU2003255376A1 (en)	2002-08-10	2004-03-11	Altana Pharma Ag	Piperidine-derivatives as pde4 inhibitors
WO2004018451A1 (fr) *	2002-08-10	2004-03-04	Altana Pharma Ag	Derives de pyridazinone utilises comme inhibiteurs de pde4
CA2494613C (fr) *	2002-08-10	2011-06-28	Altana Pharma Ag	Piperidine-phthalazones a substitution pyrrolidinedione utilises comme inhibiteurs de la phosphodiesterase-4 (pde4)
EP1539801B1 (fr) *	2002-08-20	2015-03-25	Biosurface Engineering Technologies, Inc.	Analogues synthetiques du facteur de croissance de liaison a l'heparine
JP2007504123A (ja) *	2003-08-29	2007-03-01	ランバクシーラボラトリーズリミテッド	Ｉｖ型ホスホジエステラーゼの阻害剤
WO2005075457A1 (fr)	2004-02-04	2005-08-18	Altana Pharma Ag	Derives de phtalazinone utilises en tant qu'inhibiteurs de pde4
EP1716133B1 (fr)	2004-02-04	2008-03-26	Nycomed GmbH	Dérivés de 2-(pipéridine-4-yl)-4,5-dihydro-2h-pyridazin-3-one comme inhibiteurs de pde4
JP2006169138A (ja) *	2004-12-14	2006-06-29	Kyorin Pharmaceut Co Ltd	ピラゾロピリジンピラゾロン誘導体とその付加塩及びｐｄｅ阻害剤
CA2686909C (fr) *	2007-05-16	2016-07-05	Nycomed Gmbh	Derives de pyrazolone en tant qu'inhibiteurs de la pde4

2008
- 2008-05-14 CA CA2686909A patent/CA2686909C/fr not_active Expired - Fee Related
- 2008-05-14 CN CN2008800119475A patent/CN101657441B/zh not_active Expired - Fee Related
- 2008-05-14 ME MEP-2009-327A patent/ME00952B/fr unknown
- 2008-05-14 CN CN201310349480.8A patent/CN103463086B/zh not_active Expired - Fee Related
- 2008-05-14 PT PT08759563T patent/PT2148876E/pt unknown
- 2008-05-14 ES ES08759563T patent/ES2374337T3/es active Active
- 2008-05-14 SI SI200830491T patent/SI2148876T1/sl unknown
- 2008-05-14 KR KR1020097025745A patent/KR101601284B1/ko not_active Expired - Fee Related
- 2008-05-14 ES ES11182678T patent/ES2427442T3/es active Active
- 2008-05-14 NZ NZ581547A patent/NZ581547A/en not_active IP Right Cessation
- 2008-05-14 HR HR20110940T patent/HRP20110940T1/hr unknown
- 2008-05-14 MX MX2009012062A patent/MX2009012062A/es active IP Right Grant
- 2008-05-14 EP EP11182678.0A patent/EP2402330B1/fr active Active
- 2008-05-14 DK DK08759563.3T patent/DK2148876T3/da active
- 2008-05-14 AU AU2008250069A patent/AU2008250069B2/en not_active Ceased
- 2008-05-14 PL PL08759563T patent/PL2148876T3/pl unknown
- 2008-05-14 UA UAA200912770A patent/UA100019C2/uk unknown
- 2008-05-14 EA EA200901504A patent/EA018984B1/ru not_active IP Right Cessation
- 2008-05-14 BR BRPI0811214-2A2A patent/BRPI0811214A2/pt active Search and Examination
- 2008-05-14 MY MYPI20094317A patent/MY154498A/en unknown
- 2008-05-14 JP JP2010507909A patent/JP5529010B2/ja not_active Expired - Fee Related
- 2008-05-14 EP EP08759563A patent/EP2148876B1/fr active Active
- 2008-05-14 RS RS20110570A patent/RS52074B/sr unknown
- 2008-05-14 WO PCT/EP2008/055867 patent/WO2008138939A1/fr not_active Ceased
- 2008-05-14 US US12/451,348 patent/US8304436B2/en not_active Expired - Fee Related
- 2008-05-14 EP EP12174018A patent/EP2508520A1/fr not_active Withdrawn
- 2008-05-14 AT AT08759563T patent/ATE526326T1/de active
- 2008-05-15 AR ARP080102055A patent/AR066576A1/es not_active Application Discontinuation
- 2008-05-16 TW TW102129216A patent/TWI460174B/zh not_active IP Right Cessation
- 2008-05-16 TW TW097118165A patent/TWI414521B/zh not_active IP Right Cessation
2009
- 2009-09-15 ZA ZA200906423A patent/ZA200906423B/xx unknown
- 2009-10-16 CO CO09115665A patent/CO6220956A2/es active IP Right Grant
- 2009-11-05 IL IL201959A patent/IL201959A/en not_active IP Right Cessation
- 2009-11-13 EC EC2009009738A patent/ECSP099738A/es unknown
2011
- 2011-12-20 CY CY20111101261T patent/CY1112152T1/el unknown
2012
- 2012-09-14 US US13/618,026 patent/US8865745B2/en not_active Expired - Fee Related
2014
- 2014-04-16 JP JP2014084704A patent/JP5850972B2/ja not_active Expired - Fee Related
- 2014-08-29 US US14/473,338 patent/US9090597B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EA018984B1 (ru)	2013-12-30
TW201406752A (zh)	2014-02-16
US20140378509A1 (en)	2014-12-25
ME00952B (fr)	2012-06-20
EP2402330A1 (fr)	2012-01-04
CN103463086B (zh)	2015-10-21
EP2508520A1 (fr)	2012-10-10
JP5850972B2 (ja)	2016-02-03
US8304436B2 (en)	2012-11-06
TWI460174B (zh)	2014-11-11
EP2402330B1 (fr)	2013-06-26
TWI414521B (zh)	2013-11-11
MY154498A (en)	2015-06-30
US8865745B2 (en)	2014-10-21
JP2014159452A (ja)	2014-09-04
WO2008138939A1 (fr)	2008-11-20
CA2686909C (fr)	2016-07-05
AU2008250069A1 (en)	2008-11-20
US9090597B2 (en)	2015-07-28
TW200914439A (en)	2009-04-01
PL2148876T3 (pl)	2012-02-29
ES2427442T3 (es)	2013-10-30
IL201959A0 (en)	2010-06-16
KR20100017745A (ko)	2010-02-16
US20130012544A1 (en)	2013-01-10
ECSP099738A (es)	2009-12-28
PT2148876E (pt)	2011-12-28
BRPI0811214A2 (pt)	2014-10-29
AU2008250069B2 (en)	2013-07-25
EP2148876A1 (fr)	2010-02-03
HK1141017A1 (en)	2010-10-29
RS52074B (sr)	2012-06-30
DK2148876T3 (da)	2012-01-16
HRP20110940T1 (hr)	2012-01-31
CN101657441A (zh)	2010-02-24
NZ581547A (en)	2012-02-24
JP2010526852A (ja)	2010-08-05
UA100019C2 (en)	2012-11-12
ATE526326T1 (de)	2011-10-15
CN101657441B (zh)	2013-09-11
MX2009012062A (es)	2009-11-19
CA2686909A1 (fr)	2008-11-20
KR101601284B1 (ko)	2016-03-08
EP2148876B1 (fr)	2011-09-28
CY1112152T1 (el)	2015-12-09
JP5529010B2 (ja)	2014-06-25
SI2148876T1 (sl)	2012-01-31
HK1191574A1 (zh)	2014-08-01
AR066576A1 (es)	2009-08-26
EA200901504A1 (ru)	2010-04-30
IL201959A (en)	2015-04-30
ES2374337T3 (es)	2012-02-15
CN103463086A (zh)	2013-12-25
US20100120757A1 (en)	2010-05-13
CO6220956A2 (es)	2010-11-19

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