ZA754997B - Improvements relating to 5,9-bela-disubstituted 2-tetra-hydrofurfuryl-6,7-benzomorphans - Google Patents

Improvements relating to 5,9-bela-disubstituted 2-tetra-hydrofurfuryl-6,7-benzomorphans

Info

Publication number
ZA754997B
ZA754997B ZA754997A ZA754997A ZA754997B ZA 754997 B ZA754997 B ZA 754997B ZA 754997 A ZA754997 A ZA 754997A ZA 754997 A ZA754997 A ZA 754997A ZA 754997 B ZA754997 B ZA 754997B
Authority
ZA
South Africa
Prior art keywords
hydrofurfuryl
benzomorphans
bela
disubstituted
tetra
Prior art date
Application number
ZA754997A
Other languages
English (en)
Inventor
H Merz
A Langbein
G Walther
K Stockhaus
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Publication of ZA754997B publication Critical patent/ZA754997B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA754997A 1974-08-05 1975-08-04 Improvements relating to 5,9-bela-disubstituted 2-tetra-hydrofurfuryl-6,7-benzomorphans ZA754997B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2437610A DE2437610A1 (de) 1974-08-05 1974-08-05 Neue 5,9-beta-disubstituierte 2-tetrahydrofurfuryl-6,7-benzomorphane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung

Publications (1)

Publication Number Publication Date
ZA754997B true ZA754997B (en) 1977-04-27

Family

ID=5922448

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA754997A ZA754997B (en) 1974-08-05 1975-08-04 Improvements relating to 5,9-bela-disubstituted 2-tetra-hydrofurfuryl-6,7-benzomorphans

Country Status (27)

Country Link
US (1) US3982005A (sr)
JP (1) JPS60358B2 (sr)
AT (1) AT348140B (sr)
BE (1) BE832099R (sr)
BG (3) BG25089A3 (sr)
CA (1) CA1049008A (sr)
CH (7) CH613963A5 (sr)
CS (1) CS189717B2 (sr)
DD (1) DD122685A5 (sr)
DE (1) DE2437610A1 (sr)
DK (1) DK138992C (sr)
ES (6) ES452763A1 (sr)
FI (1) FI63229C (sr)
FR (1) FR2320096A2 (sr)
GB (1) GB1513950A (sr)
HU (1) HU177952B (sr)
IE (1) IE42216B1 (sr)
IL (1) IL47860A (sr)
LU (1) LU73138A1 (sr)
NL (1) NL7509249A (sr)
NO (1) NO143460C (sr)
PH (1) PH13687A (sr)
PL (3) PL99816B1 (sr)
RO (3) RO67390A (sr)
SE (1) SE425392B (sr)
SU (3) SU591147A3 (sr)
ZA (1) ZA754997B (sr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4087532A (en) * 1974-03-09 1978-05-02 Boehringer Ingelheim Gmbh Analgesically useful 2-tetrahydrofurfuryl-5-lower alkyl-2-oxy-6,7-benzomorphans and salts thereof
GB1575009A (en) * 1976-06-21 1980-09-17 Acf Chemiefarma Nv 6,7-benzomorphan derivatives
DE2716687A1 (de) * 1977-04-15 1978-10-19 Boehringer Sohn Ingelheim 2'-hydroxy-2-(5-isoxazolylmethyl)-6,7benzomorphane, deren saeureadditionssalze und diese enthaltende arzneimittel
NL7804509A (nl) * 1978-04-26 1979-10-30 Acf Chemiefarma Nv Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan.
DE2828039A1 (de) * 1978-06-26 1980-01-10 Boehringer Sohn Ingelheim 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung
JPS5636521A (en) * 1979-08-31 1981-04-09 Shin Etsu Chem Co Ltd Production of alkenyloxy group-containing organopolysiloxane
US8329897B2 (en) 2007-07-26 2012-12-11 Vitae Pharmaceuticals, Inc. Synthesis of inhibitors of 11β-hydroxysteroid dehydrogenase type 1
EP2220048B1 (en) 2007-11-16 2017-01-25 Boehringer Ingelheim International GmbH Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
JP5490014B2 (ja) 2007-12-11 2014-05-14 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の環状尿素阻害剤
TW200934490A (en) 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
EP2252601B1 (en) 2008-01-24 2012-12-19 Vitae Pharmaceuticals, Inc. Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2254872A2 (en) 2008-02-15 2010-12-01 Vitae Pharmaceuticals, Inc. Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
JP5538365B2 (ja) 2008-05-01 2014-07-02 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤
CA2722427A1 (en) 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CL2009001058A1 (es) 2008-05-01 2010-09-10 Vitae Pharmaceuticals Inc Compuestos derivados de oxazinas sustituidas, inhibidores de la 11b-hidroxiesteroide deshidrogenasa de tipo-1; composicion farmaceutica; y uso del compuesto para inhibir la actividad de 11b-hsd1, como en el tratamiento de la diabetes, dislipidemia, hipertension, obesidad, cancer, glaucoma, entre otras.
WO2009138386A2 (en) 2008-05-13 2009-11-19 Boehringer Ingelheim International Gmbh Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use
JP5777030B2 (ja) 2008-07-25 2015-09-09 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング １１β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤
RU2539979C2 (ru) 2008-07-25 2015-01-27 Вайтаи Фармасьютиклз, Инк. Циклические ингибиторы 11бета-гидроксистероид-дегидрогеназы 1
MA33216B1 (fr) 2009-04-30 2012-04-02 Boehringer Ingelheim Int Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1
EP2440537A1 (en) 2009-06-11 2012-04-18 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure
TWI531571B (zh) * 2009-11-06 2016-05-01 維它藥物公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜芳基羰基衍生物
EP2582698B1 (en) 2010-06-16 2016-09-14 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
TWI537258B (zh) 2010-11-05 2016-06-11 百靈佳殷格翰國際股份有限公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物
JP2014524438A (ja) 2011-08-17 2014-09-22 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング インデノピリジン誘導体
CN116507689A (zh) 2020-11-26 2023-07-28 信越化学工业株式会社 室温固化性有机聚硅氧烷组合物及物品以及水解性有机硅烷化合物及其制造方法
WO2023032745A1 (ja) 2021-09-03 2023-03-09 信越化学工業株式会社 オルガノポリシロキサン化合物、室温硬化性オルガノポリシロキサン組成物、及び物品

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE582575A (sr) * 1958-09-22
US3700734A (en) * 1969-01-23 1972-10-24 Merck & Co Inc 2{40 -hydroxy-2,3,5-trimethyl-6,7-benzomorphan
DE2105743C3 (de) * 1971-02-08 1979-11-29 Boehringer Sohn Ingelheim 2-(Furylmethyl)- a -5,9-dialkyl -6,7benzomorphane, Verfahren zu ihrer Herstellung und deren Verwendung
CS166804B2 (sr) * 1971-02-08 1976-03-29 Boehringer Sohn Ingelheim
DE2200596A1 (de) * 1972-01-07 1973-07-12 Boehringer Sohn Ingelheim N-(furyl-methyl)-2'-hydroxy-5-phenyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung
DE2217420C3 (de) * 1972-04-12 1981-03-12 C.H. Boehringer Sohn, 6507 Ingelheim N-Thienylmethyl-Heterocyclen, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zubereitungen
DE2229695A1 (de) * 1972-06-19 1974-01-31 Boehringer Sohn Ingelheim 2-(heteroaryl-methyl)-5,9 beta-dialkyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung

Also Published As

Publication number Publication date
AT348140B (de) 1979-01-25
NO143460B (no) 1980-11-10
NO752731L (sr) 1976-02-06
GB1513950A (en) 1978-06-14
BE832099R (fr) 1976-02-04
DK352875A (da) 1976-02-06
IL47860A0 (en) 1975-11-25
ES452767A1 (es) 1977-10-01
FR2320096B2 (sr) 1978-09-01
ES452765A1 (es) 1977-10-16
CH613963A5 (sr) 1979-10-31
DD122685A5 (sr) 1976-10-20
FR2320096A2 (fr) 1977-03-04
PL99816B1 (pl) 1978-08-31
SU587859A3 (ru) 1978-01-05
DK138992B (da) 1978-11-27
FI63229C (fi) 1983-05-10
RO72736A (ro) 1982-09-09
SU587858A3 (ru) 1978-01-05
CH615678A5 (sr) 1980-02-15
IE42216L (en) 1976-02-05
BG25089A3 (bg) 1978-07-12
PL99819B1 (pl) 1978-08-31
FI752211A7 (sr) 1976-02-06
CH615679A5 (sr) 1980-02-15
IL47860A (en) 1979-01-31
NL7509249A (nl) 1976-02-09
AU8364675A (en) 1977-02-10
DE2437610A1 (de) 1976-02-26
ATA523775A (de) 1978-06-15
PH13687A (en) 1980-09-01
RO67390A (ro) 1981-06-30
CH616420A5 (sr) 1980-03-31
CH615680A5 (sr) 1980-02-15
IE42216B1 (en) 1980-07-02
CH615677A5 (sr) 1980-02-15
SE425392B (sv) 1982-09-27
BG25090A3 (bg) 1978-07-12
ES452768A1 (es) 1977-10-01
NO143460C (no) 1981-02-18
ES452763A1 (es) 1977-10-01
DK138992C (da) 1979-04-30
PL99838B1 (pl) 1978-08-31
JPS60358B2 (ja) 1985-01-07
HU177952B (en) 1982-02-28
JPS5139673A (en) 1976-04-02
SU591147A3 (ru) 1978-01-30
BG25088A3 (bg) 1978-07-12
RO72735A (ro) 1982-09-09
FI63229B (fi) 1983-01-31
ES452766A1 (es) 1977-10-01
US3982005A (en) 1976-09-21
ES452764A1 (es) 1977-10-16
LU73138A1 (sr) 1977-04-13
SE7508789L (sv) 1976-02-10
CH616421A5 (sr) 1980-03-31
CA1049008A (en) 1979-02-20
CS189717B2 (en) 1979-04-30

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