ZA794923B - New n-pyrrolyl-pyridazineamines,process for their manufacture and their use as antihypertensive agents - Google Patents

New n-pyrrolyl-pyridazineamines,process for their manufacture and their use as antihypertensive agents

Info

Publication number: ZA794923B
Authority: ZA; South Africa
Prior art keywords: formula; lower alkyl; new; hydrogen; pyrrolyl
Prior art date: 1978-10-02

Application number

ZA00794923A

Other languages

English (en)

Inventor

E Bellasio

N Mola

A Campi

E Baldoli

Original Assignee

Lepetit Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-10-02

Filing date

1979-09-17

Publication date

1980-09-24

1979-09-17 Application filed by Lepetit Spa filed Critical Lepetit Spa

1980-09-24 Publication of ZA794923B publication Critical patent/ZA794923B/xx

Links

229940030600 antihypertensive agent Drugs 0.000 title abstract 2
239000002220 antihypertensive agent Substances 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 title 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
125000001424 substituent group Chemical group 0.000 abstract 3
150000003839 salts Chemical class 0.000 abstract 2
125000006569 (C5-C6) heterocyclic group Chemical group 0.000 abstract 1
FNDJBMQTFVHDPR-UHFFFAOYSA-N 1-[4-[(2,5-dimethylpyrrol-1-yl)amino]phthalazin-1-yl]piperidin-4-ol Chemical compound CC1=CC=C(C)N1NC(C1=CC=CC=C11)=NN=C1N1CCC(O)CC1 FNDJBMQTFVHDPR-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
239000003377 acid catalyst Substances 0.000 abstract 1
125000005605 benzo group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
-1 dicarbonyl compound Chemical class 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 abstract 1
PXYUEEJAXOCGBZ-UHFFFAOYSA-N n-(1h-pyrrol-2-yl)pyridazin-3-amine Chemical class C=1C=CN=NC=1NC1=CC=CN1 PXYUEEJAXOCGBZ-UHFFFAOYSA-N 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical group C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/20—Nitrogen atoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Heart & Thoracic Surgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

ZA00794923A 1978-10-02 1979-09-17 New n-pyrrolyl-pyridazineamines,process for their manufacture and their use as antihypertensive agents ZA794923B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB7838898		1978-10-02

Publications (1)

Publication Number	Publication Date
ZA794923B true ZA794923B (en)	1980-09-24

Family

ID=10500040

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA00794923A ZA794923B (en)	1978-10-02	1979-09-17	New n-pyrrolyl-pyridazineamines,process for their manufacture and their use as antihypertensive agents

Country Status (15)

Country	Link
EP (1)	EP0009655B1 (2)
JP (1)	JPS5569577A (2)
AT (1)	ATE3294T1 (2)
AU (1)	AU529482B2 (2)
CA (1)	CA1144165A (2)
DE (1)	DE2965377D1 (2)
DK (1)	DK151803C (2)
ES (1)	ES484616A1 (2)
FI (1)	FI65998C (2)
GR (1)	GR69856B (2)
IE (1)	IE49017B1 (2)
IL (1)	IL58256A (2)
NO (1)	NO151620C (2)
YU (1)	YU41886B (2)
ZA (1)	ZA794923B (2)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1150070B (it) *	1980-12-22	1986-12-10	Lepetit Spa	Procedimento per preparare derivati n-pirrolipiridazinamminici
US5254622A (en) *	1988-12-09	1993-10-19	Asahi Kasei Kogyo Kabushiki Kaisha	ABS resin compositions and molded articles thereof having improved coating performances
KR20060037410A (ko) *	2003-07-30	2006-05-03	제논 파마슈티칼스 인크.	피리다진 유도체 및 그의 치료제로서의 용도
US7951805B2 (en)	2004-09-20	2011-05-31	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase
EP1804799B1 (en) *	2004-09-20	2013-08-21	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
EP2289510A1 (en)	2004-09-20	2011-03-02	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes
CA2580856A1 (en)	2004-09-20	2006-03-30	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
EP2316458A1 (en)	2004-09-20	2011-05-04	Xenon Pharmaceuticals Inc.	Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase
EP1799667B1 (en)	2004-09-20	2013-03-20	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives and their use as therapeutic agents
US7767677B2 (en)	2004-09-20	2010-08-03	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
EP2029138A1 (en)	2005-06-03	2009-03-04	Xenon Pharmaceuticals Inc.	Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
USD916552S1 (en) *	2019-07-26	2021-04-20	Spectrum Diversified Designs, Llc	Trivet

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1168334A (en) *	1967-01-25	1969-10-22	Lepetit Spa	New Pharmacologically Active Pyridazines
GB1378102A (en) *	1972-03-14	1974-12-18	Lepetit Spa	Antihypertensive compositions
GB1408362A (en) *	1973-05-25	1975-10-01	Lepetit Spa	2-pyrrol-1-yl amino 4,5-dihydro-1-h-imidazole derivatives
AU477837B2 (en) *	1973-05-30	1974-12-05	I. S. F. Sp. A	New anti-hypertensive compounds having a high therapeutic index and a long-term hypotensive effect
ES431009A1 (es) *	1974-05-09	1976-10-16	Isf Spa	Procedimiento para la preparacion de derivados de 3-benci- lidenhidracino-6-aminopiridacina.

1979
- 1979-09-07 AT AT79103326T patent/ATE3294T1/de active
- 1979-09-07 EP EP79103326A patent/EP0009655B1/en not_active Expired
- 1979-09-07 DE DE7979103326T patent/DE2965377D1/de not_active Expired
- 1979-09-12 FI FI792832A patent/FI65998C/fi not_active IP Right Cessation
- 1979-09-14 AU AU50866/79A patent/AU529482B2/en not_active Ceased
- 1979-09-17 ZA ZA00794923A patent/ZA794923B/xx unknown
- 1979-09-17 IL IL58256A patent/IL58256A/xx unknown
- 1979-09-24 GR GR60097A patent/GR69856B/el unknown
- 1979-09-25 DK DK400679A patent/DK151803C/da not_active IP Right Cessation
- 1979-09-28 YU YU2374/79A patent/YU41886B/xx unknown
- 1979-10-01 NO NO793151A patent/NO151620C/no unknown
- 1979-10-01 ES ES484616A patent/ES484616A1/es not_active Expired
- 1979-10-01 IE IE1866/79A patent/IE49017B1/en not_active IP Right Cessation
- 1979-10-02 JP JP12647779A patent/JPS5569577A/ja active Granted
- 1979-10-02 CA CA000336843A patent/CA1144165A/en not_active Expired

Also Published As

Publication number	Publication date
FI65998B (fi)	1984-04-30
IL58256A (en)	1984-02-29
EP0009655B1 (en)	1983-05-11
YU41886B (en)	1988-02-29
GR69856B (2)	1982-07-19
DK151803C (da)	1988-06-13
FI65998C (fi)	1984-08-10
ATE3294T1 (de)	1983-05-15
FI792832A7 (fi)	1980-04-03
IL58256A0 (en)	1979-12-30
DE2965377D1 (en)	1983-06-16
ES484616A1 (es)	1980-05-16
IE791866L (en)	1980-04-02
NO151620C (no)	1985-05-08
NO151620B (no)	1985-01-28
DK151803B (da)	1988-01-04
NO793151L (no)	1980-04-08
YU237479A (en)	1983-02-28
AU5086679A (en)	1980-04-17
AU529482B2 (en)	1983-06-09
JPS5569577A (en)	1980-05-26
CA1144165A (en)	1983-04-05
IE49017B1 (en)	1985-07-10
DK400679A (da)	1980-04-03
EP0009655A1 (en)	1980-04-16
JPH0321553B2 (2)	1991-03-22

Publication	Publication Date	Title
SE8200815L (sv)	1982-02-23	Kemisk forening till anvendning som mellanprodukt vid framstellning av vissa triazolforeningar
NO175256C (no)	1994-09-21	Analogifremgangsmåte til fremstilling av terapeutisk aktive 4-oksokinolin-3-karboksylsyrederivater
AU529482B2 (en)	1983-06-09	N-pyrrolyl-pyridazineamines
DK519985A (da)	1986-07-01	Quinoloncarboxylsyrederivater, fremgangsmaade til fremstilling deraf og antibakterielt middel indeholdende saadanne derivater
ES482701A1 (es)	1980-04-01	Procedimiento para la obtencion de alfa-azolil-ceto-derivados.
ES466366A1 (es)	1978-10-01	Un procedimiento para preparar derivados de metasulfonamido-benzamida.
OA06585A (fr)	1981-07-31	Dérivés triazonyl-alcéniques, leur procédé de production et leur utilisation comme fongicides.
DK412581A (da)	1982-03-18	Ethenylimidazolderivater og fremgangsmaade til fremstilling heraf
MY109714A (en)	1997-04-30	Process for preparing 8-chloroquinolone derivatives
GR78472B (2)	1984-09-27
ES445339A1 (es)	1977-06-01	Un procedimiento para la preparacion de derivados pirrolidi-nicos.
DK601883A (da)	1984-06-29	Phenyl-propanolderivater
GB1036419A (en)	1966-07-20	A process for the manufacture of isoquinoline derivatives
ES8200661A1 (es)	1981-11-16	Un procedimiento para la preparacion de nuevos derivados de dihidropiridina
ES8200090A3 (es)	1981-10-16	Un procedimiento para preparar un compuesto de bezamida
GB951653A (en)	1964-03-11	Improvements in or relating to 6-pteridinehydrazide and amidrazone derivatives
JO1047B1 (en)	1982-07-10	Vehicles
DK145948C (da)	1983-09-26	Fremgangsmaade til fremstilling af sulfonimidoylxanthon-2-carboxylsyrederivater