ZA8082B - Novel (piperidinylalkyl) quinazoline derivatives - Google Patents

Novel (piperidinylalkyl) quinazoline derivatives

Info

Publication number: ZA8082B
Authority: ZA; South Africa
Prior art keywords: alkyl; group; aryl; independently selected; substituents
Prior art date: 1979-01-08

Application number

ZA00800082A

Other languages

English (en)

Inventor

L Kennis

Aa M Van Der

A Van Heertum

J Vandenberk

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-01-08

Filing date

1980-01-07

Publication date

1981-08-26

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26669096&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA8082(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1980-01-07 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

1981-08-26 Publication of ZA8082B publication Critical patent/ZA8082B/xx

Links

125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 title abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 7
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
125000003545 alkoxy group Chemical group 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 3
125000001424 substituent group Chemical group 0.000 abstract 3
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
125000002947 alkylene group Chemical group 0.000 abstract 2
125000001475 halogen functional group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
229940076279 serotonin Drugs 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1
125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C07D239/96—Two oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Hydrogenated Pyridines (AREA)

ZA00800082A 1979-01-08 1980-01-07 Novel (piperidinylalkyl) quinazoline derivatives ZA8082B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US149379A	1979-01-08	1979-01-08
US06/084,272 US4335127A (en)	1979-01-08	1979-10-12	Piperidinylalkyl quinazoline compounds, composition and method of use

Publications (1)

Publication Number	Publication Date
ZA8082B true ZA8082B (en)	1981-08-26

Family

ID=26669096

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA00800082A ZA8082B (en)	1979-01-08	1980-01-07	Novel (piperidinylalkyl) quinazoline derivatives

Country Status (32)

Country	Link
US (1)	US4335127A (2)
EP (1)	EP0013612B1 (2)
JP (1)	JPS55105679A (2)
KR (3)	KR850000684B1 (2)
AT (1)	ATE5258T1 (2)
AU (1)	AU536175B2 (2)
CA (1)	CA1132557A (2)
CS (1)	CS223977B2 (2)
CY (1)	CY1252A (2)
DE (1)	DE3065489D1 (2)
DK (1)	DK170669B1 (2)
ES (1)	ES8101586A1 (2)
FI (1)	FI66609C (2)
GR (1)	GR67304B (2)
HK (1)	HK76284A (2)
HU (1)	HU184222B (2)
IE (1)	IE49351B1 (2)
IL (1)	IL59084A (2)
LU (1)	LU88219I2 (2)
MA (1)	MA18694A1 (2)
MY (1)	MY8700555A (2)
NL (1)	NL930018I2 (2)
NO (1)	NO155243C (2)
NZ (1)	NZ192551A (2)
PH (1)	PH17114A (2)
PL (1)	PL125789B1 (2)
PT (1)	PT70662A (2)
RO (1)	RO79148A (2)
SG (1)	SG48684G (2)
SU (1)	SU1041034A3 (2)
YU (1)	YU42957B (2)
ZA (1)	ZA8082B (2)

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1979
- 1979-10-12 US US06/084,272 patent/US4335127A/en not_active Expired - Lifetime
- 1979-12-21 GR GR60828A patent/GR67304B/el unknown
1980
- 1980-01-04 MA MA18891A patent/MA18694A1/fr unknown
- 1980-01-07 JP JP18680A patent/JPS55105679A/ja active Granted
- 1980-01-07 IL IL59084A patent/IL59084A/xx unknown
- 1980-01-07 PT PT70662A patent/PT70662A/pt unknown
- 1980-01-07 HU HU8025A patent/HU184222B/hu unknown
- 1980-01-07 CS CS80157A patent/CS223977B2/cs unknown
- 1980-01-07 IE IE21/80A patent/IE49351B1/en not_active IP Right Cessation
- 1980-01-07 PL PL1980221249A patent/PL125789B1/pl unknown
- 1980-01-07 NO NO800034A patent/NO155243C/no unknown
- 1980-01-07 DE DE8080300059T patent/DE3065489D1/de not_active Expired
- 1980-01-07 AU AU54381/80A patent/AU536175B2/en not_active Expired
- 1980-01-07 CA CA343,181A patent/CA1132557A/en not_active Expired
- 1980-01-07 LU LU88219C patent/LU88219I2/xx unknown
- 1980-01-07 SU SU802863403A patent/SU1041034A3/ru active
- 1980-01-07 NZ NZ192551A patent/NZ192551A/en unknown
- 1980-01-07 DK DK007280A patent/DK170669B1/da not_active IP Right Cessation
- 1980-01-07 EP EP80300059A patent/EP0013612B1/en not_active Expired
- 1980-01-07 ZA ZA00800082A patent/ZA8082B/xx unknown
- 1980-01-07 FI FI800047A patent/FI66609C/fi not_active IP Right Cessation
- 1980-01-07 AT AT80300059T patent/ATE5258T1/de not_active IP Right Cessation
- 1980-01-07 CY CY1252A patent/CY1252A/xx unknown
- 1980-01-08 PH PH23489A patent/PH17114A/en unknown
- 1980-01-08 ES ES487537A patent/ES8101586A1/es not_active Expired
- 1980-01-08 YU YU46/80A patent/YU42957B/xx unknown
- 1980-01-21 KR KR1019800000201A patent/KR850000684B1/ko not_active Expired
- 1980-02-20 RO RO80100248A patent/RO79148A/ro unknown
1984
- 1984-07-06 SG SG486/84A patent/SG48684G/en unknown
- 1984-08-02 KR KR1019840004608A patent/KR850000677B1/ko not_active Expired
- 1984-10-11 HK HK762/84A patent/HK76284A/en not_active IP Right Cessation
- 1984-12-20 KR KR1019840008162A patent/KR850000683B1/ko not_active Expired
1987
- 1987-12-30 MY MY555/87A patent/MY8700555A/xx unknown
1993
- 1993-03-02 NL NL930018C patent/NL930018I2/nl unknown

Also Published As

Publication number	Publication date
KR850000684B1 (ko)	1985-05-14
IL59084A0 (en)	1980-05-30
DK7280A (da)	1980-07-09
NL930018I2 (nl)	1993-09-16
AU536175B2 (en)	1984-04-19
PL125789B1 (en)	1983-06-30
SG48684G (en)	1985-03-29
IE800021L (en)	1980-07-08
FI66609B (fi)	1984-07-31
DE3065489D1 (en)	1983-12-15
NO155243C (no)	1987-03-04
HK76284A (en)	1984-10-19
CS223977B2 (en)	1983-11-25
KR850000683B1 (ko)	1985-05-14
NZ192551A (en)	1984-07-06
CY1252A (en)	1984-08-31
PH17114A (en)	1984-06-01
YU4680A (en)	1983-06-30
MY8700555A (en)	1987-12-31
CA1132557A (en)	1982-09-28
AU5438180A (en)	1980-07-17
JPS6346753B2 (2)	1988-09-19
NO800034L (no)	1980-07-09
YU42957B (en)	1989-02-28
IE49351B1 (en)	1985-09-18
EP0013612A2 (en)	1980-07-23
HU184222B (en)	1984-07-30
SU1041034A3 (ru)	1983-09-07
PT70662A (en)	1980-02-01
KR850000677B1 (ko)	1985-05-10
DK170669B1 (da)	1995-11-27
PL221249A1 (2)	1980-12-01
GR67304B (2)	1981-06-29
RO79148A (ro)	1982-08-17
EP0013612B1 (en)	1983-11-09
KR830001926A (ko)	1983-05-19
EP0013612A3 (en)	1980-10-15
ES487537A0 (es)	1980-12-16
ATE5258T1 (de)	1983-11-15
FI66609C (fi)	1984-11-12
IL59084A (en)	1984-02-29
LU88219I2 (2)	1994-02-03
US4335127A (en)	1982-06-15
NO155243B (no)	1986-11-24
NL930018I1 (nl)	1993-05-03
FI800047A7 (fi)	1980-07-09
ES8101586A1 (es)	1980-12-16
KR850002015A (ko)	1985-04-10
MA18694A1 (fr)	1980-10-01
JPS55105679A (en)	1980-08-13

Publication	Publication Date	Title
ZA8082B (en)	1981-08-26	Novel (piperidinylalkyl) quinazoline derivatives
NZ330656A (en)	1999-06-29	Tricyclic compounds, their production and use
ES8504718A1 (es)	1985-05-01	Un metodo para preparar derivados de 4-hidroxi-2-quinolona.
IE802684L (en)	1981-06-21	Quinoline derivatives
ES8103746A1 (es)	1981-03-16	Procedimiento para la preparacion de 4-aril-5,6,7,8-tetrahi-dropirazolo (3,4b) (1,5) diazepin-1h,4h-5,7-dionas
AU4934685A (en)	1986-05-15	3-Amino-2,3-dihydro-1-benzoxepine-compounds and methods for their preparation and pharmaceutical preparations containing these compounds
DE3361834D1 (en)	1986-02-27	Dithiino (1,4) (2,3-c) pyrrole derivatives, their preparation and pharmaceutical compositions containing them
DE3775905D1 (de)	1992-02-20	Purin-histamin-h1-antagonisten, ihre herstellung und sie enthaltende pharmazeutische praeparate.