ZA828744B - (+)-2-(1-(2,6-dichlorophenoxy)-ethyl)-1,3-diazacyclopent-2-ene, the production thereof and the use in pharmaceutical preparations - Google Patents

(+)-2-(1-(2,6-dichlorophenoxy)-ethyl)-1,3-diazacyclopent-2-ene, the production thereof and the use in pharmaceutical preparations

Info

Publication number
ZA828744B
ZA828744B ZA828744A ZA828744A ZA828744B ZA 828744 B ZA828744 B ZA 828744B ZA 828744 A ZA828744 A ZA 828744A ZA 828744 A ZA828744 A ZA 828744A ZA 828744 B ZA828744 B ZA 828744B
Authority
ZA
South Africa
Prior art keywords
diazacyclopent
dichlorophenoxy
ene
ethyl
production
Prior art date
Application number
ZA828744A
Other languages
English (en)
Inventor
Juergen Dr Biedermann
Gerrit Dr Prop
Ille-Stephanie Doppelfeld
Original Assignee
Nattermann A & Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nattermann A & Cie filed Critical Nattermann A & Cie
Publication of ZA828744B publication Critical patent/ZA828744B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/22—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Anesthesiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA828744A 1981-12-10 1982-11-26 (+)-2-(1-(2,6-dichlorophenoxy)-ethyl)-1,3-diazacyclopent-2-ene, the production thereof and the use in pharmaceutical preparations ZA828744B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813149010 DE3149010A1 (de) 1981-12-10 1981-12-10 (+)-2-(1-(2,6-dichlorphenoxy)-ethyl)-1,3- diazacyclopent-2-en, dessen herstellung und seine verwendung in pharamazeutischen praeparaten

Publications (1)

Publication Number Publication Date
ZA828744B true ZA828744B (en) 1983-09-28

Family

ID=6148419

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA828744A ZA828744B (en) 1981-12-10 1982-11-26 (+)-2-(1-(2,6-dichlorophenoxy)-ethyl)-1,3-diazacyclopent-2-ene, the production thereof and the use in pharmaceutical preparations

Country Status (9)

Country Link
US (1) US4443464A (da)
EP (1) EP0082364B1 (da)
JP (1) JPS58105969A (da)
AT (1) ATE19397T1 (da)
DE (2) DE3149010A1 (da)
DK (1) DK548082A (da)
GR (1) GR77769B (da)
IE (1) IE54221B1 (da)
ZA (1) ZA828744B (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4801617A (en) * 1987-04-06 1989-01-31 Leclerc Gerard Iminoimidazolidines useful in lowering intraocular pressure
US20050282879A1 (en) * 2004-06-17 2005-12-22 Foad Salehani Methods and composition for treatment of migraine and symptoms thereof
CN101687812A (zh) * 2007-07-02 2010-03-31 弗·哈夫曼-拉罗切有限公司 对痕量胺相关受体(taar)具有良好亲和性的2-咪唑啉化合物
JP2011530504A (ja) * 2008-08-08 2011-12-22 アジーン リミテッド ライアビリティー カンパニー Ｃｎｓ疾患及び病理の治療に用いるロフェキシジンエナンチオマー、並びにそのキラル合成法
CA2937222C (en) 2009-06-25 2019-06-04 Alkermes Pharma Ireland Limited Prodrugs of nh-acidic compounds
US8431576B2 (en) 2009-06-25 2013-04-30 Alkermes Pharma Ireland Limited Heterocyclic compounds for the treatment of neurological and psychological disorders
HUE065359T2 (hu) 2011-03-18 2024-05-28 Alkermes Pharma Ireland Ltd Szorbitán-észtereket tartalmazó gyógyászati készítmények
JP5952912B2 (ja) 2011-12-15 2016-07-13 アルカーメス ファーマ アイルランド リミテッド 二級アミン化合物のプロドラッグ
JP6219918B2 (ja) 2012-03-19 2017-10-25 アルカームス ファーマ アイルランド リミテッド グリセロールエステルを含む医薬組成物
ES2765036T3 (es) 2012-03-19 2020-06-05 Alkermes Pharma Ireland Ltd Composiciones farmacéuticas que comprenden esteres de ácidos grasos
ES2950418T3 (es) 2012-03-19 2023-10-09 Alkermes Pharma Ireland Ltd Composiciones farmacéuticas que comprenden alcohol bencílico
EP2897592B1 (en) 2012-09-19 2020-02-19 Alkermes Pharma Ireland Limited Pharmaceutical compositions having improved storage stability
BR112016021535A8 (pt) 2014-03-20 2021-07-20 Alkermes Pharma Ireland Ltd kit compreendendo formulações de aripiprazol tendo velocidades de injeção aumentadas útil para o tratamento de uma desordem do sistema nervoso central e uso
EP3761983A1 (en) 2018-03-05 2021-01-13 Alkermes Pharma Ireland Limited Aripiprazole dosing strategy
IT201900009777A1 (it) 2019-06-21 2020-12-21 Procos Spa Processo per la sintesi di lofexidina
ES2993182T3 (en) 2020-04-17 2024-12-23 Medichem Sa Process for the synthesis of lofexidine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3966757A (en) * 1967-02-23 1976-06-29 A. Nattermann & Cie Gmbh Imidazoline derivatives and processes for the production thereof
DE1695555A1 (de) * 1967-02-23 1970-07-16 Nordmark Werke Gmbh Neue Aryloxy-isoalkyl-delta2-imidazoline und deren Saeureadditionssalze sowie Verfahren zu ihrer Herstellung
JPS5855129B2 (ja) * 1974-11-21 1983-12-08 株式会社クラレ ２−置換または無置換のゲラニル酢酸エステル類の製造方法
AU3546478A (en) * 1977-04-29 1979-11-01 Ciba Geigy Ag Ectoparasiticides

Also Published As

Publication number Publication date
DE3270806D1 (en) 1986-05-28
IE822811L (en) 1983-06-10
DK548082A (da) 1983-06-11
DE3149010A1 (de) 1983-07-07
EP0082364B1 (de) 1986-04-23
ATE19397T1 (de) 1986-05-15
GR77769B (da) 1984-09-25
US4443464A (en) 1984-04-17
IE54221B1 (en) 1989-07-19
JPS58105969A (ja) 1983-06-24
EP0082364A2 (de) 1983-06-29
EP0082364A3 (en) 1984-04-04

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