DK548082A - (+)-2-(1-(2,6-dichlorphenoxy)-ethyl)-1,3-diazacyclopent-2-en, dens fremstilling og anvendelse i farmaceutiske praeparater - Google Patents

(+)-2-(1-(2,6-dichlorphenoxy)-ethyl)-1,3-diazacyclopent-2-en, dens fremstilling og anvendelse i farmaceutiske praeparater Download PDF

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Publication number
DK548082A
DK548082A DK548082A DK548082A DK548082A DK 548082 A DK548082 A DK 548082A DK 548082 A DK548082 A DK 548082A DK 548082 A DK548082 A DK 548082A DK 548082 A DK548082 A DK 548082A
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DK
Denmark
Prior art keywords
diazacyclopent
ethyl
dichlorphenoxy
production
pharmaceutical preparations
Prior art date
Application number
DK548082A
Other languages
English (en)
Inventor
Juergen Biedermann
Gerrit Prop
Ille-Stephanie Doppelfeld
Original Assignee
Nattermann A & Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nattermann A & Cie filed Critical Nattermann A & Cie
Publication of DK548082A publication Critical patent/DK548082A/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/22—Radicals substituted by oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Anesthesiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK548082A 1981-12-10 1982-12-09 (+)-2-(1-(2,6-dichlorphenoxy)-ethyl)-1,3-diazacyclopent-2-en, dens fremstilling og anvendelse i farmaceutiske praeparater DK548082A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813149010 DE3149010A1 (de) 1981-12-10 1981-12-10 (+)-2-(1-(2,6-dichlorphenoxy)-ethyl)-1,3- diazacyclopent-2-en, dessen herstellung und seine verwendung in pharamazeutischen praeparaten

Publications (1)

Publication Number Publication Date
DK548082A true DK548082A (da) 1983-06-11

Family

ID=6148419

Family Applications (1)

Application Number Title Priority Date Filing Date
DK548082A DK548082A (da) 1981-12-10 1982-12-09 (+)-2-(1-(2,6-dichlorphenoxy)-ethyl)-1,3-diazacyclopent-2-en, dens fremstilling og anvendelse i farmaceutiske praeparater

Country Status (9)

Country Link
US (1) US4443464A (da)
EP (1) EP0082364B1 (da)
JP (1) JPS58105969A (da)
AT (1) ATE19397T1 (da)
DE (2) DE3149010A1 (da)
DK (1) DK548082A (da)
GR (1) GR77769B (da)
IE (1) IE54221B1 (da)
ZA (1) ZA828744B (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4801617A (en) * 1987-04-06 1989-01-31 Leclerc Gerard Iminoimidazolidines useful in lowering intraocular pressure
US20050282879A1 (en) * 2004-06-17 2005-12-22 Foad Salehani Methods and composition for treatment of migraine and symptoms thereof
WO2009003868A2 (en) * 2007-07-02 2009-01-08 F. Hoffmann-La Roche Ag 2 -imidazolines having a good affinity to the trace amine associated receptors (taars)
EP2334297A1 (en) * 2008-08-08 2011-06-22 Agean Llc Lofexidine enantiomers for use as a treatment for cns disease and pathologies and its chiral synthesis
LT2445502T (lt) 2009-06-25 2017-09-25 Alkermes Pharma Ireland Limited Heterocikliniai junginiai, skirti neurologinių ir fiziologinių susirgimų gydymui
CA2937222C (en) * 2009-06-25 2019-06-04 Alkermes Pharma Ireland Limited Prodrugs of nh-acidic compounds
BR112013023847B1 (pt) 2011-03-18 2021-02-23 Alkermes Pharma Ireland Limited composições farmacêuticas compreendendo ésteres de sorbitano e uso das mesmas
NZ722096A (en) 2011-12-15 2016-11-25 Alkermes Pharma Ireland Ltd Prodrugs of secondary amine compounds
CA2867121C (en) 2012-03-19 2021-05-25 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising fatty acid esters
AU2013235523B9 (en) 2012-03-19 2018-01-04 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising glycerol esters
AU2013235526B2 (en) 2012-03-19 2017-11-30 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising benzyl alcohol
JP6654042B2 (ja) 2012-09-19 2020-02-26 アルカームス ファーマ アイルランド リミテッド 貯蔵安定性が改善された医薬組成物
CN106132415A (zh) 2014-03-20 2016-11-16 奥克梅斯制药爱尔兰有限公司 具有增加的注射速度的阿立哌唑制剂
EP3761983A1 (en) 2018-03-05 2021-01-13 Alkermes Pharma Ireland Limited Aripiprazole dosing strategy
IT201900009777A1 (it) 2019-06-21 2020-12-21 Procos Spa Processo per la sintesi di lofexidina
ES2993182T3 (en) 2020-04-17 2024-12-23 Medichem Sa Process for the synthesis of lofexidine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3966757A (en) * 1967-02-23 1976-06-29 A. Nattermann & Cie Gmbh Imidazoline derivatives and processes for the production thereof
DE1695555A1 (de) * 1967-02-23 1970-07-16 Nordmark Werke Gmbh Neue Aryloxy-isoalkyl-delta2-imidazoline und deren Saeureadditionssalze sowie Verfahren zu ihrer Herstellung
JPS5855129B2 (ja) * 1974-11-21 1983-12-08 株式会社クラレ ２−置換または無置換のゲラニル酢酸エステル類の製造方法
AU3546478A (en) * 1977-04-29 1979-11-01 Ciba Geigy Ag Ectoparasiticides

Also Published As

Publication number Publication date
EP0082364A3 (en) 1984-04-04
US4443464A (en) 1984-04-17
JPS58105969A (ja) 1983-06-24
IE822811L (en) 1983-06-10
DE3270806D1 (en) 1986-05-28
EP0082364A2 (de) 1983-06-29
ATE19397T1 (de) 1986-05-15
GR77769B (da) 1984-09-25
ZA828744B (en) 1983-09-28
IE54221B1 (en) 1989-07-19
DE3149010A1 (de) 1983-07-07
EP0082364B1 (de) 1986-04-23

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