ZA844402B - Hexahydropyrrolo(2,1-a)isoquinoline derivatives - Google Patents
Hexahydropyrrolo(2,1-a)isoquinoline derivativesInfo
- Publication number
- ZA844402B ZA844402B ZA844402A ZA844402A ZA844402B ZA 844402 B ZA844402 B ZA 844402B ZA 844402 A ZA844402 A ZA 844402A ZA 844402 A ZA844402 A ZA 844402A ZA 844402 B ZA844402 B ZA 844402B
- Authority
- ZA
- South Africa
- Prior art keywords
- hexahydropyrrolo
- isoquinoline derivatives
- derivatives
- isoquinolines
- depression
- Prior art date
Links
- SMMNWJYSCYKBRA-UHFFFAOYSA-N 1,2,3,5,6,6a-hexahydropyrrolo[2,1-a]isoquinoline Chemical class C1CC2C=CC=CC2=C2N1CCC2 SMMNWJYSCYKBRA-UHFFFAOYSA-N 0.000 title 1
- UFFWABKYFLFHDG-UHFFFAOYSA-N 1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline Chemical class C1=CC=C2C3CCCN3CCC2=C1 UFFWABKYFLFHDG-UHFFFAOYSA-N 0.000 abstract 1
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Detergent Compositions (AREA)
- Fats And Perfumes (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50725083A | 1983-06-23 | 1983-06-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA844402B true ZA844402B (en) | 1986-01-29 |
Family
ID=24017860
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA844402A ZA844402B (en) | 1983-06-23 | 1984-06-11 | Hexahydropyrrolo(2,1-a)isoquinoline derivatives |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0130069B1 (de) |
| JP (1) | JPS6069082A (de) |
| KR (1) | KR910002564B1 (de) |
| AT (1) | ATE59041T1 (de) |
| AU (1) | AU563990B2 (de) |
| CA (1) | CA1253155A (de) |
| DE (1) | DE3483735D1 (de) |
| DK (1) | DK305184A (de) |
| ES (1) | ES533657A0 (de) |
| FI (1) | FI76798C (de) |
| HK (1) | HK54891A (de) |
| HU (1) | HU193937B (de) |
| NO (1) | NO164474C (de) |
| NZ (1) | NZ208480A (de) |
| SG (1) | SG44391G (de) |
| ZA (1) | ZA844402B (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4572911A (en) * | 1984-08-02 | 1986-02-25 | Mcneilab, Inc. | Hexahydroindolinzine compounds, pharmaceutical compositions and methods and intermediates |
| DE3717395A1 (de) * | 1987-05-23 | 1988-12-08 | Basf Ag | 5-phenyl-1,2,3a,4,5,9b-hexahydro-3h-benz(e) indole, ihre herstellung und verwendung als arzneimittel |
| GB8718980D0 (en) * | 1987-08-11 | 1987-09-16 | May & Baker Ltd | Compositions of matter |
| GB9326699D0 (en) * | 1993-12-22 | 1994-03-02 | Celltech Ltd | Chemical compounds |
| CA2612495A1 (en) * | 2005-06-17 | 2006-12-28 | Janssen Pharmaceutica N.V. | Hexahydro-pyrrolo-isoquinoline compounds for the treatment of cns disorders |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE690792A (de) * | 1966-12-07 | 1967-05-16 | ||
| CH538477A (de) * | 1970-01-06 | 1973-06-30 | Hoffmann La Roche | Verfahren zur Herstellung von Isochinolin-Derivaten |
-
1984
- 1984-06-11 ZA ZA844402A patent/ZA844402B/xx unknown
- 1984-06-12 NO NO842345A patent/NO164474C/no unknown
- 1984-06-12 NZ NZ208480A patent/NZ208480A/en unknown
- 1984-06-14 CA CA000456578A patent/CA1253155A/en not_active Expired
- 1984-06-21 FI FI842533A patent/FI76798C/fi not_active IP Right Cessation
- 1984-06-22 ES ES533657A patent/ES533657A0/es active Granted
- 1984-06-22 DE DE8484304247T patent/DE3483735D1/de not_active Expired - Lifetime
- 1984-06-22 DK DK305184A patent/DK305184A/da unknown
- 1984-06-22 EP EP84304247A patent/EP0130069B1/de not_active Expired - Lifetime
- 1984-06-22 AT AT84304247T patent/ATE59041T1/de not_active IP Right Cessation
- 1984-06-22 AU AU29777/84A patent/AU563990B2/en not_active Ceased
- 1984-06-22 HU HU842443A patent/HU193937B/hu not_active IP Right Cessation
- 1984-06-23 JP JP59129917A patent/JPS6069082A/ja active Pending
- 1984-06-23 KR KR1019840003577A patent/KR910002564B1/ko not_active Expired
-
1991
- 1991-06-14 SG SG44391A patent/SG44391G/en unknown
- 1991-07-18 HK HK548/91A patent/HK54891A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI842533A7 (fi) | 1984-12-24 |
| FI76798C (fi) | 1988-12-12 |
| DE3483735D1 (en) | 1991-01-24 |
| KR910002564B1 (ko) | 1991-04-26 |
| FI76798B (fi) | 1988-08-31 |
| HK54891A (en) | 1991-07-26 |
| EP0130069B1 (de) | 1990-12-12 |
| NO842345L (no) | 1984-12-27 |
| CA1253155A (en) | 1989-04-25 |
| KR850000440A (ko) | 1985-02-27 |
| NO164474C (no) | 1990-10-10 |
| EP0130069A3 (en) | 1985-09-11 |
| AU563990B2 (en) | 1987-07-30 |
| NO164474B (no) | 1990-07-02 |
| HU193937B (en) | 1987-12-28 |
| DK305184D0 (da) | 1984-06-22 |
| NZ208480A (en) | 1986-08-08 |
| DK305184A (da) | 1984-12-24 |
| ATE59041T1 (de) | 1990-12-15 |
| AU2977784A (en) | 1985-01-03 |
| SG44391G (en) | 1991-07-26 |
| ES8602676A1 (es) | 1985-10-01 |
| ES533657A0 (es) | 1985-10-01 |
| FI842533A0 (fi) | 1984-06-21 |
| JPS6069082A (ja) | 1985-04-19 |
| EP0130069A2 (de) | 1985-01-02 |
| HUT34478A (en) | 1985-03-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUT63305A (en) | Fungicidal compositions comprising triazolopyrimidine derivatives and process for producing the triazolopyrimidine derivatives | |
| HUT66660A (en) | Intermediates for producing 9-[(substituted glicyl)-amido]-6-demetyl-6-deoxy-tetracyclines and pharmaceutical compositions containing them | |
| IL94915A0 (en) | Substituted quinazolinones and pharmaceutical compositions containing them | |
| ZA90479B (en) | Novel 1,2-cyclohexylaminoaryl amides useful as analgesic agents | |
| IL77395A (en) | Pharmaceutical compositions containing 1-benzo-fused heterocyclyl)-piperazine derivatives,certain such novel compounds and their preparation | |
| GB8819024D0 (en) | Chemical compounds | |
| HUT55055A (en) | Process for producing pyranyl-cyano-guanidine derivatives and pharmaceutical compositions containing them | |
| ZA883444B (de) | ||
| DE3476392D1 (en) | Purine derivatives | |
| GR3004353T3 (de) | ||
| GB9302046D0 (en) | Antiumoral compound-v | |
| HUT51295A (en) | Process for producing peptidalcohol derivatives of anticoagulant activity | |
| IL93161A0 (en) | 3-phenyl-5,6-dihydrobenz(c)acridine-7-carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them | |
| EP0130069A3 (en) | Hexahydropyrrolo (2,1-a) isoquinoline derivatives | |
| EP0551844A3 (de) | ||
| DE3461189D1 (en) | New 3-alkylthio-2-o-carbamoyl-propane-1.2-diol-1-o-phosphocholines, and processes for their preparation |