ZA845681B - Derivatives of alpha-alkyl polyolefinic carboxylic acid useful in the treatment of psoriasis - Google Patents

Derivatives of alpha-alkyl polyolefinic carboxylic acid useful in the treatment of psoriasis

Info

Publication number
ZA845681B
ZA845681B ZA845681A ZA845681A ZA845681B ZA 845681 B ZA845681 B ZA 845681B ZA 845681 A ZA845681 A ZA 845681A ZA 845681 A ZA845681 A ZA 845681A ZA 845681 B ZA845681 B ZA 845681B
Authority
ZA
South Africa
Prior art keywords
psoriasis
alpha
derivatives
alkyl
treatment
Prior art date
Application number
ZA845681A
Other languages
English (en)
Inventor
Bernard Loev
Howard Jones
Wan-Kit Chan
Original Assignee
Usv Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Usv Pharma Corp filed Critical Usv Pharma Corp
Publication of ZA845681B publication Critical patent/ZA845681B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/14—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by doubly-bound oxygen atoms
    • C07C403/16—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by doubly-bound oxygen atoms not being part of —CHO groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/02—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains containing only carbon and hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
    • C07C403/08—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
    • C07C403/10—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by etherified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
    • C07C403/12—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/18—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/22—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA845681A 1983-07-29 1984-07-23 Derivatives of alpha-alkyl polyolefinic carboxylic acid useful in the treatment of psoriasis ZA845681B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/518,785 US4523042A (en) 1983-07-29 1983-07-29 Derivatives of alpha-alkyl polyolefinic carboxylic acid useful in the treatment of psoriasis

Publications (1)

Publication Number Publication Date
ZA845681B true ZA845681B (en) 1985-02-27

Family

ID=24065493

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA845681A ZA845681B (en) 1983-07-29 1984-07-23 Derivatives of alpha-alkyl polyolefinic carboxylic acid useful in the treatment of psoriasis

Country Status (5)

Country Link
US (1) US4523042A (fr)
EP (1) EP0137155A3 (fr)
JP (1) JPS6084231A (fr)
AU (1) AU566333B2 (fr)
ZA (1) ZA845681B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3784738T2 (de) * 1987-06-12 1993-07-08 Molecular Design Int Topische vorstufen von arzneimitteln zur behandlung von akne und hautkrankheiten.
FR2681784B1 (fr) * 1991-10-01 1995-06-09 Fabre Pierre Cosmetique Composition dermatologique et/ou cosmetologique contenant des retinouides et utilisation de nouveaux retinouides.
US5567855A (en) * 1994-04-21 1996-10-22 Ligand Pharmaceuticals Incorporated Methods for stereospecific synthesis of polyene aldehydes
WO1994024082A1 (fr) * 1993-04-21 1994-10-27 Ligand Pharmaceuticals Incorporated Synthese stereospecifique de composes de polyene
US5837728A (en) * 1995-01-27 1998-11-17 Molecular Design International 9-cis retinoic acid esters and amides and uses thereof
US5716982A (en) * 1995-06-07 1998-02-10 Institute Of Materia Medica, An Institute Of The Chinese Academy Of Medical Sciences Retinoids and methods of use of same
US5703130A (en) * 1995-06-07 1997-12-30 Institute Of Materia Medica, An Institute Of The Chinese Academy Of Medical Sciences Chalcone retinoids and methods of use of same
US5968940A (en) * 1995-06-08 1999-10-19 Institute Of Materia Medica Retinoids and methods of use of same
EP2109597A1 (fr) * 2007-01-30 2009-10-21 DSM IP Assets B.V. Procede d'elaboration de dienones

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2709711A (en) * 1950-04-22 1955-05-31 Eastman Kodak Co Synthesis of carotenoid polyenes
US2709712A (en) * 1950-04-22 1955-05-31 Eastman Kodak Co Synthesis of vitamin a-active polyenes
DE1001258C2 (de) * 1954-07-01 1957-07-04 Eastman Kodak Co Verfahren zur Herstellung von konjugierten Polyenen der Vitamin-A-Reihe
US2951853A (en) * 1957-06-08 1960-09-06 Sumitomo Chemical Co Method for preparing polyenecarboxylic acid derivatives
US3043863A (en) * 1958-08-28 1962-07-10 Hoffmann La Roche Polyene alcohols and acyl derivatives thereof
FR1243824A (fr) * 1959-07-06 1960-10-21 Aec Chim Organ Biolog Procédé de préparation de composés isopréniques de la famille des caroténoïdes et produits intermédiaires nouveaux en résultant
FR1271048A (fr) * 1959-07-31 1961-09-08 Hoffmann La Roche Procédé pour la préparation d'alcools polyéniques et de dérivés acylés de ces derniers
US3408414A (en) * 1964-12-04 1968-10-29 Hoffmann La Roche Novel processes and intermediates
US3446801A (en) * 1966-03-23 1969-05-27 Eastman Kodak Co Carotenoid compounds
US3496170A (en) * 1966-03-23 1970-02-17 Eastman Kodak Co Carotenoid compounds
CH585709A5 (fr) * 1973-08-24 1977-03-15 Hoffmann La Roche
US4132723A (en) * 1973-08-24 1979-01-02 Hoffmann-La Roche Inc. Substituted phenyl- or cyclohex-1-en-1-yl-3,7-demethyl-nona-2,4,6-trienoic acids and derivatives thereof
US4054589A (en) * 1974-09-26 1977-10-18 Hoffmann-La Roche Inc. Novel 9-substituted phenyl-3,7-dimethyl-nona-2,4,6,8-tetraene esters
US4092366A (en) * 1975-04-10 1978-05-30 Scm Corporation Synthesis of Vitamin A, intermediates and conversion thereof to Vitamin A
DE2649138A1 (de) * 1975-10-30 1977-05-12 Hoffmann La Roche Verfahren zur herstellung von polyenverbindungen
FR2359821A1 (fr) * 1976-07-28 1978-02-24 Rhone Poulenc Ind Perfectionnement au procede de preparation de la vitamine a a partir de sulfones
US4472430A (en) * 1982-06-28 1984-09-18 Usv Pharmaceutical Corporation Alpha-alkyl polyolefinic carboxylic acids and derivatives thereof useful in the treatment of psoriasis

Also Published As

Publication number Publication date
JPS6084231A (ja) 1985-05-13
AU566333B2 (en) 1987-10-15
US4523042A (en) 1985-06-11
EP0137155A2 (fr) 1985-04-17
EP0137155A3 (fr) 1985-12-18
AU3097284A (en) 1985-01-31

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