ZA851778B - Carboxy containing ester prodrugs of corticosteroids - Google Patents

Carboxy containing ester prodrugs of corticosteroids

Info

Publication number
ZA851778B
ZA851778B ZA851778A ZA851778A ZA851778B ZA 851778 B ZA851778 B ZA 851778B ZA 851778 A ZA851778 A ZA 851778A ZA 851778 A ZA851778 A ZA 851778A ZA 851778 B ZA851778 B ZA 851778B
Authority
ZA
South Africa
Prior art keywords
corticosteroids
containing ester
ester prodrugs
carboxy containing
carboxy
Prior art date
Application number
ZA851778A
Other languages
English (en)
Inventor
Bradley Dale Anderson
Robert Allen Conradi
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of ZA851778B publication Critical patent/ZA851778B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/347—Saturated compounds containing more than one carboxyl group containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA851778A 1984-03-28 1985-03-08 Carboxy containing ester prodrugs of corticosteroids ZA851778B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/594,098 US4588718A (en) 1984-03-28 1984-03-28 Carboxy containing ester prodrugs of corticosteroids

Publications (1)

Publication Number Publication Date
ZA851778B true ZA851778B (en) 1985-11-27

Family

ID=24377510

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA851778A ZA851778B (en) 1984-03-28 1985-03-08 Carboxy containing ester prodrugs of corticosteroids

Country Status (6)

Country Link
US (1) US4588718A (fr)
EP (1) EP0157567B1 (fr)
JP (1) JPS60222495A (fr)
CA (1) CA1230328A (fr)
DE (1) DE3574473D1 (fr)
ZA (1) ZA851778B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3511588A1 (de) * 1985-03-27 1986-10-02 Schering AG, Berlin und Bergkamen, 1000 Berlin Waessrige kristallsuspension von steroidglykoestern
EP0221705A1 (fr) * 1985-10-23 1987-05-13 The Upjohn Company Tétrahydro-stéroides à activité angiostatique
NZ259596A (en) * 1993-01-08 1997-04-24 Astra Ab Sugar-substituted glucocorticosteroid and use in medicaments specific to the colon or ileum
IT1293510B1 (it) * 1997-07-30 1999-03-01 Gentili Ist Spa Anticorpi monoclonali catalitici per la trasformazione in vivo di profarmaci di corticosteroidi
EP1177281B1 (fr) * 1999-04-30 2009-01-21 Cyclops Genome Sciences Limited Isolation d'acide nucleique
CN101970042A (zh) 2008-02-25 2011-02-09 眼门药品公司 经由离子电渗法增强递送治疗药物至眼部组织
US12410209B2 (en) 2021-06-29 2025-09-09 Board Of Regents, The University Of Texas System Modified glucocorticoids

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2656366A (en) * 1950-07-27 1953-10-20 Merck & Co Inc Water-soluble esters of cortisone and related compounds
US3089881A (en) * 1957-10-29 1963-05-14 Schering Corp Sulfocarboxylic acid esters of hydroxylated steroids
US2986559A (en) * 1959-01-07 1961-05-30 Schering Corp Novel therapeutic salts and processes for their manufacture
US3626063A (en) * 1959-08-11 1971-12-07 Upjohn Co Therapeutic compositions comprising 6-fluoro-16-methyl prednisolone, the 21 acylates and salts thereof
FR1426922A (fr) * 1964-07-16 1966-02-04 Dausse Lab Nouveaux dérivés de stéroïdes et d'amino-alcools et leur procédé de préparation
US3415817A (en) * 1965-03-02 1968-12-10 Scherling Ag Bacteria-inhibiting steroids and method of making the same
US3396918A (en) * 1967-01-09 1968-08-13 Goodyear Tire & Rubber Expandable adapter
US3471477A (en) * 1967-10-18 1969-10-07 Syntex Corp 6-gem-difluoro (3,2-c) and (2,3-d) pyrazole steroids
US3546215A (en) * 1967-10-18 1970-12-08 Syntex Corp 6-gem-difluoro steroids
FR2193576B1 (fr) * 1972-05-19 1975-08-08 Roussel Uclaf
DE2753838A1 (de) * 1977-11-30 1979-06-07 Schering Ag Wasserloesliche kortikoide
SU818489A3 (ru) * 1978-10-04 1981-03-30 Шеринг Аг (Фирма) Способ получени кортикоид -21- СульфОпРОпиОНАТОВ или иХ СОлЕй
US4381307A (en) * 1980-10-31 1983-04-26 Merck & Co., Inc. Soft tertiary amine esters of bio-affecting carboxylic acids
US4456602A (en) * 1982-08-23 1984-06-26 The Upjohn Company Amine containing ester prodrugs of corticosteroids
US4443440A (en) * 1982-08-30 1984-04-17 The Upjohn Company Amine containing ester prodrugs of corticosteroids
US4472392A (en) * 1983-01-21 1984-09-18 The Upjohn Company Sulfonate containing ester prodrugs of corticosteroids

Also Published As

Publication number Publication date
EP0157567A3 (en) 1986-08-27
EP0157567B1 (fr) 1989-11-29
EP0157567A2 (fr) 1985-10-09
JPS60222495A (ja) 1985-11-07
CA1230328A (fr) 1987-12-15
DE3574473D1 (de) 1990-01-04
US4588718A (en) 1986-05-13

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