ZA854164B - 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-oxo-1-piperazinyl)-3-quinolinecarboxylic acids,process for their preparation and antibacterial agents containing them - Google Patents
1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-oxo-1-piperazinyl)-3-quinolinecarboxylic acids,process for their preparation and antibacterial agents containing themInfo
- Publication number
- ZA854164B ZA854164B ZA854164A ZA854164A ZA854164B ZA 854164 B ZA854164 B ZA 854164B ZA 854164 A ZA854164 A ZA 854164A ZA 854164 A ZA854164 A ZA 854164A ZA 854164 B ZA854164 B ZA 854164B
- Authority
- ZA
- South Africa
- Prior art keywords
- oxo
- piperazinyl
- cyclopropyl
- dihydro
- fluoro
- Prior art date
Links
- MYYZZOHRULFPOQ-UHFFFAOYSA-N 3-oxociprofloxacin Chemical class C12=CC(N3CC(=O)NCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYYZZOHRULFPOQ-UHFFFAOYSA-N 0.000 title 1
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052731 fluorine Chemical group 0.000 abstract 1
- 239000011737 fluorine Chemical group 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fodder In General (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843420770 DE3420770A1 (de) | 1984-06-04 | 1984-06-04 | 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-(3-oxo-1-piperazinyl)-3-chinoloncarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA854164B true ZA854164B (en) | 1986-01-29 |
Family
ID=6237581
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA854164A ZA854164B (en) | 1984-06-04 | 1985-06-03 | 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-oxo-1-piperazinyl)-3-quinolinecarboxylic acids,process for their preparation and antibacterial agents containing them |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4588726A (da) |
| EP (1) | EP0166939B1 (da) |
| JP (1) | JPS611682A (da) |
| KR (1) | KR860000279A (da) |
| AT (1) | ATE35264T1 (da) |
| CA (1) | CA1248953A (da) |
| DE (2) | DE3420770A1 (da) |
| DK (1) | DK249385A (da) |
| ES (1) | ES8607278A1 (da) |
| IL (1) | IL75367A (da) |
| ZA (1) | ZA854164B (da) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3420116A1 (de) * | 1984-05-30 | 1985-12-05 | Bayer Ag, 5090 Leverkusen | Immunstimulierende mittel |
| DE3509546A1 (de) * | 1985-03-16 | 1986-09-25 | Bayer Ag, 5090 Leverkusen | 7-amino-1-(subst.cyclopropyl)-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
| DE3705621C2 (de) * | 1986-02-25 | 1997-01-09 | Otsuka Pharma Co Ltd | Heterocyclisch substituierte Chinoloncarbonsäurederivate |
| US5563138A (en) * | 1987-04-16 | 1996-10-08 | Otsuka Pharmaceutical Company, Limited | Benzoheterocyclic compounds |
| US5262417A (en) * | 1988-12-06 | 1993-11-16 | The Upjohn Company | Antibacterial quinolone compounds |
| US4992449A (en) * | 1990-02-01 | 1991-02-12 | American Cyanamid Company | 7-(substituted)cycloalkylamino-1-(substituted)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids |
| JP2613139B2 (ja) * | 1990-07-19 | 1997-05-21 | エスエス製薬 株式会社 | キノロンカルボン酸誘導体 |
| DE4301247A1 (de) * | 1993-01-19 | 1994-07-21 | Bayer Ag | Verfahren zur Herstellung mehrfach halogenierter Benzotrichloride und Benzoylchloride sowie neue Trihalogenbenzotrichloride und -benzoylchloride |
| MX9700497A (es) * | 1994-07-18 | 1997-04-30 | Ube Industries | Derivado de acido trifluorometilquinolinocarboxilico. |
| DE19503471A1 (de) * | 1995-02-03 | 1996-08-08 | Bayer Ag | Verfahren zur Herstellung von kernhalogenierten Benzoylchloriden |
| IN186245B (da) | 1997-09-19 | 2001-07-14 | Ranbaxy Lab Ltd | |
| CN101851164A (zh) * | 2010-05-28 | 2010-10-06 | 南京大唐医药科技有限公司 | 取代的含氟,氮类苯甲酰乙酸乙酯的合成方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5845426B2 (ja) * | 1978-09-29 | 1983-10-08 | 杏林製薬株式会社 | 置換キノリンカルボン酸誘導体 |
| DE3033157A1 (de) * | 1980-09-03 | 1982-04-01 | Bayer Ag, 5090 Leverkusen | 7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-naphthyridin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
| SE440354B (sv) * | 1981-02-19 | 1985-07-29 | Kyorin Seiyaku Kk | Kinolinkarboxylsyraderivat |
| DE3248506A1 (de) * | 1982-12-29 | 1984-07-05 | Bayer Ag, 5090 Leverkusen | 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7(alkyl-1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
| DE3306771A1 (de) * | 1983-02-25 | 1984-08-30 | Bayer Ag, 5090 Leverkusen | Chinoloncarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
-
1984
- 1984-06-04 DE DE19843420770 patent/DE3420770A1/de not_active Withdrawn
-
1985
- 1985-05-17 US US06/735,499 patent/US4588726A/en not_active Expired - Fee Related
- 1985-05-22 EP EP85106254A patent/EP0166939B1/de not_active Expired
- 1985-05-22 DE DE8585106254T patent/DE3563441D1/de not_active Expired
- 1985-05-22 AT AT85106254T patent/ATE35264T1/de not_active IP Right Cessation
- 1985-05-31 IL IL75367A patent/IL75367A/xx unknown
- 1985-05-31 CA CA000482910A patent/CA1248953A/en not_active Expired
- 1985-05-31 JP JP60116835A patent/JPS611682A/ja active Pending
- 1985-06-03 DK DK249385A patent/DK249385A/da not_active Application Discontinuation
- 1985-06-03 KR KR1019850003854A patent/KR860000279A/ko not_active Ceased
- 1985-06-03 ZA ZA854164A patent/ZA854164B/xx unknown
- 1985-06-03 ES ES543837A patent/ES8607278A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DK249385D0 (da) | 1985-06-03 |
| ES8607278A1 (es) | 1986-06-01 |
| DE3563441D1 (en) | 1988-07-28 |
| EP0166939B1 (de) | 1988-06-22 |
| EP0166939A1 (de) | 1986-01-08 |
| IL75367A0 (en) | 1985-09-29 |
| JPS611682A (ja) | 1986-01-07 |
| CA1248953A (en) | 1989-01-17 |
| ATE35264T1 (de) | 1988-07-15 |
| US4588726A (en) | 1986-05-13 |
| IL75367A (en) | 1988-09-30 |
| DE3420770A1 (de) | 1985-12-05 |
| DK249385A (da) | 1985-12-05 |
| ES543837A0 (es) | 1986-06-01 |
| KR860000279A (ko) | 1986-01-27 |
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