ZA85453B - Use of some2-(2-(4-phenyl-1-piperazinyl)ethyl)-1h-naphth-(1,2-d)imidazole derivatives and their pharmaceutically acceptable salts in the treatment of cardiovascular diseases - Google Patents

Use of some2-(2-(4-phenyl-1-piperazinyl)ethyl)-1h-naphth-(1,2-d)imidazole derivatives and their pharmaceutically acceptable salts in the treatment of cardiovascular diseases

Info

Publication number: ZA85453B
Authority: ZA; South Africa
Prior art keywords: piperazinyl; phenyl; ethyl; pharmaceutically acceptable; some2
Prior art date: 1984-02-07

Application number

ZA85453A

Other languages

English (en)

Inventor

Emilio Toja

Domenico Barone

Emiliana Baldoli

Original Assignee

Lepetit Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-02-07

Filing date

1985-01-21

Publication date

1986-05-28

1985-01-21 Application filed by Lepetit Spa filed Critical Lepetit Spa

1986-05-28 Publication of ZA85453B publication Critical patent/ZA85453B/xx

Links

150000003839 salts Chemical class 0.000 title abstract 2
208000024172 Cardiovascular disease Diseases 0.000 title 1
KKAMJECDKNIUQY-UHFFFAOYSA-N 2-[2-(4-phenylpiperazin-1-yl)ethyl]-3h-benzo[e]benzimidazole Chemical class N=1C2=CC=C3C=CC=CC3=C2NC=1CCN(CC1)CCN1C1=CC=CC=C1 KKAMJECDKNIUQY-UHFFFAOYSA-N 0.000 abstract 1
HCCNHYWZYYIOFM-UHFFFAOYSA-N 3h-benzo[e]benzimidazole Chemical class C1=CC=C2C(N=CN3)=C3C=CC2=C1 HCCNHYWZYYIOFM-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
230000003276 anti-hypertensive effect Effects 0.000 abstract 1
-1 chloro, methoxy Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Heart & Thoracic Surgery (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

ZA85453A 1984-02-07 1985-01-21 Use of some2-(2-(4-phenyl-1-piperazinyl)ethyl)-1h-naphth-(1,2-d)imidazole derivatives and their pharmaceutically acceptable salts in the treatment of cardiovascular diseases ZA85453B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB848403141A GB8403141D0 (en)	1984-02-07	1984-02-07	Imidazole derivatives

Publications (1)

Publication Number	Publication Date
ZA85453B true ZA85453B (en)	1986-05-28

Family

ID=10556175

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA85453A ZA85453B (en)	1984-02-07	1985-01-21	Use of some2-(2-(4-phenyl-1-piperazinyl)ethyl)-1h-naphth-(1,2-d)imidazole derivatives and their pharmaceutically acceptable salts in the treatment of cardiovascular diseases

Country Status (8)

Country	Link
US (1)	US4594348A (de)
EP (1)	EP0155459B1 (de)
JP (1)	JPS60248613A (de)
AT (1)	ATE42548T1 (de)
CA (1)	CA1246455A (de)
DE (1)	DE3569733D1 (de)
GB (1)	GB8403141D0 (de)
ZA (1)	ZA85453B (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US11173146B2 (en)	2014-04-25	2021-11-16	The Regents Of The University Of California	Selective activators of the intermediate conductance CA2+activated K+ channel KCa3.1 and their methods of use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2964567D1 (en) *	1978-12-21	1983-02-24	Lepetit Spa	New 3h-naphtho(1,2-d)imidazoles, processes for preparing them, compounds for use as antiinflammatory and antimicrobial agents and compositions for that use containing them
EP0034249B1 (de) *	1980-02-08	1984-10-24	Gruppo Lepetit S.P.A.	Naphthimidazol- und Naphthoxazol-Derivate, ihre Herstellung und ihre Verwendung in Pharmazeutika
EP0034294A3 (de) *	1980-02-13	1982-07-07	Uniroyal, Inc.	Vulkanisierter Schlauch mit Verstärkungen für Klimaanlagen und Verfahren zu dessen Herstellung

1984
- 1984-02-07 GB GB848403141A patent/GB8403141D0/en active Pending
1985
- 1985-01-21 ZA ZA85453A patent/ZA85453B/xx unknown
- 1985-01-23 AT AT85100667T patent/ATE42548T1/de not_active IP Right Cessation
- 1985-01-23 DE DE8585100667T patent/DE3569733D1/de not_active Expired
- 1985-01-23 EP EP85100667A patent/EP0155459B1/de not_active Expired
- 1985-01-30 CA CA000473151A patent/CA1246455A/en not_active Expired
- 1985-02-06 US US06/698,653 patent/US4594348A/en not_active Expired - Fee Related
- 1985-02-06 JP JP60020161A patent/JPS60248613A/ja active Granted

Also Published As

Publication number	Publication date
US4594348A (en)	1986-06-10
EP0155459B1 (de)	1989-04-26
DE3569733D1 (en)	1989-06-01
CA1246455A (en)	1988-12-13
GB8403141D0 (en)	1984-03-14
JPH0553775B2 (de)	1993-08-10
EP0155459A1 (de)	1985-09-25
ATE42548T1 (de)	1989-05-15
JPS60248613A (ja)	1985-12-09

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