ZA855492B - Novel n-hydroxyl protecting groups and process for the preparation of 3-acylamino-1-hydroxy-2-azetidinones - Google Patents

Novel n-hydroxyl protecting groups and process for the preparation of 3-acylamino-1-hydroxy-2-azetidinones

Info

Publication number
ZA855492B
ZA855492B ZA855492A ZA855492A ZA855492B ZA 855492 B ZA855492 B ZA 855492B ZA 855492 A ZA855492 A ZA 855492A ZA 855492 A ZA855492 A ZA 855492A ZA 855492 B ZA855492 B ZA 855492B
Authority
ZA
South Africa
Prior art keywords
novel
azetidinones
acylamino
hydroxy
preparation
Prior art date
Application number
ZA855492A
Other languages
English (en)
Inventor
Richard Henry Mueller
Jakob-Matthias Drossard
Peter Hans Ermann
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of ZA855492B publication Critical patent/ZA855492B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
    • C07C239/08—Hydroxylamino compounds or their ethers or esters
    • C07C239/20—Hydroxylamino compounds or their ethers or esters having oxygen atoms of hydroxylamino groups etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Accommodation For Nursing Or Treatment Tables (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cephalosporin Compounds (AREA)
ZA855492A 1984-08-03 1985-07-19 Novel n-hydroxyl protecting groups and process for the preparation of 3-acylamino-1-hydroxy-2-azetidinones ZA855492B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/637,260 US4581170A (en) 1984-08-03 1984-08-03 N-hydroxyl protecting groups and process and intermediates for the preparation of 3-acylamino-1-hydroxy-2-azetidinones

Publications (1)

Publication Number Publication Date
ZA855492B true ZA855492B (en) 1986-03-26

Family

ID=24555200

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA855492A ZA855492B (en) 1984-08-03 1985-07-19 Novel n-hydroxyl protecting groups and process for the preparation of 3-acylamino-1-hydroxy-2-azetidinones

Country Status (12)

Country Link
US (1) US4581170A (fr)
EP (2) EP0371004A1 (fr)
JP (2) JPH06732B2 (fr)
AT (1) ATE58896T1 (fr)
AU (2) AU589567B2 (fr)
CA (1) CA1268780C (fr)
DE (1) DE3580803D1 (fr)
DK (1) DK353385A (fr)
FI (1) FI852974L (fr)
IE (2) IE58758B1 (fr)
NZ (1) NZ212750A (fr)
ZA (1) ZA855492B (fr)

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EP0233607B1 (fr) * 1986-02-18 1991-03-13 E.R. Squibb & Sons, Inc. [(2,2,2-Trichloroéthoxy)méthoxy]amine
US5037974A (en) * 1988-05-23 1991-08-06 Merck & Co., Inc. Cyclization process for synthesis of a beta-lactam carbapenem intermediate
US5631365A (en) 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
US6068993A (en) * 1997-07-02 2000-05-30 Biobras Sa Vector for expression of heterologous protein and methods for extracting recombinant protein and for purifying isolated recombinant insulin
US6982251B2 (en) * 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
US20060287254A1 (en) * 2001-01-26 2006-12-21 Schering Corporation Use of substituted azetidinone compounds for the treatment of sitosterolemia
PT1355644E (pt) * 2001-01-26 2006-11-30 Schering Corp Utilização de compostos azetidinona substituídos para o tratamento de sitosterolemia
CA2434033A1 (fr) * 2001-01-26 2002-08-01 Schering Corporation Combinaisons de chelateur(s) des acides biliaires et d'inhibiteur(s) d'absorption des sterols, et traitements pour troubles vasculaires
ES2274013T3 (es) * 2001-01-26 2007-05-16 Schering Corporation Combinaciones de activador(es) del receptor activado por el proliferador de los peroxisomas (ppar) e inhibidor(es)m de la absorcion de estelores y tratamientos para trastornos vasculares.
JP2004517916A (ja) * 2001-01-26 2004-06-17 シェーリング　コーポレイション ニコチン酸およびその誘導体ならびにステロール吸収阻害剤の併用、および血管適応症の治療
DE60220269T2 (de) * 2001-01-26 2008-01-17 Schering Corp. Kombinationen eines hemmers der sterolabsorption und eines kardiovaskulären wirkstoffes zur behandlung von kardiovaskulären indikationen
AR032403A1 (es) * 2001-01-26 2003-11-05 Schering Corp Combinaciones de inhibidor(es) de la absorcion de esterol con modificador(es) sanguineos para tratar cuadros vasculares
US7071181B2 (en) * 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
AU2002308778A1 (en) * 2001-05-25 2002-12-09 Schering Corporation Use of azetidinone substituted derivatives in the treatment of alzheimer's disease
CN101785772A (zh) * 2001-09-21 2010-07-28 先灵公司 使用甾醇吸收抑制剂治疗或预防脉管炎的方法
US7053080B2 (en) * 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
US7056906B2 (en) * 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
JP2005504091A (ja) * 2001-09-21 2005-02-10 シェーリング　コーポレイション ステロール吸収阻害剤としてアゼチジノンを用いる黄色腫の処置
US20030119808A1 (en) * 2001-09-21 2003-06-26 Schering Corporation Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects
US7560449B2 (en) * 2002-11-06 2009-07-14 Schering Corporation Methods and therapeutic combinations for the treatment of demyelination
ES2311806T3 (es) * 2003-03-07 2009-02-16 Schering Corporation Compuesto de azetidinona sustituidos, fornulaciones y usos de los mismos para el tratamiento de hipercolesterolemia.
US7459442B2 (en) * 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
EP1606287B1 (fr) * 2003-03-07 2013-10-02 Merck Sharp & Dohme Corp. Composés d'azetidinone substitués, formulations et utilisations de ceux-ci pour traiter l'hypercholestérolémie
WO2004081003A1 (fr) * 2003-03-07 2004-09-23 Schering Corporation Composes d'azetidinone substitues, leurs formulations et leur utilisation pour traiter l'hypercholesterolemie
JP2007510659A (ja) * 2003-11-05 2007-04-26 シェーリング　コーポレイション 脂質調節剤および置換アゼチジノンの組み合わせならびに血管状態の処置
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US9427189B2 (en) 2013-03-04 2016-08-30 Hello Inc. Monitoring system and device with sensors that are responsive to skin pigmentation
US9445651B2 (en) 2013-03-04 2016-09-20 Hello Inc. Wearable device with overlapping ends coupled by magnets
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US9367793B2 (en) 2013-03-04 2016-06-14 Hello Inc. Wearable device with magnets distanced from exterior surfaces of the wearable device
US9149189B2 (en) 2013-03-04 2015-10-06 Hello, Inc. User or patient monitoring methods using one or more analysis tools
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US9425627B2 (en) 2013-03-04 2016-08-23 Hello Inc. Telemetry system with remote firmware updates
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US9420857B2 (en) 2013-03-04 2016-08-23 Hello Inc. Wearable device with interior frame
US9427160B2 (en) 2013-03-04 2016-08-30 Hello Inc. Wearable device with overlapping ends coupled by magnets positioned in the wearable device by an undercut
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Also Published As

Publication number Publication date
JPH06732B2 (ja) 1994-01-05
CA1268780C (fr) 1990-05-08
AU589567B2 (en) 1989-10-19
FI852974A0 (fi) 1985-08-01
IE851917L (en) 1986-02-03
JPH069528A (ja) 1994-01-18
DK353385A (da) 1986-02-04
AU614663B2 (en) 1991-09-05
EP0170280A1 (fr) 1986-02-05
US4581170A (en) 1986-04-08
AU4083589A (en) 1990-02-08
IE58771B1 (en) 1993-11-03
JPH0662532B2 (ja) 1994-08-17
FI852974A7 (fi) 1986-02-04
JPS6147445A (ja) 1986-03-07
AU4535685A (en) 1986-02-06
FI852974L (fi) 1986-02-04
DK353385D0 (da) 1985-08-02
DE3580803D1 (de) 1991-01-17
NZ212750A (en) 1989-04-26
CA1262357A (fr) 1989-10-17
EP0170280B1 (fr) 1990-12-05
IE58758B1 (en) 1993-11-03
ATE58896T1 (de) 1990-12-15
EP0371004A1 (fr) 1990-05-30

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