ZA857945B - 4-hydroxy-3-quinoline carboxylic acid derivatives substituted at position 2 by an alpha-hydroxylated chain,process for their preparation,their use as medicaments and compositions containing them - Google Patents

4-hydroxy-3-quinoline carboxylic acid derivatives substituted at position 2 by an alpha-hydroxylated chain,process for their preparation,their use as medicaments and compositions containing them

Info

Publication number: ZA857945B
Authority: ZA; South Africa
Prior art keywords: carbon atoms; alkyl; group; hydrogen; hydroxy
Prior art date: 1984-10-30

Application number

ZA857945A

Other languages

English (en)

Inventor

Francois Clemence

Odile Le Martret

Francoise Delevallee

Original Assignee

Roussel Uclaf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-10-30

Filing date

1985-10-16

Publication date

1986-12-30

1985-10-16 Application filed by Roussel Uclaf filed Critical Roussel Uclaf

1986-12-30 Publication of ZA857945B publication Critical patent/ZA857945B/xx

Links

ILNJBIQQAIIMEY-UHFFFAOYSA-N 4-oxo-1h-quinoline-3-carboxylic acid Chemical group C1=CC=CC2=C(O)C(C(=O)O)=CN=C21 ILNJBIQQAIIMEY-UHFFFAOYSA-N 0.000 title abstract 2
239000003814 drug Substances 0.000 title 1
239000000203 mixture Substances 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 13
125000000217 alkyl group Chemical group 0.000 abstract 8
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 4
125000003118 aryl group Chemical group 0.000 abstract 3
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
-1 4,5-dihydrothiazolyl Chemical group 0.000 abstract 2
125000003342 alkenyl group Chemical group 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 1
230000000202 analgesic effect Effects 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000002883 imidazolyl group Chemical group 0.000 abstract 1
125000000842 isoxazolyl group Chemical group 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
230000003287 optical effect Effects 0.000 abstract 1
125000002971 oxazolyl group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000003831 tetrazolyl group Chemical group 0.000 abstract 1
125000000335 thiazolyl group Chemical group 0.000 abstract 1
125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
- C07D265/22—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Pain & Pain Management (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Rheumatology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Quinoline Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Crystals, And After-Treatments Of Crystals (AREA)
Thiazole And Isothizaole Compounds (AREA)

ZA857945A 1984-10-30 1985-10-16 4-hydroxy-3-quinoline carboxylic acid derivatives substituted at position 2 by an alpha-hydroxylated chain,process for their preparation,their use as medicaments and compositions containing them ZA857945B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR8416573A FR2572404B2 (fr)	1984-10-30	1984-10-30	Nouveaux derives de l'acide 4-oh-3-quinoleine carboxylique substitues en 2, leur procede de preparation, leur application comme medicaments et les compositions les renfermant

Publications (1)

Publication Number	Publication Date
ZA857945B true ZA857945B (en)	1986-12-30

Family

ID=9309131

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA857945A ZA857945B (en)	1984-10-30	1985-10-16	4-hydroxy-3-quinoline carboxylic acid derivatives substituted at position 2 by an alpha-hydroxylated chain,process for their preparation,their use as medicaments and compositions containing them

Country Status (14)

Country	Link
US (1)	US4735951A (cs)
EP (1)	EP0183584B1 (cs)
JP (1)	JPH0788379B2 (cs)
KR (1)	KR920008822B1 (cs)
AT (1)	ATE48424T1 (cs)
AU (1)	AU601942B2 (cs)
CA (1)	CA1259072A (cs)
DE (1)	DE3574592D1 (cs)
ES (2)	ES8702360A1 (cs)
FR (1)	FR2572404B2 (cs)
GR (1)	GR852568B (cs)
HU (1)	HU197327B (cs)
PT (1)	PT81391B (cs)
ZA (1)	ZA857945B (cs)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4845105A (en) *	1984-10-30	1989-07-04	Roussel Uclaf	4-OH-quinoline carboxylic acid amides having analgesic and anti-inflammatory activity
JPH02237443A (ja) *	1989-03-07	1990-09-20	Matsushita Electric Ind Co Ltd	コアレスモータの回転子
US5382572A (en) *	1990-09-07	1995-01-17	Schering Corporation	Alkyl and acyl substituted quinolines

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2530633A1 (fr) *	1982-06-03	1984-01-27	Roussel Uclaf	Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur preparation, leur application comme medicament, et les compositions les renfermant
FR2566405B1 (fr) *	1984-06-25	1986-09-26	Roussel Uclaf	Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2 par une fonction aminee, leur preparation, leur application comme medicaments, les compositions les renfermant et les intermediaires nouveaux obtenus

1984
- 1984-10-30 FR FR8416573A patent/FR2572404B2/fr not_active Expired
1985
- 1985-10-16 ZA ZA857945A patent/ZA857945B/xx unknown
- 1985-10-22 US US06/790,064 patent/US4735951A/en not_active Expired - Fee Related
- 1985-10-23 EP EP85402052A patent/EP0183584B1/fr not_active Expired
- 1985-10-23 DE DE8585402052T patent/DE3574592D1/de not_active Expired - Fee Related
- 1985-10-23 AT AT85402052T patent/ATE48424T1/de not_active IP Right Cessation
- 1985-10-24 GR GR852568A patent/GR852568B/el unknown
- 1985-10-28 CA CA000494012A patent/CA1259072A/fr not_active Expired
- 1985-10-29 AU AU49173/85A patent/AU601942B2/en not_active Ceased
- 1985-10-29 HU HU854147A patent/HU197327B/hu not_active IP Right Cessation
- 1985-10-29 PT PT81391A patent/PT81391B/pt not_active IP Right Cessation
- 1985-10-29 JP JP60240735A patent/JPH0788379B2/ja not_active Expired - Lifetime
- 1985-10-29 ES ES548300A patent/ES8702360A1/es not_active Expired
- 1985-10-30 KR KR1019850008025A patent/KR920008822B1/ko not_active Expired
1986
- 1986-06-16 ES ES556096A patent/ES8800162A1/es not_active Expired

Also Published As

Publication number	Publication date
PT81391B (pt)	1988-02-17
FR2572404B2 (fr)	1987-12-11
EP0183584B1 (fr)	1989-12-06
FR2572404A2 (fr)	1986-05-02
CA1259072A (fr)	1989-09-05
ATE48424T1 (de)	1989-12-15
EP0183584A1 (fr)	1986-06-04
PT81391A (fr)	1985-11-01
AU4917385A (en)	1986-05-08
ES556096A0 (es)	1987-11-01
ES548300A0 (es)	1987-01-01
ES8702360A1 (es)	1987-01-01
KR860003250A (ko)	1986-05-21
JPH0788379B2 (ja)	1995-09-27
GR852568B (cs)	1986-02-21
HU197327B (en)	1989-03-28
JPS61109770A (ja)	1986-05-28
HUT40649A (en)	1987-01-28
DE3574592D1 (de)	1990-01-11
US4735951A (en)	1988-04-05
AU601942B2 (en)	1990-09-27
ES8800162A1 (es)	1987-11-01
KR920008822B1 (ko)	1992-10-09

Publication	Publication Date	Title
SE7700804L (sv)	1977-08-12	Sett att framstella nya 3-kinolinkarboxylsyraderivat
ES8103045A1 (es)	1981-02-16	Procedimiento para preparar nuevos derivados del acido 3- quinoleincarboxilico
ZA889023B (en)	1989-08-30	2-(piperazinyl)-2-oxoethylene substituted flavonoid derivatives,processes for preparing them and pharmaceutical compositions containing them
SE8302474L (sv)	1983-12-04	Nya derivat av 4-hydroxi-3-kinolein-karboxylsyraderivat, substituerade i 2-stellning framstellning derav, anvendning derav som lekemedel samt kompositioner innehallande dem samt erhallna mellanprodukter
IL61687A (en)	1984-08-31	(benzothiazole-2-yl-thio)-phenylpropionic acid derivatives,pharmaceutical formulations containing them and a process for their preparation
DE3061561D1 (en)	1983-02-17	Phenyl piperazine derivatives, their preparation and antiagressive medicines containing them
ES447646A1 (es)	1977-06-01	Procedimiento para la preparacion de nuevas tiazolinas.
ATE15370T1 (de)	1985-09-15	3-piperidinyl-indole derivate, ihre salze, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel und diese enthaltende arzneimittel.
AU601942B2 (en)	1990-09-27	New esters derived from 4-hydroxy-3-quinoline carboxylic acid substituted by an alpha-hydroxyl chain at position 2, their preparation, their use as a medicament and the compositions containing them
EP0169755A3 (en)	1986-04-09	4-hydroxy-3-quinoline-carboxylic-acid derivatives substituted at 2 by a nitrogen-containing group, their preparation, their use as medicaments, compositions containing them and intermediates
DE3069173D1 (en)	1984-10-18	Substituted phenylamino-2-imidazoline-2 derivatives, their acid addition salts, medicaments containing them and process for their preparation
GR3002417T3 (en)	1992-12-30	Derivatives of 8-phenylthiotetrahydroquinolines and their salts, their synthesis for use as medicaments and compositions containing them
HU894471D0 (en)	1990-09-28	Process for the preparation of 15-amino-20,21-dinor-eburnamenine derivatives and pharmaceutical compositions containing them
IL70272A (en)	1986-11-30	Acridanone(2-thiazolyl)-hydrazone derivatives,their manufacture and pharmaceutical compositions containing them
FI844131A0 (fi)	1984-10-19	Menetelmä 2-substituoitujen 3-kinoliinikarboksamidien valmistuksessa välituotteina käytettävien 2-asyyliamino- -oksobentseenipropaaniamidien valmistamiseksi