ZA865685B - Substituted phenylipiperazine derivatives - Google Patents

Substituted phenylipiperazine derivatives

Info

Publication number: ZA865685B
Authority: ZA; South Africa
Prior art keywords: phenylpiperazine; formula; alkyl; group; see diagramm
Prior art date: 1985-07-31

Application number

ZA865685A

Other languages

English (en)

Inventor

Louis Lafon

Original Assignee

Lafon Labor

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-07-31

Filing date

1986-07-30

Publication date

1987-03-25

1986-07-30 Application filed by Lafon Labor filed Critical Lafon Labor

1987-03-25 Publication of ZA865685B publication Critical patent/ZA865685B/xx

Links

125000000217 alkyl group Chemical group 0.000 abstract 5
150000001875 compounds Chemical class 0.000 abstract 4
229910052801 chlorine Inorganic materials 0.000 abstract 2
229910052731 fluorine Inorganic materials 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
YZTJYBJCZXZGCT-UHFFFAOYSA-N phenylpiperazine Chemical class C1CNCCN1C1=CC=CC=C1 YZTJYBJCZXZGCT-UHFFFAOYSA-N 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
DLCHHOUUUHBPTB-UHFFFAOYSA-N 1,2,4-trimethyl-3-phenylpiperazine Chemical compound CN1CCN(C)C(C)C1C1=CC=CC=C1 DLCHHOUUUHBPTB-UHFFFAOYSA-N 0.000 abstract 1
ITYRNNPBHAPPDY-UHFFFAOYSA-N 1-ethyl-2-methyl-3-phenylpiperazine Chemical compound CC1N(CC)CCNC1C1=CC=CC=C1 ITYRNNPBHAPPDY-UHFFFAOYSA-N 0.000 abstract 1
WISXSZAVLBTQKR-UHFFFAOYSA-N 2-methyl-3-phenyl-1-propan-2-ylpiperazine Chemical compound CC1N(C(C)C)CCNC1C1=CC=CC=C1 WISXSZAVLBTQKR-UHFFFAOYSA-N 0.000 abstract 1
FGMBXZFXOUIKOT-UHFFFAOYSA-N 2-methyl-3-phenylpiperazine Chemical compound CC1NCCNC1C1=CC=CC=C1 FGMBXZFXOUIKOT-UHFFFAOYSA-N 0.000 abstract 1
REMUSKKHPCZIGD-UHFFFAOYSA-N 2-phenyl-1,2-dihydropyrazine Chemical compound N1C=CN=CC1C1=CC=CC=C1 REMUSKKHPCZIGD-UHFFFAOYSA-N 0.000 abstract 1
RIMRLBGNCLMSNH-UHFFFAOYSA-N 2-phenylpiperazine Chemical compound C1NCCNC1C1=CC=CC=C1 RIMRLBGNCLMSNH-UHFFFAOYSA-N 0.000 abstract 1
GFQHZHMRYXWCBK-UHFFFAOYSA-N 3-phenyl-1-propan-2-ylpiperazine Chemical compound C1N(C(C)C)CCNC1C1=CC=CC=C1 GFQHZHMRYXWCBK-UHFFFAOYSA-N 0.000 abstract 1
PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 abstract 1
229910010084 LiAlH4 Inorganic materials 0.000 abstract 1
238000005804 alkylation reaction Methods 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
239000003638 chemical reducing agent Substances 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
239000012280 lithium aluminium hydride Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000004193 piperazinyl group Chemical group 0.000 abstract 1
238000006722 reduction reaction Methods 0.000 abstract 1
239000012279 sodium borohydride Substances 0.000 abstract 1
229910000033 sodium borohydride Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Neurosurgery (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Luminescent Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

ZA865685A 1985-07-31 1986-07-30 Substituted phenylipiperazine derivatives ZA865685B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR8511684A FR2585702B1 (fr)	1985-07-31	1985-07-31	Derives de phenyl-piperazine, procede de preparation et utilisation en therapeutique

Publications (1)

Publication Number	Publication Date
ZA865685B true ZA865685B (en)	1987-03-25

Family

ID=9321805

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA865685A ZA865685B (en)	1985-07-31	1986-07-30	Substituted phenylipiperazine derivatives

Country Status (13)

Country	Link
US (1)	US4912110A (da)
EP (1)	EP0211746B1 (da)
JP (1)	JPH0730047B2 (da)
AT (1)	ATE53026T1 (da)
AU (1)	AU580179B2 (da)
CA (1)	CA1263392A (da)
DE (1)	DE3671445D1 (da)
DK (1)	DK165876C (da)
FR (1)	FR2585702B1 (da)
GR (1)	GR862010B (da)
IE (1)	IE59320B1 (da)
PT (1)	PT83109B (da)
ZA (1)	ZA865685B (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2699533A1 (fr) *	1992-12-21	1994-06-24	Mouhtaram Mohamed	Dérivés de N-((1,4-dialkyl-6-arylpipérazine-2-yl)méthyl)benzamides. (Isomères cis et trans) Propriétés pharmacologiques et applications.
SK14802001A3 (sk) *	1999-04-19	2002-07-02	Teva Pharmaceutical Industries Ltd.	Syntéza piperazínového kruhu
ES2190305B1 (es) *	2000-05-24	2004-07-01	Medichem S.A.	Compuestos intermedios para la preparacion de mirtazapina y sus procedimientos de obtencion.
IN190478B (da)	2000-11-07	2003-08-02	Sun Pharmaceutical Ind Ltd
ATE392410T1 (de) *	2001-09-14	2008-05-15	Medichem Sa	Zwischenprodukte für die herstellung von mirtazapin und verfahren zu deren herstellung

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA919590A (en) *	1967-05-24	1973-01-23	Neher Robert	Process for the manufacture of thyrocalcitonin
GB1181322A (en) *	1967-06-29	1970-02-11	Chugai Pharmaceutical Co Ltd	Piperazine Derivatives and processes for preparing the same
JPS52139085A (en) *	1976-05-13	1977-11-19	Hokuriku Pharmaceutical	22allylpiperazine derivative and method for its preparation
DE3420782A1 (de) *	1984-06-04	1985-12-05	Bayer Ag, 5090 Leverkusen	Verfahren zur herstellung von 2-cyclohexylpiperazinen

1985
- 1985-07-31 FR FR8511684A patent/FR2585702B1/fr not_active Expired
1986
- 1986-07-23 DE DE8686401644T patent/DE3671445D1/de not_active Expired - Lifetime
- 1986-07-23 EP EP86401644A patent/EP0211746B1/fr not_active Expired - Lifetime
- 1986-07-23 AT AT86401644T patent/ATE53026T1/de not_active IP Right Cessation
- 1986-07-29 GR GR862010A patent/GR862010B/el unknown
- 1986-07-29 DK DK360286A patent/DK165876C/da active
- 1986-07-30 ZA ZA865685A patent/ZA865685B/xx unknown
- 1986-07-30 AU AU60691/86A patent/AU580179B2/en not_active Ceased
- 1986-07-30 PT PT83109A patent/PT83109B/pt not_active IP Right Cessation
- 1986-07-30 IE IE203286A patent/IE59320B1/en not_active IP Right Cessation
- 1986-07-31 CA CA000515056A patent/CA1263392A/fr not_active Expired
- 1986-07-31 JP JP61181806A patent/JPH0730047B2/ja not_active Expired - Lifetime
1988
- 1988-12-13 US US07/283,736 patent/US4912110A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DK165876C (da)	1993-06-21
PT83109B (pt)	1989-02-28
JPS6229576A (ja)	1987-02-07
EP0211746B1 (fr)	1990-05-23
DK360286D0 (da)	1986-07-29
IE862032L (en)	1987-01-31
AU580179B2 (en)	1989-01-05
CA1263392A (fr)	1989-11-28
PT83109A (fr)	1986-08-01
GR862010B (en)	1986-12-23
US4912110A (en)	1990-03-27
ATE53026T1 (de)	1990-06-15
FR2585702A1 (fr)	1987-02-06
JPH0730047B2 (ja)	1995-04-05
EP0211746A1 (fr)	1987-02-25
IE59320B1 (en)	1994-02-09
DE3671445D1 (de)	1990-06-28
AU6069186A (en)	1987-02-05
DK360286A (da)	1987-02-01
FR2585702B1 (fr)	1989-03-03
DK165876B (da)	1993-02-01

Publication	Publication Date	Title
DK135891D0 (da)	1991-07-16	1h-imidazooe4,5-caaquinolin-4-chlorforbindelse
DK253583A (da)	1983-12-05	Fremgangsmaade til fremstilling af benzhydrylsulfinylacetamidderivater
SE8404712D0 (sv)	1984-09-20	Azole derivatives, process for their production compositions containing them and their use
YU42355B (en)	1988-08-31	Process for preparing diphenylethers
ATE19066T1 (de)	1986-04-15	1,3-dihydro 4-(1-hydroxy-2-aminoethyl)2-h-indol-2-on-deriva e, ihre saelze, verfahren zu ihrer herstellung, verwendung als heilmittel und zusammenstellungen die sie enthalten.
AU580179B2 (en)	1989-01-05	Substituted phenylpiperazine derivatives
ATE75737T1 (de)	1992-05-15	Indenothiazolderivate und verfahren zu ihrer herstellung.
KR840001555A (ko)	1984-05-07	치환된 2-페닐-2-(피리딜욕시)-에틸아민과 그의 등 배전자화합물 및 그들의 산부가염을 제조하는 방법
ES451934A1 (es)	1977-11-01	Procedimiento para la preparacion de n-derivados de anilinasde actividad microbicida.
GB1507414A (en)	1978-04-12	Hydantoin derivatives
ATE30718T1 (de)	1987-11-15	Herstellung von 1-benzyl azetidin-3-ol und von dem entsprechenden halid acid.
GB1061946A (en)	1967-03-15	Novel dibenzocycloheptene derivatives and a process for the manufacture thereof
ES423746A1 (es)	1976-05-01	Procedimiento para preparar derivados de 2-aminoindano.
DE68926016D1 (de)	1996-04-25	Halogeno-4-Methylpyrazole und Verfahren zu ihrer Herstellung
ES423745A1 (es)	1976-04-16	Procedimiento para preparar derivados de 2-aminoindano.
FR2448544B1 (da)	1982-11-12
DE3268984D1 (en)	1986-03-20	Imidazolylcarboxylic acids, their derivatives and production
GB1436970A (en)	1976-05-26	2-aminoindane derivatives
ES8403869A1 (es)	1984-04-01	Procedimiento para preparar derivados de aminometil-1h-indol-4-metanol.
ES272000A1 (es)	1962-06-16	Procedimiento para la preparación de nuevos derivados de cumarina
ES486629A1 (es)	1980-07-01	Procedimiento para la obtencion de derivados tiadiazolicos
ES421929A1 (es)	1976-05-01	Procedimiento para la preparacion de sulfonanilidas susti- tuidas.
ES349158A1 (es)	1969-04-01	Procedimiento para la preparacion de nuevas 4 - arilsulfo- nilsemicarbacidas 1 - sustituidas.
ES289533A1 (es)	1964-03-01	Procedimiento de preparaciën de nuevos compuestos biciclicos