ZA865917B - 2-substituted-1,4-dihydropyridines,method for their preparation and pharmaceutical compositions containing them - Google Patents

2-substituted-1,4-dihydropyridines,method for their preparation and pharmaceutical compositions containing them

Info

Publication number
ZA865917B
ZA865917B ZA865917A ZA865917A ZA865917B ZA 865917 B ZA865917 B ZA 865917B ZA 865917 A ZA865917 A ZA 865917A ZA 865917 A ZA865917 A ZA 865917A ZA 865917 B ZA865917 B ZA 865917B
Authority
ZA
South Africa
Prior art keywords
substituted
dihydropyridines
preparation
pharmaceutical compositions
group
Prior art date
Application number
ZA865917A
Other languages
English (en)
Inventor
Carmelo A Gandolfi
Marco Frigerio
Silvano Spinelli
Ernesto Menta
Odoardo Tofanetti
Sergio Tognella
Original Assignee
Boehringer Biochemia Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Biochemia Srl filed Critical Boehringer Biochemia Srl
Publication of ZA865917B publication Critical patent/ZA865917B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Liquid Crystal Substances (AREA)
ZA865917A 1985-08-19 1986-08-06 2-substituted-1,4-dihydropyridines,method for their preparation and pharmaceutical compositions containing them ZA865917B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT21944/85A IT1201454B (it) 1985-08-19 1985-08-19 1,4-diidropiridine-2-sostituite

Publications (1)

Publication Number Publication Date
ZA865917B true ZA865917B (en) 1987-04-29

Family

ID=11189184

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA865917A ZA865917B (en) 1985-08-19 1986-08-06 2-substituted-1,4-dihydropyridines,method for their preparation and pharmaceutical compositions containing them

Country Status (7)

Country Link
US (1) US4845113A (de)
EP (1) EP0215250B1 (de)
JP (1) JPS6270359A (de)
AT (1) ATE84027T1 (de)
DE (1) DE3687385D1 (de)
IT (1) IT1201454B (de)
ZA (1) ZA865917B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1204948B (it) * 1987-03-13 1989-03-10 Boheringer Biochemia Robin S P 2-tiometil-sostituite-piridine, metodo per la loro preparazione e composizioni farmaceutiche che le contengono.
IT1222591B (it) * 1987-09-04 1990-09-05 Boehringer Biochemia Srl 1,4-diidropiridine 2-alchil- ed alchenil-sostituite,metodo per la loro preparazione e composizione farmaceutiche che le contengono
DE68924456T2 (de) * 1988-08-02 1996-05-30 Nissan Chemical Ind Ltd Mittel zur Verbesserung von Arzneimitteleffekten für Antitumormittel.
IL92646A0 (en) * 1988-12-15 1990-08-31 Erba Carlo Spa Imidazolyl and pyridyl derivatives of phenyl substituted 1,4-dihydropyridines,their preparation and pharmaceutical compositions containing them
US5514693A (en) * 1988-12-15 1996-05-07 Farmitalia Carlo Erba S.R.L. Imidazolyl and pyridyl derivatives of phenyl substituted 1,4-dihydropyridines and process for their preparation
GB9119983D0 (en) * 1991-09-19 1991-11-06 Erba Carlo Spa Dihydropyridine derivatives useful in antitumor therapy
US6887870B1 (en) * 1999-10-12 2005-05-03 Bristol-Myers Squibb Company Heterocyclic sodium/proton exchange inhibitors and method
SI1309555T1 (sl) * 2000-12-29 2005-12-31 Pfizer Ltd Postopek izdelave amlodipin-maleata
CN105622493B (zh) * 2016-03-22 2020-10-16 江西师范大学 一种烯胺酮和醛串联反应合成全取代吡啶类化合物的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4307103A (en) * 1978-09-08 1981-12-22 Fujisawa Pharmaceutical Co., Ltd. Dihydropyridine derivative, processes for preparation thereof and pharmaceutical composition comprising the same
DE2949464A1 (de) * 1978-12-18 1980-06-26 Sandoz Ag Benzoxadiazole und benzothiadiazole, ihre herstellung und verwendung
NZ201395A (en) * 1981-07-30 1987-02-20 Bayer Ag Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines
DE3207982A1 (de) * 1982-03-05 1983-09-08 Bayer Ag, 5090 Leverkusen Neue 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihrer verwendung in arzneimitteln
GB8306666D0 (en) * 1983-03-10 1983-04-13 Pfizer Ltd Therapeutic agents
US4690935A (en) * 1983-03-31 1987-09-01 Wayne State University Inhibition of tumor growth and metastasis with calcium channel blocker compounds
US4568677A (en) * 1983-07-23 1986-02-04 Pfizer Inc. 2-(4-Pyrimidone alkoxyalkyl) dihydropyridine anti-ischaemic and antihypertensive agents
DE3327650A1 (de) * 1983-07-30 1985-02-14 Gödecke AG, 1000 Berlin 1,6-naphthyridinon-derivate, verfahren zu deren herstellung und deren verwendung bei der bekaempfung von gefaesserkrankungen
JPS60120861A (ja) * 1983-12-02 1985-06-28 Otsuka Pharmaceut Co Ltd ジヒドロピリジン誘導体

Also Published As

Publication number Publication date
IT1201454B (it) 1989-02-02
DE3687385D1 (de) 1993-02-11
JPS6270359A (ja) 1987-03-31
IT8521944A0 (it) 1985-08-19
ATE84027T1 (de) 1993-01-15
EP0215250A1 (de) 1987-03-25
EP0215250B1 (de) 1992-12-30
US4845113A (en) 1989-07-04

Similar Documents

Publication Publication Date Title
ES8800150A1 (es) Un procedimiento para la preparacion de derivados de indol
ZA852251B (en) Carbapenem derivatives and compositions containing them
MY102082A (en) Dihydropyridine derivatives, their production and use
LU90026I2 (fr) Topotecan et ses sels et dérivés pharmaceutiquement acceptables (Hycamtin R)
IE883391L (en) Novel compounds
HUT36113A (en) Process for preparing dihydro-pyridibes with anti-ischaemic activity and blood pressure decreasing effect and pharmaceutical compositions containing such compounds
ATE84027T1 (de) 2-substituierte-1,4-dihydropyridine, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
IL70341A0 (en) Pyrimidone derivatives,processes for their preparation,pharmaceutical compositions containing them and their use as histamine antagonists
ES8801637A1 (es) Un procedimiento para la preparacion de benzimidazoles.
EP0282904A3 (en) 2-thiomethyl-substituted-pyridines, a method for their preparation and pharmaceutical compositions containing them
AP2000002001A0 (en) Hydroxamic acid derivatives as inhibitors of the production of human CD23 and of the tnf relaease.
IL115085A0 (en) Bicyclic carboxamide derivatives their preparation and pharmaceutical compositions containing them
GR3002560T3 (en) 2-selenomethyl-1, 4-dihydropyridines, a process for the preparation thereof and pharmaceutical compositions containing them
IL81052A0 (en) 6h-isoxazolo(3,4-d)pyrazolo(3,4-b)pyridines,a process for their preparation and pharmaceutical compositions containing them
IL116382A0 (en) Trisubstituted t hoxanthines and pharmaceutical compositions containing the same
ES8801794A1 (es) Un procedimiento para la obtencion de 5-aril-1.4-dihidroporidinas
HUT34943A (en) Process for the production of new 1,1-diphenyl-propanol-derivatives, as well as of therapeutic preparations containing them
ES8103747A1 (es) Procedimiento para la preparacion de 5,6,7,8-tetrahidropira-zolo (3,4-b)(1,5)diazepin-1h,4h-5,7-dionas