ZA8665B - Dopamine-beta-hydroxylase inhibitors - Google Patents

Dopamine-beta-hydroxylase inhibitors

Info

Publication number: ZA8665B
Authority: ZA; South Africa
Prior art keywords: dopamine; beta; alkyl; hydroxylase inhibitors; hydrogen
Prior art date: 1985-01-08

Application number

ZA8665A

Other languages

English (en)

Inventor

Carl Kaiser

Lawrence Ivan Kruse

Original Assignee

Smithkline Beckman Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-01-08

Filing date

1986-01-06

Publication date

1986-08-27

1986-01-06 Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp

1986-08-27 Publication of ZA8665B publication Critical patent/ZA8665B/xx

Links

108010015720 Dopamine beta-Hydroxylase Proteins 0.000 title 1
102100033156 Dopamine beta-hydroxylase Human genes 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
229910006074 SO2NH2 Inorganic materials 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
239000002220 antihypertensive agent Substances 0.000 abstract 1
229940030600 antihypertensive agent Drugs 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000003709 fluoroalkyl group Chemical group 0.000 abstract 1
125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000000565 sulfonamide group Chemical group 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/10—Radicals substituted by halogen atoms or nitro radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/14—Radicals substituted by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Diabetes (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Enzymes And Modification Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

ZA8665A 1985-01-08 1986-01-06 Dopamine-beta-hydroxylase inhibitors ZA8665B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/689,680 US4728741A (en)	1985-01-08	1985-01-08	1-substituted-2-mercapto benzimidazole compounds and intermediates

Publications (1)

Publication Number	Publication Date
ZA8665B true ZA8665B (en)	1986-08-27

Family

ID=24769487

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA8665A ZA8665B (en)	1985-01-08	1986-01-06	Dopamine-beta-hydroxylase inhibitors

Country Status (12)

Country	Link
US (1)	US4728741A (da)
EP (1)	EP0190817B1 (da)
JP (1)	JPS61161267A (da)
AT (1)	ATE56207T1 (da)
AU (2)	AU588562B2 (da)
CA (1)	CA1269668A (da)
DE (1)	DE3673835D1 (da)
DK (1)	DK2886A (da)
ES (1)	ES8703844A1 (da)
GR (1)	GR860018B (da)
PT (1)	PT81786B (da)
ZA (1)	ZA8665B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS61151176A (ja) *	1984-12-24	1986-07-09	Sumitomo Chem Co Ltd	ベンズイミダゾール誘導体およびそれを有効成分とする殺虫、殺ダニ剤
JPS63101380A (ja) *	1986-10-17	1988-05-06	Zeria Shinyaku Kogyo Kk	新規な２−メルカプトベンズイミダゾ−ル誘導体、それらの製造法およびそれらを有効成分として含有する抗潰瘍剤
IT1226100B (it) *	1988-07-07	1990-12-10	Dompe Farmaceutici Spa	Derivati benzimidazolici farmacologicamente attivi.
GB8904174D0 (en) *	1989-02-23	1989-04-05	British Bio Technology	Compounds
EP0515535A4 (en) *	1990-02-13	1996-01-17	Merck & Co Inc	Angiotensin ii antagonists incorporating a substituted benzyl element
US5106863A (en) *	1990-03-26	1992-04-21	Ortho Pharmaceutical Corporation	Substituted imidazole and pyridine derivatives
EP0474109A1 (de) *	1990-09-03	1992-03-11	Richter Gedeon Vegyeszeti Gyar R.T.	Neue 5-Benzyl-substituierte Benzimidazolin-2-Thion-Derivate und Verfahren zu ihrer Herstellung
GB9101448D0 (en) *	1991-01-23	1991-03-06	Cox John H	Improved door assembly
TW300219B (da) *	1991-09-14	1997-03-11	Hoechst Ag
US6114532A (en) *	1998-02-03	2000-09-05	Boehringer Ingelheim Pharma Kg	Bicyclic heterocycles, the preparation thereof, and their use as pharmaceuticals
US20060148805A1 (en) *	2003-07-01	2006-07-06	Meng Hsin Chen	Opthalmic compositions for treating ocular hypertension
DE102007037579B4 (de) *	2007-08-09	2012-05-16	Emc Microcollections Gmbh	Neue Benzimidazol-2-yl-alkylamine und ihre Anwendung als mikrobizide Wirkstoffe
JOP20190050A1 (ar) *	2016-09-23	2019-03-20	Bial Portela & C? S A	مثبطات دوبامين-b-هيدروكسيلاز تخترق حاجز المخ الدموي

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL302847A (da) *	1963-01-10
DE1542886A1 (de) *	1966-10-04	1970-05-14	Bayer Ag	Fungizide Mittel
BE732508A (da) *	1968-05-08	1969-10-16
DE2235093C2 (de) *	1972-07-18	1974-07-04	Bayer Ag, 5090 Leverkusen	Korrosionsschutzmittel
FR2521141A1 (fr) *	1982-02-09	1983-08-12	Rhone Poulenc Agrochimie	Nouveaux derives du cyano-2 benzimidazole, leur preparation et leur utilisation comme fongicides
US4492708A (en) *	1982-09-27	1985-01-08	Eli Lilly And Company	Antiviral benzimidazoles
GB8307865D0 (en) *	1983-03-22	1983-04-27	Fujisawa Pharmaceutical Co	Benzimidazole derivatives
EP0269230A1 (en) *	1986-10-09	1988-06-01	The Wellcome Foundation Limited	Heterocyclic compounds

1985
- 1985-01-08 US US06/689,680 patent/US4728741A/en not_active Expired - Fee Related
1986
- 1986-01-02 AU AU51801/86A patent/AU588562B2/en not_active Ceased
- 1986-01-03 PT PT81786A patent/PT81786B/pt not_active IP Right Cessation
- 1986-01-03 DK DK2886A patent/DK2886A/da not_active Application Discontinuation
- 1986-01-06 ZA ZA8665A patent/ZA8665B/xx unknown
- 1986-01-06 CA CA000499050A patent/CA1269668A/en not_active Expired - Lifetime
- 1986-01-07 EP EP86300056A patent/EP0190817B1/en not_active Expired - Lifetime
- 1986-01-07 DE DE8686300056T patent/DE3673835D1/de not_active Expired - Fee Related
- 1986-01-07 ES ES550699A patent/ES8703844A1/es not_active Expired
- 1986-01-07 AT AT86300056T patent/ATE56207T1/de not_active IP Right Cessation
- 1986-01-07 JP JP61001957A patent/JPS61161267A/ja active Pending
- 1986-01-07 GR GR860018A patent/GR860018B/el unknown
1989
- 1989-07-05 AU AU37887/89A patent/AU3788789A/en not_active Abandoned

Also Published As

Publication number	Publication date
US4728741A (en)	1988-03-01
DK2886A (da)	1986-07-09
ES8703844A1 (es)	1987-03-01
AU3788789A (en)	1989-10-19
CA1269668A (en)	1990-05-29
AU588562B2 (en)	1989-09-21
DE3673835D1 (de)	1990-10-11
ATE56207T1 (de)	1990-09-15
PT81786B (pt)	1988-05-27
ES550699A0 (es)	1987-03-01
GR860018B (en)	1986-04-29
JPS61161267A (ja)	1986-07-21
EP0190817B1 (en)	1990-09-05
DK2886D0 (da)	1986-01-03
EP0190817A1 (en)	1986-08-13
AU5180186A (en)	1986-07-17
PT81786A (en)	1986-02-01

Publication	Publication Date	Title
PL262105A1 (en)	1988-08-18	The method of manufacture of new derivatives of benzimidazole
IL74631A0 (en)	1985-06-30	3-substituted 2-oxindole-1-carboxamides and pharmaceutical compositions containing them
ZA8665B (en)	1986-08-27	Dopamine-beta-hydroxylase inhibitors
CO4290432A1 (es)	1996-04-17	Nuevos derivados de pirazinacarboxamida, su preparacion y su utilizacion en medicamentos.
MX9204637A (es)	1993-02-01	Nuevos derivados de pirazina y procedimiento para su preparacion.
SE8404065D0 (sv)	1984-08-10	Novel biologically active compounds
GB8511890D0 (en)	1985-06-19	Benzene derivatives
NO168428C (no)	1992-02-19	Analogifremgangsmaate ved fremstilling av et terapeutisk aktivt pyrrolidonderivat
ES8706651A1 (es)	1987-07-01	Un procedimiento para preparar derivados de tetrazol.
GB2152508A (en)	1985-08-07	Pyrimidine derivatives
ATE24716T1 (de)	1987-01-15	Lenkotrien-antagonisten.
FI885662A7 (fi)	1990-06-08	Ruokasuolan haittojen vähentämisaine
MX9303392A (es)	1994-06-30	Derivados de imidazo benzoxazin-1-ona substituidos y proceso para su preparacion.
IT8647762A0 (it)	1986-03-13	Miscele di composti formazilici,loro preparazione e loro impiego come coloranti reattivi
TH2892A (th)	1985-11-01	อนุพันธ์ต่างๆ ของออกซิซาลิซิลอะมิโด
DE3576687D1 (de)	1990-04-26	Chinatsalze der antimalarischen verbindung mefloquin.
ATE90942T1 (de)	1993-07-15	(3-diethylaminopropyl)-1-amino-5methyldipyrido(4,3-b>(3,4-f>indoltrihydrochlori .
IT8519620A0 (it)	1985-02-22	Procedimento per la preparazione di amidinouree e composizioni farmaceutiche che le contengono