ZA868122B - 5-naphthyl-2,4-dialkyl-3h-1,2,4-triazole-3-thiones and their use as antidepressants - Google Patents

5-naphthyl-2,4-dialkyl-3h-1,2,4-triazole-3-thiones and their use as antidepressants

Info

Publication number
ZA868122B
ZA868122B ZA868122A ZA868122A ZA868122B ZA 868122 B ZA868122 B ZA 868122B ZA 868122 A ZA868122 A ZA 868122A ZA 868122 A ZA868122 A ZA 868122A ZA 868122 B ZA868122 B ZA 868122B
Authority
ZA
South Africa
Prior art keywords
thiones
antidepressants
triazole
dialkyl
naphthyl
Prior art date
Application number
ZA868122A
Other languages
English (en)
Inventor
John M Kane
Francis P Miller
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of ZA868122B publication Critical patent/ZA868122B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA868122A 1985-10-29 1986-10-24 5-naphthyl-2,4-dialkyl-3h-1,2,4-triazole-3-thiones and their use as antidepressants ZA868122B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US79235885A 1985-10-29 1985-10-29

Publications (1)

Publication Number Publication Date
ZA868122B true ZA868122B (en) 1987-06-24

Family

ID=25156627

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA868122A ZA868122B (en) 1985-10-29 1986-10-24 5-naphthyl-2,4-dialkyl-3h-1,2,4-triazole-3-thiones and their use as antidepressants

Country Status (18)

Country Link
US (1) US4775689A (da)
EP (1) EP0220704A1 (da)
JP (1) JPH0759569B2 (da)
KR (1) KR900003878B1 (da)
CN (1) CN1014519B (da)
AR (1) AR243169A1 (da)
AU (1) AU587645B2 (da)
CA (1) CA1285952C (da)
DK (1) DK514686A (da)
FI (1) FI87775C (da)
HU (1) HU196190B (da)
IE (1) IE59207B1 (da)
IL (1) IL80436A (da)
NO (1) NO164539C (da)
NZ (1) NZ218084A (da)
PH (1) PH22548A (da)
PT (1) PT83635B (da)
ZA (1) ZA868122B (da)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR243171A1 (es) * 1985-10-29 1993-07-30 Merrell Pharma Inc Procedimiento para preparar 5-aril-2,4-dialquil-3h-1,2,4-triazol-3-tionas.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1545646B1 (de) * 1965-12-15 1969-09-18 Boehringer Sohn Ingelheim 1,3-Dimethyl-4-(2',4'-dichlorphenyl)-1,2,4-triazolon-(5) und Verfahren zu dessen Herstellung
EP0036711B1 (en) * 1980-03-22 1985-12-04 Fbc Limited Pesticidal heterocyclic compounds, processes for preparing them, compositions containing them, and their use
AR243171A1 (es) * 1985-10-29 1993-07-30 Merrell Pharma Inc Procedimiento para preparar 5-aril-2,4-dialquil-3h-1,2,4-triazol-3-tionas.
DK570987A (da) * 1986-12-01 1988-06-02 Hoffmann La Roche Oxadiazol-, thiadiazol- og triazolforbindelser

Also Published As

Publication number Publication date
HU196190B (en) 1988-10-28
AU587645B2 (en) 1989-08-24
IL80436A (en) 1991-01-31
PT83635B (pt) 1988-10-14
NO164539B (no) 1990-07-09
IE59207B1 (en) 1994-01-26
JPS62106086A (ja) 1987-05-16
NO864305D0 (no) 1986-10-28
HUT45029A (en) 1988-05-30
IL80436A0 (en) 1987-01-30
PH22548A (en) 1988-10-17
CA1285952C (en) 1991-07-09
AR243169A1 (es) 1993-07-30
JPH0759569B2 (ja) 1995-06-28
IE862834L (en) 1987-04-29
US4775689A (en) 1988-10-04
DK514686D0 (da) 1986-10-28
KR870004005A (ko) 1987-05-06
FI87775C (fi) 1993-02-25
CN1014519B (zh) 1991-10-30
AU6438586A (en) 1987-04-30
PT83635A (en) 1986-11-01
FI864376L (fi) 1987-04-30
FI864376A0 (fi) 1986-10-28
NO164539C (no) 1990-10-17
DK514686A (da) 1987-04-30
KR900003878B1 (ko) 1990-06-04
CN86107127A (zh) 1987-07-15
NO864305L (no) 1987-04-30
FI87775B (fi) 1992-11-13
EP0220704A1 (en) 1987-05-06
NZ218084A (en) 1989-05-29

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