ZA871304B - 2-alkoxy-n-(1-azabicyclo(2.2.2.)oct-3-yl)benzamides and thiobenzamides for alleviating emesis caused by non-platinum anticancer drugs - Google Patents

2-alkoxy-n-(1-azabicyclo(2.2.2.)oct-3-yl)benzamides and thiobenzamides for alleviating emesis caused by non-platinum anticancer drugs

Info

Publication number
ZA871304B
ZA871304B ZA871304A ZA871304A ZA871304B ZA 871304 B ZA871304 B ZA 871304B ZA 871304 A ZA871304 A ZA 871304A ZA 871304 A ZA871304 A ZA 871304A ZA 871304 B ZA871304 B ZA 871304B
Authority
ZA
South Africa
Prior art keywords
thiobenzamides
benzamides
azabicyclo
oct
alkoxy
Prior art date
Application number
ZA871304A
Other languages
English (en)
Inventor
Reevis Stancil Alphin
Stancil Alphin Reevis
William Levi Smith
Levi Smith William
Harry Randall Munson Jr
Randall Munson Harry Jr
Robert Frederick Boswell
Frederick Boswell Robert
Original Assignee
Robins Co Inc A H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robins Co Inc A H filed Critical Robins Co Inc A H
Publication of ZA871304B publication Critical patent/ZA871304B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Otolaryngology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA871304A 1986-03-05 1987-02-23 2-alkoxy-n-(1-azabicyclo(2.2.2.)oct-3-yl)benzamides and thiobenzamides for alleviating emesis caused by non-platinum anticancer drugs ZA871304B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/836,518 US4717563A (en) 1986-03-05 1986-03-05 2-alkoxy-N-(1-azabicyclo(2.2.2)oct-3-yl) benzamides and thiobenzamides in a method for alleviating emesis caused by non-platinum anticancer drugs

Publications (1)

Publication Number Publication Date
ZA871304B true ZA871304B (en) 1987-11-25

Family

ID=25272132

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA871304A ZA871304B (en) 1986-03-05 1987-02-23 2-alkoxy-n-(1-azabicyclo(2.2.2.)oct-3-yl)benzamides and thiobenzamides for alleviating emesis caused by non-platinum anticancer drugs

Country Status (11)

Country Link
US (1) US4717563A (da)
EP (1) EP0240180A1 (da)
JP (1) JPH0681723B2 (da)
KR (1) KR870008886A (da)
AU (1) AU592623B2 (da)
CA (1) CA1284953C (da)
DK (1) DK112287A (da)
HU (1) HU197842B (da)
PH (1) PH22678A (da)
PT (1) PT84404B (da)
ZA (1) ZA871304B (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4888353A (en) * 1986-02-28 1989-12-19 Erbamont, Inc. Carboxamides useful as antiemetic or antipsychotic agents
US4820715A (en) * 1984-06-28 1989-04-11 Bristol-Myers Company Anti-emetic quinuclidinyl benzamides
US4772459A (en) * 1986-09-09 1988-09-20 Erbamont, Inc. Method for controlling emesis caused by chemotherapeutic agents and antiemetic agents useful therein
US5246941A (en) 1986-12-17 1993-09-21 Glaxo Group Limited Method for the treatment of depression
GB8718345D0 (en) * 1987-08-03 1987-09-09 Fordonal Sa N-substituted benzamides
US5206246A (en) * 1987-10-16 1993-04-27 A. H. Robins Company, Incorporated Anxiolytic-R-n(1-azabicyclo[2.2.2]oct-3-yl) benzamides and thiobenzamides
CA1304082C (en) * 1987-10-22 1992-06-23 Tetsuya Tahara Benzoxazine compounds and pharmaceutical use thereof
US4863919A (en) * 1988-02-01 1989-09-05 A. H. Robins Company, Incorporated Method of enhancing memory or correcting memory deficiency with arylamido(and arylthiomido)-azabicycloalkanes
US5039528A (en) * 1989-12-11 1991-08-13 Olney John W EAA antagonists as anti-emetic drugs
US5723103A (en) * 1994-12-09 1998-03-03 Vanderbilt University Substituted benzamides and radioligand analogs and methods of use
EP1381603A2 (en) 2000-08-18 2004-01-21 PHARMACIA & UPJOHN COMPANY Quinuclidine-substituedaryl moieties for treatment of disease ( nicotinic acetylcholine receptor ligands )
US6486172B2 (en) 2000-08-18 2002-11-26 Pharmacia & Upjohn Company Quinuclidine-substituted aryl compounds for treatment of disease
PE20021019A1 (es) 2001-04-19 2002-11-13 Upjohn Co Grupos azabiciclicos sustituidos
BR0212123A (pt) * 2001-08-24 2004-07-20 Upjohn Co 7-aza[2.2.1]biciclo-heptanos substituìdos com arila para o tratamento de doenças
JP2005522456A (ja) 2002-02-15 2005-07-28 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー Ｃｎｓ関連障害治療のためのアザビシクロ置換ベンゾイルアミドおよびチオアミド
WO2003072578A1 (en) * 2002-02-20 2003-09-04 Pharmacia & Upjohn Company Azabicyclic compounds with alfa7 nicotinic acetylcholine receptor activity
WO2010042799A2 (en) 2008-10-09 2010-04-15 Howard Hughes Medical Institute Novel chimeric ligand-gated ion channels and methods of use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2548968A1 (de) * 1975-11-03 1977-05-12 Thomae Gmbh Dr K Neue amino-benzoesaeureamide
US4536386B1 (en) * 1981-01-26 1995-03-07 Robins Co Inc A H Method of controlling emesis caused by cisplatin in cancer chemotherapy
FR2531083B1 (fr) * 1982-06-29 1986-11-28 Sandoz Sa Nouveaux derives de la piperidine, leur preparation et leur utilisation comme medicaments
FR2529548A1 (fr) * 1982-07-02 1984-01-06 Delalande Sa Nouveaux derives de l'amino-3 quinuclidine, leur procede et leur application en therapeutique
DE3429830A1 (de) * 1983-08-26 1985-03-07 Sandoz-Patent-GmbH, 7850 Lörrach Automatische carbonsaeure- und sulfonsaeureester oder -amide
US4593034A (en) * 1984-04-06 1986-06-03 A. H. Robins Company, Inc. 2-alkoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamides and thiobenzamides

Also Published As

Publication number Publication date
EP0240180A1 (en) 1987-10-07
JPH0681723B2 (ja) 1994-10-19
PT84404B (pt) 1989-10-04
KR870008886A (ko) 1987-10-21
AU6904687A (en) 1987-09-10
DK112287A (da) 1987-09-06
PH22678A (en) 1988-11-14
HUT43955A (en) 1988-01-28
DK112287D0 (da) 1987-03-04
JPS62228016A (ja) 1987-10-06
HU197842B (en) 1989-06-28
PT84404A (en) 1987-04-01
AU592623B2 (en) 1990-01-18
US4717563A (en) 1988-01-05
CA1284953C (en) 1991-06-18

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