ZA872874B - Novel quinoline derivatives and processes for preparation thereof - Google Patents

Novel quinoline derivatives and processes for preparation thereof

Info

Publication number
ZA872874B
ZA872874B ZA872874A ZA872874A ZA872874B ZA 872874 B ZA872874 B ZA 872874B ZA 872874 A ZA872874 A ZA 872874A ZA 872874 A ZA872874 A ZA 872874A ZA 872874 B ZA872874 B ZA 872874B
Authority
ZA
South Africa
Prior art keywords
processes
preparation
quinoline derivatives
novel quinoline
novel
Prior art date
Application number
ZA872874A
Other languages
English (en)
Inventor
Matsumoto Jun-Ichi
Miyamoto Teruyuki
Egawa Hiroshi
Nakamura Shinichi
Original Assignee
Dainippon Pharmaceutical Company Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Company Limited filed Critical Dainippon Pharmaceutical Company Limited
Publication of ZA872874B publication Critical patent/ZA872874B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA872874A 1986-04-25 1987-04-23 Novel quinoline derivatives and processes for preparation thereof ZA872874B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9754386 1986-04-25

Publications (1)

Publication Number Publication Date
ZA872874B true ZA872874B (en) 1987-10-12

Family

ID=14195155

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA872874A ZA872874B (en) 1986-04-25 1987-04-23 Novel quinoline derivatives and processes for preparation thereof

Country Status (17)

Country Link
US (1) US4886810A (fr)
EP (1) EP0242789A3 (fr)
JP (1) JP2572591B2 (fr)
KR (1) KR870010005A (fr)
CN (1) CN87103138A (fr)
AU (1) AU7190987A (fr)
DD (1) DD263290A5 (fr)
DK (1) DK208787A (fr)
FI (1) FI871788A7 (fr)
HU (1) HU198198B (fr)
IL (1) IL82246A0 (fr)
NO (1) NO871727L (fr)
PH (1) PH23326A (fr)
PT (1) PT84749B (fr)
SU (3) SU1582986A3 (fr)
YU (4) YU73987A (fr)
ZA (1) ZA872874B (fr)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4822801A (en) * 1984-07-20 1989-04-18 Warner-Lambert Company 4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivative as antibacterial agents
EP0207420B1 (fr) * 1985-06-26 1992-05-06 Daiichi Pharmaceutical Co., Ltd. Dérivés d'acide pyridonecarboxylique
AU594983B2 (en) * 1985-10-29 1990-03-22 Dainippon Pharmaceutical Co. Ltd. Novel quinoline derivatives and processes for preparation thereof
DE3711193A1 (de) * 1987-04-02 1988-10-13 Bayer Ag 5-substituierte chinolon- und naphthyridoncarbonsaeure-derivate
US5563138A (en) * 1987-04-16 1996-10-08 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic compounds
IL88003A (en) * 1987-10-16 1992-11-15 Dainippon Pharmaceutical Co Quinoline derivatives,their preparation and pharmaceutical compositions containing them
NO885426L (no) * 1987-12-11 1989-06-12 Dainippon Pharmaceutical Co Kinolinderivater, samt fremgangsmaate ved fremstilling derav.
US4920120A (en) * 1988-01-25 1990-04-24 Warner-Lambert Company Antibacterial agents
US5585491A (en) * 1988-01-25 1996-12-17 Otsuka Pharmaceutical Co., Ltd. Antibacterial agents
US5173484A (en) * 1988-02-05 1992-12-22 Bayer Aktiengesellschaft Quinolone- and naphthyridone carboxylic acid derivatives, process for their production, antibacterial compositions and feed additives containing them
DE3814517A1 (de) * 1988-02-05 1989-08-17 Bayer Ag Chinolon- und naphthyridoncarbonsaeurederivate, verfahren zu ihrer herstellung und sie enthaltende antibakterielle mittel und futterzusatzstoffe
AU609974B2 (en) * 1988-05-18 1991-05-09 Warner-Lambert Company Improved process for the preparation of 5-amino-7- (substituted amino)-quinoline-3-carboxylic acids
JPH0674261B2 (ja) * 1988-06-21 1994-09-21 塩野義製薬株式会社 キノロンカルボン酸誘導体
US5057523A (en) * 1988-09-22 1991-10-15 Abbott Laboratories Dipeptide quinolone derivatives
CA1332605C (fr) * 1988-10-03 1994-10-18 Yasuhiro Nishitani Acides pyridonecarboxyliques
US5262417A (en) * 1988-12-06 1993-11-16 The Upjohn Company Antibacterial quinolone compounds
US5324735A (en) * 1989-07-21 1994-06-28 Ss Pharmaceutical Co., Ltd. Quinoline carboxylic acid derivatives
ES2019551A6 (es) * 1990-04-11 1991-06-16 Ercros Sa Procedimiento para la obtencion de derivados del acido 6-fluor-1, 4-dihidro-4-oxo-7-piperacinil-3-quinlincarboxilico.
DK0525057T3 (da) 1990-04-18 2000-07-31 Procter & Gamble Pharma Antimikrobielle quinolonyllactamer
DE4019023A1 (de) * 1990-06-14 1991-12-19 Bayer Ag Verfahren zur herstellung von chinolincarbonsaeuren
US5221676A (en) * 1992-02-06 1993-06-22 Warner-Lambert Company 7-substituted quinolones and naphthyridones as antibacterial agents
WO1994014794A1 (fr) * 1992-12-28 1994-07-07 Yoshitomi Pharmaceutical Industries, Ltd. Derive d'acide 8-methoxyquinolonecarboxylique
CA2152828A1 (fr) * 1993-03-16 1994-07-07 Shin-Ichi Uesato Derives de l'acide 8-methoxyquinolonecarboxylique
TW252107B (fr) * 1993-08-27 1995-07-21 Hokuriku Pharmacetical Co Ltd
DE69428206T2 (de) * 1993-10-28 2002-06-13 Kaken Pharmaceutical Co., Ltd. Chinolincarbonsäurederivate und ihre salze
CN1159809A (zh) * 1994-08-02 1997-09-17 普罗克特和甘保尔公司 喹诺酮基内酰胺抗微生物化合物和新型的中间体化合物的制备方法
BR9508514A (pt) * 1994-08-02 1997-12-23 Procter & Gamble Processo para fabricação de compostos antimicrobiais
KR19980701625A (ko) * 1995-01-24 1998-06-25 이토 마사노리 퀴놀린카르본산유도체
EP0882049B1 (fr) * 1996-02-23 2002-11-20 Bayer Ag Acides 8-cyano-1-cyclopropyl-7-(2,8-diazabicyclo-(4.3.0)-nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinocarboxyliques eventuellement substitues et leurs derives
CN1268132A (zh) * 1997-06-24 2000-09-27 第一制药株式会社 顺式－取代的氟甲基吡咯烷衍生物
ES2321042T3 (es) * 1997-09-15 2009-06-01 THE PROCTER & GAMBLE COMPANY Quinolonas antimicrobianas, composiciones y usos de las mismas.
RU2275361C3 (ru) * 2002-11-20 2021-10-01 Джапан Тобакко Инк. Соединение 4-оксохинолина и его применение в качестве ингибитора вич интегразы
SG144936A1 (en) 2003-09-10 2008-08-28 Kyorin Seiyaku Kk 7-(4-substituted-3-cyclopropylaminomethyl-1- pyrrolidinyl)quinolonecarboxylic acid derivative
GB0505969D0 (en) * 2005-03-23 2005-04-27 Novartis Ag Organic compounds
US7563805B2 (en) 2005-05-19 2009-07-21 Daiichi Pharmaceutical Co., Ltd. Tri-, tetra-substituted-3-aminopyrrolidine derivative
JP5063032B2 (ja) * 2005-05-19 2012-10-31 第一三共株式会社 トリ−、テトラ−置換−３−アミノピロリジン誘導体
RU2399616C1 (ru) * 2006-06-23 2010-09-20 Джапан Тобакко Инк. Производное 6-(гетероциклзамещенный бензил)-4-оксохинолина и его применение в качестве ингибитора интегразы вич
MX2009007291A (es) 2007-01-05 2009-07-14 Daiichi Sankyo Co Ltd Derivado de aminopirrolidina sustituido fusionado.
CA2688008A1 (fr) * 2007-05-24 2008-11-27 Kyorin Pharmaceutical Co., Ltd. Derive de la mutiline ayant une structure d'acide carboxylique a noyau aromatique heterocyclique en substituant a la position 14

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4665079A (en) * 1984-02-17 1987-05-12 Warner-Lambert Company Antibacterial agents
DE3318145A1 (de) * 1983-05-18 1984-11-22 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-difluor-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US4571396A (en) * 1984-04-16 1986-02-18 Warner-Lambert Company Antibacterial agents
ZA852369B (en) * 1984-04-26 1985-12-24 Abbott Lab Quinoline antibacterial compounds
IE58742B1 (en) * 1984-07-20 1993-11-05 Warner Lambert Co Substituted-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7h-pyrido[1,2,3-de] [1,4]benzoxauine-6-carboxylic acids; sibstituted-5-amino-6-6fluoro-4-oxo.1,4-dihydroquinoline-3 carboxylic acids; substituted-5-amino-6-fluoro-1,4-dihydro-4-oxo-1.8-naphthyridine-3-carboxylic acids; derivatives thereof; pharmaceutical compositions comprising the compounds; and processes for producing the compounds
US4771054A (en) * 1985-01-23 1988-09-13 Warner-Lambert Company Antibacterial agents
US4657913A (en) * 1985-04-18 1987-04-14 Warner-Lambert Company Trifluoro- quinoline -3- carboxylic acids and their use as anti-bacterial agents
AU594983B2 (en) * 1985-10-29 1990-03-22 Dainippon Pharmaceutical Co. Ltd. Novel quinoline derivatives and processes for preparation thereof
US4977154A (en) * 1985-12-12 1990-12-11 Warner-Lambert Company 5-amino and 5-hydroxy-6-fluoroquinolones as antibacterial agents
US4668680A (en) * 1985-12-12 1987-05-26 Warner-Lambert Company 5-amino-6,8-difluoroquinolones as antibacterial agents
US4771055A (en) * 1986-07-28 1988-09-13 Warner-Lambert Company 7-[[3-(aminomethyl)-3-alkyl]-1-pyrrolidinyl]-quinoline-carboxylic acids

Also Published As

Publication number Publication date
FI871788A7 (fi) 1987-10-26
PT84749B (en) 1989-06-07
KR870010005A (ko) 1987-11-30
HUT45520A (en) 1988-07-28
YU73987A (en) 1988-08-31
YU27788A (en) 1990-04-30
HU198198B (en) 1989-08-28
SU1588281A3 (ru) 1990-08-23
JPS6345261A (ja) 1988-02-26
AU7190987A (en) 1987-10-29
DK208787D0 (da) 1987-04-24
NO871727D0 (no) 1987-04-24
EP0242789A3 (fr) 1990-09-05
YU27488A (en) 1988-10-31
US4886810A (en) 1989-12-12
PT84749A (en) 1987-05-01
IL82246A0 (en) 1987-10-30
DK208787A (da) 1987-10-26
YU27688A (en) 1988-12-31
PH23326A (en) 1989-07-14
CN87103138A (zh) 1987-11-04
NO871727L (no) 1987-10-26
SU1582986A3 (ru) 1990-07-30
DD263290A5 (de) 1988-12-28
FI871788A0 (fi) 1987-04-23
EP0242789A2 (fr) 1987-10-28
SU1588282A3 (ru) 1990-08-23
JP2572591B2 (ja) 1997-01-16

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