ZA883443B - Cyclic anticoagulant peptides - Google Patents

Cyclic anticoagulant peptides

Info

Publication number
ZA883443B
ZA883443B ZA883443A ZA883443A ZA883443B ZA 883443 B ZA883443 B ZA 883443B ZA 883443 A ZA883443 A ZA 883443A ZA 883443 A ZA883443 A ZA 883443A ZA 883443 B ZA883443 B ZA 883443B
Authority
ZA
South Africa
Prior art keywords
cyclic
anticoagulant peptides
anticoagulant
peptides
chem
Prior art date
Application number
ZA883443A
Other languages
English (en)
Inventor
L. Krstenansky John
J.T. Mao Simon
Original Assignee
Merrell Dow Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc. filed Critical Merrell Dow Pharmaceuticals Inc.
Publication of ZA883443B publication Critical patent/ZA883443B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
ZA883443A 1987-05-21 1988-05-16 Cyclic anticoagulant peptides ZA883443B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5316987A 1987-05-21 1987-05-21

Publications (1)

Publication Number Publication Date
ZA883443B true ZA883443B (en) 1988-11-16

Family

ID=21982364

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA883443A ZA883443B (en) 1987-05-21 1988-05-16 Cyclic anticoagulant peptides

Country Status (17)

Country Link
EP (1) EP0291982B1 (fr)
JP (1) JP2858249B2 (fr)
KR (1) KR970010926B1 (fr)
CN (1) CN88103015A (fr)
AT (1) ATE91490T1 (fr)
AU (1) AU613627B2 (fr)
CA (1) CA1340646C (fr)
DE (1) DE3882279T2 (fr)
DK (1) DK278488A (fr)
ES (1) ES2058176T3 (fr)
FI (1) FI89063C (fr)
HU (1) HU198513B (fr)
IL (1) IL86438A (fr)
NO (1) NO882238L (fr)
NZ (1) NZ224678A (fr)
PT (1) PT87536B (fr)
ZA (1) ZA883443B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5192745A (en) * 1987-05-21 1993-03-09 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
US5236898A (en) * 1987-05-21 1993-08-17 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
NZ228995A (en) * 1988-05-10 1992-03-26 Merrell Dow Pharma Hirudin peptide derivatives and pharmaceutical compositions
US5240913A (en) * 1989-08-18 1993-08-31 Biogen, Inc. Inhibitors of thrombin
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
US5192747A (en) * 1989-10-03 1993-03-09 Merrell Dow Pharmaceuticals Inc. Anticoagulant peptides
ZA907743B (en) * 1989-10-03 1991-07-31 Merrell Dow Pharma Radiolabeled anticoagulant peptides
AU641215B2 (en) * 1990-02-13 1993-09-16 Merrell Dow Pharmaceuticals Inc. Stabilized sulfonate, sulfate, phosphonate and phosphate derivatives of hirudin
US6060451A (en) * 1990-06-15 2000-05-09 The National Research Council Of Canada Thrombin inhibitors based on the amino acid sequence of hirudin
FR2667071A1 (fr) * 1990-09-26 1992-03-27 Adir Nouveaux derives de peptides et de pseudopeptides therapeutiquement actifs dans la cascade de coagulation sanguine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5242810A (en) * 1990-12-07 1993-09-07 Biogen, Inc. Bifunctional inhibitors of thrombin and platelet activation
SE9103489L (sv) * 1991-11-26 1993-02-22 Flaekt Ab Saett att reglera stroempulsmatningen till en elektrostatisk stoftavskiljare
GB9303275D0 (en) * 1993-02-18 1993-04-07 Ciba Geigy Ag Pharmaceutical compositions
CN1113389A (zh) * 1993-08-04 1995-12-13 西巴-盖尔基股份公司 高分子量的脱硫水蛭素
US6057314A (en) * 1995-12-21 2000-05-02 Biochem Pharma Inc. Low molecular weight bicyclic thrombin inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3445532A1 (de) * 1984-12-13 1986-06-19 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten

Also Published As

Publication number Publication date
PT87536B (pt) 1992-09-30
DE3882279T2 (de) 1993-10-28
FI89063C (fi) 1993-08-10
CN88103015A (zh) 1988-12-21
KR970010926B1 (ko) 1997-07-02
CA1340646C (fr) 1999-07-13
JP2858249B2 (ja) 1999-02-17
NO882238D0 (no) 1988-05-20
DK278488D0 (da) 1988-05-20
DK278488A (da) 1988-11-22
ATE91490T1 (de) 1993-07-15
EP0291982A3 (en) 1990-07-11
DE3882279D1 (de) 1993-08-19
ES2058176T3 (es) 1994-11-01
IL86438A (en) 1992-11-15
EP0291982B1 (fr) 1993-07-14
HUT46933A (en) 1988-12-28
PT87536A (pt) 1989-05-31
JPS63303996A (ja) 1988-12-12
AU1634288A (en) 1988-11-24
HU198513B (en) 1989-10-30
FI882358A0 (fi) 1988-05-19
AU613627B2 (en) 1991-08-08
NO882238L (no) 1988-11-22
FI882358A7 (fi) 1988-11-22
NZ224678A (en) 1990-08-28
EP0291982A2 (fr) 1988-11-23
IL86438A0 (en) 1988-11-15
KR880013976A (ko) 1988-12-22
FI89063B (fi) 1993-04-30

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