ZA885824B - Novel antidepressants - Google Patents

Novel antidepressants

Info

Publication number: ZA885824B
Authority: ZA; South Africa
Prior art keywords: present; uptake; serotonin; novel antidepressants; provides
Prior art date: 1987-08-14

Application number

ZA885824A

Other languages

English (en)

Inventor

Jules Freedman

Freedman Jules

Mark W Dudley

W Dudley Mark

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-08-14

Filing date

1988-08-08

Publication date

1989-04-26

1988-08-08 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1989-04-26 Publication of ZA885824B publication Critical patent/ZA885824B/xx

Links

239000000935 antidepressant agent Substances 0.000 title abstract 2
229940005513 antidepressants Drugs 0.000 title abstract 2
QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
230000000946 synaptic effect Effects 0.000 abstract 2
SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 abstract 1
208000020401 Depressive disease Diseases 0.000 abstract 1
UCTWMZQNUQWSLP-UHFFFAOYSA-N adrenaline Chemical compound CNCC(O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-UHFFFAOYSA-N 0.000 abstract 1
230000001430 anti-depressive effect Effects 0.000 abstract 1
-1 aryloxy indanamines Chemical class 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
229960002748 norepinephrine Drugs 0.000 abstract 1
SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 abstract 1
230000012154 norepinephrine uptake Effects 0.000 abstract 1
229940076279 serotonin Drugs 0.000 abstract 1
230000013275 serotonin uptake Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Psychiatry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Plant Substances (AREA)
Saccharide Compounds (AREA)
Steroid Compounds (AREA)

ZA885824A 1987-08-14 1988-08-08 Novel antidepressants ZA885824B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US8566587A	1987-08-14	1987-08-14

Publications (1)

Publication Number	Publication Date
ZA885824B true ZA885824B (en)	1989-04-26

Family

ID=22193153

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA885824A ZA885824B (en)	1987-08-14	1988-08-08	Novel antidepressants

Country Status (19)

Country	Link
US (2)	US5880120A (de)
EP (1)	EP0303961B1 (de)
JP (1)	JP2650045B2 (de)
KR (1)	KR0126137B1 (de)
CN (1)	CN1021323C (de)
AT (1)	ATE104269T1 (de)
AU (2)	AU606444B2 (de)
CA (1)	CA1327795C (de)
DE (1)	DE3889032T2 (de)
DK (1)	DK454688A (de)
ES (1)	ES2054747T3 (de)
FI (1)	FI91852C (de)
HU (1)	HU204504B (de)
IE (1)	IE63082B1 (de)
IL (1)	IL87412A (de)
NO (1)	NO167913C (de)
NZ (1)	NZ225758A (de)
PT (1)	PT88251B (de)
ZA (1)	ZA885824B (de)

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US7419980B2 (en)	2003-10-14	2008-09-02	Wyeth	Fused-aryl and heteroaryl derivatives and methods of their use
US7365076B2 (en)	2003-10-14	2008-04-29	Wyeth	Substituted aryl cycloalkanol derivatives and methods of their use
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US7531543B2 (en)	2003-10-14	2009-05-12	Wyeth	Phenylpiperazine cycloalkanol derivatives and methods of their use
US7524846B2 (en)	2003-10-14	2009-04-28	Wyeth	Arylalkyl- and cycloalkylalkyl-piperazine derivatives and methods of their use
US7550485B2 (en)	2003-10-14	2009-06-23	Wyeth	Substituted N-heterocycle derivatives and methods of their use
US7402698B2 (en)	2003-10-14	2008-07-22	Wyeth	Secondary amino-and cycloamino-cycloalkanol derivatives and methods of their use
US7491723B2 (en)	2003-10-14	2009-02-17	Wyeth	Alkanol and cycloalkanol-amine derivatives and methods of their use
US7517899B2 (en)	2004-03-30	2009-04-14	Wyeth	Phenylaminopropanol derivatives and methods of their use
US7414052B2 (en)	2004-03-30	2008-08-19	Wyeth	Phenylaminopropanol derivatives and methods of their use
US7439399B2 (en) *	2004-06-28	2008-10-21	Teva Pharmaceutical Fine Chemicals	Processes for the preparation of atomoxetine hydrochloride
AU2005274927B2 (en)	2004-07-15	2011-11-03	Albany Molecular Research, Inc.	Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
US20060111385A1 (en) *	2004-11-22	2006-05-25	Molino Bruce F	Novel 4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof
US20060111394A1 (en) *	2004-11-22	2006-05-25	Molino Bruce F	Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
US20060111393A1 (en) *	2004-11-22	2006-05-25	Molino Bruce F	4-Phenyl substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
WO2006121922A1 (en) *	2005-05-06	2006-11-16	Neurocrine Biosciences, Inc.	Monoamine re-uptake inhibitors and methods relating thereto
US7378552B2 (en)	2005-06-07	2008-05-27	Neurocrine Biosciences, Inc.	Monoamine re-uptake inhibitors and methods relating thereto
KR101594898B1 (ko)	2005-07-15	2016-02-18	알바니 몰레큘라 리써치, 인크.	아릴- 및 헤테로아릴-치환된 테트라히드로벤자제핀, 및 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도
ES2397764T3 (es)	2008-04-01	2013-03-11	Abbott Gmbh & Co. Kg	Tetrahidroisoquinolinas, composiciones farmacéuticas que las contienen, y su uso en terapia
US8461389B2 (en)	2008-04-18	2013-06-11	University College Dublin, National University Of Ireland, Dublin	Psycho-pharmaceuticals
US9156812B2 (en)	2008-06-04	2015-10-13	Bristol-Myers Squibb Company	Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
AR071997A1 (es) *	2008-06-04	2010-07-28	Bristol Myers Squibb Co	Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
AU2009289846B2 (en) *	2008-09-02	2014-10-16	Sanofi-Aventis	Substituted aminoindanes and analogs thereof, and the pharmaceutical use thereof
AR075442A1 (es)	2009-02-16	2011-03-30	Abbott Gmbh & Co Kg	Derivados de aminotetralina, composiciones farmaceuticas que las contienen y sus usos en terapia
WO2010132487A1 (en)	2009-05-12	2010-11-18	Bristol-Myers Squibb Company	CRYSTALLINE FORMS OF (S)-7-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)-4-(3,4-DICHLOROHPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE AND USE THEREOF
CN102458123A (zh) *	2009-05-12	2012-05-16	阿尔巴尼分子研究公司	芳基、杂芳基和杂环取代的四氢异喹啉及其用途
US8802696B2 (en)	2009-05-12	2014-08-12	Albany Molecular Research, Inc.	7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoqu inoli and use thereof
EP2368876A1 (de) *	2010-03-01	2011-09-28	Sanofi	Derivate von Aminoindanen, deren Herstellung und deren Anwendung in der Therapeutik
US8877794B2 (en)	2010-08-13	2014-11-04	Abbott Laboratories	Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US8883839B2 (en)	2010-08-13	2014-11-11	Abbott Laboratories	Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9045459B2 (en)	2010-08-13	2015-06-02	AbbVie Deutschland GmbH & Co. KG	Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9051280B2 (en)	2010-08-13	2015-06-09	AbbVie Deutschland GmbH & Co. KG	Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US8846743B2 (en)	2010-08-13	2014-09-30	Abbott Laboratories	Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9309200B2 (en)	2011-05-12	2016-04-12	AbbVie Deutschland GmbH & Co. KG	Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy
JP2014521682A (ja)	2011-08-05	2014-08-28	アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー	アミノクロマン、アミノチオクロマンおよびアミノ−１，２，３，４−テトラヒドロキノリン誘導体、これらを含有する医薬組成物、ならびに治療におけるこれらの使用
EP2780328A1 (de)	2011-11-18	2014-09-24	Abbvie Deutschland GmbH & Co. KG	N-substituierte aminobenzocyclohepten-, aminotetralin-, aminoindan- und phenylalkylaminderivate, diese enthaltende pharmazeutische zusammensetzungen und ihre therapeutische verwendung
US9365512B2 (en)	2012-02-13	2016-06-14	AbbVie Deutschland GmbH & Co. KG	Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy
US9656955B2 (en)	2013-03-15	2017-05-23	Abbvie Inc.	Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9650334B2 (en)	2013-03-15	2017-05-16	Abbvie Inc.	Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
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1988
- 1988-08-08 ZA ZA885824A patent/ZA885824B/xx unknown
- 1988-08-08 CA CA000574102A patent/CA1327795C/en not_active Expired - Lifetime
- 1988-08-09 AU AU20579/88A patent/AU606444B2/en not_active Ceased
- 1988-08-09 NZ NZ225758A patent/NZ225758A/xx unknown
- 1988-08-10 DE DE3889032T patent/DE3889032T2/de not_active Expired - Lifetime
- 1988-08-10 EP EP88112996A patent/EP0303961B1/de not_active Expired - Lifetime
- 1988-08-10 ES ES88112996T patent/ES2054747T3/es not_active Expired - Lifetime
- 1988-08-10 AT AT88112996T patent/ATE104269T1/de not_active IP Right Cessation
- 1988-08-11 FI FI883739A patent/FI91852C/fi not_active IP Right Cessation
- 1988-08-11 PT PT88251A patent/PT88251B/pt not_active IP Right Cessation
- 1988-08-11 JP JP63199045A patent/JP2650045B2/ja not_active Expired - Lifetime
- 1988-08-11 IL IL8741288A patent/IL87412A/en not_active IP Right Cessation
- 1988-08-12 DK DK454688A patent/DK454688A/da not_active Application Discontinuation
- 1988-08-12 IE IE248488A patent/IE63082B1/en not_active IP Right Cessation
- 1988-08-12 HU HU884347A patent/HU204504B/hu not_active IP Right Cessation
- 1988-08-12 NO NO883595A patent/NO167913C/no unknown
- 1988-08-13 CN CN88106476A patent/CN1021323C/zh not_active Expired - Fee Related
- 1988-08-13 KR KR1019880010350A patent/KR0126137B1/ko not_active Expired - Fee Related
1990
- 1990-11-09 AU AU65989/90A patent/AU624278B2/en not_active Ceased
1997
- 1997-09-11 US US08/937,224 patent/US5880120A/en not_active Expired - Fee Related
1998
- 1998-12-10 US US09/209,200 patent/US6136803A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DK454688A (da)	1989-02-15
IL87412A (en)	1995-05-26
KR0126137B1 (ko)	1997-12-26
AU6598990A (en)	1991-01-24
ATE104269T1 (de)	1994-04-15
JP2650045B2 (ja)	1997-09-03
AU606444B2 (en)	1991-02-07
PT88251B (pt)	1995-03-01
IE882484L (en)	1989-02-14
FI883739A0 (fi)	1988-08-11
DE3889032T2 (de)	1994-08-11
FI883739A7 (fi)	1989-02-15
ES2054747T3 (es)	1994-08-16
FI91852B (fi)	1994-05-13
DK454688D0 (da)	1988-08-12
US5880120A (en)	1999-03-09
NO167913C (no)	1991-12-27
AU624278B2 (en)	1992-06-04
CN1021323C (zh)	1993-06-23
KR890003671A (ko)	1989-04-17
NO883595L (no)	1989-02-15
IE63082B1 (en)	1995-03-22
FI91852C (fi)	1994-08-25
US6136803A (en)	2000-10-24
EP0303961B1 (de)	1994-04-13
EP0303961A3 (en)	1989-05-17
HU204504B (en)	1992-01-28
EP0303961A2 (de)	1989-02-22
CA1327795C (en)	1994-03-15
NO883595D0 (no)	1988-08-12
IL87412A0 (en)	1989-01-31
DE3889032D1 (de)	1994-05-19
JPS6466151A (en)	1989-03-13
AU2057988A (en)	1989-02-16
NZ225758A (en)	1990-10-26
PT88251A (pt)	1989-06-30
CN1033043A (zh)	1989-05-24
HUT51593A (en)	1990-05-28
NO167913B (no)	1991-09-16

Publication	Publication Date	Title
EP0303961A3 (en)	1989-05-17	Novel antidepressants
PL320637A1 (en)	1997-10-13	Anticoagulants
DE69030212D1 (de)	1997-04-24	Verwendung von Derivaten des 4-Phenyl-1,2,3,4-tetrahydro-1-naphthalenamins zur Behandlung von Psychose, Entzündung und als Immununterdrücker
ZA948B (en)	1995-07-03	Endothelin converting enzyme inhibitors
EP0552240A4 (en)	1993-09-01	New method of treating depression
EP0343830A3 (en)	1990-11-28	Ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes
GB8727099D0 (en)	1987-12-23	Compositions containing melantonin/homologues
EP0317602A1 (de)	1989-05-31	Antioxidanz-produkte.
EP0318233A3 (de)	1990-07-11	Serotonin- und Norepinephrin-Aufnahme-Inhibitoren
DE69432626D1 (de)	2003-06-12	Melatonin-Derivate zur Verwendung in der Behandlung von Desynchronisierungs-Erkankungen
EP0435177A3 (en)	1992-01-08	4-benzyl-5-phenyl-2,4-dihydro-3h-1,2,4-triazol-3-ones and their use as anticonvulsants
ZA892517B (en)	1990-12-28	Propanamine derivatives
ATE140228T1 (de)	1996-07-15	Hydroxymethyl-indolizidine und -chinolizidine
EP0318234A3 (en)	1990-07-04	Improvements in or relating to selective serotonin uptake inhibitors
IL101743A0 (en)	1992-12-30	2-mercaptomethylene-tetrahydronaphthalene and indane-2-carboxamide derivatives as enkephalinase inhibitors
DE69203192D1 (de)	1995-08-03	Verfahren zur Herstellung von N-Ethylhydroxylamin-Hydrochlorid.
GR3020597T3 (en)	1996-10-31	Phospholipids for the treatment of multiple sclerosis