ZA886810B - Epipodophyllotoxin glucoside 4'-acyl derivatives - Google Patents

Epipodophyllotoxin glucoside 4'-acyl derivatives

Info

Publication number: ZA886810B
Authority: ZA; South Africa
Prior art keywords: acyl derivatives; epipodophyllotoxin glucoside; epipodophyllotoxin; glucoside; acyl
Prior art date: 1987-12-18

Application number

ZA886810A

Other languages

English (en)

Inventor

Mark G Saulnier

G Saulnier Mark

Dolatrai M Vyas

M Vyas Dolatrai

Original Assignee

Bristol Myers Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-12-18

Filing date

1988-09-13

Publication date

1989-08-30

1988-09-13 Application filed by Bristol Myers Co filed Critical Bristol Myers Co

1989-08-30 Publication of ZA886810B publication Critical patent/ZA886810B/xx

Links

-1 Epipodophyllotoxin glucoside Chemical class 0.000 title 1
YJGVMLPVUAXIQN-UHFFFAOYSA-N epipodophyllotoxin Natural products COC1=C(OC)C(OC)=CC(C2C3=CC=4OCOC=4C=C3C(O)C3C2C(OC3)=O)=C1 YJGVMLPVUAXIQN-UHFFFAOYSA-N 0.000 title 1
229930182478 glucoside Natural products 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biotechnology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

ZA886810A 1987-12-18 1988-09-13 Epipodophyllotoxin glucoside 4'-acyl derivatives ZA886810B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US13512987A	1987-12-18	1987-12-18

Publications (1)

Publication Number	Publication Date
ZA886810B true ZA886810B (en)	1989-08-30

Family

ID=22466687

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
ZA886810A ZA886810B (en)	1987-12-18	1988-09-13	Epipodophyllotoxin glucoside 4'-acyl derivatives
ZA889392A ZA889392B (en)	1987-12-18	1988-12-15	Epipodophyllotoxin glucoside 4"-acyl derivatives

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
ZA889392A ZA889392B (en)	1987-12-18	1988-12-15	Epipodophyllotoxin glucoside 4"-acyl derivatives

Country Status (16)

Country	Link
EP (1)	EP0320988A3 (de)
JP (1)	JPH01279896A (de)
KR (1)	KR910008799B1 (de)
CN (1)	CN1033631A (de)
AU (1)	AU616717B2 (de)
CA (1)	CA1312074C (de)
DD (2)	DD283401A5 (de)
DK (1)	DK702688A (de)
FI (1)	FI885785A7 (de)
HU (1)	HU202548B (de)
MY (1)	MY104067A (de)
NO (1)	NO167668C (de)
NZ (1)	NZ227286A (de)
PT (1)	PT89253B (de)
YU (2)	YU179088A (de)
ZA (2)	ZA886810B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4868291A (en) *	1987-08-20	1989-09-19	Bristol-Myers Company	4'-deshydroxyepipodophyllotoxin glucosides: synthesis and use
US4965348A (en) *	1989-05-19	1990-10-23	Bristol-Myers Company	Dimeric epipodophyllotoxin glucoside derivatives
US5036055A (en) *	1989-06-07	1991-07-30	Bristol-Myers Company	Acylated derivatives of etoposide
FR2655047A1 (fr) *	1989-11-24	1991-05-31	Pf Medicament	Derives d'etoposide, leur preparation et leur application comme intermediaires de synthese.
US5633158A (en) *	1991-10-23	1997-05-27	Cancer Research Campaign Technology Limited	Bacterial nitroreductase for the reduction of CB 1954 and analogues thereof to a cytotoxic form
ES2545393T3 (es) *	2001-12-03	2015-09-10	Universitätsklinikum Charité Der Humboldt- Universität Zu Berlin	Las podofilotoxinas como agentes antiproliferativos
GB0421296D0 (en) *	2004-09-24	2004-10-27	Angiogene Pharm Ltd	Bioreductively-activated prodrugs
KR101919093B1 (ko) *	2008-05-23	2018-11-16	더 유니버시티 오브 브리티쉬 콜롬비아	리포좀 나노입자에 사용하기 위한 변형된 약물

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE546388A (de) *
NL6613143A (de) *	1965-09-21	1967-03-22
EP0111058B1 (de) *	1982-11-26	1987-11-04	Nippon Kayaku Kabushiki Kaisha	Verfahren zur Herstellung von 4'-Demethyl-epipodophylotoxin-beta-D-ethyliden-glucosid und Acylderivate davon
US4609644A (en) *	1984-06-15	1986-09-02	St. Jude Children's Research Hospital	Epipodophyllotoxinquinone glucoside derivatives, method of production and use
IL77334A (en) *	1985-12-16	1991-04-15	Univ Bar Ilan	Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor

1988
- 1988-09-13 ZA ZA886810A patent/ZA886810B/xx unknown
- 1988-09-23 YU YU01790/88A patent/YU179088A/xx unknown
- 1988-12-12 NZ NZ227286A patent/NZ227286A/en unknown
- 1988-12-12 MY MYPI88001432A patent/MY104067A/en unknown
- 1988-12-14 FI FI885785A patent/FI885785A7/fi not_active Application Discontinuation
- 1988-12-15 CN CN88108637A patent/CN1033631A/zh active Pending
- 1988-12-15 ZA ZA889392A patent/ZA889392B/xx unknown
- 1988-12-15 NO NO885565A patent/NO167668C/no unknown
- 1988-12-16 PT PT89253A patent/PT89253B/pt not_active IP Right Cessation
- 1988-12-16 DD DD88323314A patent/DD283401A5/de unknown
- 1988-12-16 HU HU886466A patent/HU202548B/hu not_active IP Right Cessation
- 1988-12-16 EP EP88121146A patent/EP0320988A3/de not_active Withdrawn
- 1988-12-16 DD DD88334711A patent/DD296082A5/de not_active IP Right Cessation
- 1988-12-16 DK DK702688A patent/DK702688A/da not_active Application Discontinuation
- 1988-12-16 YU YU228388A patent/YU228388A/sh unknown
- 1988-12-17 KR KR1019880016897A patent/KR910008799B1/ko not_active Expired
- 1988-12-19 AU AU27062/88A patent/AU616717B2/en not_active Ceased
- 1988-12-19 CA CA000586374A patent/CA1312074C/en not_active Expired - Fee Related
- 1988-12-19 JP JP63320316A patent/JPH01279896A/ja active Pending

Also Published As

Publication number	Publication date
KR890009965A (ko)	1989-08-05
NO885565L (no)	1989-06-19
CA1312074C (en)	1992-12-29
MY104067A (en)	1993-11-30
DK702688A (da)	1989-06-19
NO167668C (no)	1991-11-27
YU179088A (en)	1990-02-28
AU616717B2 (en)	1991-11-07
NZ227286A (en)	1991-08-27
PT89253A (pt)	1989-12-29
YU228388A (sh)	1993-10-20
ZA889392B (en)	1989-09-27
HU202548B (en)	1991-03-28
HUT48641A (en)	1989-06-28
EP0320988A2 (de)	1989-06-21
AU2706288A (en)	1989-06-29
FI885785A7 (fi)	1989-06-19
JPH01279896A (ja)	1989-11-10
DD283401A5 (de)	1990-10-10
FI885785A0 (fi)	1988-12-14
DD296082A5 (de)	1991-11-21
NO167668B (no)	1991-08-19
EP0320988A3 (de)	1990-08-22
NO885565D0 (no)	1988-12-15
KR910008799B1 (ko)	1991-10-21
PT89253B (pt)	1993-07-30
CN1033631A (zh)	1989-07-05
DK702688D0 (da)	1988-12-16

Publication	Publication Date	Title
GB2212498B (en)	1991-07-24	Adenosine derivatives
ZA881835B (en)	1988-09-08	Avermectin derivatives
ZA89538B (en)	1989-09-27	Avermectin derivatives
ZA88755B (en)	1989-10-25	Certain adenosine 5'-carboxamide derivatives
ZA899818B (en)	1990-09-26	Avermectin derivatives
ZA904211B (en)	1991-03-27	Avermectin derivatives
EP0415453A3 (en)	1991-04-10	Epipodophyllotoxin altroside derivatives
AU7827687A (en)	1988-03-17	Macrolide derivatives
ZA903859B (en)	1991-01-30	Dimeric epipodophyllotoxin glucoside derivatives
ZA889392B (en)	1989-09-27	Epipodophyllotoxin glucoside 4"-acyl derivatives
ZA883762B (en)	1989-03-29	Novel 3',4'-dinitrogen substituted epipodophyllotoxin glucoside derivatives
ZA901032B (en)	1990-11-28	Avermectin derivatives
ZA883763B (en)	1989-10-25	3-demethoxyepipodophyllotoxin glucoside derivatives
ZA904207B (en)	1991-03-27	Avermectin derivatives
IL95884A0 (en)	1991-07-18	Alkoxymethylidene epipodophyllotoxin glucosides
ZA888368B (en)	1989-09-27	4-demethoxy anthracycline derivatives
IE881999L (en)	1989-01-01	Epipodophyllotoxin glucoside derivatives
GB8909518D0 (en)	1989-06-14	Antiparasitic avermectin derivatives
ZA885405B (en)	1989-04-26	Epipodophyliotoxin glucoside 4'-phosphate derivatives
AU610619C (en)	1991-12-19	Epipodophyllotoxin glucose 4' - phosphate derivatives
IE900143L (en)	1990-07-13	Avermectin derivatives
IE880472L (en)	1988-08-24	Erythromycin derivatives
AU2030688A (en)	1989-06-08	Epipodophyllotoxin glucose 4' - phosphate derivatives
IE882630L (en)	1989-02-28	3-demethoxyepipodophyllotoxin glucoside derivatives
IE862278L (en)	1987-02-28	Erythromycin derivatives