ZA889109B - Method of enhancing memory or correcting memory deficiency with arylamido(and arylthioamido)azabicycloalkanes - Google Patents
Method of enhancing memory or correcting memory deficiency with arylamido(and arylthioamido)azabicycloalkanesInfo
- Publication number
- ZA889109B ZA889109B ZA889109A ZA889109A ZA889109B ZA 889109 B ZA889109 B ZA 889109B ZA 889109 A ZA889109 A ZA 889109A ZA 889109 A ZA889109 A ZA 889109A ZA 889109 B ZA889109 B ZA 889109B
- Authority
- ZA
- South Africa
- Prior art keywords
- memory
- group
- correcting
- arylthioamido
- azabicycloalkanes
- Prior art date
Links
- 230000007812 deficiency Effects 0.000 title abstract 2
- 230000002708 enhancing effect Effects 0.000 title 1
- -1 methoxy-1H-benzotriazolyl Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000005871 1,3-benzodioxolyl group Chemical group 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 230000037396 body weight Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 125000003387 indolinyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C33/00—Moulds or cores; Details thereof or accessories therefor
- B29C33/44—Moulds or cores; Details thereof or accessories therefor with means for, or specially constructed to facilitate, the removal of articles, e.g. of undercut articles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Mechanical Engineering (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/150,981 US4863919A (en) | 1988-02-01 | 1988-02-01 | Method of enhancing memory or correcting memory deficiency with arylamido(and arylthiomido)-azabicycloalkanes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA889109B true ZA889109B (en) | 1989-08-30 |
Family
ID=22536826
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA889109A ZA889109B (en) | 1988-02-01 | 1988-12-05 | Method of enhancing memory or correcting memory deficiency with arylamido(and arylthioamido)azabicycloalkanes |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4863919A (de) |
| EP (1) | EP0327335B1 (de) |
| JP (1) | JPH01226818A (de) |
| KR (1) | KR890012649A (de) |
| AT (1) | ATE81457T1 (de) |
| AU (1) | AU629197B2 (de) |
| CA (1) | CA1320448C (de) |
| DE (1) | DE68903178T2 (de) |
| DK (1) | DK42589A (de) |
| ES (1) | ES2045402T3 (de) |
| GR (1) | GR3006764T3 (de) |
| IL (1) | IL88434A (de) |
| NZ (1) | NZ227794A (de) |
| PH (1) | PH25906A (de) |
| PT (1) | PT89575B (de) |
| ZA (1) | ZA889109B (de) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU654013B2 (en) * | 1991-03-13 | 1994-10-20 | Regents Of The University Of Minnesota | 2-hydroxy-3(4-iodophenyl)-1-(4-phenylpiperidinyl) propane |
| US5723103A (en) * | 1994-12-09 | 1998-03-03 | Vanderbilt University | Substituted benzamides and radioligand analogs and methods of use |
| SE0000540D0 (sv) | 2000-02-18 | 2000-02-18 | Astrazeneca Ab | New compounds |
| US6486172B2 (en) * | 2000-08-18 | 2002-11-26 | Pharmacia & Upjohn Company | Quinuclidine-substituted aryl compounds for treatment of disease |
| WO2002016356A2 (en) * | 2000-08-18 | 2002-02-28 | Pharmacia & Upjohn Company | Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands) |
| US6492385B2 (en) | 2000-08-18 | 2002-12-10 | Pharmacia & Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease |
| EP1381603A2 (de) * | 2000-08-18 | 2004-01-21 | PHARMACIA & UPJOHN COMPANY | Mit aryl gruppen substituierte chinuklidine zur behandlung von krankheiten ( nikotin acetylcholin rezeptor liganden ) |
| EP1311505A2 (de) * | 2000-08-21 | 2003-05-21 | PHARMACIA & UPJOHN COMPANY | Mit heteroaryl gruppen substituierte chinuklidine zur behandlung von krankheiten ( nikotin acetylcholin rezeptor liganden ) |
| US6500840B2 (en) | 2000-08-21 | 2002-12-31 | Pharmacia & Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease |
| AU2001284646A1 (en) | 2000-08-21 | 2002-03-04 | Pharmacia And Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease |
| PE20021019A1 (es) | 2001-04-19 | 2002-11-13 | Upjohn Co | Grupos azabiciclicos sustituidos |
| AR036041A1 (es) * | 2001-06-12 | 2004-08-04 | Upjohn Co | Compuestos aromaticos heterociclicos sustituidos con quinuclidina y composiciones farmaceuticas que los contienen |
| AR036040A1 (es) | 2001-06-12 | 2004-08-04 | Upjohn Co | Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen |
| WO2003032897A2 (en) * | 2001-10-16 | 2003-04-24 | Astrazeneca Ab | Azabicyclic compounds for the treatment of fibromyalgia syndrome |
| US6849620B2 (en) | 2001-10-26 | 2005-02-01 | Pfizer Inc | N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease |
| CA2464194A1 (en) * | 2001-10-26 | 2003-05-08 | Pharmacia & Upjohn Company | N-azabicyclo-substituted hetero-bicyclic carboxamides as nachr agonists |
| MXPA04004464A (es) * | 2001-11-08 | 2004-08-11 | Upjohn Co | Compuestos de heteroarilo sustituido con azabiciclo para el tratamiento de enfermedades. |
| DE10156719A1 (de) | 2001-11-19 | 2003-05-28 | Bayer Ag | Heteroarylcarbonsäureamide |
| DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
| JP2005522456A (ja) * | 2002-02-15 | 2005-07-28 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | Ｃｎｓ関連障害治療のためのアザビシクロ置換ベンゾイルアミドおよびチオアミド |
| BR0307782A (pt) * | 2002-02-19 | 2005-01-04 | Upjohn Co | Compostos azabiciclo para o tratamento de doença |
| WO2003072578A1 (en) * | 2002-02-20 | 2003-09-04 | Pharmacia & Upjohn Company | Azabicyclic compounds with alfa7 nicotinic acetylcholine receptor activity |
| US7176198B2 (en) | 2002-08-01 | 2007-02-13 | Pfizer Inc. | 1H-pyrazole and 1H-pyrrole-azabicyclic compounds for the treatment of disease |
| CA2503786A1 (en) * | 2002-11-01 | 2004-05-13 | Pharmacia & Upjohn Company Llc | Compounds having both alpha7 nicotinic agonist activity and 5ht, antagonist activity for treatment of cns diseases |
| US7358248B2 (en) | 2003-04-30 | 2008-04-15 | The Institute For Pharmaceutical Discovery Llc | Substituted amino carboxylic acids |
| CA2588776A1 (en) | 2004-11-18 | 2006-05-26 | The Institutes For Pharmaceutical Discovery, Llc | Substituted amino carboxylic acids |
| US20080242688A1 (en) * | 2007-03-19 | 2008-10-02 | Astrazeneca Ab | Method 741 |
| WO2010042799A2 (en) | 2008-10-09 | 2010-04-15 | Howard Hughes Medical Institute | Novel chimeric ligand-gated ion channels and methods of use thereof |
| CA2894860C (en) | 2008-11-19 | 2018-11-06 | Gerhard Koenig | Treatment of cognitive disorders with (r)-7-chloro-n-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide and pharmaceutically acceptable salts thereof |
| MX357676B (es) | 2010-05-17 | 2018-07-18 | Forum Pharmaceuticals Inc | Una forma cristalina de clorhidrato de (r)-7-cloro-n-(quinuclidin- 3-il)benzo[b]tiofeno-2-carboxamida monohidratado. |
| TWI589576B (zh) | 2011-07-15 | 2017-07-01 | 諾華公司 | 氮雜－雙環二芳基醚之鹽類及製造彼等或其前驅物之方法 |
| EP3666272A1 (de) | 2012-05-08 | 2020-06-17 | Forum Pharmaceuticals Inc. | Verwendung von encenicline bei der behandlung von kognitiver behinderung, alzheimer-krankheit, speicherdefizit |
| EP3623371A1 (de) | 2014-12-16 | 2020-03-18 | Axovant Sciences GmbH | Geminale substituierte chinuklidinamidverbindungen als agonisten von alpha-7-nikotinischen acetylcholinrezeptoren |
| CA2988968A1 (en) | 2015-06-10 | 2016-12-15 | Forum Pharmaceuticals, Inc. | Aminobenzisoxazole compounds as agonists of a7-nicotinic acetylcholine receptors |
| WO2017027600A1 (en) | 2015-08-12 | 2017-02-16 | Forum Pharmaceuticals, Inc. | GEMINAL SUBSTITUTED AMINOBENZISOXAZOLE COMPOUNDS AS AGONISTS OF α7-NICOTINIC ACETYLCHOLINE RECEPTORS |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4093734A (en) * | 1975-11-03 | 1978-06-06 | Boehringer Ingelheim Gmbh | Amino-benzoic acid amides |
| GB1593146A (en) * | 1976-11-05 | 1981-07-15 | Beecham Group Ltd | Octahydro-quinolizinyl benzamide derivatives |
| EP0067565A1 (de) * | 1981-06-16 | 1982-12-22 | Beecham Group Plc | Bicyclische Benzamide, Verfahren zu ihrer Herstellung und ihre Verwendung |
| FR2531083B1 (fr) * | 1982-06-29 | 1986-11-28 | Sandoz Sa | Nouveaux derives de la piperidine, leur preparation et leur utilisation comme medicaments |
| FR2529548A1 (fr) * | 1982-07-02 | 1984-01-06 | Delalande Sa | Nouveaux derives de l'amino-3 quinuclidine, leur procede et leur application en therapeutique |
| US4593034A (en) * | 1984-04-06 | 1986-06-03 | A. H. Robins Company, Inc. | 2-alkoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamides and thiobenzamides |
| DE3446484A1 (de) * | 1984-12-20 | 1986-07-03 | Sandoz-Patent-GmbH, 7850 Lörrach | Therapeutische verwendung von benzoesaeurepiperidylestern oder -amiden |
| US4605652A (en) * | 1985-02-04 | 1986-08-12 | A. H. Robins Company, Inc. | Method of enhancing memory or correcting memory deficiency with arylamido (and arylthioamido)-azabicycloalkanes |
| US4870181A (en) * | 1985-02-04 | 1989-09-26 | A. H. Robins Company, Incorporated | Process for the preparation of 2-alkoxy-N-(1-azabicyclo[2.2.2])octan-3-yl)aminobenzamides |
| EP0385517B1 (de) * | 1985-03-14 | 1993-04-14 | BEECHAM GROUP plc | Arzneimittel zur Behandlung von Erbrechen |
| GB8511988D0 (en) * | 1985-05-11 | 1985-06-19 | Beecham Group Plc | Compounds |
| GB8515845D0 (en) * | 1985-06-22 | 1985-07-24 | Beecham Group Plc | Treatment |
| US4717563A (en) * | 1986-03-05 | 1988-01-05 | A. H. Robins Company, Inc. | 2-alkoxy-N-(1-azabicyclo(2.2.2)oct-3-yl) benzamides and thiobenzamides in a method for alleviating emesis caused by non-platinum anticancer drugs |
-
1988
- 1988-02-01 US US07/150,981 patent/US4863919A/en not_active Expired - Fee Related
- 1988-11-21 IL IL88434A patent/IL88434A/xx not_active IP Right Cessation
- 1988-12-05 ZA ZA889109A patent/ZA889109B/xx unknown
-
1989
- 1989-01-23 JP JP1013894A patent/JPH01226818A/ja active Pending
- 1989-01-26 CA CA000589194A patent/CA1320448C/en not_active Expired - Fee Related
- 1989-01-30 NZ NZ227794A patent/NZ227794A/en unknown
- 1989-01-31 KR KR1019890001079A patent/KR890012649A/ko not_active Ceased
- 1989-01-31 PT PT89575A patent/PT89575B/pt active IP Right Grant
- 1989-01-31 PH PH38133A patent/PH25906A/en unknown
- 1989-01-31 DK DK042589A patent/DK42589A/da not_active Application Discontinuation
- 1989-02-01 EP EP89300961A patent/EP0327335B1/de not_active Expired - Lifetime
- 1989-02-01 AU AU29506/89A patent/AU629197B2/en not_active Ceased
- 1989-02-01 AT AT89300961T patent/ATE81457T1/de not_active IP Right Cessation
- 1989-02-01 DE DE8989300961T patent/DE68903178T2/de not_active Expired - Fee Related
- 1989-02-01 ES ES89300961T patent/ES2045402T3/es not_active Expired - Lifetime
-
1993
- 1993-01-11 GR GR930400020T patent/GR3006764T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2045402T3 (es) | 1994-01-16 |
| PH25906A (en) | 1991-12-19 |
| IL88434A0 (en) | 1989-06-30 |
| AU2950689A (en) | 1989-08-03 |
| DK42589D0 (da) | 1989-01-31 |
| PT89575B (pt) | 1994-01-31 |
| ATE81457T1 (de) | 1992-10-15 |
| AU629197B2 (en) | 1992-10-01 |
| PT89575A (pt) | 1989-10-04 |
| DE68903178T2 (de) | 1993-03-18 |
| CA1320448C (en) | 1993-07-20 |
| EP0327335A1 (de) | 1989-08-09 |
| NZ227794A (en) | 1991-12-23 |
| IL88434A (en) | 1992-09-06 |
| GR3006764T3 (de) | 1993-06-30 |
| JPH01226818A (ja) | 1989-09-11 |
| EP0327335B1 (de) | 1992-10-14 |
| KR890012649A (ko) | 1989-09-18 |
| US4863919A (en) | 1989-09-05 |
| DK42589A (da) | 1989-08-02 |
| DE68903178D1 (de) | 1992-11-19 |
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