ZA893086B - 4-quinoline carboxylic acid derivatives useful for treating skin and muco-epithelial disease - Google Patents

4-quinoline carboxylic acid derivatives useful for treating skin and muco-epithelial disease

Info

Publication number: ZA893086B
Authority: ZA; South Africa
Prior art keywords: muco; carboxylic acid; acid derivatives; treating skin; derivatives useful
Prior art date: 1988-04-26

Application number

ZA893086A

Other languages

English (en)

Inventor

Neil Richard Ackerman

Richard Ackerman Neil

Richard Russell Harris

Russell Harris Richard

Scott Edward Loveless

Edward Loveless Scott

Russell Howard Neubauer

Howard Neubauer Russell

Original Assignee

Du Pont

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-04-26

Filing date

1989-04-26

Publication date

1990-12-28

1989-04-26 Application filed by Du Pont filed Critical Du Pont

1990-12-28 Publication of ZA893086B publication Critical patent/ZA893086B/xx

Links

201000010099 disease Diseases 0.000 title abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
VQMSRUREDGBWKT-UHFFFAOYSA-N quinoline-4-carboxylic acid Chemical class C1=CC=C2C(C(=O)O)=CC=NC2=C1 VQMSRUREDGBWKT-UHFFFAOYSA-N 0.000 title 1
JIPUGCBCIYYRSB-UHFFFAOYSA-N 3-phenylquinoline-2-carboxylic acid Chemical class OC(=O)C1=NC2=CC=CC=C2C=C1C1=CC=CC=C1 JIPUGCBCIYYRSB-UHFFFAOYSA-N 0.000 abstract 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 abstract 1
229910052708 sodium Inorganic materials 0.000 abstract 1
239000011734 sodium Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
- C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Pulmonology (AREA)
Immunology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

ZA893086A 1988-04-26 1989-04-26 4-quinoline carboxylic acid derivatives useful for treating skin and muco-epithelial disease ZA893086B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/186,242 US4861783A (en)	1988-04-26	1988-04-26	4-quinoline carboxylic acid derivatives useful for treating skin and muco-epithelial diseases

Publications (1)

Publication Number	Publication Date
ZA893086B true ZA893086B (en)	1990-12-28

Family

ID=22684175

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA893086A ZA893086B (en)	1988-04-26	1989-04-26	4-quinoline carboxylic acid derivatives useful for treating skin and muco-epithelial disease

Country Status (16)

Country	Link
US (1)	US4861783A (de)
EP (1)	EP0339484B1 (de)
JP (1)	JP2650756B2 (de)
KR (1)	KR0124817B1 (de)
AT (1)	ATE84716T1 (de)
AU (1)	AU610469B2 (de)
CA (1)	CA1336263C (de)
DE (1)	DE68904462T2 (de)
DK (1)	DK199789A (de)
ES (1)	ES2053856T3 (de)
IE (1)	IE64285B1 (de)
IL (1)	IL90056A (de)
MY (1)	MY104006A (de)
NZ (1)	NZ228894A (de)
PT (1)	PT90362B (de)
ZA (1)	ZA893086B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5102883A (en) *	1989-10-31	1992-04-07	Du Pont Merck Pharmaceutical Company	Pyrimidine biosynthesis inhibitors useful as immunosuppressive agents
US5204329A (en) *	1990-06-11	1993-04-20	Du Pont Merck Pharmaceutical Company	Treatment of organ transplantation rejection
US5135934A (en) *	1990-07-06	1992-08-04	Du Pont Merck Pharmaceutical Company	3-phenyl-5,6-dihydrobenz(c) acridine-7-carboxylic acids and related compounds as immunosuppressive agents
US5281196A (en) *	1992-05-22	1994-01-25	Sultenfuss Thomas J	Skin treatment composition and method of use
US5409886A (en) *	1993-02-18	1995-04-25	Mitsui Toatsu Chemicals, Incorporated	3-pyrroline-2-one derivatives and herbicidal compositions containing same
US5578609A (en) *	1994-03-25	1996-11-26	The Dupont Merck Pharmaceutical Company	2-carbocyclic and 2-heterocyclic quinoline-4-carboxylic acids and salts thereof useful as immunosuppressive agents
US6172084B1 (en)	1997-06-19	2001-01-09	Sepracor, Inc.	Quinoline-indole antimicrobial agents, uses and compositions related thereto
US6103905A (en) *	1997-06-19	2000-08-15	Sepracor, Inc.	Quinoline-indole antimicrobial agents, uses and compositions related thereto
US6376670B1 (en)	1997-06-19	2002-04-23	Sepracor Inc.	Quinoline-indole antimicrobial agents, uses and compositions related thereto
US6207679B1 (en)	1997-06-19	2001-03-27	Sepracor, Inc.	Antimicrobial agents uses and compositions related thereto
BRPI0519012A2 (pt) *	2004-12-13	2008-12-23	Ono Pharmaceutical Co	derivado do Ácido aminocarboxÍlico e seu uso medicinal
WO2014070769A1 (en)	2012-10-29	2014-05-08	The University Of North Carolina At Chapel Hill	Methods and compositions for treating mucosal tissue disorders
EP3071199A2 (de)	2013-11-22	2016-09-28	Genzyme Corporation	Neuartiges verfahren zur behandlung neurodegenerativer erkrankungen
KR20230117644A (ko)	2016-11-17	2023-08-08	레노비온, 아이엔씨.	글루타티온 조성물에 의한 호흡기 질환 및 감염 치료
ES3008699T3 (en)	2017-11-17	2025-03-24	Renovion Inc	Stable ascorbic acid compositions and methods of using the same
IL313997A (en)	2022-01-04	2024-08-01	Renovion Inc	Aqueous solution including glutathione salt

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4181725A (en) *	1977-05-02	1980-01-01	The Regents Of The University Of Michigan	Method for alleviating psoriasis
DE3483704D1 (de) *	1983-07-22	1991-01-17	Du Pont	Phenylchinolinsaeure und derivate als antitumormittel.
US4680299A (en) *	1984-04-30	1987-07-14	E.I. Du Pont De Nemours And Company	2-phenyl-4-quinolinecarboxylic acids and pharmaceutical compositions thereof
US4889862A (en) *	1986-08-28	1989-12-26	E. I. Du Pont De Nemours And Company	Freeze-dried pharmaceutical compositions of phenylquinoline carboxylic acids

1988
- 1988-04-26 US US07/186,242 patent/US4861783A/en not_active Expired - Fee Related
1989
- 1989-04-20 ES ES89107098T patent/ES2053856T3/es not_active Expired - Lifetime
- 1989-04-20 DE DE8989107098T patent/DE68904462T2/de not_active Expired - Fee Related
- 1989-04-20 AT AT89107098T patent/ATE84716T1/de not_active IP Right Cessation
- 1989-04-20 EP EP89107098A patent/EP0339484B1/de not_active Expired - Lifetime
- 1989-04-21 CA CA000597449A patent/CA1336263C/en not_active Expired - Fee Related
- 1989-04-24 AU AU33318/89A patent/AU610469B2/en not_active Ceased
- 1989-04-24 PT PT90362A patent/PT90362B/pt not_active IP Right Cessation
- 1989-04-24 IL IL90056A patent/IL90056A/xx not_active IP Right Cessation
- 1989-04-25 KR KR1019890005406A patent/KR0124817B1/ko not_active Expired - Fee Related
- 1989-04-25 DK DK199789A patent/DK199789A/da not_active Application Discontinuation
- 1989-04-25 IE IE132989A patent/IE64285B1/en not_active IP Right Cessation
- 1989-04-25 JP JP1103585A patent/JP2650756B2/ja not_active Expired - Lifetime
- 1989-04-26 MY MYPI89000546A patent/MY104006A/en unknown
- 1989-04-26 ZA ZA893086A patent/ZA893086B/xx unknown
- 1989-04-26 NZ NZ228894A patent/NZ228894A/en unknown

Also Published As

Publication number	Publication date
PT90362B (pt)	1994-07-29
KR900016135A (ko)	1990-11-12
IL90056A0 (en)	1989-12-15
AU610469B2 (en)	1991-05-16
NZ228894A (en)	1992-02-25
KR0124817B1 (ko)	1997-11-25
DK199789D0 (da)	1989-04-25
IL90056A (en)	1993-04-04
AU3331889A (en)	1989-11-02
IE64285B1 (en)	1995-07-26
DK199789A (da)	1989-10-27
ES2053856T3 (es)	1994-08-01
EP0339484A1 (de)	1989-11-02
EP0339484B1 (de)	1993-01-20
US4861783A (en)	1989-08-29
JPH0272163A (ja)	1990-03-12
CA1336263C (en)	1995-07-11
PT90362A (pt)	1989-11-10
ATE84716T1 (de)	1993-02-15
JP2650756B2 (ja)	1997-09-03
MY104006A (en)	1993-10-30
DE68904462D1 (de)	1993-03-04
DE68904462T2 (de)	1993-05-13
IE891329L (en)	1989-10-26

Publication	Publication Date	Title
ZA893086B (en)	1990-12-28	4-quinoline carboxylic acid derivatives useful for treating skin and muco-epithelial disease
RU92016445A (ru)	1996-11-10	Применение амидов изоксазол-4-карбоновой кислоты и амидов гидроксиалкилиденциануксусной кислоты
MA21682A1 (fr)	1990-07-01	Procede de preparation d'agents therapeutiques derives de la quainclidine.
AU2080988A (en)	1989-01-30	Esters of 13-trans-retinoic acid
AU1808488A (en)	1988-12-06	Compounds for the treatment of alzheimer's disease
AU1331588A (en)	1988-09-29	Method for treatment of alcohol abuse
AU8091787A (en)	1988-05-12	The use of paroxetine to treat pain
AU4759390A (en)	1990-06-26	Method of medical treatment of alzheimer's disease
KR0148213B1 (en)	1998-08-17	Phenyla lkan(en)oic acid and pharmaceutical composition comprising the same
IT8721115A0 (it)	1987-06-30	Fitopreparato per la cura di affezioni cutanee.
IL98387A0 (en)	1992-07-15	Pyridyl-benzoic acid derivatives for treating leukotriene-related diseases
GR3006674T3 (de)	1993-06-30
ZA895959B (en)	1990-04-25	New 6-fluoro-3,5-dihydroxy carboxylic acids and derivatives thereof,a process for the preparation thereof,the use thereof as medicinal agents,pharmaceutical products and intermediates
ATE183088T1 (de)	1999-08-15	Arzneimittel zur behandlung von hauterkrankungen
RU94011321A (ru)	1996-01-20	Способ профилактики и лечения заболеваний кожи
NO893256L (no)	1990-02-16	Fremgangsmaate for fremstilling av furyltiazolderivater.
CS22891A2 (en)	1991-09-15	Application of benzylphosphonic acid's derivatives for treatment of virusinduced diseases
NO168825C (no)	1992-04-08	Analogifremgangsmaate for fremstilling av terapeutisk aktive 3-pyrrolidinyltio-1-azabicyklo (3.2.0) hept-2-en-2-karboksylsyrederivater
EP0274892A3 (en)	1988-08-10	Method of killing weeds comprising the use of diflufenican
AU1162788A (en)	1988-08-18	Oxime-ethers of 2,6-dioxobicyclo-(3.3.0)octanones for treatment of heart and circulation diseases
AU2564188A (en)	1989-05-18	Agent for the treatment of heart disease
OA09790A (en)	1994-04-15	"Paromomycin or its derivatives or salts thereof for parenteral treatment of human parasitic diseases".
PH25092A (en)	1991-02-19	A method of preventing and treating renal diseases
IT8919215A0 (it)	1989-01-27	Dispositivo per la cura chirurgica dell'ametropia.
EG19465A (en)	1995-04-30	Process for the production of basically substituted benzylphthalazone derivatives and acid addition salts thereof.