ZA893087B - 4-quinoline carboxylic acid derivatives useful as immunosuppressive agents - Google Patents

4-quinoline carboxylic acid derivatives useful as immunosuppressive agents

Info

Publication number: ZA893087B
Authority: ZA; South Africa
Prior art keywords: carboxylic acid; acid derivatives; immunosuppressive agents; derivatives useful; quinoline carboxylic
Prior art date: 1988-04-26

Application number

ZA893087A

Other languages

English (en)

Inventor

Neil Richard Ackerman

Richard Ackerman Neil

Bruce Donald Jaffee

Donald Jaffee Bruce

Scott Edward Loveless

Edward Loveless Scott

Russell Howard Neubauer

Howard Neubauer Russell

Original Assignee

Du Pont

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-04-26

Filing date

1989-04-26

Publication date

1990-12-28

1989-04-26 Application filed by Du Pont filed Critical Du Pont

1990-12-28 Publication of ZA893087B publication Critical patent/ZA893087B/xx

Links

VQMSRUREDGBWKT-UHFFFAOYSA-N quinoline-4-carboxylic acid Chemical class C1=CC=C2C(C(=O)O)=CC=NC2=C1 VQMSRUREDGBWKT-UHFFFAOYSA-N 0.000 title abstract 2
229940125721 immunosuppressive agent Drugs 0.000 title 1
239000003018 immunosuppressive agent Substances 0.000 title 1
208000023275 Autoimmune disease Diseases 0.000 abstract 1
229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
239000002260 anti-inflammatory agent Substances 0.000 abstract 1
208000037976 chronic inflammation Diseases 0.000 abstract 1
208000037893 chronic inflammatory disorder Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
208000024908 graft versus host disease Diseases 0.000 abstract 1
230000002519 immonomodulatory effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
238000002054 transplantation Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Immunology (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Transplantation (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)

ZA893087A 1988-04-26 1989-04-26 4-quinoline carboxylic acid derivatives useful as immunosuppressive agents ZA893087B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/186,243 US4968701A (en)	1988-04-26	1988-04-26	4-Quinoline carboxylic acid derivatives useful as immunosuppressive agents

Publications (1)

Publication Number	Publication Date
ZA893087B true ZA893087B (en)	1990-12-28

Family

ID=22684181

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA893087A ZA893087B (en)	1988-04-26	1989-04-26	4-quinoline carboxylic acid derivatives useful as immunosuppressive agents

Country Status (13)

Country	Link
US (1)	US4968701A (fr)
EP (1)	EP0339485B1 (fr)
JP (1)	JP2650757B2 (fr)
KR (1)	KR0134376B1 (fr)
AT (1)	ATE87480T1 (fr)
CA (1)	CA1333155C (fr)
DE (1)	DE68905642T2 (fr)
DK (1)	DK170414B1 (fr)
IE (1)	IE64760B1 (fr)
IL (1)	IL90055A (fr)
MY (1)	MY106038A (fr)
PT (1)	PT90363B (fr)
ZA (1)	ZA893087B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5102883A (en) *	1989-10-31	1992-04-07	Du Pont Merck Pharmaceutical Company	Pyrimidine biosynthesis inhibitors useful as immunosuppressive agents
US5204329A (en) *	1990-06-11	1993-04-20	Du Pont Merck Pharmaceutical Company	Treatment of organ transplantation rejection
US5135934A (en) *	1990-07-06	1992-08-04	Du Pont Merck Pharmaceutical Company	3-phenyl-5,6-dihydrobenz(c) acridine-7-carboxylic acids and related compounds as immunosuppressive agents
MX9200299A (es) *	1991-02-07	1992-12-01	Roussel Uclaf	Nuevos derivados biciclicos nitrogenados, su procedimiento de preparacion los nuevos compuestos intermedios obtenidos su aplicacion como medicamentos y las composiciones farmaceuticas que los contienen.
US6004979A (en) *	1991-02-07	1999-12-21	Hoechst Marion Roussel	Nitrogenous bicycles
US6077823A (en) *	1991-03-11	2000-06-20	Creative Biomolecules, Inc.	Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury
US6194376B1 (en)	1991-03-11	2001-02-27	Creative Biomolecules, Inc.	Method for modulating inflammatory response comprising administering morphogen
TW232013B (fr) *	1992-04-24	1994-10-11	Takeda Pharm Industry Co Ltd
US5409886A (en) *	1993-02-18	1995-04-25	Mitsui Toatsu Chemicals, Incorporated	3-pyrroline-2-one derivatives and herbicidal compositions containing same
US5428040A (en) *	1993-08-31	1995-06-27	The Du Pont Merck Pharmaceutical Company	Carbocyclic fused-ring quinolinecarboxylic acids useful as immunosuppressive agents
US5578609A (en) *	1994-03-25	1996-11-26	The Dupont Merck Pharmaceutical Company	2-carbocyclic and 2-heterocyclic quinoline-4-carboxylic acids and salts thereof useful as immunosuppressive agents
EP0830133A1 (fr) *	1995-04-28	1998-03-25	Takeda Chemical Industries, Ltd.	Composition therapeutique destinee a traiter l'arthrite
AU2896097A (en) *	1996-05-10	1997-12-05	Novartis Ag	Use of brequinar and derivatives in chronic rejection of allografts and xenotransplantation
DK0825186T3 (da) *	1996-08-16	2002-07-22	Pfizer	2-aminobenzazepinderivater og deres anvendelse til behandling af immunosuppression
US6207679B1 (en)	1997-06-19	2001-03-27	Sepracor, Inc.	Antimicrobial agents uses and compositions related thereto
US6103905A (en) *	1997-06-19	2000-08-15	Sepracor, Inc.	Quinoline-indole antimicrobial agents, uses and compositions related thereto
AU757059B2 (en)	1997-06-19	2003-01-30	Sepracor, Inc.	Quinoline-indole antimicrobial agents, uses and compositions related thereto
US6376670B1 (en)	1997-06-19	2002-04-23	Sepracor Inc.	Quinoline-indole antimicrobial agents, uses and compositions related thereto
AU2108099A (en) *	1998-01-30	1999-08-16	Procept, Inc.	Immunosuppressive agents
CN101056540A (zh)	2004-09-27	2007-10-17	诺维信公司	酶颗粒
WO2015077535A2 (fr)	2013-11-22	2015-05-28	Genzyme Corporation	Nouvelles méthodes pour traiter des maladies neurodégénératives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR6592M (fr) *	1967-10-31	1968-12-30
GB1334705A (en) *	1970-06-19	1973-10-24	Ici Ltd	Pharmaceutical compositions containing kynurenic acid derivatives
CH576447A5 (fr) *	1972-03-10	1976-06-15	Ciba Geigy Ag
US4407803A (en) *	1981-08-17	1983-10-04	Abbott Laboratories	Antiinflammatory 1-(quinolinyl)-2-pyrazoline derivatives
US4680299A (en) *	1984-04-30	1987-07-14	E.I. Du Pont De Nemours And Company	2-phenyl-4-quinolinecarboxylic acids and pharmaceutical compositions thereof
US4625034A (en) *	1985-02-04	1986-11-25	Usv Pharmaceutical Corp.	1,2-Dihydro; 1,2,3,4-tetrahydro; 5,8 dihydro; and 5,6,7,8-tetrahydroquinoline derivatives
US4847381A (en) *	1987-08-31	1989-07-11	American Cyanamid Company	2-Phenyl-4-quinoline carboxylic acids

1988
- 1988-04-26 US US07/186,243 patent/US4968701A/en not_active Expired - Fee Related
1989
- 1989-04-20 AT AT89107099T patent/ATE87480T1/de active
- 1989-04-20 DE DE8989107099T patent/DE68905642T2/de not_active Expired - Fee Related
- 1989-04-20 EP EP89107099A patent/EP0339485B1/fr not_active Expired - Lifetime
- 1989-04-24 IL IL90055A patent/IL90055A/xx not_active IP Right Cessation
- 1989-04-24 PT PT90363A patent/PT90363B/pt not_active IP Right Cessation
- 1989-04-24 KR KR1019890005349A patent/KR0134376B1/ko not_active Expired - Fee Related
- 1989-04-25 DK DK200289A patent/DK170414B1/da not_active IP Right Cessation
- 1989-04-25 JP JP1103586A patent/JP2650757B2/ja not_active Expired - Lifetime
- 1989-04-25 IE IE132889A patent/IE64760B1/en not_active IP Right Cessation
- 1989-04-26 CA CA000597842A patent/CA1333155C/fr not_active Expired - Fee Related
- 1989-04-26 ZA ZA893087A patent/ZA893087B/xx unknown
- 1989-04-26 MY MYPI89000544A patent/MY106038A/en unknown

Also Published As

Publication number	Publication date
IL90055A (en)	1993-05-13
PT90363B (pt)	1994-08-31
CA1333155C (fr)	1994-11-22
IL90055A0 (en)	1989-12-15
AU628045B2 (en)	1992-09-10
MY106038A (en)	1994-03-31
DE68905642D1 (de)	1993-05-06
IE891328L (en)	1989-10-26
DE68905642T2 (de)	1993-08-12
ATE87480T1 (de)	1993-04-15
EP0339485A1 (fr)	1989-11-02
KR900016137A (ko)	1990-11-12
IE64760B1 (en)	1995-09-06
DK200289A (da)	1989-10-27
AU3332189A (en)	1989-11-02
PT90363A (pt)	1989-11-10
JPH01313428A (ja)	1989-12-18
KR0134376B1 (ko)	1998-04-21
DK170414B1 (da)	1995-08-28
JP2650757B2 (ja)	1997-09-03
EP0339485B1 (fr)	1993-03-31
US4968701A (en)	1990-11-06
DK200289D0 (da)	1989-04-25

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