ZA89389B - Use of 1,4-disubstituted-piperidinyl compounds in the manufacture of a medicament for the treatment of insomnia - Google Patents

Use of 1,4-disubstituted-piperidinyl compounds in the manufacture of a medicament for the treatment of insomnia

Info

Publication number
ZA89389B
ZA89389B ZA89389A ZA89389A ZA89389B ZA 89389 B ZA89389 B ZA 89389B ZA 89389 A ZA89389 A ZA 89389A ZA 89389 A ZA89389 A ZA 89389A ZA 89389 B ZA89389 B ZA 89389B
Authority
ZA
South Africa
Prior art keywords
insomnia
disubstituted
treatment
medicament
manufacture
Prior art date
Application number
ZA89389A
Other languages
English (en)
Inventor
Paul J Schechter
J Schechter Paul
John M Orwin
M Orwin John
Christian K Hinze
K Hinze Christian
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of ZA89389B publication Critical patent/ZA89389B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F02—COMBUSTION ENGINES; HOT-GAS OR COMBUSTION-PRODUCT ENGINE PLANTS
    • F02D—CONTROLLING COMBUSTION ENGINES
    • F02D45/00—Electrical control not provided for in groups F02D41/00 - F02D43/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Anesthesiology (AREA)
  • Combustion & Propulsion (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA89389A 1988-01-21 1989-01-17 Use of 1,4-disubstituted-piperidinyl compounds in the manufacture of a medicament for the treatment of insomnia ZA89389B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP88400131A EP0325063B1 (fr) 1988-01-21 1988-01-21 Utilisation des composés piperidinyliques 1,4-disubstitués pour la manufacture d'un médicament pour le traitement de l'insomnie

Publications (1)

Publication Number Publication Date
ZA89389B true ZA89389B (en) 1989-10-25

Family

ID=8200343

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA89389A ZA89389B (en) 1988-01-21 1989-01-17 Use of 1,4-disubstituted-piperidinyl compounds in the manufacture of a medicament for the treatment of insomnia

Country Status (10)

Country Link
US (1) US4908369A (fr)
EP (1) EP0325063B1 (fr)
JP (1) JP2852933B2 (fr)
KR (1) KR890011596A (fr)
AT (1) ATE102482T1 (fr)
AU (1) AU610972B2 (fr)
DE (1) DE3888340T2 (fr)
DK (1) DK26289A (fr)
IE (1) IE62992B1 (fr)
ZA (1) ZA89389B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6004980A (en) * 1990-06-01 1999-12-21 Merrell Pharmaceuticals, Inc. (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol
KR100211713B1 (ko) * 1990-06-01 1999-08-02 슈테펜 엘. 네스비트 (+)-알파-(2,3-디메톡시페닐)-1-[2-(4-플루오로페닐)에틸]-4-피페리딘메탄올
EP0796619A1 (fr) 1996-03-21 1997-09-24 Merrell Pharmaceuticals Inc. Utilisation de (+)-alpha-(2,3-diméthoxyphényle)-1-(2-(4-fluorophényle)éthyle)-4-pipéridineméthanol pour le traitement des troubles dépressifs et bipolaires
US6028083A (en) * 1997-07-25 2000-02-22 Hoechst Marion Roussel, Inc. Esters of (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol
US6713627B2 (en) 1998-03-13 2004-03-30 Aventis Pharmaceuticals Inc. Processes for the preparation of (R)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol
US20050261341A1 (en) * 1998-03-13 2005-11-24 Aventis Pharmaceuticals Inc. Novel processes for the preparation of (R)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol
US6939879B2 (en) * 1998-08-28 2005-09-06 Aventis Pharmaceuticals Inc. Use of R (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol for the treatment of substance induced insomnia
US6277864B1 (en) 1998-08-28 2001-08-21 Aventis Pharmaceuticals Inc. Use of R- +)-α-(2,3-dimethoxyphenyl-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol for the treatment of sleep disorders
HRP20080389A2 (hr) * 1998-08-28 2008-11-30 Aventis Pharmaceuticals Inc. UPOTREBA R-(+)-α-(2,3-DIMETOKSIFENIL)-1-[2-(4-FLUORFENIL)ETIL]-4-PIPERIDINMETANOLA ZA LIJEČENJE POREMEĆAJA SPAVANJA
US6465490B1 (en) 1999-07-16 2002-10-15 Aventis Pharmaceuticals Inc. Sulfuric acid mono-[3({1-[2-(4-fluoro-phenyl)-ethyl]-piperidin-4-yl}-hydroxy-methyl)-2-methoxy-phenyl]ester
NZ521576A (en) * 2000-02-29 2005-06-24 Mitsubishi Pharma Corp Novel cyclic amide derivatives
US20020099076A1 (en) * 2000-05-25 2002-07-25 Richard Scheyer D. Use of (+)-a-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol or its prodrug in the treatment of symptoms of dementia and dopamine induced psychosis
US20050261278A1 (en) 2004-05-21 2005-11-24 Weiner David M Selective serotonin receptor inverse agonists as therapeutics for disease
WO2012012542A1 (fr) 2010-07-20 2012-01-26 Cyrenaic Pharmaceuticals, Inc. Méthodes d'utilisation de dérivés d'amide cyclique pour traiter la schizophrénie
ES2910528T3 (es) 2014-12-02 2022-05-12 Minerva Neurosciences Inc Composiciones que comprenden 2-((1-(2(4-fluorofenil)-2-oxoetil)piperidin-4-il)metil)isoindolin-1-ona para tratar la esquizofrenia
IL308650B2 (en) 2017-06-21 2025-08-01 Minerva Neurosciences Inc Gastro-resistant controlled release oral dosage forms
KR102886241B1 (ko) 2018-08-21 2025-11-14 미쓰비시 타나베 파마 코퍼레이션 음성 증상 및 장애를 치료하고, 신경가소성을 증가시키고, 신경보호를 촉진시키기 위한 롤루페리돈의 용도

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1280421C (fr) * 1985-07-02 1991-02-19 Albert A. Carr Derives piperidinyl disubstitutes en 1,4

Also Published As

Publication number Publication date
DK26289D0 (da) 1989-01-20
KR890011596A (ko) 1989-08-21
JP2852933B2 (ja) 1999-02-03
IE890177L (en) 1989-07-21
JPH01279832A (ja) 1989-11-10
AU610972B2 (en) 1991-05-30
AU2868689A (en) 1989-07-27
DK26289A (da) 1989-07-22
DE3888340D1 (de) 1994-04-14
DE3888340T2 (de) 1994-06-30
EP0325063A1 (fr) 1989-07-26
US4908369A (en) 1990-03-13
IE62992B1 (en) 1995-03-08
ATE102482T1 (de) 1994-03-15
EP0325063B1 (fr) 1994-03-09

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