ZA894678B - Condensed pyrazole 3-oxo-propanenitrile derivatives and process for their preparation - Google Patents

Condensed pyrazole 3-oxo-propanenitrile derivatives and process for their preparation

Info

Publication number: ZA894678B
Authority: ZA; South Africa
Prior art keywords: oxo; group; preparation; agents; condensed pyrazole
Prior art date: 1988-06-20

Application number

ZA894678A

Other languages

English (en)

Inventor

Gianfederico Doria

Doria Gianfederico

Anna Maria Isetta

Maria Isetta Anna

Mario Ferrari

Ferrari Mario

Domenico Trizio

Trizio Domenico

Original Assignee

Farmitalia Darlo Erba S R L

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-06-20

Filing date

1989-06-20

Publication date

1991-02-27

1989-06-20 Application filed by Farmitalia Darlo Erba S R L filed Critical Farmitalia Darlo Erba S R L

1991-02-27 Publication of ZA894678B publication Critical patent/ZA894678B/xx

Links

JHKHZUNDFBNXET-UHFFFAOYSA-N 3-oxopropanenitrile;1h-pyrazole Chemical class C=1C=NNC=1.O=CCC#N JHKHZUNDFBNXET-UHFFFAOYSA-N 0.000 title abstract 2
239000003795 chemical substances by application Substances 0.000 abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
125000006828 (C2-C7) alkoxycarbonyl group Chemical group 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
208000037581 Persistent Infection Diseases 0.000 abstract 1
230000001154 acute effect Effects 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
230000001580 bacterial effect Effects 0.000 abstract 1
230000003115 biocidal effect Effects 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
230000002519 immonomodulatory effect Effects 0.000 abstract 1
239000003022 immunostimulating agent Substances 0.000 abstract 1
230000001613 neoplastic effect Effects 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000003612 virological effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Immunology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Cosmetics (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Steroid Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

ZA894678A 1988-06-20 1989-06-20 Condensed pyrazole 3-oxo-propanenitrile derivatives and process for their preparation ZA894678B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB888814587A GB8814587D0 (en)	1988-06-20	1988-06-20	Condensed pyrazole 3-oxo-propanenitrile derivatives & process for their preparation

Publications (1)

Publication Number	Publication Date
ZA894678B true ZA894678B (en)	1991-02-27

Family

ID=10638992

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA894678A ZA894678B (en)	1988-06-20	1989-06-20	Condensed pyrazole 3-oxo-propanenitrile derivatives and process for their preparation

Country Status (21)

Country	Link
US (1)	US5424308A (cs)
EP (2)	EP0347773B1 (cs)
JP (1)	JPH03505205A (cs)
KR (1)	KR900701756A (cs)
CN (1)	CN1022322C (cs)
AT (1)	ATE88700T1 (cs)
AU (1)	AU634966B2 (cs)
CZ (1)	CZ284336B6 (cs)
DE (1)	DE68906200T2 (cs)
DK (1)	DK163581C (cs)
ES (1)	ES2054930T3 (cs)
GB (1)	GB8814587D0 (cs)
HU (1)	HU206872B (cs)
IE (1)	IE63189B1 (cs)
IL (1)	IL90552A (cs)
NZ (1)	NZ229450A (cs)
PT (1)	PT90905B (cs)
RU (1)	RU2109735C1 (cs)
WO (1)	WO1989012630A1 (cs)
YU (1)	YU46937B (cs)
ZA (1)	ZA894678B (cs)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8907799D0 (en) *	1989-04-06	1989-05-17	Erba Carlo Spa	Heteroaryl-3-oxo-propanenitrile derivatives useful in the treatment of rheumatoid arthritis and other autoimmune diseases
US5260328A (en) *	1989-04-06	1993-11-09	Farmitalia Carlo Erba Srl	Phenyl-indenopurazol 3-oxo-propanamide derivatives useful in the treatment of rheumatoid arthritis
GB8916290D0 (en) *	1989-07-17	1989-08-31	Erba Carlo Spa	Heteroaryl-3-oxo-propanenitrile derivatives useful in stimulating myelopoiesis
US5466823A (en) *	1993-11-30	1995-11-14	G.D. Searle & Co.	Substituted pyrazolyl benzenesulfonamides
US6492411B1 (en)	1993-11-30	2002-12-10	G. D. Searle & Co.	Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation
CA2277954A1 (en) *	1993-11-30	1995-06-08	G.D. Searle & Co.	Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation
US6716991B1 (en)	1993-11-30	2004-04-06	G. D. Searle & Co.	Process for preparing a substituted pyrazolyl benzenesulfonamide for the treatment of inflammation
US5547975A (en) *	1994-09-20	1996-08-20	Talley; John J.	Benzopyranopyrazolyl derivatives for the treatment of inflammation
US5886016A (en) *	1995-09-15	1999-03-23	G.D. Searle & Co.	Benzopyranopyrazolyl derivatives for the treatment of inflammation
US5756529A (en) *	1995-09-29	1998-05-26	G.D. Searle & Co.	Substituted pyrazolyl benzenesulfonamides for use in veterinary therapies
GB9716103D0 (en) *	1997-07-30	1997-10-01	Pharmacia & Upjohn Spa	Condensed heterocyclic compounds
CA2460939C (en)	2001-09-19	2008-07-29	Pharmacia Corporation	Substituted pyrazolyl compounds for the treatment of inflammation
JP2005507892A (ja)	2001-09-19	2005-03-24	ファルマシア・コーポレーション	炎症の治療のための置換されたピラゾリルベンゼンスルファミド化合物
EP1444207A2 (en)	2001-09-19	2004-08-11	Pharmacia Corporation	Substituted pyrazolyl-compounds for the treatment of inflammation
CN114718407A (zh) *	2022-03-01	2022-07-08	东风柳州汽车有限公司	车窗控制方法、装置、设备及存储介质

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2989538A (en) *	1960-02-10	1961-06-20	Smith Kline French Lab	Process for preparing pyrazoloindenone hydrazones
US3004983A (en) *	1960-05-16	1961-10-17	Smith Kline French Lab	4-aminopyrazolo [3, 4-a] indene derivatives
US4140785A (en) *	1978-05-08	1979-02-20	E. I. Du Pont De Nemours And Company	N-(benzothienopyrazol)amide antirhinoviral agents
US4173634A (en) *	1979-02-23	1979-11-06	E. R. Squibb & Sons, Inc.	Basically-substituted tricyclic pyrazoles useful as antiinflammatory agents
US4431657A (en) *	1982-05-24	1984-02-14	Ayerst, Mckenna & Harrison Inc.	Analgesic compositions consisting of 2H-benzothieno[3,2-c]pyrazol-3-amine derivatives
US4420476A (en) *	1982-05-24	1983-12-13	Averst McKenna & Harrison, Inc.	Benzofuro[3,2-c]pyrazol-3-amine derivatives
US4816467A (en) *	1987-01-09	1989-03-28	Farmitalia Carlo Erba S.R.L	Heteroaryl 3-oxo-propanenitrile derivatives, pharmaceutical compositions and use
EP0362216A1 (en) *	1987-04-09	1990-04-11	E.I. Du Pont De Nemours And Company	Insecticidal substituted indazoles
GB8814586D0 (en) *	1988-06-20	1988-07-27	Erba Carlo Spa	Tricyclic 3-oxo-propanenitrile derivatives & process for their preparation
GB8916290D0 (en) *	1989-07-17	1989-08-31	Erba Carlo Spa	Heteroaryl-3-oxo-propanenitrile derivatives useful in stimulating myelopoiesis

1988
- 1988-06-20 GB GB888814587A patent/GB8814587D0/en active Pending
1989
- 1989-06-07 IL IL9055289A patent/IL90552A/en not_active IP Right Cessation
- 1989-06-08 NZ NZ229450A patent/NZ229450A/xx unknown
- 1989-06-16 WO PCT/EP1989/000682 patent/WO1989012630A1/en not_active Ceased
- 1989-06-16 AT AT89110986T patent/ATE88700T1/de not_active IP Right Cessation
- 1989-06-16 EP EP89110986A patent/EP0347773B1/en not_active Expired - Lifetime
- 1989-06-16 ES ES89110986T patent/ES2054930T3/es not_active Expired - Lifetime
- 1989-06-16 US US07/635,157 patent/US5424308A/en not_active Expired - Fee Related
- 1989-06-16 JP JP1506679A patent/JPH03505205A/ja active Pending
- 1989-06-16 DE DE8989110986T patent/DE68906200T2/de not_active Expired - Fee Related
- 1989-06-16 AU AU37692/89A patent/AU634966B2/en not_active Ceased
- 1989-06-16 HU HU894019A patent/HU206872B/hu not_active IP Right Cessation
- 1989-06-16 EP EP89907133A patent/EP0422051A1/en active Pending
- 1989-06-16 RU SU4894213A patent/RU2109735C1/ru active
- 1989-06-19 PT PT90905A patent/PT90905B/pt active IP Right Grant
- 1989-06-19 YU YU125489A patent/YU46937B/sh unknown
- 1989-06-19 CZ CS893701A patent/CZ284336B6/cs not_active IP Right Cessation
- 1989-06-19 IE IE198289A patent/IE63189B1/en not_active IP Right Cessation
- 1989-06-20 CN CN89104203A patent/CN1022322C/zh not_active Expired - Fee Related
- 1989-06-20 ZA ZA894678A patent/ZA894678B/xx unknown
1990
- 1990-02-19 KR KR1019900700337A patent/KR900701756A/ko not_active Ceased
- 1990-12-19 DK DK300890A patent/DK163581C/da active

Also Published As

Publication number	Publication date
RU2109735C1 (ru)	1998-04-27
ATE88700T1 (de)	1993-05-15
JPH03505205A (ja)	1991-11-14
DK163581C (da)	1992-08-10
YU46937B (sh)	1994-06-24
EP0422051A1 (en)	1991-04-17
YU125489A (en)	1991-04-30
CN1022322C (zh)	1993-10-06
KR900701756A (ko)	1990-12-04
EP0347773A1 (en)	1989-12-27
IE63189B1 (en)	1995-03-22
IL90552A0 (en)	1990-01-18
DK300890D0 (da)	1990-12-19
CZ370189A3 (cs)	1998-07-15
PT90905B (pt)	1994-12-30
US5424308A (en)	1995-06-13
WO1989012630A1 (en)	1989-12-28
AU3769289A (en)	1990-01-12
EP0347773B1 (en)	1993-04-28
DE68906200D1 (de)	1993-06-03
PT90905A (pt)	1989-12-29
HU894019D0 (en)	1991-06-28
CN1038642A (zh)	1990-01-10
DK300890A (da)	1991-02-20
HUT56076A (en)	1991-07-29
AU634966B2 (en)	1993-03-11
HU206872B (en)	1993-01-28
GB8814587D0 (en)	1988-07-27
IL90552A (en)	1994-08-26
ES2054930T3 (es)	1994-08-16
DK163581B (da)	1992-03-16
DE68906200T2 (de)	1993-08-05
CZ284336B6 (cs)	1998-10-14
NZ229450A (en)	1990-08-28

Publication	Publication Date	Title
GB8814587D0 (en)	1988-07-27	Condensed pyrazole 3-oxo-propanenitrile derivatives & process for their preparation
AU589427B2 (en)	1989-10-12	Pyridonecarboxylic acid derivatives and process for their preparation
HU908076D0 (en)	1991-06-28	Process for producing amino acid derivatives
HU900228D0 (en)	1990-03-28	Process for preparation of pyrazolo-pyridines
PH27219A (en)	1993-05-04	Pyrimidine derivatives
AU658175B2 (en)	1995-04-06	Use of 2-iminothiazolidin-4-one derivatives as novel pharmaceutical active ingredients
AU1120688A (en)	1988-08-04	- 8-heterocyclo-ergoline derivatives useful in the treatment of extrapyramidal syndromes
MY111630A (en)	2000-10-31	Amino acid derivatives.