ZA895842B - Antischizophrenic-s-n-(1-azabicyclo(2.2.2)oct-3-yl)benzamides and thiobenzamides - Google Patents

Antischizophrenic-s-n-(1-azabicyclo(2.2.2)oct-3-yl)benzamides and thiobenzamides

Info

Publication number: ZA895842B
Authority: ZA; South Africa
Prior art keywords: chem; general formula; antischizophrenic; azabicyclo; oct
Prior art date: 1988-08-04

Application number

ZA895842A

Other languages

English (en)

Inventor

Robert John Naylor

John Naylor Robert

Brenda Naylor

Naylor Brenda

Alain Renaud

Renaud Alain

Michel Langlois

Langlois Michel

Original Assignee

Robins Co Inc A H

Delalande Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-08-04

Filing date

1989-07-31

Publication date

1991-03-27

1989-07-31 Application filed by Robins Co Inc A H, Delalande Sa filed Critical Robins Co Inc A H

1991-03-27 Publication of ZA895842B publication Critical patent/ZA895842B/xx

Links

229940054066 benzamide antipsychotics Drugs 0.000 title 1
150000003936 benzamides Chemical class 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
150000001204 N-oxides Chemical class 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000005864 Sulphur Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
-1 amino, methylamino Chemical group 0.000 abstract 1
230000002932 anti-schizophrenic effect Effects 0.000 abstract 1
239000000164 antipsychotic agent Substances 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Neurosurgery (AREA)
General Chemical & Material Sciences (AREA)
Psychiatry (AREA)
Neurology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

ZA895842A 1988-08-04 1989-07-31 Antischizophrenic-s-n-(1-azabicyclo(2.2.2)oct-3-yl)benzamides and thiobenzamides ZA895842B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP88402042A EP0353372B1 (de)	1988-08-04	1988-08-04	Antischizophren-wirksame S-N-(1-azabicyclo [2.2.2.]oct-3-yl)Benzamide und Thiobenzamide

Publications (1)

Publication Number	Publication Date
ZA895842B true ZA895842B (en)	1991-03-27

Family

ID=8200415

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA895842A ZA895842B (en)	1988-08-04	1989-07-31	Antischizophrenic-s-n-(1-azabicyclo(2.2.2)oct-3-yl)benzamides and thiobenzamides

Country Status (11)

Country	Link
US (1)	US5025022A (de)
EP (1)	EP0353372B1 (de)
JP (1)	JPH02104529A (de)
KR (1)	KR900002777A (de)
AT (1)	ATE85217T1 (de)
AU (1)	AU615323B2 (de)
DE (1)	DE3878235T2 (de)
DK (1)	DK382089A (de)
IL (1)	IL91217A0 (de)
PH (1)	PH25426A (de)
ZA (1)	ZA895842B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0353371A1 (de) *	1988-08-04	1990-02-07	Synthelabo	Steigerung der Gedächtnisleistung durch R-N-(1-azabicyclo[2.2.2]oct-3-yl)Benzamide und Thiobenzamide
US5723103A (en) *	1994-12-09	1998-03-03	Vanderbilt University	Substituted benzamides and radioligand analogs and methods of use
US6492385B2 (en)	2000-08-18	2002-12-10	Pharmacia & Upjohn Company	Quinuclidine-substituted heteroaryl moieties for treatment of disease
EP1381603A2 (de)	2000-08-18	2004-01-21	PHARMACIA & UPJOHN COMPANY	Mit aryl gruppen substituierte chinuklidine zur behandlung von krankheiten ( nikotin acetylcholin rezeptor liganden )
US6486172B2 (en)	2000-08-18	2002-11-26	Pharmacia & Upjohn Company	Quinuclidine-substituted aryl compounds for treatment of disease
AU2001284646A1 (en)	2000-08-21	2002-03-04	Pharmacia And Upjohn Company	Quinuclidine-substituted heteroaryl moieties for treatment of disease
US6500840B2 (en)	2000-08-21	2002-12-31	Pharmacia & Upjohn Company	Quinuclidine-substituted heteroaryl moieties for treatment of disease
PE20021019A1 (es)	2001-04-19	2002-11-13	Upjohn Co	Grupos azabiciclicos sustituidos
BR0212123A (pt) *	2001-08-24	2004-07-20	Upjohn Co	7-aza[2.2.1]biciclo-heptanos substituìdos com arila para o tratamento de doenças
MXPA04004464A (es) *	2001-11-08	2004-08-11	Upjohn Co	Compuestos de heteroarilo sustituido con azabiciclo para el tratamiento de enfermedades.
JP2005522456A (ja)	2002-02-15	2005-07-28	ファルマシア・アンド・アップジョン・カンパニー・エルエルシー	Ｃｎｓ関連障害治療のためのアザビシクロ置換ベンゾイルアミドおよびチオアミド
WO2003072578A1 (en) *	2002-02-20	2003-09-04	Pharmacia & Upjohn Company	Azabicyclic compounds with alfa7 nicotinic acetylcholine receptor activity
US7176198B2 (en)	2002-08-01	2007-02-13	Pfizer Inc.	1H-pyrazole and 1H-pyrrole-azabicyclic compounds for the treatment of disease
GB0310867D0 (en)	2003-05-12	2003-06-18	Novartis Ag	Organic compounds
WO2010042799A2 (en)	2008-10-09	2010-04-15	Howard Hughes Medical Institute	Novel chimeric ligand-gated ion channels and methods of use thereof
MA37975B2 (fr)	2012-09-11	2021-03-31	Genzyme Corp	Inhibiteurs de synthase de glucosylcéramide
CN104418851A (zh) *	2013-09-02	2015-03-18	上海龙翔生物医药开发有限公司	奎宁环衍生物的制备方法及纯化方法
US12527776B2 (en)	2019-02-04	2026-01-20	Genzyme Corporation	Treatment of ciliopathies using inhibitors of glucosylceramide synthase (GCS)
EP4100009A1 (de)	2020-02-03	2022-12-14	Genzyme Corporation	Verfahren zur behandlung neurologischer symptome im zusammenhang mit lysosomalen speicherkrankheiten
KR20230043024A (ko)	2020-07-24	2023-03-30	젠자임 코포레이션	벤글루스타트를 포함하는 제약 조성물

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2531083B1 (fr) *	1982-06-29	1986-11-28	Sandoz Sa	Nouveaux derives de la piperidine, leur preparation et leur utilisation comme medicaments
FR2529548A1 (fr) *	1982-07-02	1984-01-06	Delalande Sa	Nouveaux derives de l'amino-3 quinuclidine, leur procede et leur application en therapeutique
GB8515845D0 (en) *	1985-06-22	1985-07-24	Beecham Group Plc	Treatment
EP0235878A3 (de) *	1986-01-16	1989-06-14	Beecham Group Plc	Neue Verbindungen
EP0272052B1 (de) *	1986-12-16	1992-07-08	A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation)	Angstlösende N-(1-Azabicyclo[2.2.2)oct-3-yl)benzamide und -thiobenzamide
GB8720805D0 (en) *	1987-09-04	1987-10-14	Naylor R J	2-alkoxy-n-(1-azabicyclo(2 2 2)oct-3-yl)benzamides & thiobenzamides
US4857517A (en) *	1988-02-04	1989-08-15	Rorer Pharmaceutical Corporation	Quinuclidyl benzoxepins as 5-HT3 antagonists
EP0353371A1 (de) *	1988-08-04	1990-02-07	Synthelabo	Steigerung der Gedächtnisleistung durch R-N-(1-azabicyclo[2.2.2]oct-3-yl)Benzamide und Thiobenzamide

1988
- 1988-08-04 DE DE8888402042T patent/DE3878235T2/de not_active Expired - Fee Related
- 1988-08-04 AT AT88402042T patent/ATE85217T1/de not_active IP Right Cessation
- 1988-08-04 EP EP88402042A patent/EP0353372B1/de not_active Expired - Lifetime
1989
- 1989-07-31 ZA ZA895842A patent/ZA895842B/xx unknown
- 1989-08-01 AU AU39178/89A patent/AU615323B2/en not_active Ceased
- 1989-08-01 PH PH39032A patent/PH25426A/en unknown
- 1989-08-03 DK DK382089A patent/DK382089A/da not_active Application Discontinuation
- 1989-08-03 US US07/389,364 patent/US5025022A/en not_active Expired - Fee Related
- 1989-08-03 KR KR1019890011092A patent/KR900002777A/ko not_active Withdrawn
- 1989-08-04 IL IL91217A patent/IL91217A0/xx unknown
- 1989-08-04 JP JP1202711A patent/JPH02104529A/ja active Pending

Also Published As

Publication number	Publication date
AU615323B2 (en)	1991-09-26
KR900002777A (ko)	1990-03-23
DK382089D0 (da)	1989-08-03
DK382089A (da)	1990-02-05
PH25426A (en)	1991-07-01
EP0353372B1 (de)	1993-02-03
AU3917889A (en)	1990-02-08
EP0353372A1 (de)	1990-02-07
ATE85217T1 (de)	1993-02-15
DE3878235D1 (de)	1993-03-18
DE3878235T2 (de)	1993-06-03
JPH02104529A (ja)	1990-04-17
IL91217A0 (en)	1990-07-12
US5025022A (en)	1991-06-18

Publication	Publication Date	Title
PH25426A (en)	1991-07-01	Antischizoprenic-s-n(1-azabicyclo£2.2.2\|oct-3-yl)benzamides, thiobenzamides
AU6601294A (en)	1995-01-12	Amide and urea derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses
AU591640B2 (en)	1989-12-14	Quinolonecarboxylic acid derivatives
NZ232283A (en)	1991-08-27	Substituted imidazo(1,2-b)pyridazine derivatives; pharmaceutical compositions and preparatory processes
EP0612751A3 (en)	1994-09-21	Compounds for the preparation of cephem derivatives.
NO176911C (no)	1995-06-21	Diiodforbindelser for anvendelse ved fremstilling av morfolinylderivater av doxorubicin, og deres fremstilling
IL97429A0 (en)	1992-06-21	Substituted urea compounds,their preparation and pharmaceutical compositions comprising them
AU1312292A (en)	1992-10-01	New thiazolidinone and oxazolidinone derivatives, their preparation and their use as vasodilators
DK492688D0 (da)	1988-09-05	Anvendelse af benzamider
GB8829593D0 (en)	1989-02-08	Novel compounds
DE68927554D1 (de)	1997-01-30	Cephalosporinverbindungen und Verfahren zu ihrer Herstellung
DK0567767T3 (da)	1999-02-01	Krystallinske former af endo-2,3-dihydro-N-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-2-oxo-1H-benzimidazol-1-carboxamid-hydroc
DE68913099D1 (de)	1994-03-24	Amino-substituierte verbrückte azabicyclische Chinoloncarbonsäure und Ester.
AU586089B2 (en)	1989-06-29	Phosphodiesterace type 111 inhibitors having a thiadiazinone ring as part of a tricyclic structure