ZA895842B - Antischizophrenic-s-n-(1-azabicyclo(2.2.2)oct-3-yl)benzamides and thiobenzamides - Google Patents

Antischizophrenic-s-n-(1-azabicyclo(2.2.2)oct-3-yl)benzamides and thiobenzamides

Info

Publication number: ZA895842B
Authority: ZA; South Africa
Prior art keywords: chem; general formula; antischizophrenic; azabicyclo; oct
Prior art date: 1988-08-04

Application number

ZA895842A

Other languages

English (en)

Inventor

Robert John Naylor

John Naylor Robert

Brenda Naylor

Naylor Brenda

Alain Renaud

Renaud Alain

Michel Langlois

Langlois Michel

Original Assignee

Robins Co Inc A H

Delalande Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-08-04

Filing date

1989-07-31

Publication date

1991-03-27

1989-07-31 Application filed by Robins Co Inc A H, Delalande Sa filed Critical Robins Co Inc A H

1991-03-27 Publication of ZA895842B publication Critical patent/ZA895842B/xx

Links

229940054066 benzamide antipsychotics Drugs 0.000 title 1
150000003936 benzamides Chemical class 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
150000001204 N-oxides Chemical class 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000005864 Sulphur Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
-1 amino, methylamino Chemical group 0.000 abstract 1
230000002932 anti-schizophrenic effect Effects 0.000 abstract 1
239000000164 antipsychotic agent Substances 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Psychiatry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

ZA895842A 1988-08-04 1989-07-31 Antischizophrenic-s-n-(1-azabicyclo(2.2.2)oct-3-yl)benzamides and thiobenzamides ZA895842B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP88402042A EP0353372B1 (de)	1988-08-04	1988-08-04	Antischizophren-wirksame S-N-(1-azabicyclo [2.2.2.]oct-3-yl)Benzamide und Thiobenzamide

Publications (1)

Publication Number	Publication Date
ZA895842B true ZA895842B (en)	1991-03-27

Family

ID=8200415

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA895842A ZA895842B (en)	1988-08-04	1989-07-31	Antischizophrenic-s-n-(1-azabicyclo(2.2.2)oct-3-yl)benzamides and thiobenzamides

Country Status (11)

Country	Link
US (1)	US5025022A (de)
EP (1)	EP0353372B1 (de)
JP (1)	JPH02104529A (de)
KR (1)	KR900002777A (de)
AT (1)	ATE85217T1 (de)
AU (1)	AU615323B2 (de)
DE (1)	DE3878235T2 (de)
DK (1)	DK382089A (de)
IL (1)	IL91217A0 (de)
PH (1)	PH25426A (de)
ZA (1)	ZA895842B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0353371A1 (de) *	1988-08-04	1990-02-07	Synthelabo	Steigerung der Gedächtnisleistung durch R-N-(1-azabicyclo[2.2.2]oct-3-yl)Benzamide und Thiobenzamide
US5723103A (en) *	1994-12-09	1998-03-03	Vanderbilt University	Substituted benzamides and radioligand analogs and methods of use
US6486172B2 (en)	2000-08-18	2002-11-26	Pharmacia & Upjohn Company	Quinuclidine-substituted aryl compounds for treatment of disease
US6492385B2 (en)	2000-08-18	2002-12-10	Pharmacia & Upjohn Company	Quinuclidine-substituted heteroaryl moieties for treatment of disease
US6479510B2 (en)	2000-08-18	2002-11-12	Pharmacia & Upjohn Company	Quinuclidine-substituted aryl compounds for treatment of disease
US6599916B2 (en)	2000-08-21	2003-07-29	Pharmacia & Upjohn Company	Quinuclidine-substituted heteroaryl moieties for treatment of disease
WO2002017358A2 (en)	2000-08-21	2002-02-28	Pharmacia & Upjohn Company	Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic acetylcholine receptor antagonists)
PE20021019A1 (es)	2001-04-19	2002-11-13	Upjohn Co	Grupos azabiciclicos sustituidos
EP1419162A1 (de) *	2001-08-24	2004-05-19	Pharmacia & Upjohn Company	Substituierte aryl-7-aza 2,2,1 bicycloheptane zur behandlung von krankheiten
US6919359B2 (en) *	2001-11-08	2005-07-19	Pfizer Inc	Azabicyclic-substituted-heteroaryl compounds for the treatment of disease
US6852716B2 (en)	2002-02-15	2005-02-08	Pfizer Inc	Substituted-aryl compounds for treatment of disease
CA2475773A1 (en) *	2002-02-20	2003-09-04	Pharmacia & Upjohn Company	Azabicyclic compounds with alfa7 nicotinic acetylcholine receptor activity
EP1542999A1 (de)	2002-08-01	2005-06-22	Pharmacia & Upjohn Company LLC	1h-pyrazol- und 1h-pyrrol-azabicyclische verbindungen mit alpha-7-nachr-aktivität
GB0310867D0 (en)	2003-05-12	2003-06-18	Novartis Ag	Organic compounds
EP2344636B1 (de)	2008-10-09	2017-12-06	Howard Hughes Medical Institute	Neue chimäre ligandgesteuerte ionenkanäle und anwendungsverfahren dafür
MA37975B2 (fr)	2012-09-11	2021-03-31	Genzyme Corp	Inhibiteurs de synthase de glucosylcéramide
CN104418851A (zh) *	2013-09-02	2015-03-18	上海龙翔生物医药开发有限公司	奎宁环衍生物的制备方法及纯化方法
CN114040762A (zh)	2019-02-04	2022-02-11	建新公司	使用葡糖神经酰胺合酶(gcs)的抑制剂治疗纤毛疾病
TW202142236A (zh)	2020-02-03	2021-11-16	美商健臻公司	用於治療與溶體儲積症相關的神經症狀之方法
KR20230043024A (ko)	2020-07-24	2023-03-30	젠자임 코포레이션	벤글루스타트를 포함하는 제약 조성물

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI74707C (fi) *	1982-06-29	1988-03-10	Sandoz Ag	Foerfarande foer framstaellning av terapeutiskt anvaendbara alkylenoeverbryggade piperidylestrar eller -amider av bicykliska karboxylsyror.
FR2529548A1 (fr) *	1982-07-02	1984-01-06	Delalande Sa	Nouveaux derives de l'amino-3 quinuclidine, leur procede et leur application en therapeutique
GB8515845D0 (en) *	1985-06-22	1985-07-24	Beecham Group Plc	Treatment
EP0235878A3 (de) *	1986-01-16	1989-06-14	Beecham Group Plc	Neue Verbindungen
ES2051753T3 (es) *	1986-12-16	1994-07-01	Robins Co Inc A H	N-(1-azabiciclo(2.2.2)octo-3-il) benzamidas y tiobenzamidas ansioliticas.
GB8720805D0 (en) *	1987-09-04	1987-10-14	Naylor R J	2-alkoxy-n-(1-azabicyclo(2 2 2)oct-3-yl)benzamides & thiobenzamides
US4857517A (en) *	1988-02-04	1989-08-15	Rorer Pharmaceutical Corporation	Quinuclidyl benzoxepins as 5-HT3 antagonists
EP0353371A1 (de) *	1988-08-04	1990-02-07	Synthelabo	Steigerung der Gedächtnisleistung durch R-N-(1-azabicyclo[2.2.2]oct-3-yl)Benzamide und Thiobenzamide

1988
- 1988-08-04 DE DE8888402042T patent/DE3878235T2/de not_active Expired - Fee Related
- 1988-08-04 EP EP88402042A patent/EP0353372B1/de not_active Expired - Lifetime
- 1988-08-04 AT AT88402042T patent/ATE85217T1/de not_active IP Right Cessation
1989
- 1989-07-31 ZA ZA895842A patent/ZA895842B/xx unknown
- 1989-08-01 PH PH39032A patent/PH25426A/en unknown
- 1989-08-01 AU AU39178/89A patent/AU615323B2/en not_active Ceased
- 1989-08-03 KR KR1019890011092A patent/KR900002777A/ko not_active Withdrawn
- 1989-08-03 US US07/389,364 patent/US5025022A/en not_active Expired - Fee Related
- 1989-08-03 DK DK382089A patent/DK382089A/da not_active Application Discontinuation
- 1989-08-04 IL IL91217A patent/IL91217A0/xx unknown
- 1989-08-04 JP JP1202711A patent/JPH02104529A/ja active Pending

Also Published As

Publication number	Publication date
PH25426A (en)	1991-07-01
JPH02104529A (ja)	1990-04-17
US5025022A (en)	1991-06-18
DK382089A (da)	1990-02-05
ATE85217T1 (de)	1993-02-15
AU615323B2 (en)	1991-09-26
IL91217A0 (en)	1990-07-12
KR900002777A (ko)	1990-03-23
DE3878235D1 (de)	1993-03-18
DE3878235T2 (de)	1993-06-03
EP0353372A1 (de)	1990-02-07
EP0353372B1 (de)	1993-02-03
DK382089D0 (da)	1989-08-03
AU3917889A (en)	1990-02-08

Publication	Publication Date	Title
ZA895842B (en)	1991-03-27	Antischizophrenic-s-n-(1-azabicyclo(2.2.2)oct-3-yl)benzamides and thiobenzamides
CA2047848A1 (en)	1992-02-01	Azabicyclo derivatives
AU6601294A (en)	1995-01-12	Amide and urea derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses
AU591640B2 (en)	1989-12-14	Quinolonecarboxylic acid derivatives
NZ232283A (en)	1991-08-27	Substituted imidazo(1,2-b)pyridazine derivatives; pharmaceutical compositions and preparatory processes
EP0612751A3 (en)	1994-09-21	Compounds for the preparation of cephem derivatives.
NO176911C (no)	1995-06-21	Diiodforbindelser for anvendelse ved fremstilling av morfolinylderivater av doxorubicin, og deres fremstilling
IL97429A0 (en)	1992-06-21	Substituted urea compounds,their preparation and pharmaceutical compositions comprising them
DK492688D0 (da)	1988-09-05	Anvendelse af benzamider
IE893956L (en)	1990-06-19	Novel compounds
DE68927554D1 (de)	1997-01-30	Cephalosporinverbindungen und Verfahren zu ihrer Herstellung
DE68913099D1 (de)	1994-03-24	Amino-substituierte verbrückte azabicyclische Chinoloncarbonsäure und Ester.
AU586089B2 (en)	1989-06-29	Phosphodiesterace type 111 inhibitors having a thiadiazinone ring as part of a tricyclic structure