ATE85217T1 - Antischizophren-wirksame s-n-(1-azabicyclo (2.2.2.>oct-3-yl)benzamide und thiobenzamide. - Google Patents

Antischizophren-wirksame s-n-(1-azabicyclo (2.2.2.>oct-3-yl)benzamide und thiobenzamide.

Info

Publication number: ATE85217T1
Authority: AT; Austria
Prior art keywords: chem; general formula; azabicyclo; oct; alkyl
Prior art date: 1988-08-04

Application number

AT88402042T

Other languages

English (en)

Inventor

Alain Renaud

Michel Langlois

Robert John Naylor

Brenda Naylor

Original Assignee

Synthelabo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-08-04

Filing date

1988-08-04

Publication date

1993-02-15

1988-08-04 Application filed by Synthelabo filed Critical Synthelabo

1993-02-15 Application granted granted Critical

1993-02-15 Publication of ATE85217T1 publication Critical patent/ATE85217T1/de

Links

230000002932 anti-schizophrenic effect Effects 0.000 title abstract 2
229940054066 benzamide antipsychotics Drugs 0.000 title 1
150000003936 benzamides Chemical class 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
150000001204 N-oxides Chemical class 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000005864 Sulphur Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
-1 amino, methylamino Chemical group 0.000 abstract 1
239000000164 antipsychotic agent Substances 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Neurosurgery (AREA)
General Chemical & Material Sciences (AREA)
Psychiatry (AREA)
Neurology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT88402042T 1988-08-04 1988-08-04 Antischizophren-wirksame s-n-(1-azabicyclo (2.2.2.>oct-3-yl)benzamide und thiobenzamide. ATE85217T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP88402042A EP0353372B1 (de)	1988-08-04	1988-08-04	Antischizophren-wirksame S-N-(1-azabicyclo [2.2.2.]oct-3-yl)Benzamide und Thiobenzamide

Publications (1)

Publication Number	Publication Date
ATE85217T1 true ATE85217T1 (de)	1993-02-15

Family

ID=8200415

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88402042T ATE85217T1 (de)	1988-08-04	1988-08-04	Antischizophren-wirksame s-n-(1-azabicyclo (2.2.2.>oct-3-yl)benzamide und thiobenzamide.

Country Status (11)

Country	Link
US (1)	US5025022A (de)
EP (1)	EP0353372B1 (de)
JP (1)	JPH02104529A (de)
KR (1)	KR900002777A (de)
AT (1)	ATE85217T1 (de)
AU (1)	AU615323B2 (de)
DE (1)	DE3878235T2 (de)
DK (1)	DK382089A (de)
IL (1)	IL91217A0 (de)
PH (1)	PH25426A (de)
ZA (1)	ZA895842B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0353371A1 (de) *	1988-08-04	1990-02-07	Synthelabo	Steigerung der Gedächtnisleistung durch R-N-(1-azabicyclo[2.2.2]oct-3-yl)Benzamide und Thiobenzamide
US5723103A (en) *	1994-12-09	1998-03-03	Vanderbilt University	Substituted benzamides and radioligand analogs and methods of use
AU2001282874A1 (en)	2000-08-18	2002-03-04	Pharmacia And Upjohn Company	Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands)
US6486172B2 (en)	2000-08-18	2002-11-26	Pharmacia & Upjohn Company	Quinuclidine-substituted aryl compounds for treatment of disease
US6492385B2 (en)	2000-08-18	2002-12-10	Pharmacia & Upjohn Company	Quinuclidine-substituted heteroaryl moieties for treatment of disease
WO2002015662A2 (en)	2000-08-21	2002-02-28	Pharmacia & Upjohn Company	Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic acetylcholine receptor antagonists
WO2002017358A2 (en)	2000-08-21	2002-02-28	Pharmacia & Upjohn Company	Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic acetylcholine receptor antagonists)
PE20021019A1 (es)	2001-04-19	2002-11-13	Upjohn Co	Grupos azabiciclicos sustituidos
MXPA04000779A (es) *	2001-08-24	2004-04-20	Pharmacia & Up John Company	7-aza[2.2.1]bicicloheptanos sustituidos con arilo para el tratamiento de enfermedades.
WO2003040147A1 (en) *	2001-11-08	2003-05-15	Pharmacia & Upjohn Company	Azabicyclic-substituted-heteroaryl compounds for the treatment of disease__________________________________________________________________________________________________________________________
US6852716B2 (en)	2002-02-15	2005-02-08	Pfizer Inc	Substituted-aryl compounds for treatment of disease
MXPA04007083A (es) *	2002-02-20	2004-10-29	Upjohn Co	Compuestos azabiciclicos para el tratamiento de enfermedades.
WO2004013137A1 (en)	2002-08-01	2004-02-12	Pharmacia & Upjohn Company Llc	1h-pyrazole and 1h-pyrrole-azabicyclic compounds with alfa-7 nachr activity
GB0310867D0 (en)	2003-05-12	2003-06-18	Novartis Ag	Organic compounds
WO2010042799A2 (en)	2008-10-09	2010-04-15	Howard Hughes Medical Institute	Novel chimeric ligand-gated ion channels and methods of use thereof
MA37975B2 (fr) *	2012-09-11	2021-03-31	Genzyme Corp	Inhibiteurs de synthase de glucosylcéramide
CN104418851A (zh) *	2013-09-02	2015-03-18	上海龙翔生物医药开发有限公司	奎宁环衍生物的制备方法及纯化方法
PT3920912T (pt)	2019-02-04	2025-09-09	Genzyme Corp	Tratamento de ciliopatias usando inibidores da glucosilceramida sintase (gcs)
IL295255A (en)	2020-02-03	2022-10-01	Genzyme Corp	Methods for treating neurological symptoms associated with lysosomal storage diseases
IL300090A (en)	2020-07-24	2023-03-01	Genzyme Corp	Pharmaceutical preparations containing VENGLUSTAT

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2531083B1 (fr) *	1982-06-29	1986-11-28	Sandoz Sa	Nouveaux derives de la piperidine, leur preparation et leur utilisation comme medicaments
FR2529548A1 (fr) *	1982-07-02	1984-01-06	Delalande Sa	Nouveaux derives de l'amino-3 quinuclidine, leur procede et leur application en therapeutique
GB8515845D0 (en) *	1985-06-22	1985-07-24	Beecham Group Plc	Treatment
EP0235878A3 (de) *	1986-01-16	1989-06-14	Beecham Group Plc	Neue Verbindungen
ES2051753T3 (es) *	1986-12-16	1994-07-01	Robins Co Inc A H	N-(1-azabiciclo(2.2.2)octo-3-il) benzamidas y tiobenzamidas ansioliticas.
GB8720805D0 (en) *	1987-09-04	1987-10-14	Naylor R J	2-alkoxy-n-(1-azabicyclo(2 2 2)oct-3-yl)benzamides & thiobenzamides
US4857517A (en) *	1988-02-04	1989-08-15	Rorer Pharmaceutical Corporation	Quinuclidyl benzoxepins as 5-HT3 antagonists
EP0353371A1 (de) *	1988-08-04	1990-02-07	Synthelabo	Steigerung der Gedächtnisleistung durch R-N-(1-azabicyclo[2.2.2]oct-3-yl)Benzamide und Thiobenzamide

1988
- 1988-08-04 AT AT88402042T patent/ATE85217T1/de not_active IP Right Cessation
- 1988-08-04 EP EP88402042A patent/EP0353372B1/de not_active Expired - Lifetime
- 1988-08-04 DE DE8888402042T patent/DE3878235T2/de not_active Expired - Fee Related
1989
- 1989-07-31 ZA ZA895842A patent/ZA895842B/xx unknown
- 1989-08-01 AU AU39178/89A patent/AU615323B2/en not_active Ceased
- 1989-08-01 PH PH39032A patent/PH25426A/en unknown
- 1989-08-03 KR KR1019890011092A patent/KR900002777A/ko not_active Withdrawn
- 1989-08-03 DK DK382089A patent/DK382089A/da not_active Application Discontinuation
- 1989-08-03 US US07/389,364 patent/US5025022A/en not_active Expired - Fee Related
- 1989-08-04 JP JP1202711A patent/JPH02104529A/ja active Pending
- 1989-08-04 IL IL91217A patent/IL91217A0/xx unknown

Also Published As

Publication number	Publication date
AU3917889A (en)	1990-02-08
DK382089D0 (da)	1989-08-03
AU615323B2 (en)	1991-09-26
DK382089A (da)	1990-02-05
US5025022A (en)	1991-06-18
IL91217A0 (en)	1990-07-12
DE3878235D1 (de)	1993-03-18
DE3878235T2 (de)	1993-06-03
JPH02104529A (ja)	1990-04-17
EP0353372B1 (de)	1993-02-03
EP0353372A1 (de)	1990-02-07
PH25426A (en)	1991-07-01
KR900002777A (ko)	1990-03-23
ZA895842B (en)	1991-03-27

Legal Events

Date	Code	Title	Description
1993-07-15	UEP	Publication of translation of european patent specification
1994-11-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DK382089A (da)	1990-02-05	Benzamidderivater
NO942452D0 (no)	1994-06-29	Amid- og ureaderivater med antihyperkolesteremisk aktivitet, deres fremstilling og terapeutiske anvendelser
DE69019859D1 (de)	1995-07-13	Chinolon-Derivate und deren Salze, Verfahren zu deren Herstellung und diese enthaltende antibakterielle Wirkstoffe.
FI854445A0 (fi)	1985-11-12	Kinolonkarboxylsyraderivat.
ZA902633B (en)	1991-01-30	New sulphonamides derived from benzo-cyclic or benzo heterocyclic acids,their preparation and their application in therapy
FI900461A0 (fi)	1990-01-30	Imidazopyridaziner, deras framstaellning och anvaendning.
DE68929368D1 (de)	2002-02-21	Cephemderivate und Verfahren zu ihrer Herstellung
DK43683D0 (da)	1983-02-03	Aromatiske forbindelser med antihistamin-aktivitet, fremgangsmade til deres fremstilling samt deres anvendelse
DE69220048D1 (de)	1997-07-03	Imidazoacridine und ihre antineoplastische anwendung
AU635445B2 (en)	1993-03-18	New compounds
NO940831L (no)	1991-08-14	Diiodforbindelser for anvendelse ved fremstilling av morfolinylderivater av doxorubicin, og deres fremstilling
IE890464L (en)	1989-08-15	New 1,4-Benzoxazine and 1,4-Benzothiazine Derivatives and process for their preparation
DK0506434T3 (da)	1995-07-24	Thiazolidinon- og oxazolidinon-derivater, fremstilling deraf og deres anvendelse som vasodilaterende midler
DK492688D0 (da)	1988-09-05	Anvendelse af benzamider
PT92540A (pt)	1990-06-29	Processo para a preparacao de derivados de anfotericina b
ATE192927T1 (de)	2000-06-15	Neue cephem-derivate
ATE113286T1 (de)	1994-11-15	Cephalosporinverbindungen und antibakterielle mittel.
GB8805642D0 (en)	1988-04-07	New cephem compounds & processes for preparation thereof
AU586089B2 (en)	1989-06-29	Phosphodiesterace type 111 inhibitors having a thiadiazinone ring as part of a tricyclic structure
DE68913099D1 (de)	1994-03-24	Amino-substituierte verbrückte azabicyclische Chinoloncarbonsäure und Ester.