ATE85217T1 - Antischizophren-wirksame s-n-(1-azabicyclo (2.2.2.>oct-3-yl)benzamide und thiobenzamide. - Google Patents

Antischizophren-wirksame s-n-(1-azabicyclo (2.2.2.>oct-3-yl)benzamide und thiobenzamide.

Info

Publication number: ATE85217T1
Authority: AT; Austria
Prior art keywords: chem; general formula; azabicyclo; oct; alkyl
Prior art date: 1988-08-04

Application number

AT88402042T

Other languages

English (en)

Inventor

Alain Renaud

Michel Langlois

Robert John Naylor

Brenda Naylor

Original Assignee

Synthelabo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-08-04

Filing date

1988-08-04

Publication date

1993-02-15

1988-08-04 Application filed by Synthelabo filed Critical Synthelabo

1993-02-15 Application granted granted Critical

1993-02-15 Publication of ATE85217T1 publication Critical patent/ATE85217T1/de

Links

230000002932 anti-schizophrenic effect Effects 0.000 title abstract 2
229940054066 benzamide antipsychotics Drugs 0.000 title 1
150000003936 benzamides Chemical class 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
150000001204 N-oxides Chemical class 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000005864 Sulphur Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
-1 amino, methylamino Chemical group 0.000 abstract 1
239000000164 antipsychotic agent Substances 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Neurosurgery (AREA)
General Chemical & Material Sciences (AREA)
Psychiatry (AREA)
Neurology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT88402042T 1988-08-04 1988-08-04 Antischizophren-wirksame s-n-(1-azabicyclo (2.2.2.>oct-3-yl)benzamide und thiobenzamide. ATE85217T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP88402042A EP0353372B1 (de)	1988-08-04	1988-08-04	Antischizophren-wirksame S-N-(1-azabicyclo [2.2.2.]oct-3-yl)Benzamide und Thiobenzamide

Publications (1)

Publication Number	Publication Date
ATE85217T1 true ATE85217T1 (de)	1993-02-15

Family

ID=8200415

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88402042T ATE85217T1 (de)	1988-08-04	1988-08-04	Antischizophren-wirksame s-n-(1-azabicyclo (2.2.2.>oct-3-yl)benzamide und thiobenzamide.

Country Status (11)

Country	Link
US (1)	US5025022A (de)
EP (1)	EP0353372B1 (de)
JP (1)	JPH02104529A (de)
KR (1)	KR900002777A (de)
AT (1)	ATE85217T1 (de)
AU (1)	AU615323B2 (de)
DE (1)	DE3878235T2 (de)
DK (1)	DK382089A (de)
IL (1)	IL91217A0 (de)
PH (1)	PH25426A (de)
ZA (1)	ZA895842B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0353371A1 (de) *	1988-08-04	1990-02-07	Synthelabo	Steigerung der Gedächtnisleistung durch R-N-(1-azabicyclo[2.2.2]oct-3-yl)Benzamide und Thiobenzamide
US5723103A (en) *	1994-12-09	1998-03-03	Vanderbilt University	Substituted benzamides and radioligand analogs and methods of use
US6479510B2 (en)	2000-08-18	2002-11-12	Pharmacia & Upjohn Company	Quinuclidine-substituted aryl compounds for treatment of disease
WO2002016357A2 (en)	2000-08-18	2002-02-28	Pharmacia & Upjohn Company	Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands)
US6492385B2 (en)	2000-08-18	2002-12-10	Pharmacia & Upjohn Company	Quinuclidine-substituted heteroaryl moieties for treatment of disease
US6599916B2 (en)	2000-08-21	2003-07-29	Pharmacia & Upjohn Company	Quinuclidine-substituted heteroaryl moieties for treatment of disease
AU2001282875A1 (en)	2000-08-21	2002-03-04	Pharmacia And Upjohn Company	Quinuclidine-substituted heteroaryl moieties for treatment of disease
PE20021019A1 (es)	2001-04-19	2002-11-13	Upjohn Co	Grupos azabiciclicos sustituidos
JP2005504059A (ja) *	2001-08-24	2005-02-10	ファルマシアアンドアップジョンカンパニーリミティドライアビリティーカンパニー	疾患を処置するための置換アリール７−アザ［２．２．１］ビシクロヘプタン
CA2466375A1 (en) *	2001-11-08	2003-05-15	Pharmacia & Upjohn Company	Azabicyclic-substituted-heteroaryl compounds for the treatment of disease
EP1480977A2 (de)	2002-02-15	2004-12-01	PHARMACIA & UPJOHN COMPANY	Substituierte arylverbindungen zur behandlung von krankheiten
WO2003072578A1 (en) *	2002-02-20	2003-09-04	Pharmacia & Upjohn Company	Azabicyclic compounds with alfa7 nicotinic acetylcholine receptor activity
US7176198B2 (en)	2002-08-01	2007-02-13	Pfizer Inc.	1H-pyrazole and 1H-pyrrole-azabicyclic compounds for the treatment of disease
GB0310867D0 (en)	2003-05-12	2003-06-18	Novartis Ag	Organic compounds
EP2344636B1 (de)	2008-10-09	2017-12-06	Howard Hughes Medical Institute	Neue chimäre ligandgesteuerte ionenkanäle und anwendungsverfahren dafür
MA37975B2 (fr)	2012-09-11	2021-03-31	Genzyme Corp	Inhibiteurs de synthase de glucosylcéramide
CN104418851A (zh) *	2013-09-02	2015-03-18	上海龙翔生物医药开发有限公司	奎宁环衍生物的制备方法及纯化方法
CN114040762A (zh)	2019-02-04	2022-02-11	建新公司	使用葡糖神经酰胺合酶(gcs)的抑制剂治疗纤毛疾病
JP2023512366A (ja)	2020-02-03	2023-03-27	ジェンザイム・コーポレーション	リソソーム蓄積性疾患と関連する神経学的症状を処置するための方法
AU2021311131B2 (en)	2020-07-24	2026-02-19	Genzyme Corporation	Pharmaceutical compositions comprising venglustat

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2531083B1 (fr) *	1982-06-29	1986-11-28	Sandoz Sa	Nouveaux derives de la piperidine, leur preparation et leur utilisation comme medicaments
FR2529548A1 (fr) *	1982-07-02	1984-01-06	Delalande Sa	Nouveaux derives de l'amino-3 quinuclidine, leur procede et leur application en therapeutique
GB8515845D0 (en) *	1985-06-22	1985-07-24	Beecham Group Plc	Treatment
EP0235878A3 (de) *	1986-01-16	1989-06-14	Beecham Group Plc	Neue Verbindungen
DE3780276T2 (de) *	1986-12-16	1993-02-25	Robins Co Inc A H	Angstloesende n-(1-azabicyclo(2.2.2)oct-3-yl)benzamide und -thiobenzamide.
GB8720805D0 (en) *	1987-09-04	1987-10-14	Naylor R J	2-alkoxy-n-(1-azabicyclo(2 2 2)oct-3-yl)benzamides & thiobenzamides
US4857517A (en) *	1988-02-04	1989-08-15	Rorer Pharmaceutical Corporation	Quinuclidyl benzoxepins as 5-HT3 antagonists
EP0353371A1 (de) *	1988-08-04	1990-02-07	Synthelabo	Steigerung der Gedächtnisleistung durch R-N-(1-azabicyclo[2.2.2]oct-3-yl)Benzamide und Thiobenzamide

1988
- 1988-08-04 DE DE8888402042T patent/DE3878235T2/de not_active Expired - Fee Related
- 1988-08-04 AT AT88402042T patent/ATE85217T1/de not_active IP Right Cessation
- 1988-08-04 EP EP88402042A patent/EP0353372B1/de not_active Expired - Lifetime
1989
- 1989-07-31 ZA ZA895842A patent/ZA895842B/xx unknown
- 1989-08-01 PH PH39032A patent/PH25426A/en unknown
- 1989-08-01 AU AU39178/89A patent/AU615323B2/en not_active Ceased
- 1989-08-03 DK DK382089A patent/DK382089A/da not_active Application Discontinuation
- 1989-08-03 US US07/389,364 patent/US5025022A/en not_active Expired - Fee Related
- 1989-08-03 KR KR1019890011092A patent/KR900002777A/ko not_active Withdrawn
- 1989-08-04 JP JP1202711A patent/JPH02104529A/ja active Pending
- 1989-08-04 IL IL91217A patent/IL91217A0/xx unknown

Also Published As

Publication number	Publication date
KR900002777A (ko)	1990-03-23
AU615323B2 (en)	1991-09-26
PH25426A (en)	1991-07-01
AU3917889A (en)	1990-02-08
ZA895842B (en)	1991-03-27
DK382089A (da)	1990-02-05
US5025022A (en)	1991-06-18
DE3878235D1 (de)	1993-03-18
DE3878235T2 (de)	1993-06-03
DK382089D0 (da)	1989-08-03
IL91217A0 (en)	1990-07-12
EP0353372B1 (de)	1993-02-03
JPH02104529A (ja)	1990-04-17
EP0353372A1 (de)	1990-02-07

Legal Events

Date	Code	Title	Description
1993-07-15	UEP	Publication of translation of european patent specification
1994-11-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE85217T1 (de)	1993-02-15	Antischizophren-wirksame s-n-(1-azabicyclo (2.2.2.>oct-3-yl)benzamide und thiobenzamide.
NO942452D0 (no)	1994-06-29	Amid- og ureaderivater med antihyperkolesteremisk aktivitet, deres fremstilling og terapeutiske anvendelser
DE3572170D1 (de)	1989-09-14	Quinolonecarboxylic acid derivatives
ZA902633B (en)	1991-01-30	New sulphonamides derived from benzo-cyclic or benzo heterocyclic acids,their preparation and their application in therapy
FI900461A0 (fi)	1990-01-30	Imidazopyridaziner, deras framstaellning och anvaendning.
DE68929368D1 (de)	2002-02-21	Cephemderivate und Verfahren zu ihrer Herstellung
DK43683A (da)	1983-08-05	Aromatiske forbindelser med antihistamin-aktivitet, fremgangsmaade til deres fremstilling samt deres anvendelse
DE69220048D1 (de)	1997-07-03	Imidazoacridine und ihre antineoplastische anwendung
NO940831D0 (no)	1994-03-09	Diiodforbindelser for anvendelse ved fremstilling av morfolinylderivater av doxorubicin, og deres fremstilling
IE890464L (en)	1989-08-15	New 1,4-Benzoxazine and 1,4-Benzothiazine Derivatives and process for their preparation
AU8813891A (en)	1992-06-04	New compounds
SE8802402D0 (sv)	1988-06-28	Novel esters
DK0506434T3 (da)	1995-07-24	Thiazolidinon- og oxazolidinon-derivater, fremstilling deraf og deres anvendelse som vasodilaterende midler
DK492688A (da)	1989-03-05	Anvendelse af benzamider
ATE113286T1 (de)	1994-11-15	Cephalosporinverbindungen und antibakterielle mittel.
AU586089B2 (en)	1989-06-29	Phosphodiesterace type 111 inhibitors having a thiadiazinone ring as part of a tricyclic structure