ZA895966B - Crystalline(5r,6s)-2-carbamoyloxymethyl-6-((1r)-hydroxyethyl)-2-penemcarboxylic acid and its pharmaceutical formulation - Google Patents

Crystalline(5r,6s)-2-carbamoyloxymethyl-6-((1r)-hydroxyethyl)-2-penemcarboxylic acid and its pharmaceutical formulation

Info

Publication number: ZA895966B
Authority: ZA; South Africa
Prior art keywords: carbamoyloxymethyl; hydroxyethyl; crystalline; pharmaceutical formulation; acid
Prior art date: 1988-08-08

Application number

ZA895966A

Other languages

English (en)

Inventor

Carlo Battistini

Battistini Carlo

Roberto Bianchini

Bianchini Roberto

Stefano Del Nero

Del Nero Stefano

Pierluigi Griggi

Griggi Pierluigi

Sergio Vioglio

Vioglio Sergio

Original Assignee

Erba Carlo Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-08-08

Filing date

1989-08-04

Publication date

1990-06-27

1989-08-04 Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa

1990-06-27 Publication of ZA895966B publication Critical patent/ZA895966B/xx

Links

239000002253 acid Substances 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/86—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
Oncology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

ZA895966A 1988-08-08 1989-08-04 Crystalline(5r,6s)-2-carbamoyloxymethyl-6-((1r)-hydroxyethyl)-2-penemcarboxylic acid and its pharmaceutical formulation ZA895966B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB888818789A GB8818789D0 (en)	1988-08-08	1988-08-08	Crystalline(5r 6s)-2-carbamoyloxymethyl-6-((1r)-hydroxyethyl)-2-penem-carboxylic acid & pharmaceutical formulation

Publications (1)

Publication Number	Publication Date
ZA895966B true ZA895966B (en)	1990-06-27

Family

ID=10641768

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA895966A ZA895966B (en)	1988-08-08	1989-08-04	Crystalline(5r,6s)-2-carbamoyloxymethyl-6-((1r)-hydroxyethyl)-2-penemcarboxylic acid and its pharmaceutical formulation

Country Status (21)

Country	Link
US (1)	US5302588A (da)
EP (1)	EP0407478B1 (da)
JP (1)	JP2954956B2 (da)
KR (1)	KR900701799A (da)
AT (1)	ATE112777T1 (da)
AU (1)	AU626576B2 (da)
CA (1)	CA1339422C (da)
DE (1)	DE68918849T2 (da)
DK (1)	DK171235B1 (da)
ES (1)	ES2015770A6 (da)
FI (1)	FI95575C (da)
GB (1)	GB8818789D0 (da)
GR (1)	GR1002251B (da)
HU (1)	HU205934B (da)
IE (1)	IE68447B1 (da)
IL (1)	IL91216A (da)
NZ (1)	NZ230196A (da)
PT (1)	PT91383B (da)
RU (1)	RU2074858C1 (da)
WO (1)	WO1990001484A1 (da)
ZA (1)	ZA895966B (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5492903A (en) *	1990-06-19	1996-02-20	Takeda Chemical Industries Ltd.	Crystalline esters of (+)-(5R, 6S)-6-[(R)-1-hydroxyethyl]-3-(3-pyridyl)-7-oxo-4-thia-1-azabicyclo[3.2.0]he
WO2008012830A1 (en) *	2006-07-28	2008-01-31	Hetero Drugs Limited	Soup faropenem free acid
KR20160109904A (ko) *	2015-03-13	2016-09-21	주식회사 대웅제약	결정형 도리페넴의 제조방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4482565A (en) *	1980-02-22	1984-11-13	Farmitalia Carlo Erba S.P.A.	β-Lactam-containing antibacterial agents and β-lactamase inhibitors
NL8204720A (nl) *	1981-12-11	1983-07-01	Erba Farmitalia	Werkwijze voor het bereiden van optisch actieve penemverbindingen.
US4761408A (en) *	1984-11-02	1988-08-02	Ciba-Geigy Corporation	Crystalline aminomethyl compound
US4634556A (en) *	1985-05-10	1987-01-06	Schering Corporation	Crystalline sodium (5R, 6S, 8R)-6-(1-hydroxyethyl)-2-(2-carbamoyloxyethylthio)-penem-3-carboxylate and process for making same
DD268946A5 (de) *	1986-04-29	1989-06-14	��`��@��k��	Verfahren zur herstellung des (5r,6s)-2-aminopethyl-6-[(1r)-1-hydroxyaethyl]-2-penem-3-carbonsaeure-minophyrats
GB8915392D0 (en) *	1989-07-05	1989-08-23	Erba Carlo Spa	Process for penems

1988
- 1988-08-08 GB GB888818789A patent/GB8818789D0/en active Pending
1989
- 1989-08-03 GR GR890100493A patent/GR1002251B/el unknown
- 1989-08-03 NZ NZ230196A patent/NZ230196A/xx unknown
- 1989-08-04 PT PT91383A patent/PT91383B/pt not_active IP Right Cessation
- 1989-08-04 CA CA000607546A patent/CA1339422C/en not_active Expired - Fee Related
- 1989-08-04 WO PCT/EP1989/000924 patent/WO1990001484A1/en not_active Ceased
- 1989-08-04 HU HU894594A patent/HU205934B/hu not_active IP Right Cessation
- 1989-08-04 DE DE68918849T patent/DE68918849T2/de not_active Expired - Fee Related
- 1989-08-04 IL IL9121689A patent/IL91216A/en not_active IP Right Cessation
- 1989-08-04 EP EP89908980A patent/EP0407478B1/en not_active Expired - Lifetime
- 1989-08-04 AU AU40490/89A patent/AU626576B2/en not_active Ceased
- 1989-08-04 IE IE252889A patent/IE68447B1/en not_active IP Right Cessation
- 1989-08-04 AT AT89908980T patent/ATE112777T1/de active
- 1989-08-04 ES ES898902797A patent/ES2015770A6/es not_active Expired - Lifetime
- 1989-08-04 RU SU894743591A patent/RU2074858C1/ru active
- 1989-08-04 ZA ZA895966A patent/ZA895966B/xx unknown
- 1989-08-04 JP JP1508464A patent/JP2954956B2/ja not_active Expired - Fee Related
- 1989-08-04 KR KR1019900700723A patent/KR900701799A/ko not_active Ceased
1990
- 1990-04-04 FI FI901710A patent/FI95575C/fi not_active IP Right Cessation
- 1990-04-05 DK DK085490A patent/DK171235B1/da not_active IP Right Cessation
1992
- 1992-06-16 US US07/899,057 patent/US5302588A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US5302588A (en)	1994-04-12
HUT56571A (en)	1991-09-30
FI95575B (fi)	1995-11-15
HU894594D0 (en)	1991-07-29
IL91216A (en)	1994-10-21
AU4049089A (en)	1990-03-05
NZ230196A (en)	1990-09-26
GR890100493A (el)	1990-08-22
WO1990001484A1 (en)	1990-02-22
JPH03500781A (ja)	1991-02-21
KR900701799A (ko)	1990-12-04
FI901710A0 (fi)	1990-04-04
CA1339422C (en)	1997-09-02
IE892528L (en)	1990-02-08
EP0407478B1 (en)	1994-10-12
DE68918849T2 (de)	1995-02-23
ES2015770A6 (es)	1990-09-01
GR1002251B (en)	1996-04-23
DK171235B1 (da)	1996-08-05
EP0407478A1 (en)	1991-01-16
DK85490A (da)	1990-06-07
JP2954956B2 (ja)	1999-09-27
IE68447B1 (en)	1996-06-26
HU205934B (en)	1992-07-28
FI95575C (fi)	1996-02-26
PT91383A (pt)	1990-03-08
DK85490D0 (da)	1990-04-05
AU626576B2 (en)	1992-08-06
GB8818789D0 (en)	1988-09-07
ATE112777T1 (de)	1994-10-15
RU2074858C1 (ru)	1997-03-10
IL91216A0 (en)	1990-03-19
DE68918849D1 (de)	1994-11-17
PT91383B (pt)	1995-05-31

Publication	Publication Date	Title
RU95114376A (ru)	1997-02-20	Нитроэфиры, обладающие фармакологической активностью, и способ их получения
TW352384B (en)	1999-02-11	Sulfonamido- or sulfonamidocarbonylpyridine-2-carboxamides, process for their preparation and their use as pharmaceuticals
AU7993694A (en)	1995-05-23	Novel pyrazine carboxamide derivatives, their production and their use in medicaments
AU5799294A (en)	1994-07-07	Isoxazole-4-carboxamides and hydroxy-alkylidenecyanoacetamides, pharmaceuticals containing these compounds and their use
AU5485698A (en)	1998-06-29	Oxyiminopregnancarbolactone
CA2194885A1 (en)	1996-02-01	Substituted benzamidines, their preparation and their use as pharmaceutical compounds
IE892528L (en)	1990-02-08	Crystalline¹(5r,6s)-2-carbamoyloxymethyl-6-£ (1r)-hydroxyethyl\|¹-2-penem-carboxylic acid and its pharmaceutical formulation
AU545885B2 (en)	1985-08-08	Oral absorption of glycosidic antibiotics
PH23259A (en)	1989-06-16	Crystalline (5r,6s)-2-aminomethyl-6-/(1r)-1-hydroxyethyl/-2-penem-3-carboxylic acid, its pharmaceutical composition and method of use thereof
AU559521B2 (en)	1987-03-12	5r,6s,8r-6-(1-hydroxyethyl)-2-(2-carbamoyloxyethylthio)- penem-3-carboxylic acid derivatives
AU7212687A (en)	1987-11-05	(5r,6s)-2-aminomethyl-6-((1r)-1-hydroxyethyl)-2-penem-3 carboxylic acid monohydrates
FI883505A7 (fi)	1989-06-08	(1R,5S,6S)-2-substituoitu-tio-6 /(R)-1-hydroksietyyli/-1-metyyli-karbapenem-3 -karboksyylihappojohdannaisia.
GT198500039A (es)	1986-11-07	Nuevas cefalosporinas y preparacion de las mismas.
TH27769A (th)	1998-01-30	สารประกอบชนิดใหม่
JPS57102890A (en)	1982-06-26	Beta-lactam antibiotic pa-31088-ii and its preparation