ZA902033B - New 1h,3h-pyrrolo(1,2-c)thiazole-7-carboxamide derivatives,their preparation and pharmaceutical compositions containing them - Google Patents

New 1h,3h-pyrrolo(1,2-c)thiazole-7-carboxamide derivatives,their preparation and pharmaceutical compositions containing them

Info

Publication number: ZA902033B
Authority: ZA; South Africa
Prior art keywords: phenyl; alkyl; phenylalkyl; pyridyl; hydroxyalkyl
Prior art date: 1989-03-17

Application number

ZA902033A

Other languages

English (en)

Inventor

Claude James

James Claude

Daniel Lave

Lave Daniel

Francoise Soler

Soler Francoise

Original Assignee

Rhone Poulenc Sante

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-03-17

Filing date

1990-03-16

Publication date

1990-12-28

1990-03-16 Application filed by Rhone Poulenc Sante filed Critical Rhone Poulenc Sante

1990-12-28 Publication of ZA902033B publication Critical patent/ZA902033B/xx

Links

AALKFJNRZXKTRD-UHFFFAOYSA-N 1,3-dihydropyrrolo[1,2-c][1,3]thiazole-7-carboxamide Chemical class C1SCC2=C(C(=O)N)C=CN21 AALKFJNRZXKTRD-UHFFFAOYSA-N 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 9
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 8
125000003884 phenylalkyl group Chemical group 0.000 abstract 6
-1 thieno[2,3-b]thienyl Chemical group 0.000 abstract 6
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 4
125000004076 pyridyl group Chemical group 0.000 abstract 4
RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
125000004575 3-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 2
YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000003282 alkyl amino group Chemical group 0.000 abstract 2
MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 2
125000004663 dialkyl amino group Chemical group 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
125000004193 piperazinyl group Chemical group 0.000 abstract 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
125000004485 2-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])C1([H])* 0.000 abstract 1
125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
GLUUGHFHXGJENI-UHFFFAOYSA-N diethylenediamine Natural products C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000005956 isoquinolyl group Chemical group 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
125000005493 quinolyl group Chemical group 0.000 abstract 1
125000004621 quinuclidinyl group Chemical group N12C(CC(CC1)CC2)* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1
BRNULMACUQOKMR-UHFFFAOYSA-N thiomorpholine Chemical compound C1CSCCN1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Oncology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Thiazole And Isothizaole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

ZA902033A 1989-03-17 1990-03-16 New 1h,3h-pyrrolo(1,2-c)thiazole-7-carboxamide derivatives,their preparation and pharmaceutical compositions containing them ZA902033B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR8903510A FR2644456B1 (fr)	1989-03-17	1989-03-17	Nouveaux derives du 1h, 3h-pyrrolo(1,2-c)thiazolecarboxamide-7, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number	Publication Date
ZA902033B true ZA902033B (en)	1990-12-28

Family

ID=9379793

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA902033A ZA902033B (en)	1989-03-17	1990-03-16	New 1h,3h-pyrrolo(1,2-c)thiazole-7-carboxamide derivatives,their preparation and pharmaceutical compositions containing them

Country Status (24)

Country	Link
US (1)	US5086051A (cs)
EP (1)	EP0388309B1 (cs)
JP (1)	JPH02289586A (cs)
KR (1)	KR900014408A (cs)
AT (1)	ATE102210T1 (cs)
BG (1)	BG51159A3 (cs)
CA (1)	CA2012343A1 (cs)
CS (2)	CS276785B6 (cs)
DD (1)	DD297822A5 (cs)
DE (1)	DE69006872T2 (cs)
DK (1)	DK0388309T3 (cs)
ES (1)	ES2062432T3 (cs)
FI (1)	FI92069C (cs)
FR (1)	FR2644456B1 (cs)
IE (1)	IE63313B1 (cs)
IL (1)	IL93760A (cs)
MA (1)	MA21771A1 (cs)
MX (1)	MX26542A (cs)
NO (1)	NO172392C (cs)
NZ (1)	NZ232960A (cs)
PL (1)	PL284321A1 (cs)
PT (1)	PT93485B (cs)
TN (1)	TNSN90030A1 (cs)
ZA (1)	ZA902033B (cs)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW214545B (cs) *	1992-02-17	1993-10-11	Ciba Geigy Ag
US5530141A (en) *	1992-03-04	1996-06-25	Center For Innovative Technology	2,4-diaryl-1,3-dithiolanes; 2,4-diaryl-1,3-dioxolanes; 2,4-diaryl-1,3-oxathiolanes; and 2,5-diaryl-1,3-oxathiolanes for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
US5639782A (en) *	1992-03-04	1997-06-17	Center For Innovative Technology	Neolignan derivatives as platelet activating factor receptor antagonists and 5-lipoxygenase inhibitors
US5463083A (en)	1992-07-13	1995-10-31	Cytomed, Inc.	Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5358938A (en) *	1992-07-13	1994-10-25	Cytomed, Inc.	Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
US5648486A (en) *	1992-07-13	1997-07-15	Cytomed, Inc.	Compounds and methods for the treatment of inflammatory and immune disorders
JPH08502243A (ja)	1992-07-13	1996-03-12	サイトメッド，インコーポレイテッド	炎症性および免疫性疾患の治療のための２，５‐ジアリールテトラヒドロ‐チオフェン、‐フランおよび類似体
US5434151A (en) *	1992-08-24	1995-07-18	Cytomed, Inc.	Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
TW266206B (cs) *	1993-04-28	1995-12-21	Takeda Pharm Industry Co Ltd
US5792776A (en) *	1994-06-27	1998-08-11	Cytomed, Inc.,	Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5703093A (en) *	1995-05-31	1997-12-30	Cytomed, Inc.	Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5750565A (en)	1995-05-25	1998-05-12	Cytomed, Inc.	Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
CA2202578A1 (en) *	1996-04-15	1997-10-15	Mitsuru Shiraishi	Hydroxypyridine derivatives, their production and use
JP5169216B2 (ja) *	2005-08-19	2013-03-27	独立行政法人産業技術総合研究所	色可逆変化表示装置用電極体及びその製造方法、並びに色可逆変化表示装置及び色可逆変化調光装置
WO2009125434A2 (en) *	2008-04-07	2009-10-15	Cadila Healthcare Limited	Oxime derivatives
WO2014192023A1 (en) *	2013-05-22	2014-12-04	Cadila Healthcare Limited	Novel compounds suitable for the treatment of dyslipidemia

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2541280B1 (fr) *	1983-01-13	1985-06-21	Rhone Poulenc Sante	Nouveaux derives du 1h, 3h-pyrrolo (1,2c) thiazolecarboxamide-7, leur preparation et les medicaments qui les contiennent
FR2601016B1 (fr) *	1986-07-04	1988-10-07	Rhone Poulenc Sante	Nouveaux derives du 1h,3h-pyrrolo (1,2-c) thiazole, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2601015B1 (fr) *	1986-07-04	1988-08-05	Rhone Poulenc Sante	Nouveaux derives du 1h,3h-pyrrolo (1,2-c) thiazole, leur preparation et les compositions pharmaceutiques qui les contiennent

1989
- 1989-03-17 FR FR8903510A patent/FR2644456B1/fr not_active Expired - Lifetime
1990
- 1990-03-12 MA MA22035A patent/MA21771A1/fr unknown
- 1990-03-14 US US07/493,439 patent/US5086051A/en not_active Expired - Fee Related
- 1990-03-15 CS CS901252A patent/CS276785B6/cs unknown
- 1990-03-15 CS CS904389A patent/CS438990A3/cs unknown
- 1990-03-15 MX MX2654290A patent/MX26542A/es unknown
- 1990-03-15 DD DD90338778A patent/DD297822A5/de not_active IP Right Cessation
- 1990-03-15 PL PL28432190A patent/PL284321A1/xx unknown
- 1990-03-15 IL IL9376090A patent/IL93760A/en not_active IP Right Cessation
- 1990-03-16 BG BG091500A patent/BG51159A3/bg unknown
- 1990-03-16 EP EP90400704A patent/EP0388309B1/fr not_active Expired - Lifetime
- 1990-03-16 AT AT90400704T patent/ATE102210T1/de not_active IP Right Cessation
- 1990-03-16 CA CA002012343A patent/CA2012343A1/fr not_active Abandoned
- 1990-03-16 DE DE69006872T patent/DE69006872T2/de not_active Expired - Fee Related
- 1990-03-16 TN TNTNSN90030A patent/TNSN90030A1/fr unknown
- 1990-03-16 DK DK90400704.4T patent/DK0388309T3/da active
- 1990-03-16 NZ NZ232960A patent/NZ232960A/xx unknown
- 1990-03-16 FI FI901325A patent/FI92069C/fi not_active IP Right Cessation
- 1990-03-16 KR KR1019900003553A patent/KR900014408A/ko not_active Withdrawn
- 1990-03-16 NO NO901237A patent/NO172392C/no unknown
- 1990-03-16 IE IE98490A patent/IE63313B1/en not_active IP Right Cessation
- 1990-03-16 PT PT93485A patent/PT93485B/pt not_active IP Right Cessation
- 1990-03-16 ES ES90400704T patent/ES2062432T3/es not_active Expired - Lifetime
- 1990-03-16 ZA ZA902033A patent/ZA902033B/xx unknown
- 1990-03-17 JP JP2068010A patent/JPH02289586A/ja active Pending

Also Published As

Publication number	Publication date
NO172392C (no)	1993-07-14
IL93760A (en)	1994-08-26
MA21771A1 (fr)	1990-10-01
FI901325A0 (fi)	1990-03-16
DE69006872D1 (de)	1994-04-07
MX26542A (es)	1993-09-01
ES2062432T3 (es)	1994-12-16
PT93485B (pt)	1996-02-29
IE63313B1 (en)	1995-04-05
EP0388309B1 (fr)	1994-03-02
IE900984L (en)	1990-09-17
CS276785B6 (en)	1992-08-12
FI92069B (fi)	1994-06-15
DK0388309T3 (da)	1994-04-11
IL93760A0 (en)	1990-12-23
KR900014408A (ko)	1990-10-23
PT93485A (pt)	1990-11-07
PL284321A1 (en)	1991-07-29
FI92069C (fi)	1994-09-26
DE69006872T2 (de)	1994-06-30
BG51159A3 (bg)	1993-02-15
FR2644456B1 (fr)	1991-07-05
NZ232960A (en)	1991-02-26
CS125290A3 (en)	1992-03-18
CS438990A3 (en)	1992-03-18
JPH02289586A (ja)	1990-11-29
NO172392B (no)	1993-04-05
US5086051A (en)	1992-02-04
NO901237L (no)	1990-09-18
NO901237D0 (no)	1990-03-16
ATE102210T1 (de)	1994-03-15
DD297822A5 (de)	1992-01-23
CA2012343A1 (fr)	1990-09-17
EP0388309A2 (fr)	1990-09-19
TNSN90030A1 (fr)	1991-03-05
EP0388309A3 (fr)	1991-07-24
FR2644456A1 (fr)	1990-09-21

Publication	Publication Date	Title
IL93760A0 (en)	1990-12-23	1h,3h-pyrrolo(1,2-c)thiazole-7-carboxamide derivatives,their preparation and pharmaceutical compositions containing them
PH23739A (en)	1989-11-03	Piperidine derivative and pharmaceutical composition
IL102833A0 (en)	1993-01-31	Azacyclic compounds,their preparation and pharmaceutical compositions containing them
NZ234110A (en)	1993-01-27	Dibenzoazepine, -oxepine and -cycloheptane substituted alkylidene amines; pharmaceutical compositions containing such compounds or various other aryl substituted amines
YU130584A (en)	1986-12-31	Process for making 1,4-dihydropyridine
HU900141D0 (en)	1990-03-28	Process for preparation of new 1,8 benzonapthridine-derivatives and for manufacturing of the pharmaceutical composition containing these compounds
IL76175A (en)	1989-08-15	N-substituted tricyclic oxindole carboxamides and pharmaceutical compositions containing them
IL112102A0 (en)	1995-03-15	Annelated dihydropyridinoacetic acid derivatives, their preparation and pharmaceutical compositions containing them
BR8400549A (pt)	1984-09-18	Derivados e sais inertes de hidroxido de aminopiridinios e processos de preparacao;e composicao farmaceutica
IL76535A0 (en)	1986-02-28	Furo(3,2-c)pyridine derivatives,their preparation and pharmaceutical compositions containing them
HUT39741A (en)	1986-10-29	Process for preparing pyridine derivatives and pharmaceutical compositions containing such compounds as active ingredients
IL61911A (en)	1983-10-31	2,3-dihydro-imidazo(1,2-b)pyridazine derivatives,their preparation and pharmaceutical compositions containing them
ES8300776A1 (es)	1982-11-01	Procedimiento para la obtencion de nuevos derivados de la tiazolo (3,2-a)pirimidina
ES8502981A1 (es)	1985-02-01	Procedimiento de preparacion de derivados de piperacina.
IL90172A (en)	1992-11-15	2,3-dihydro-5-(substituted phenyl)-imidazo(1,2-a)furo and thieno pyridine derivatives,their preparation and pharmaceutical compositions containing them
NZ222973A (en)	1989-12-21	Substituted piperidine and azepine derivatives and pharmaceutical compositions