ZA902668B - Tetrahydrobenz(c,d)indole serotonin agonists - Google Patents

Tetrahydrobenz(c,d)indole serotonin agonists

Info

Publication number: ZA902668B
Authority: ZA; South Africa
Prior art keywords: hydrogen; tetrahydrobenz; alkyl; serotonin agonists; indole serotonin
Prior art date: 1989-04-11

Application number

ZA902668A

Other languages

English (en)

Inventor

Michael Edward Flaugh

Edward Flaugh Michael

Mark Mortensen Foreman

Mortensen Foreman Mark

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-04-11

Filing date

1990-04-05

Publication date

1991-12-24

1990-04-05 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1991-12-24 Publication of ZA902668B publication Critical patent/ZA902668B/xx

Links

SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title abstract 4
PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 title abstract 2
RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 title abstract 2
239000000952 serotonin receptor agonist Substances 0.000 title abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
150000002431 hydrogen Chemical class 0.000 abstract 4
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000004455 (C1-C3) alkylthio group Chemical group 0.000 abstract 1
125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
229920002554 vinyl polymer Polymers 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Obesity (AREA)
Diabetes (AREA)
Child & Adolescent Psychology (AREA)
Anesthesiology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

ZA902668A 1989-04-11 1990-04-05 Tetrahydrobenz(c,d)indole serotonin agonists ZA902668B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US33640989A	1989-04-11	1989-04-11

Publications (1)

Publication Number	Publication Date
ZA902668B true ZA902668B (en)	1991-12-24

Family

ID=23315961

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA902668A ZA902668B (en)	1989-04-11	1990-04-05	Tetrahydrobenz(c,d)indole serotonin agonists

Country Status (18)

Country	Link
US (2)	US5204340A (de)
EP (1)	EP0392768B1 (de)
JP (1)	JP2944140B2 (de)
KR (1)	KR900016196A (de)
CN (1)	CN1024626C (de)
AT (1)	ATE115129T1 (de)
AU (1)	AU631863B2 (de)
CA (1)	CA2013893C (de)
DE (1)	DE69014697T2 (de)
ES (1)	ES2064618T3 (de)
HU (1)	HUT53869A (de)
IL (1)	IL94014A (de)
MX (1)	MX20222A (de)
NZ (1)	NZ233239A (de)
PT (1)	PT93687A (de)
RU (1)	RU2007393C1 (de)
TW (1)	TW219895B (de)
ZA (1)	ZA902668B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5204340A (en) *	1989-04-11	1993-04-20	Eli Lilly And Company	Tetrahydrobenz(c,d)indole serotonin agonists
TW219933B (de) *	1990-02-26	1994-02-01	Lilly Co Eli
IL97308A (en) *	1990-02-26	1996-10-31	Lilly Co Eli	6-Substituted-hexahydrobenz (cd) indoles process for their preparation and pharmaceutical compositions containing them
US5302612A (en) *	1990-02-26	1994-04-12	Eli Lilly And Company	6-substituted-hexahydrobenz[cd]indoles
US5039820A (en) *	1990-02-26	1991-08-13	Eli Lilly And Company	4-amino-6-iodo-hexahydrobenz(cd)indoles
US5340838A (en) *	1990-05-04	1994-08-23	Eli Lilly And Company	Method of inhibiting gastric acid secretion with 2-phenylcyclopropylamines
US5229409A (en) *	1990-08-15	1993-07-20	Eli Lilly And Company	6-substituted-tetrahydrobenz[cd]indoles
US5364856A (en) *	1991-03-28	1994-11-15	Eli Lilly And Company	6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[CD]indoles
US5643934A (en) *	1991-03-28	1997-07-01	Eli Lilly And Company	6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz [CD]indoles
US5347013A (en) *	1991-03-28	1994-09-13	Eli Lilly And Company	6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz[cd]indoles
TW248556B (de) *	1993-01-18	1995-06-01	Takeda Pharm Industry Co
NZ314570A (en) *	1993-06-10	2000-11-24	Lilly Co Eli	Treatment of emesis using tetrahydrobenz[cd]indole-6-carboxamides
US5385928A (en) *	1994-05-18	1995-01-31	Eli Lilly And Company	Tetrahydrobenz [CD] indazoles, compositions and use
US5498727A (en) *	1994-07-19	1996-03-12	Agouron Pharmaceuticals, Inc.	Preparation of benzindole compounds from naphthalene compounds
US6193993B1 (en) *	1998-03-03	2001-02-27	Eisai Co., Ltd.	Suppository containing an antidementia medicament
US6218421B1 (en) *	1999-07-01	2001-04-17	Smithkline Beecham P.L.C.	Method of promoting smoking cessation
AU2003225277A1 (en) *	2002-05-02	2003-11-17	Robert Harris	Lipid removal from the body
US8609162B2 (en) *	2012-10-04	2013-12-17	Invivo Beverages Llc	Integrated neuromodulation system for mood enhancement of a living human subject

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4110339A (en) *	1977-11-25	1978-08-29	Eli Lilly And Company	4-(Di-n-propyl)amino-1,3,4,5-tetrahydrobenz[cd]indole
US4282240A (en) *	1979-11-23	1981-08-04	Merck & Co., Inc.	Amino substituted tetrahydrobenzindoles
DE3346573A1 (de) *	1983-12-23	1985-07-04	Troponwerke GmbH & Co KG, 5000 Köln	1,3,4,5-tetrahydrobenz(c,d)indole, ein verfahren zu ihrer herstellung und ihre verwendung
IL74222A (en) *	1984-02-06	1988-07-31	Lilly Co Eli	6-substituted-4-dialkylamino tetrahydrobenz(c,d)indoles,their preparation and pharmaceutical compositions comprising them
US4576959A (en) *	1984-02-06	1986-03-18	Eli Lilly And Company	6-Substituted-4-dialkylaminotetrahydrobenz[c,d]indoles
US4983622A (en) *	1984-02-06	1991-01-08	Eli Lilly And Company	6-substituted-4-dialkylaminotetrahydrobenz(c,d)indoles
CA1266482A1 (en) *	1984-05-24	1990-03-06	Carl Kaiser	6-oxygenated-1,3,4,5-tetrahydrobenz(cd)indol-4-amines
US4640921A (en) *	1986-02-04	1987-02-03	Bristol-Myers	Treatment of sexual dysfunction with buspirone
US4745126A (en) *	1987-03-12	1988-05-17	Eli Lilly And Company	Method of treating anxiety with tetrahydrobenz[c,d]indole-6-carboxamides
DE3809155A1 (de) *	1988-03-18	1989-09-28	Bayer Ag	1,3,4,5-tetrahydrobenz-(c,d)-indole
DE3826371A1 (de) *	1988-08-03	1990-02-08	Bayer Ag	Tetrahydro-1-benz-(c,d)-indolpropionsaeure-sulfonamide
US5204340A (en) *	1989-04-11	1993-04-20	Eli Lilly And Company	Tetrahydrobenz(c,d)indole serotonin agonists
US5302612A (en) *	1990-02-26	1994-04-12	Eli Lilly And Company	6-substituted-hexahydrobenz[cd]indoles
US5229410A (en) *	1990-08-15	1993-07-20	Eli Lilly And Company	6-substituted-hexahydrobenz[cd]indoles
US5229409A (en) *	1990-08-15	1993-07-20	Eli Lilly And Company	6-substituted-tetrahydrobenz[cd]indoles

1990
- 1990-02-26 US US07/482,811 patent/US5204340A/en not_active Expired - Lifetime
- 1990-04-05 ZA ZA902668A patent/ZA902668B/xx unknown
- 1990-04-05 IL IL9401490A patent/IL94014A/en not_active IP Right Cessation
- 1990-04-05 CA CA002013893A patent/CA2013893C/en not_active Expired - Fee Related
- 1990-04-06 MX MX2022290A patent/MX20222A/es unknown
- 1990-04-06 RU SU904743759A patent/RU2007393C1/ru active
- 1990-04-06 PT PT93687A patent/PT93687A/pt not_active Application Discontinuation
- 1990-04-06 AU AU53047/90A patent/AU631863B2/en not_active Ceased
- 1990-04-06 NZ NZ233239A patent/NZ233239A/xx unknown
- 1990-04-09 HU HU902129A patent/HUT53869A/hu unknown
- 1990-04-09 TW TW079102776A patent/TW219895B/zh active
- 1990-04-09 AT AT90303775T patent/ATE115129T1/de not_active IP Right Cessation
- 1990-04-09 EP EP90303775A patent/EP0392768B1/de not_active Expired - Lifetime
- 1990-04-09 KR KR1019900004810A patent/KR900016196A/ko not_active Withdrawn
- 1990-04-09 DE DE69014697T patent/DE69014697T2/de not_active Expired - Fee Related
- 1990-04-09 CN CN90102153A patent/CN1024626C/zh not_active Expired - Fee Related
- 1990-04-09 ES ES90303775T patent/ES2064618T3/es not_active Expired - Lifetime
- 1990-04-09 JP JP2093836A patent/JP2944140B2/ja not_active Expired - Fee Related
1992
- 1992-12-15 US US07/992,410 patent/US5462962A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
MX20222A (es)	1994-01-31
EP0392768B1 (de)	1994-12-07
IL94014A0 (en)	1991-01-31
CA2013893A1 (en)	1990-10-11
KR900016196A (ko)	1990-11-12
US5204340A (en)	1993-04-20
PT93687A (pt)	1990-11-20
RU2007393C1 (ru)	1994-02-15
CN1046330A (zh)	1990-10-24
HUT53869A (en)	1990-12-28
US5462962A (en)	1995-10-31
TW219895B (de)	1994-02-01
IL94014A (en)	1994-10-21
CN1024626C (zh)	1994-05-25
DE69014697D1 (de)	1995-01-19
ATE115129T1 (de)	1994-12-15
DE69014697T2 (de)	1995-05-11
CA2013893C (en)	2001-06-19
JPH02290849A (ja)	1990-11-30
EP0392768A1 (de)	1990-10-17
JP2944140B2 (ja)	1999-08-30
NZ233239A (en)	1991-09-25
HU902129D0 (en)	1990-07-28
AU631863B2 (en)	1992-12-10
AU5304790A (en)	1990-10-18
ES2064618T3 (es)	1995-02-01

Publication	Publication Date	Title
AU631863B2 (en)	1992-12-10	Tetrahydrobenz(c,d)indole serotonin agonists
NO940737L (de)	1994-05-03
AU586337B2 (en)	1989-07-06	Antiallergy and antiinflammatory agents
EP0546181A4 (en)	1993-07-21	Indole derivative and medicine
ATE87921T1 (de)	1993-04-15	Cycloalkylamide von (8beta)-1-alkyl-6(substituierten) ergolinen.
DE69525145D1 (en)	2002-03-14	Carbamoylmethylharnstoffderivate
ES2157952T3 (es)	2001-09-01	Preparacion de derivados de beta-lactama e intermediarios.
DE3671623D1 (de)	1990-07-05	Diphenyletherherbizide.
EP0878475A3 (de)	1998-11-25	5-(4-Piperidinyl)dibenzothiazepine derivate und 5-(4-piperidinyl)dibenzoxazepinderivate, und antiarrhythmische Mittel
EP0443474A3 (en)	1992-04-22	1-phenoxycarbonyl-2-pyrrolidinone derivatives and nootropic agents