ZA905604B - Heteroaryl-3-oxo-propanenitrile derivatives useful in stimulating myelopoiesis - Google Patents

Heteroaryl-3-oxo-propanenitrile derivatives useful in stimulating myelopoiesis

Info

Publication number: ZA905604B
Authority: ZA; South Africa
Prior art keywords: pct; heteroaryl; oxo; derivatives useful; stimulating myelopoiesis
Prior art date: 1989-07-17

Application number

ZA905604A

Other languages

English (en)

Inventor

Gianfederico Doria

Doria Gianfederico

Anna Maria Isetta

Maria Isetta Anna

Rinaldo Ferreccio

Ferreccio Rinaldo

Mario Ferrari

Ferrari Mario

Maria Chiara Fornasiero

Chiara Fornasiero Maria

Domenico Trizio

Trizio Domenico

Original Assignee

Erba Carlo Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-07-17

Filing date

1990-07-17

Publication date

1991-05-29

1990-07-17 Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa

1991-05-29 Publication of ZA905604B publication Critical patent/ZA905604B/xx

Links

230000004936 stimulating effect Effects 0.000 title abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
125000006828 (C2-C7) alkoxycarbonyl group Chemical group 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
210000001185 bone marrow Anatomy 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04D—NON-POSITIVE-DISPLACEMENT PUMPS
- F04D25/00—Pumping installations or systems
- F04D25/02—Units comprising pumps and their driving means
- F04D25/08—Units comprising pumps and their driving means the working fluid being air, e.g. for ventilation
- F04D25/10—Units comprising pumps and their driving means the working fluid being air, e.g. for ventilation the unit having provisions for automatically changing direction of output air
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04D—NON-POSITIVE-DISPLACEMENT PUMPS
- F04D29/00—Details, component parts, or accessories
- F04D29/60—Mounting; Assembling; Disassembling
- F04D29/601—Mounting; Assembling; Disassembling specially adapted for elastic fluid pumps

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Mechanical Engineering (AREA)
General Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

ZA905604A 1989-07-17 1990-07-17 Heteroaryl-3-oxo-propanenitrile derivatives useful in stimulating myelopoiesis ZA905604B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB898916290A GB8916290D0 (en)	1989-07-17	1989-07-17	Heteroaryl-3-oxo-propanenitrile derivatives useful in stimulating myelopoiesis

Publications (1)

Publication Number	Publication Date
ZA905604B true ZA905604B (en)	1991-05-29

Family

ID=10660137

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA905604A ZA905604B (en)	1989-07-17	1990-07-17	Heteroaryl-3-oxo-propanenitrile derivatives useful in stimulating myelopoiesis

Country Status (17)

Country	Link
US (1)	US5206258A (da)
EP (1)	EP0434807B1 (da)
JP (1)	JPH04501267A (da)
KR (1)	KR920701165A (da)
AT (1)	ATE106875T1 (da)
AU (1)	AU636375B2 (da)
CA (1)	CA2036375A1 (da)
DE (1)	DE69009717T2 (da)
DK (1)	DK0434807T3 (da)
GB (1)	GB8916290D0 (da)
HU (1)	HU208631B (da)
IE (1)	IE64936B1 (da)
IL (1)	IL95044A (da)
MY (1)	MY106985A (da)
PT (1)	PT94713A (da)
WO (1)	WO1991001309A1 (da)
ZA (1)	ZA905604B (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8814587D0 (en) *	1988-06-20	1988-07-27	Erba Carlo Spa	Condensed pyrazole 3-oxo-propanenitrile derivatives & process for their preparation
US5547975A (en) *	1994-09-20	1996-08-20	Talley; John J.	Benzopyranopyrazolyl derivatives for the treatment of inflammation
US5886016A (en) *	1995-09-15	1999-03-23	G.D. Searle & Co.	Benzopyranopyrazolyl derivatives for the treatment of inflammation
AU5147598A (en) *	1996-10-17	1998-05-11	Smithkline Beecham Corporation	Methods for reversibly inhibiting myelopoiesis in mammalian tissue
GB9720899D0 (en) *	1997-10-01	1997-12-03	Pharmacia & Upjohn Spa	Condensed heterocyclic compounds
GB9720901D0 (en) *	1997-10-01	1997-12-03	Pharmacia & Upjohn Spa	Condensed benzothiopyranic compounds
US6485740B1 (en) *	2000-03-14	2002-11-26	Yutoku Pharmaceutical Ind., Co., Ltd.	Transdermal methotrexate preparations
CA2460939C (en) *	2001-09-19	2008-07-29	Pharmacia Corporation	Substituted pyrazolyl compounds for the treatment of inflammation
EP1444207A2 (en)	2001-09-19	2004-08-11	Pharmacia Corporation	Substituted pyrazolyl-compounds for the treatment of inflammation
US20050014690A1 (en) *	2001-10-11	2005-01-20	Chaim Roifman	Styryl acrylonitrile compounds and their use to promote myelopoiesis
US11564901B2 (en) *	2007-01-31	2023-01-31	Biosuccess Biotech Co., Ltd.	Compositions and methods of use of phorbol esters
RU2366452C1 (ru) *	2008-04-28	2009-09-10	Государственное учреждение Научно-исследовательский институт фармакологии Томского научного центра Сибирского отделения Российской Академии медицинских наук (ГУ НИИ фармакологии ТНЦ СО РАМН)	Способ стимуляции миелопоэза
MX2012005518A (es) *	2009-11-13	2012-06-19	Merck Serono Sa	Derivados de pirazol amina triciclica.
KR101702468B1 (ko)	2015-07-27	2017-02-06	충남대학교산학협력단	암 예방 및 치료용 조성물

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3404157A (en) *	1965-02-24	1968-10-01	American Cyanamid Co	Substituted pyrroloindazole compounds
US3969527A (en) *	1975-07-28	1976-07-13	E. R. Squibb & Sons, Inc.	CNS active compounds
US4140755A (en) *	1976-02-13	1979-02-20	Hoffmann-La Roche Inc.	Sustained release tablet formulations
JPS5615287A (en) *	1979-07-16	1981-02-14	Chugai Pharmaceut Co Ltd	Pyrazoloindazole derivative and its preparation
US4420476A (en) *	1982-05-24	1983-12-13	Averst McKenna & Harrison, Inc.	Benzofuro[3,2-c]pyrazol-3-amine derivatives
JPS60130521A (ja) *	1983-12-19	1985-07-12	Morishita Seiyaku Kk	抗癌剤
JPS6299361A (ja) *	1985-10-25	1987-05-08	Morishita Seiyaku Kk	インデノ〔１，２−ｃ〕ピラゾ−ル誘導体
US4816467A (en) *	1987-01-09	1989-03-28	Farmitalia Carlo Erba S.R.L	Heteroaryl 3-oxo-propanenitrile derivatives, pharmaceutical compositions and use
GB8814587D0 (en) *	1988-06-20	1988-07-27	Erba Carlo Spa	Condensed pyrazole 3-oxo-propanenitrile derivatives & process for their preparation
GB8814586D0 (en) *	1988-06-20	1988-07-27	Erba Carlo Spa	Tricyclic 3-oxo-propanenitrile derivatives & process for their preparation

1989
- 1989-07-17 GB GB898916290A patent/GB8916290D0/en active Pending
1990
- 1990-07-11 DK DK90910624.7T patent/DK0434807T3/da active
- 1990-07-11 US US07/663,843 patent/US5206258A/en not_active Expired - Fee Related
- 1990-07-11 CA CA002036375A patent/CA2036375A1/en not_active Abandoned
- 1990-07-11 AT AT90910624T patent/ATE106875T1/de active
- 1990-07-11 DE DE69009717T patent/DE69009717T2/de not_active Expired - Fee Related
- 1990-07-11 WO PCT/EP1990/001129 patent/WO1991001309A1/en not_active Ceased
- 1990-07-11 KR KR1019910700280A patent/KR920701165A/ko not_active Withdrawn
- 1990-07-11 EP EP90910624A patent/EP0434807B1/en not_active Expired - Lifetime
- 1990-07-11 HU HU905486A patent/HU208631B/hu not_active IP Right Cessation
- 1990-07-11 IL IL9504490A patent/IL95044A/en not_active IP Right Cessation
- 1990-07-11 AU AU60360/90A patent/AU636375B2/en not_active Ceased
- 1990-07-11 JP JP2510292A patent/JPH04501267A/ja active Pending
- 1990-07-16 IE IE258390A patent/IE64936B1/en not_active IP Right Cessation
- 1990-07-16 PT PT94713A patent/PT94713A/pt not_active Application Discontinuation
- 1990-07-17 ZA ZA905604A patent/ZA905604B/xx unknown
- 1990-07-17 MY MYPI90001197A patent/MY106985A/en unknown

Also Published As

Publication number	Publication date
WO1991001309A1 (en)	1991-02-07
CA2036375A1 (en)	1991-01-18
IL95044A (en)	1994-08-26
DE69009717D1 (de)	1994-07-14
HUT59310A (en)	1992-05-28
IL95044A0 (en)	1991-06-10
PT94713A (pt)	1991-03-20
EP0434807A1 (en)	1991-07-03
EP0434807B1 (en)	1994-06-08
DK0434807T3 (da)	1994-07-04
AU636375B2 (en)	1993-04-29
MY106985A (en)	1995-08-30
KR920701165A (ko)	1992-08-11
HU208631B (en)	1993-12-28
GB8916290D0 (en)	1989-08-31
US5206258A (en)	1993-04-27
IE64936B1 (en)	1995-09-20
HU905486D0 (en)	1991-07-29
AU6036090A (en)	1991-02-22
IE902583A1 (en)	1991-02-27
DE69009717T2 (de)	1994-09-29
ATE106875T1 (de)	1994-06-15
JPH04501267A (ja)	1992-03-05

Publication	Publication Date	Title
GB8916290D0 (en)	1989-08-31	Heteroaryl-3-oxo-propanenitrile derivatives useful in stimulating myelopoiesis
DE69223989D1 (en)	1998-02-12	Azyklische ethylendiaminderivate als 'substance p rezeptor' antagonisten
HUT51864A (da)	1990-06-28
EG20280A (en)	1998-07-30	Process for preparing of fluoroalkoxybenzylamino derivatives of nitrogen containing heterocycles
GB9300194D0 (en)	1993-03-03	Piperazine derivatives
ID26622A (id)	2001-01-25	Senyawa-senyawa pengganti 2-benzylamino-2-phenyl-acetamide
IL75273A (en)	1991-06-10	Cephalosporin derivatives,process for their preparation and pharmaceutical compositions containing them
ATE242236T1 (de)	2003-06-15	N-substituierte 3-azabicyclo(3.2.0)heptan- derivate als neuroleptika
HU9202919D0 (en)	1992-12-28	Urea derivatives, method for producing them and pharmaceutical preparatives containing these compounds
SG82540A1 (en)	2001-08-21	N-substituted azabicyclo [3.2.0] heptane derivatives as neuroleptics, the preparation and use thereof
DE3871741D1 (de)	1992-07-09	Mischung, bestehend aus pyrimidinderivaten und calcium-antagonisten zum induzieren und stimulieren des haarwuchses und zum vermindern des haarausfalls.
ATE176235T1 (de)	1999-02-15	Verwendung von cephem-derivaten als antimetastatische mittel
IL99777A0 (en)	1992-08-18	Indole derivatives,processes for their preparation and pharmaceutical compositions containing them
ZA911210B (en)	1991-11-27	N-phenyl-n-alkoxycarbonylalkyl glycinamides,their preparation and the medicaments containing them
GR3000773T3 (en)	1991-10-10	2,2;6,6-diethylene-3-oxo-17-alpha-pregn-4-ene-21,17-carbolactones, process for their preparation and pharmaceutical compositions containing them
GB2071093B (en)	1984-01-18	Benzothiopyrano(2,3-c)pyridines
ES2009283A6 (es)	1989-09-16	Procedimiento para preparar nuevos aminoacilatos de glicerol-acetal.