ATE176235T1 - Verwendung von cephem-derivaten als antimetastatische mittel - Google Patents

Verwendung von cephem-derivaten als antimetastatische mittel

Info

Publication number
ATE176235T1
ATE176235T1 AT94921624T AT94921624T ATE176235T1 AT E176235 T1 ATE176235 T1 AT E176235T1 AT 94921624 T AT94921624 T AT 94921624T AT 94921624 T AT94921624 T AT 94921624T AT E176235 T1 ATE176235 T1 AT E176235T1
Authority
AT
Austria
Prior art keywords
pct
defined above
organic radical
sec
cephem derivatives
Prior art date
Application number
AT94921624T
Other languages
English (en)
Inventor
Marco Alpegiani
Pierluigi Bissolino
Ettore Perrone
Enrico Pesenti
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Application granted granted Critical
Publication of ATE176235T1 publication Critical patent/ATE176235T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
AT94921624T 1993-07-14 1994-06-24 Verwendung von cephem-derivaten als antimetastatische mittel ATE176235T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939314562A GB9314562D0 (en) 1993-07-14 1993-07-14 Use of cephem derivatives as anti-metastatic agents

Publications (1)

Publication Number Publication Date
ATE176235T1 true ATE176235T1 (de) 1999-02-15

Family

ID=10738806

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94921624T ATE176235T1 (de) 1993-07-14 1994-06-24 Verwendung von cephem-derivaten als antimetastatische mittel

Country Status (15)

Country Link
US (1) US5777104A (de)
EP (1) EP0708779B1 (de)
JP (1) JPH09500118A (de)
KR (1) KR960703599A (de)
AT (1) ATE176235T1 (de)
AU (1) AU680526B2 (de)
CA (1) CA2167194A1 (de)
DE (1) DE69416311T2 (de)
ES (1) ES2128572T3 (de)
GB (1) GB9314562D0 (de)
HU (1) HUT72739A (de)
IL (1) IL110273A0 (de)
PL (1) PL312582A1 (de)
WO (1) WO1995002603A2 (de)
ZA (1) ZA945093B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9513818D0 (en) * 1995-07-06 1995-09-06 Pharmacia Spa 7,7-Disubstituted cephem-4-ketones
JPH11511463A (ja) * 1995-08-31 1999-10-05 スミスクライン・ビーチャム・コーポレイション インターロイキン変換酵素およびアポプトーシス
WO1997007805A1 (en) * 1995-08-31 1997-03-06 Smithkline Beecham Corporation Interleukin converting enzyme and apoptosis
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
EP2926815A1 (de) * 2014-04-03 2015-10-07 Institut Curie Cephalosporinderivate zur Behandlung von Krebs
US12404332B2 (en) * 2020-03-13 2025-09-02 Research Development Foundation Methods for diagnosing and treating cancers

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0383987A (ja) * 1989-08-26 1991-04-09 Fujisawa Pharmaceut Co Ltd 新規セフェム化合物およびその塩類
AU649275B2 (en) * 1990-11-06 1994-05-19 Bristol-Myers Squibb Company Prodrugs for beta-lactamase and uses thereof
GB2266525A (en) * 1992-03-17 1993-11-03 Merck & Co Inc Substituted cephalosporin sulfone compositions useful in the treatment of leukemia

Also Published As

Publication number Publication date
HU9503852D0 (en) 1996-02-28
EP0708779B1 (de) 1999-01-27
WO1995002603A3 (en) 1995-03-09
PL312582A1 (en) 1996-04-29
DE69416311T2 (de) 1999-08-26
DE69416311D1 (de) 1999-03-11
AU680526B2 (en) 1997-07-31
KR960703599A (ko) 1996-08-31
ZA945093B (en) 1995-02-22
IL110273A0 (en) 1994-10-21
JPH09500118A (ja) 1997-01-07
US5777104A (en) 1998-07-07
EP0708779A1 (de) 1996-05-01
WO1995002603A2 (en) 1995-01-26
AU7227794A (en) 1995-02-13
HUT72739A (en) 1996-05-28
GB9314562D0 (en) 1993-08-25
ES2128572T3 (es) 1999-05-16
CA2167194A1 (en) 1995-01-26

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties