ZA914165B - Pharmacologically active CNS compounds. - Google Patents

Pharmacologically active CNS compounds.

Info

Publication number: ZA914165B
Authority: ZA; South Africa
Prior art keywords: hydrogen; halo; alkyl; compounds; pharmacologically active
Prior art date: 1990-06-01

Application number

ZA914165A

Other languages

English (en)

Inventor

Michael John Leach

Malcolm Stuart Nobbs

Ramachandran Iyer

Clive Leonard Yeates

Philip Alan Skone

Original Assignee

Wellcom Foundation Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-01

Filing date

1991-05-30

Publication date

1993-03-01

1991-05-30 Application filed by Wellcom Foundation Limited filed Critical Wellcom Foundation Limited

1993-03-01 Publication of ZA914165B publication Critical patent/ZA914165B/xx

Links

150000001875 compounds Chemical class 0.000 title abstract 3
239000001257 hydrogen Substances 0.000 abstract 7
229910052739 hydrogen Inorganic materials 0.000 abstract 7
125000005843 halogen group Chemical group 0.000 abstract 5
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
125000000217 alkyl group Chemical group 0.000 abstract 3
150000002431 hydrogen Chemical class 0.000 abstract 3
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
208000012902 Nervous system disease Diseases 0.000 abstract 1
125000004849 alkoxymethyl group Chemical group 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
229930195712 glutamate Natural products 0.000 abstract 1
125000001188 haloalkyl group Chemical group 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
230000000626 neurodegenerative effect Effects 0.000 abstract 1
239000002858 neurotransmitter agent Substances 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
-1 nitro, amino Chemical group 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Public Health (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Psychiatry (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Liquid Crystal Substances (AREA)
Medicinal Preparation (AREA)
Paper (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

ZA914165A 1990-06-01 1991-05-30 Pharmacologically active CNS compounds. ZA914165B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB909012316A GB9012316D0 (en)	1990-06-01	1990-06-01	Pharmacologically active cns compounds

Publications (1)

Publication Number	Publication Date
ZA914165B true ZA914165B (en)	1993-03-01

Family

ID=10676964

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA914165A ZA914165B (en)	1990-06-01	1991-05-30	Pharmacologically active CNS compounds.

Country Status (25)

Country	Link
EP (2)	EP0679645A1 (cs)
JP (1)	JPH06340634A (cs)
KR (1)	KR920000733A (cs)
AT (1)	ATE141263T1 (cs)
AU (2)	AU652753B2 (cs)
CA (1)	CA2043640A1 (cs)
CZ (1)	CZ281070B6 (cs)
DE (1)	DE69121317T2 (cs)
DK (1)	DK0459819T3 (cs)
ES (1)	ES2093078T3 (cs)
FI (1)	FI912623A7 (cs)
GB (1)	GB9012316D0 (cs)
GR (1)	GR3021237T3 (cs)
HU (2)	HUT58707A (cs)
IE (1)	IE911861A1 (cs)
IL (2)	IL113599A (cs)
MY (2)	MY136248A (cs)
NO (1)	NO180375C (cs)
NZ (3)	NZ238360A (cs)
PL (2)	PL166656B1 (cs)
PT (1)	PT97827B (cs)
RU (1)	RU2091374C1 (cs)
SK (1)	SK278444B6 (cs)
TW (1)	TW224460B (cs)
ZA (1)	ZA914165B (cs)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI895821A7 (fi) *	1988-12-07	1990-06-08	The Wellcome Foundation Ltd	Farmaseuttisesti aktivisia CNS-yhdisteitä
US5629016A (en) *	1991-01-30	1997-05-13	Glaxo Wellcome Inc.	Water-dispersible tablets
ES2089498T3 (es) *	1991-01-30	1996-10-01	Wellcome Found	Comprimidos dispersables en agua.
GB9215908D0 (en) *	1992-07-27	1992-09-09	Wellcome Found	Water dispersible tablets
AU5704594A (en) *	1992-12-18	1994-07-19	Wellcome Foundation Limited, The	Pyrimidine, pyridine, pteridinone and indazole derivatives as enzyme inhibitors
GB9226377D0 (en) *	1992-12-18	1993-02-10	Babbedge Rachel C	Pharmaceutical compositions
US5698226A (en) *	1993-07-13	1997-12-16	Glaxo Wellcome Inc.	Water-dispersible tablets
GB9319341D0 (en) *	1993-09-17	1993-11-03	Wellcome Found	Novel process
FR2741879A1 (fr) *	1995-12-05	1997-06-06	Esteve Labor Dr	Derives de fluorophenyl-triazines et pyrimidines, leur preparation et leur application en tant que medicament
US6440965B1 (en)	1997-10-15	2002-08-27	Krenitsky Pharmaceuticals, Inc.	Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system
DE19751949A1 (de) *	1997-11-24	1999-05-27	Bayer Ag	Verwendung von substituierten Aminomethyl-Chromanen zur Verhinderung der neuronalen Degeneration und zur Förderung der neuronalen Regeneration
GB9726987D0 (en)	1997-12-22	1998-02-18	Glaxo Group Ltd	Compounds
US6583148B1 (en)	1999-04-08	2003-06-24	Krenitsky Pharmaceuticals, Inc.	Neurotrophic substituted pyrimidines
DE19918325A1 (de)	1999-04-22	2000-10-26	Euro Celtique Sa	Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion
TR200200701T2 (tr)	1999-09-16	2002-06-21	Tanabe Seiyaku Co., Ltd.	Altı-elementli aromatik nitrojenli halka bileşimleri.
HRP20020673A2 (en) *	2000-02-25	2004-12-31	Hoffmann La Roche	Adenosine receptor modulators
WO2001083460A1 (en)	2000-04-28	2001-11-08	Tanabe Seiyaku Co., Ltd.	Cyclic compounds
US7273868B2 (en)	2000-04-28	2007-09-25	Tanabe Seiyaku Co., Ltd.	Pyrazine derivatives
DE60142236D1 (de) *	2000-07-24	2010-07-08	Krenitsky Pharmaceuticals Inc	Substituierte 5-alkinyl-pyrimidine mit neurotropher wirkung
MXPA03007623A (es)	2001-02-26	2003-12-04	Tanabe Seiyaku Co	Derivado de piridopirimidina o naftiridina.
EP1474401A2 (en) *	2002-02-05	2004-11-10	Novo Nordisk A/S	Novel aryl- and heteroarylpiperazines
TW200637556A (en) *	2005-01-31	2006-11-01	Basf Ag	Substituted 5-phenyl pyrimidines I in therapy
JP5121707B2 (ja)	2005-07-04	2013-01-16	ハイポイントファーマシューティカルズ，エルエルシー	新規医薬
JP2009537596A (ja)	2006-05-23	2009-10-29	ハイポイントファーマシューティカルズ，リミティドライアビリティカンパニー	６−（４−シクロプロピルピペリジン−１−イル）−２’−メチル−［３，４’］−ビピリジン及びその医薬としての使用
SI2079732T1 (sl)	2006-05-29	2012-03-30	High Point Pharmaceuticals Llc	benzodioksol il ciklopropilpiperazin il piridazin njegove soli in solvati in njegova uporaba kot antagonist histaminskega receptorja H
EP2014656A3 (en)	2007-06-11	2011-08-24	High Point Pharmaceuticals, LLC	New heteocyclic h3 antagonists
ES2923760T3 (es)	2011-06-10	2022-09-30	Merck Patent Gmbh	Composiciones y métodos para la producción de compuestos de pirimidina y piridina con actividad inhibidora de BTK
JP6523303B2 (ja)	2014-01-17	2019-05-29	ノバルティスアーゲー	Ｓｈｐ２の活性を阻害するための１−ピリダジン／トリアジン−３−イル−ピペラジン／ピペリジン／ピロリジン誘導体およびその組成物
JO3517B1 (ar)	2014-01-17	2020-07-05	Novartis Ag	ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2
RU2021106500A (ru)	2016-06-14	2021-04-16	Новартис Аг	Соединения и композиции для подавления активности shp2
AU2018207464B2 (en)	2017-01-10	2020-05-14	Novartis Ag	Pharmaceutical combination comprising an ALK inhibitor and a SHP2 inhibitor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE518622A (cs) *
FI895821A7 (fi) *	1988-12-07	1990-06-08	The Wellcome Foundation Ltd	Farmaseuttisesti aktivisia CNS-yhdisteitä
US5136080A (en) *	1989-12-04	1992-08-04	Burroughs Wellcome Co.	Nitrile compounds

1990
- 1990-06-01 GB GB909012316A patent/GB9012316D0/en active Pending
1991
- 1991-05-30 ZA ZA914165A patent/ZA914165B/xx unknown
- 1991-05-31 MY MYPI95001459A patent/MY136248A/en unknown
- 1991-05-31 CA CA002043640A patent/CA2043640A1/en not_active Abandoned
- 1991-05-31 TW TW080104285A patent/TW224460B/zh active
- 1991-05-31 SK SK1643-91A patent/SK278444B6/sk unknown
- 1991-05-31 KR KR1019910009010A patent/KR920000733A/ko not_active Ceased
- 1991-05-31 AT AT91304935T patent/ATE141263T1/de not_active IP Right Cessation
- 1991-05-31 DK DK91304935.9T patent/DK0459819T3/da active
- 1991-05-31 ES ES91304935T patent/ES2093078T3/es not_active Expired - Lifetime
- 1991-05-31 HU HU911826A patent/HUT58707A/hu unknown
- 1991-05-31 NO NO912100A patent/NO180375C/no unknown
- 1991-05-31 IE IE186191A patent/IE911861A1/en unknown
- 1991-05-31 AU AU78097/91A patent/AU652753B2/en not_active Ceased
- 1991-05-31 FI FI912623A patent/FI912623A7/fi not_active Application Discontinuation
- 1991-05-31 DE DE69121317T patent/DE69121317T2/de not_active Expired - Fee Related
- 1991-05-31 NZ NZ238360A patent/NZ238360A/en unknown
- 1991-05-31 IL IL113599A patent/IL113599A/xx not_active IP Right Cessation
- 1991-05-31 PL PL91290496A patent/PL166656B1/pl unknown
- 1991-05-31 CZ CS911643A patent/CZ281070B6/cs unknown
- 1991-05-31 NZ NZ272001A patent/NZ272001A/en unknown
- 1991-05-31 IL IL9833091A patent/IL98330A/en active IP Right Grant
- 1991-05-31 MY MYPI91000962A patent/MY109958A/en unknown
- 1991-05-31 PT PT97827A patent/PT97827B/pt not_active IP Right Cessation
- 1991-05-31 EP EP95111314A patent/EP0679645A1/en not_active Withdrawn
- 1991-05-31 NZ NZ248501A patent/NZ248501A/en unknown
- 1991-05-31 RU SU914895583A patent/RU2091374C1/ru active
- 1991-05-31 JP JP3235334A patent/JPH06340634A/ja active Pending
- 1991-05-31 PL PL91305331A patent/PL170373B1/pl unknown
- 1991-05-31 EP EP91304935A patent/EP0459819B1/en not_active Expired - Lifetime
1994
- 1994-07-13 AU AU67455/94A patent/AU680252B2/en not_active Expired - Fee Related
1995
- 1995-06-30 HU HU95P/P00669P patent/HU211649A9/hu unknown
1996
- 1996-10-03 GR GR960402585T patent/GR3021237T3/el unknown

Also Published As

Publication number	Publication date
AU680252B2 (en)	1997-07-24
DK0459819T3 (da)	1996-09-02
PT97827B (pt)	1998-10-30
IL98330A (en)	1996-10-31
GR3021237T3 (en)	1997-01-31
PL170373B1 (pl)	1996-12-31
PL166656B1 (pl)	1995-06-30
RU2091374C1 (ru)	1997-09-27
ES2093078T3 (es)	1996-12-16
PT97827A (pt)	1992-03-31
FI912623A0 (fi)	1991-05-31
EP0459819A2 (en)	1991-12-04
AU6745594A (en)	1994-09-15
AU7809791A (en)	1991-12-05
CA2043640A1 (en)	1991-12-02
ATE141263T1 (de)	1996-08-15
EP0459819A3 (en)	1992-03-11
KR920000733A (ko)	1992-01-29
IL98330A0 (en)	1992-06-21
JPH06340634A (ja)	1994-12-13
TW224460B (cs)	1994-06-01
HU211649A9 (en)	1995-12-28
MY109958A (en)	1997-10-31
IE911861A1 (en)	1991-12-04
NZ238360A (en)	1997-03-24
NZ272001A (en)	1997-03-24
EP0459819B1 (en)	1996-08-14
HU911826D0 (en)	1991-12-30
EP0679645A1 (en)	1995-11-02
DE69121317D1 (de)	1996-09-19
NO912100L (no)	1991-12-02
CS164391A3 (en)	1992-02-19
IL113599A (en)	1997-09-30
AU652753B2 (en)	1994-09-08
NZ248501A (en)	1997-03-24
SK278444B6 (en)	1997-05-07
FI912623A7 (fi)	1991-12-02
NO180375B (no)	1996-12-30
CZ281070B6 (cs)	1996-06-12
DE69121317T2 (de)	1997-01-02
GB9012316D0 (en)	1990-07-18
IL113599A0 (en)	1995-08-31
NO912100D0 (no)	1991-05-31
HUT58707A (en)	1992-03-30
NO180375C (no)	1997-04-09
MY136248A (en)	2008-08-29

Publication	Publication Date	Title
EP0459819A3 (en)	1992-03-11	Pharmacologically active cns compounds
FI89709B (fi)	1993-07-30	Foerfarande foer framstaellning av terapeutiskt anvaendbara arylderivat
HUP9901113A1 (hu)	1999-07-28	Herbicid hatású és növényi növekedést szabályozó hatású 2-amino-4-biciklo-amino-1,3,5-triazinok
HUT59562A (en)	1992-06-29	Cys-carboxamide derivatives, process for producing them and herbicide compositions containing them
HU896723D0 (en)	1990-03-28	Process for preparation of guanidine-derivatives and insecticid compositions comprising these compounds as active ingredient
EP0324387A3 (en)	1990-06-13	Composition for treatment of ischemic disorder in organs
HUT54667A (en)	1991-03-28	Process for producing alkyl-substituted piperazine derivatives and pharmaceutical compositions containing them
IL86462A (en)	1992-12-01	Alkanesulfonanilide derivatives, processes for preparation thereof and pharmaceutical compositions comprising the same
ES8708136A1 (es)	1987-09-16	Procedimiento para la obtencion de derivados de acido barbiturico
MY109714A (en)	1997-04-30	Process for preparing 8-chloroquinolone derivatives
ATE205209T1 (de)	2001-09-15	Chinolincarbonsäurederivate und ihre salze
ZA882374B (en)	1989-03-29	Biologically active compounds
ES8608500A1 (es)	1986-06-16	Un procedimiento para preparar nuevas 1,2,4-tiadiazinas
HU9600597D0 (en)	1996-05-28	4-alkylthio-pyrimidin-5-yl acetic acid derivates and fungicidal compositions containing them as an active ingredient
NO954109L (no)	1991-12-02	Analogifremgangsmåte for fremstilling av terapeutisk aktive substituerte 5-arylpyrimidiner
MY104630A (en)	1994-04-30	4(1h) ouinoline derivatives
DE3464053D1 (en)	1987-07-09	Pyrazine compounds, their preparation and their use, compositions containing them and method of combating undesired plant growth