ZA914830B - Novel,protracted insulin analogues - Google Patents

Novel,protracted insulin analogues

Info

Publication number: ZA914830B
Authority: ZA; South Africa
Prior art keywords: novel; insulin analogues; protracted insulin; protracted; analogues
Prior art date: 1990-06-28

Application number

ZA914830A

Other languages

English (en)

Inventor

Jan Markussen

Markussen Jan

Liselotte Langkjaer

Langkjaer Liselotte

Kjeld Norris

Norris Kjeld

Leo Boye Snel

Boye Snel Leo

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-28

Filing date

1991-06-24

Publication date

1992-03-25

1991-06-24 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1992-03-25 Publication of ZA914830B publication Critical patent/ZA914830B/xx

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Endocrinology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Toxicology (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicinal Preparation (AREA)

ZA914830A 1990-06-28 1991-06-24 Novel,protracted insulin analogues ZA914830B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK155690A DK155690D0 (da)	1990-06-28	1990-06-28	Nye peptider

Publications (1)

Publication Number	Publication Date
ZA914830B true ZA914830B (en)	1992-03-25

Family

ID=8106031

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA914830A ZA914830B (en)	1990-06-28	1991-06-24	Novel,protracted insulin analogues

Country Status (10)

Country	Link
EP (1)	EP0536245A1 (da)
JP (1)	JPH05508406A (da)
AU (1)	AU8054391A (da)
DK (1)	DK155690D0 (da)
IE (1)	IE912247A1 (da)
IL (1)	IL98596A0 (da)
NZ (1)	NZ238718A (da)
PT (1)	PT98124A (da)
WO (1)	WO1992000321A1 (da)
ZA (1)	ZA914830B (da)

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US7638618B2 (en)	2001-02-20	2009-12-29	Sanofi-Aventis Deutschland Gmbh	Nucleic acids encoding a hirudin and pro-insulin as superscretable peptides and for parallel improvement of the exported forms of one or more polypeptides of interest
US7202059B2 (en)	2001-02-20	2007-04-10	Sanofi-Aventis Deutschland Gmbh	Fusion proteins capable of being secreted into a fermentation medium
DE10114178A1 (de)	2001-03-23	2002-10-10	Aventis Pharma Gmbh	Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
DE10227232A1 (de)	2002-06-18	2004-01-15	Aventis Pharma Deutschland Gmbh	Saure Insulinzubereitungen mit verbesserter Stabilität
ES2642214T3 (es)	2004-01-21	2017-11-15	Novo Nordisk Health Care Ag	Conjugación de péptidos mediante transglutaminasa
CN101573133B (zh)	2006-07-31	2014-08-27	诺沃-诺迪斯克有限公司	Peg化延长的胰岛素
RU2524150C2 (ru)	2006-09-22	2014-07-27	Ново Нордиск А/С	Аналоги инсулина, устойчивые к протеазам
JP5496082B2 (ja)	2007-04-30	2014-05-21	ノボ・ノルデイスク・エー／エス	タンパク質組成物を乾燥させる方法、乾燥タンパク質組成物、及び乾燥タンパク質を含有する薬学的組成物
MY152979A (en)	2008-01-09	2014-12-15	Sanofi Aventis Deutschland	Novel insulin derivatives having an extremely delayed time-action profile
WO2009112583A2 (en)	2008-03-14	2009-09-17	Novo Nordisk A/S	Protease-stabilized insulin analogues
HUE032284T2 (en)	2008-03-18	2017-09-28	Novo Nordisk As	Protease-stabilized, acylated insulin analogues
RS59913B1 (sr)	2008-10-17	2020-03-31	Sanofi Aventis Deutschland	Kombinacija insulina i glp-1-agonista
DE102008053048A1 (de)	2008-10-24	2010-04-29	Sanofi-Aventis Deutschland Gmbh	Kombination von einem Insulin und einem GLP-1-Agonisten
DE102009038210A1 (de)	2009-08-20	2011-03-03	Sanofi-Aventis Deutschland Gmbh	Kombination von einem Insulin und einem GLP-1-Agonisten
DE102008051834A1 (de)	2008-10-17	2010-04-22	Sanofi-Aventis Deutschland Gmbh	Kombination von einem Insulin und einem GLP-1-Agonisten
DE102008064270A1 (de) *	2008-12-20	2010-07-01	Voith Patent Gmbh	Verfahren und Vorrichtung zur Flotation einer wässrigen Faserstoffsuspension
US20120241356A1 (en)	2009-07-06	2012-09-27	Sanofi-Aventis Deutschland Gmbh	Heat- and vibration-stable insulin preparations
CN102596175A (zh)	2009-07-06	2012-07-18	赛诺菲-安万特德国有限公司	含有甲硫氨酸的水性胰岛素制备物
JP5675799B2 (ja)	2009-07-06	2015-02-25	サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング	遅効性インスリン製剤
US9138462B2 (en)	2009-07-31	2015-09-22	Sanofi-Aventis Deutschland Gmbh	Prodrugs comprising an insulin linker conjugate
NZ597964A (en)	2009-07-31	2014-04-30	Sanofi Aventis Deutschland	Long acting insulin composition
MY180661A (en)	2009-11-13	2020-12-04	Sanofi Aventis Deutschland	Pharmaceutical composition comprising a glp-1 agonist, an insulin and methionine
PT3345593T (pt)	2009-11-13	2023-11-27	Sanofi Aventis Deutschland	Composição farmacêutica compreendendo despro36exendina- 4(1-39)-lys6-nh2 e metionina
JP5973427B2 (ja) *	2010-06-23	2016-08-23	ノヴォノルディスクアー／エス	追加のジスルフィド結合を含有するインスリン類似体
WO2011161083A1 (en) *	2010-06-23	2011-12-29	Novo Nordisk A/S	Human insulin containing additional disulfide bonds
KR20130036290A (ko) *	2010-06-23	2013-04-11	노보 노르디스크 에이/에스	추가 이황화 결합을 함유하는 인슐린 유도체
PL2611458T3 (pl)	2010-08-30	2017-02-28	Sanofi-Aventis Deutschland Gmbh	Zastosowanie AVE0010 do produkcji leku do leczenia cukrzycy typu 2
EP2438930A1 (en)	2010-09-17	2012-04-11	Sanofi-Aventis Deutschland GmbH	Prodrugs comprising an exendin linker conjugate
JP2014509603A (ja) *	2011-03-15	2014-04-21	ノヴォノルディスクアー／エス	システイン置換を含むヒトインスリン類似体およびヒトインスリン誘導体
US9821032B2 (en)	2011-05-13	2017-11-21	Sanofi-Aventis Deutschland Gmbh	Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
AR087693A1 (es)	2011-08-29	2014-04-09	Sanofi Aventis Deutschland	Combinacion farmaceutica para uso en el control glucemico en pacientes con diabetes de tipo 2
TWI559929B (en)	2011-09-01	2016-12-01	Sanofi Aventis Deutschland	Pharmaceutical composition for use in the treatment of a neurodegenerative disease
WO2014096985A2 (en)	2012-12-19	2014-06-26	Wockhardt Limited	A stable aqueous composition comprising human insulin or an analogue or derivative thereof
CN104364260B (zh)	2012-04-11	2017-02-22	诺和诺德股份有限公司	胰岛素制剂
US20130315891A1 (en)	2012-05-25	2013-11-28	Matthew Charles	Formulations of human tissue kallikrein-1 for parenteral delivery and related methods
US20130323222A1 (en)	2012-06-04	2013-12-05	Matthew Charles	Human tissue kallikrein 1 glycosylation isoforms
MX2015006997A (es)	2012-12-26	2015-09-23	Wockhardt Ltd	Composicion farmaceutica.
TWI780236B (zh)	2013-02-04	2022-10-11	法商賽諾菲公司	胰島素類似物及/或胰島素衍生物之穩定化醫藥調配物
AU2014326181A1 (en)	2013-09-30	2016-03-17	Wockhardt Limited	Pharmaceutical composition
JP6499184B2 (ja)	2013-10-07	2019-04-10	ノヴォノルディスクアー／エス	インスリン類似体の新規な誘導体
BR112016015851A2 (pt)	2014-01-09	2017-08-08	Sanofi Sa	Formulações farmacêuticas estabilizadas de insulina aspart
MX2016008979A (es)	2014-01-09	2016-10-04	Sanofi Sa	Formulaciones farmaceuticas estabilizadas de analogos de insulina y/o derivados de insulina.
MX2016008978A (es)	2014-01-09	2016-10-04	Sanofi Sa	Formulaciones farmaceuticas de analogos de insulina y/o derivados de insulina estabilizadas y que estan libres de glicerol.
WO2016001862A1 (en)	2014-07-04	2016-01-07	Wockhardt Limited	Extended release formulations of insulins
EP3229828B1 (en)	2014-12-12	2023-04-05	Sanofi-Aventis Deutschland GmbH	Insulin glargine/lixisenatide fixed ratio formulation
TWI748945B (zh)	2015-03-13	2021-12-11	德商賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患治療
TW201705975A (zh)	2015-03-18	2017-02-16	賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患之治療
PE20210857A1 (es)	2016-12-16	2021-05-18	Novo Nordisk As	Composiciones farmaceuticas que contienen insulina
AU2018230478B2 (en)	2017-03-09	2025-01-23	Diamedica Inc.	Dosage forms of tissue kallikrein 1
US10919949B2 (en)	2017-08-17	2021-02-16	Novo Nordisk A/S	Acylated insulin analogues and uses thereof
CN109646396A (zh) *	2018-12-29	2019-04-19	江苏万邦医药科技有限公司	一种稳定的胰岛素类似物注射液及其制备方法

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DE2536040A1 (de) *	1975-08-13	1977-02-24	Hoechst Ag	Insulin-analoga mit biologischer wirkung
PH25772A (en) *	1985-08-30	1991-10-18	Novo Industri As	Insulin analogues, process for their preparation
DK257988D0 (da) *	1988-05-11	1988-05-11	Novo Industri As	Nye peptider
HUT56857A (en) *	1988-12-23	1991-10-28	Novo Nordisk As	Human insulin analogues

1990
- 1990-06-28 DK DK155690A patent/DK155690D0/da not_active IP Right Cessation
1991
- 1991-06-21 AU AU80543/91A patent/AU8054391A/en not_active Abandoned
- 1991-06-21 EP EP91912264A patent/EP0536245A1/en not_active Withdrawn
- 1991-06-21 WO PCT/DK1991/000167 patent/WO1992000321A1/en not_active Ceased
- 1991-06-21 JP JP3511335A patent/JPH05508406A/ja active Pending
- 1991-06-24 ZA ZA914830A patent/ZA914830B/xx unknown
- 1991-06-24 IL IL98596A patent/IL98596A0/xx unknown
- 1991-06-26 NZ NZ238718A patent/NZ238718A/en unknown
- 1991-06-27 IE IE224791A patent/IE912247A1/en unknown
- 1991-06-27 PT PT98124A patent/PT98124A/pt not_active Application Discontinuation

Also Published As

Publication number	Publication date
EP0536245A1 (en)	1993-04-14
IE912247A1 (en)	1992-01-01
PT98124A (pt)	1992-04-30
WO1992000321A1 (en)	1992-01-09
IL98596A0 (en)	1992-07-15
AU8054391A (en)	1992-01-23
JPH05508406A (ja)	1993-11-25
NZ238718A (en)	1992-06-25
DK155690D0 (da)	1990-06-28

Publication	Publication Date	Title
ZA914830B (en)	1992-03-25	Novel,protracted insulin analogues
HU9200302D0 (en)	1992-04-28	1,3-oxatiolane-nucleotide analogues
ZA893508B (en)	1990-01-31	Insulin analogues
DE58901334D1 (en)	1992-06-11	Difluorbenzolderivate.
DE58900568D1 (en)	1992-01-30	Duennschichtsolarzellenanordnung.
DE58904529D1 (en)	1993-07-01	Thermostatisiergeraet.
DE68900557D1 (en)	1992-01-30	Foerderer.
DE68901042D1 (en)	1992-04-30	Phosphitamin-schmieroeladditive.
DE68905877D1 (en)	1993-05-13	Tuerspiegelaufbau.
DE69002642D1 (en)	1993-09-16	Flexible tampondruckmaschine.
DE58902248D1 (en)	1992-10-15	Buegeleisensohle.
DE58903464D1 (en)	1993-03-18	Chemosensitiver wandler.
DE68902332D1 (en)	1992-09-10	Oelabscheider.
DE68902898D1 (en)	1992-10-22	Ballhebemechanismus.
DE58905558D1 (en)	1993-10-14	Whirlpool-düse.
DE58904098D1 (en)	1993-05-27	N-aryltetrahydrophthalimidverbindungen.
DE68900005D1 (en)	1990-08-23	Tank-container.
DE58904923D1 (en)	1993-08-19	Fluegelzellenverdichter.
DE58902743D1 (en)	1992-12-24	Substituierte n-aryl-stickstoffheterocyclen.
ZA898608B (en)	1990-11-28	14alpha,17alpha-ethanoestratrienes
DE58902660D1 (en)	1992-12-17	Substituierte thiadiazolyloxyessigsaeureamide.
DE58902926D1 (en)	1993-01-21	Isothiazolazofarbstoffe.
DE68901326D1 (en)	1992-05-27	Brueckenlegefahrzeug.
DE68906693D1 (en)	1993-07-01	Fluegelzellenpumpe.
DE58900642D1 (en)	1992-02-13	Tuerschliesser.